Reduced number of unmyelinated sensory axons in peripherin null mice.

abstract：:Neuronal nicotinic acetylcholine receptors labelled with tritiated agonists are reduced in the cerebral cortex in Alzheimer's disease (AD), but to date it has not been demonstrated which nicotinic receptor subunits contribute to this deficit. In the present study, autopsy tissue from the temporal cortex of 14 AD cases...

journal_title：Journal of neurochemistry

authors： Martin-Ruiz CM,Court JA,Molnar E,Lee M,Gotti C,Mamalaki A,Tsouloufis T,Tzartos S,Ballard C,Perry RH,Perry EK

更新日期：1999-10-01 00:00:00

abstract：:We addressed the balance between thrombin and its serpin protease nexin I (PNI) after sciatic nerve injury in the mouse. Prothrombin levels increased twofold 24 h after nerve crush, as measured by a specific chromogenic assay, and peaked at day 3. Thrombin activity also increased 2-4 days after injury in distal sciati...

journal_title：Journal of neurochemistry

authors： Smirnova IV,Ma JY,Citron BA,Ratzlaff KT,Gregory EJ,Akaaboune M,Festoff BW

更新日期：1996-11-01 00:00:00

abstract：:High-affinity binding sites for [3H]PK 11195 and [3H]Ro 5-4864 with the properties of the peripheral-type benzodiazepine receptor were detected in primary cultures of both mouse neocortical and cerebellar astrocytes. The binding sites were enriched in mitochondrial fractions on differential centrifugation. An 18-kDa p...

journal_title：Journal of neurochemistry

authors： Moynagh PN,Schousboe A,Williams DC

更新日期：1994-02-01 00:00:00

abstract：:Among bone morphogenetic proteins (BMPs), the decapentaplegic (Dpp; BMP2, BMP4) and glass bottom boat (Gbb/60A; BMP5, BMP6, BMP7) subgroups have well-described functions guiding autonomic and sensory neuronal development, fiber formation and neurophenotypic identities. Evaluation of rat superior cervical ganglia (SCG)...

journal_title：Journal of neurochemistry

authors： Pavelock KA,Girard BM,Schutz KC,Braas KM,May V

更新日期：2007-02-01 00:00:00

abstract：:Compound AF64A, ethylcholine mustard aziridinium ion (0.4-8 nmol) was stereotaxically administered into rat dorsal hippocampus, and neurochemical changes were determined 5 days later. AF64A treatment, over an almost 10-fold dose range, resulted in a significant (up to 70%) decline in choline acetyltransferase activity...

journal_title：Journal of neurochemistry

authors： Mantione CR,Zigmond MJ,Fisher A,Hanin I

更新日期：1983-07-01 00:00:00

abstract：:Wallerian degeneration in peripheral nerves occurs after a traumatic insult when the distal nerve part degenerates while peripheral macrophages enter the nerve stump and remove the accruing debris by phagozytosis. We used an experimental model to investigate the effect of either the absence or over-expression of alpha...

journal_title：Journal of neurochemistry

authors： Siebert H,Kahle PJ,Kramer ML,Isik T,Schlüter OM,Schulz-Schaeffer WJ,Brück W

更新日期：2010-08-01 00:00:00

abstract：:Activation of microglia, the resident macrophages of the brain, around the amyloid plaques is a key hallmark of Alzheimer's disease (AD). Recent evidence in mouse models indicates that microglia are required for the neurodegenerative process of AD. Amyloid-β (Aβ) peptides, the core components of the amyloid plaques, c...

journal_title：Journal of neurochemistry

authors： Capiralla H,Vingtdeux V,Zhao H,Sankowski R,Al-Abed Y,Davies P,Marambaud P

更新日期：2012-02-01 00:00:00

abstract：:Ischemic stroke is a neurovascular disease treatable by thrombolytic therapy, but the therapy has to be initiated within 3 h of the incident. This therapeutic limitation stems from the secondary injury which results mainly from oxidative stress and inflammation. A potent antioxidant/anti-inflammatory agent, caffeic ac...

journal_title：Journal of neurochemistry

authors： Khan M,Elango C,Ansari MA,Singh I,Singh AK

更新日期：2007-07-01 00:00:00

abstract：:Binding of tetanus toxin to rat brain membranes was of lower affinity and capacity when binding was determined in 150 mM NaCl, 50 mM Tris-HCl (pH 7.4) than in 25 mM Tris-acetate (pH 6.0). Binding under both conditions was reduced by treating the membranes with neuraminidase. Pronase treatment, however, reduced toxin b...

journal_title：Journal of neurochemistry

authors： Critchley DR,Habig WH,Fishman PH

更新日期：1986-07-01 00:00:00

abstract：:Effective drugs are not available to protect against beta-amyloid peptide (A beta)-induced neurotoxicity. Cortical neurons from rat embryos were treated with the toxic fragment A beta25-35 at 1 microM in the presence or absence of flupirtine, a triaminopyridine, successfully applied clinically as a nonopiate analgesic...

journal_title：Journal of neurochemistry

authors： Müller WE,Romero FJ,Perovic S,Pergande G,Pialoglou P

更新日期：1997-06-01 00:00:00

abstract：:Spinal cord injury (SCI) elicits a neuroinflammatory reaction dominated by microglia and monocyte-derived macrophages (MDM). Because MDM do not infiltrate the spinal cord until days after injury, it may be possible to control whether they differentiate into neuroprotective or neurotoxic effector cells. However, doing ...

journal_title：Journal of neurochemistry

authors： Longbrake EE,Lai W,Ankeny DP,Popovich PG

更新日期：2007-08-01 00:00:00

abstract：:The sodium-coupled, hemicholinium-3-sensitive, high-affinity choline transporter (CHT) is responsible for transport of choline into cholinergic nerve terminals from the synaptic cleft following acetylcholine release and hydrolysis. In this study, we address regulation of CHT function by plasma membrane cholesterol. We...

journal_title：Journal of neurochemistry

authors： Cuddy LK,Winick-Ng W,Rylett RJ

更新日期：2014-03-01 00:00:00

abstract：:In vivo microdialysis was used to determine whether the 3,4-methylenedioxymethamphetamine (MDMA)-induced release of serotonin (5-HT) in vivo involves a carrier-mediated process and to investigate further the state-dependent interaction between 5-HT and dopamine. MDMA produced a dose-dependent increase in the extracell...

journal_title：Journal of neurochemistry

authors： Gudelsky GA,Nash JF

更新日期：1996-01-01 00:00:00

abstract：:A reporter epitope was inserted at 11 positions in a region encompassing proposed transmembrane segments S1 and S2 in the second repeat domain (D2) of the rat skeletal muscle type 1 sodium channel. All mutations produced full-length membrane-associated protein following transfection into cultured cells, although the l...

journal_title：Journal of neurochemistry

authors： Kraner SD,Filatov GN,Sun W,Bannerman P,Lindstrom J,Barchi RL

更新日期：1998-04-01 00:00:00

abstract：:As an initial step to study the function of the gene encoding the human neuropeptide FF (NPFF), we cloned a 4.7-kb sequence from the promoter region. Primer extension and 5'-rapid amplification of cDNA ends revealed multiple transcription initiation sites. Northern blot analysis of the mRNA expression revealed a speci...

journal_title：Journal of neurochemistry

authors： Nystedt JM,Brandt AM,Mandelin J,Vilim FS,Ziff EB,Panula P

更新日期：2002-09-01 00:00:00

abstract：:Rat brain succinyl-CoA:3-oxo-acid CoA-transferase (3-oxo-acid CoA-transferase, EC 2.8.3.5), the first committed enzyme in the oxidation of ketone bodies in mitochondria, was purified to apparent homogeneity as judged by polyacrylamide gel electrophoresis. The enzyme has an apparent molecular weight of 90,000 as determ...

journal_title：Journal of neurochemistry

authors： Russell JJ,Patel MS

更新日期：1982-05-01 00:00:00

abstract：:Ischemic stress in the brain induces acute and massive neuronal death in the targeted area, which is followed by a second round of detrimental processes, called delayed neuronal death, in the neighboring areas. To test the hypothesis that transcriptional control plays a role in the pathophysiology of the postischemic ...

journal_title：Journal of neurochemistry

authors： Kim JB,Piao CS,Lee KW,Han PL,Ahn JI,Lee YS,Lee JK

更新日期：2004-06-01 00:00:00

abstract：:Prospective studies in humans and experimental investigations in animals have correlated elevated perinatal blood lead levels with enduring behavioural and cognitive perturbations. Although deficits in neuroplastic events necessary for long-term memory consolidation have been observed during the postnatal period, ther...

journal_title：Journal of neurochemistry

authors： Murphy KJ,Regan CM

更新日期：1999-05-01 00:00:00

abstract：:Oligodendroglial cell death in the myelin proteolipid protein (PLP) mutants can be partially rescued by the environment factor(s) supplied by the wild-type cells in vivo and in vitro. It is possible that the presence of PLP or DM-20 results in secretion of a factor or factors in the CNS influencing oligodendrocyte dev...

journal_title：Journal of neurochemistry

authors： Nakao J,Yamada M,Kagawa T,Kim SU,Miyao Y,Shimizu K,Mikoshiba K,Ikenaka K

更新日期：1995-06-01 00:00:00

abstract：:Neuroactive steroid family includes molecules synthesized in peripheral glands (i.e., hormonal steroids) and directly in the nervous system (i.e., neurosteroids) which are key regulators of the nervous function. As already reported in clinical and experimental studies, neurodegenerative diseases affect the levels of n...

journal_title：Journal of neurochemistry

authors： Caruso D,Melis M,Fenu G,Giatti S,Romano S,Grimoldi M,Crippa D,Marrosu MG,Cavaletti G,Melcangi RC

更新日期：2014-08-01 00:00:00

abstract：:Voltage-gated sodium channels (VGSC) are involved in the generation of action potentials in neurons. Brevetoxins (PbTx) are potent allosteric enhancers of VGSC function and are associated with the periodic 'red tide' blooms. Using PbTx-2 as a probe, we have characterized the effects of activation of VGSC on Ca(2+) dyn...

journal_title：Journal of neurochemistry

authors： Dravid SM,Baden DG,Murray TF

更新日期：2004-05-01 00:00:00

abstract：:Muscarinic receptors mediate metabotropic actions of acetylcholine in the CNS and PNS and autocrine functions of acetylcholine in non-neuronal systems. Because of the lack of highly selective muscarinic ligands, the precise location, functional role, and roles in various diseases of the five muscarinic receptor subtyp...

journal_title：Journal of neurochemistry

authors： Servent D,Fruchart-Gaillard C

更新日期：2009-06-01 00:00:00

abstract：:The mechanism of attachment of acetylcholinesterase (AChE) to neuronal membranes in interneuronal synapses is poorly understood. We have isolated, sequenced, and cloned a hydrophobic protein that copurifies with AChE from human caudate nucleus and that we propose forms a part of a complex of membrane proteins attached...

journal_title：Journal of neurochemistry

authors： Navaratnam DS,Fernando FS,Priddle JD,Giles K,Clegg SM,Pappin DJ,Craig I,Smith AD

更新日期：2000-05-01 00:00:00

abstract：:A photolabile trifluoromethyldiazoketone derivative of kainate (KA), (2'S,3'S,4'R)-2'-carboxy-4'-(2-diazo-1-oxo-3, 3,3-trifluoropropyl)-3'-pyrrolidinyl acetate (DZKA), was synthesized and evaluated as an irreversible inhibitor of the high-affinity KA site on rat forebrain synaptic plasma membranes (SPMs). In the absen...

journal_title：Journal of neurochemistry

authors： Willis CL,Wacker DA,Bartlett RD,Bleakman D,Lodge D,Chamberlin AR,Bridges RJ

更新日期：1997-04-01 00:00:00

abstract：:We report here that anti-L1 antiserum, raised against material from embryonic brain, and anti-NILE antiserum, raised against purified NILE (nerve growth factor-inducible large external) glycoprotein of PC12 cells, immunoprecipitate from PC12 cells material of the same apparent molecular weight (230 kilodaltons) by sod...

journal_title：Journal of neurochemistry

authors： Sajovic P,Kouvelas E,Trenkner E

更新日期：1986-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative fatal disease. The only drug recognized to increase the survival time is riluzole(RLZ). In animal models, minocycline (MNC) delayed the onset of the disease and increased the survival time (in combination with RLZ). The objective of our work was to study the interac...

journal_title：Journal of neurochemistry

authors： Milane A,Fernandez C,Vautier S,Bensimon G,Meininger V,Farinotti R

更新日期：2007-10-01 00:00:00

abstract：:Myelin basic protein (MBP) dissociated from brain myelin membranes when they were incubated (37 degrees C; pH 7.4) at physiological ionic strength. Zinc ions inhibited, and calcium promoted, this process. Protease activity in the membrane preparations cleaved the dissociated MBP into both small (less than 4 kilodalton...

journal_title：Journal of neurochemistry

authors： Earl C,Chantry A,Mohammad N,Glynn P

更新日期：1988-09-01 00:00:00

abstract：:When cultured astroglia are treated with agents that elevate intracellular cyclic AMP, they become process-bearing stellate cells and resemble differentiated astrocytes in vivo. Thrombin rapidly reversed the stellation induced by dibutyryl cyclic AMP, forskolin, or isoproterenol in cultured rat astrocytes; half-maxima...

journal_title：Journal of neurochemistry

authors： Cavanaugh KP,Gurwitz D,Cunningham DD,Bradshaw RA

更新日期：1990-05-01 00:00:00

abstract：:Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures. The extracellular signal-regulated kinase (ERK) signaling cascade is activated by M(1) mAChR and is elevated during status epi...

journal_title：Journal of neurochemistry

authors： Berkeley JL,Decker MJ,Levey AI

更新日期：2002-07-01 00:00:00

abstract：:We have assessed the expression, molecular identification and functional role of Na+ channels (Na(v)) in carotid bodies (CB) obtained from normoxic and chronically hypoxic adult rats. Veratridine evoked release of catecholamines (CA) from an in vitro preparation of intact CBs obtained from normoxic animals, the respon...

journal_title：Journal of neurochemistry

authors： Caceres AI,Obeso A,Gonzalez C,Rocher A

更新日期：2007-07-01 00:00:00