Ontogenesis of alpha 2-adrenoceptor coupling with GTP-binding proteins in the rat telencephalon.

abstract：:The conversion of protease-sensitive prion protein (PrP-sen) to a high beta-sheet, protease-resistant and often fibrillar form (PrP-res) is a central event in transmissible spongiform encephalopathies (TSE) or prion diseases. This conversion can be induced by PrP-res itself in cell-free conversion reactions. The deter...

journal_title：Journal of neurochemistry

authors： Xiong LW,Raymond LD,Hayes SF,Raymond GJ,Caughey B

更新日期：2001-11-01 00:00:00

abstract：:A comparison of the pharmacological and physiological properties of the metabotropic glutamate 1 alpha and 1 beta receptors (mGluR1 alpha and mGluR1 beta) expressed in baby hamster kidney (BHK 570) cells was performed. The mGluR1 beta receptor is an alternatively spliced form of mGluR1 alpha with a modified carboxy te...

journal_title：Journal of neurochemistry

authors： Pickering DS,Thomsen C,Suzdak PD,Fletcher EJ,Robitaille R,Salter MW,MacDonald JF,Huang XP,Hampson DR

更新日期：1993-07-01 00:00:00

abstract：:Neuropeptide S (NPS) is known to produce anxiolytic-like effects and facilitate extinction of conditioned fear. Catecholaminergic neurotransmission in the medial prefrontal cortex (mPFC) has been suggested to be crucially involved in these brain functions. In the current study, we investigated the effect of NPS on the...

journal_title：Journal of neurochemistry

authors： Si W,Aluisio L,Okamura N,Clark SD,Fraser I,Sutton SW,Bonaventure P,Reinscheid RK

更新日期：2010-10-01 00:00:00

abstract：:The histamine H1 receptor binding capacity of the amygdalas of amygdaloid kindled rats was studied. In the kindled nonstimulated amygdala, significant decreases in K(D) and B(max) values compared with those of control amygdala were found 1 week after the last kindled seizure. One month after the last kindled seizure, ...

journal_title：Journal of neurochemistry

authors： Toyota H,Ito C,Yanai K,Sato M,Watanabe T

更新日期：1999-05-01 00:00:00

abstract：:The structure and function of mitochondrial respiratory-chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH-ubiquinone reductase (Complex I) and NADH cytochro...

journal_title：Journal of neurochemistry

authors： Schapira AH,Cooper JM,Dexter D,Clark JB,Jenner P,Marsden CD

更新日期：1990-03-01 00:00:00

abstract：:Deacetylation of melatonin to 5-methoxytryptamine (5-MT) in vitro and in vivo was investigated in rat liver and brain tissue, using a gas chromatographic--mass spectrometric 5-MT assay method. In vitro incubation of liver but not brain (hypothalamic, Mesencephalic) slices with melatonin led to a concentration-dependen...

journal_title：Journal of neurochemistry

authors： Beck O,Jonsson G

更新日期：1981-06-01 00:00:00

abstract：:Our interest in investigating the presynaptic modulation of acetylcholine release led to the development of a synaptosomal preparation from the guinea pig ileum myenteric plexus-longitudinal muscle. A crude synaptosomal fraction (P2) was obtained by homogenization and differential centrifugation. The preparation exhib...

journal_title：Journal of neurochemistry

authors： Briggs CA,Cooper JR

更新日期：1981-03-01 00:00:00

abstract：:Multiple lines of evidence implicate lysosomes in a variety of pathogenic events that produce neurodegeneration. Genetic mutations that cause specific enzyme deficiencies account for more than 40 lysosomal storage disorders. These mostly pre-adult diseases are associated with abnormal brain development and mental reta...

journal_title：Journal of neurochemistry

authors： Bahr BA,Bendiske J

更新日期：2002-11-01 00:00:00

abstract：:Nitric oxide (NO) is a key neuromodulator of corticostriatal synaptic transmission. We have shown previously that dopamine (DA) D1/5 receptor stimulation facilitates neuronal NO synthase (nNOS) activity in the intact striatum. To study the impact of local manipulations of D1/5 and glutamatergic NMDA receptors on stria...

journal_title：Journal of neurochemistry

authors： Park DJ,West AR

更新日期：2009-12-01 00:00:00

abstract：:Multiple C2 domains transmembrane protein 1 (MCTP1) contains two transmembrane regions and three C2 domains of high Ca(2+)-binding affinity. Single-nucleotide polymorphism (SNP) of human MCTP1 gene is reportedly associated with bipolar disorder, but expression and function of MCTP1 in the CNS is still largely unknown....

journal_title：Journal of neurochemistry

authors： Qiu L,Yu H,Liang F

更新日期：2015-11-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine, is known to be activated by brain derived neurotrophic factor (BDNF). We found that the specific removal of the carbohydrate polysialic acid (PSA) significantly increased BDNF-induced ChAT-activity in embryonic septal neurons. Using a p75 neurotr...

journal_title：Journal of neurochemistry

authors： Burgess A,Aubert I

更新日期：2006-11-01 00:00:00

abstract：:Specific binding of [3H]granisetron was examined to serotonin 5-HT3 receptors in synaptosomal membranes of rat cerebral cortex between 1 and 37 degrees C. Displacing potencies were determined for 5-HT3 antagonists (granisetron, ondansetron, tropisetron, and d-tubocurarine) and agonists (5-hydroxytryptamine, 2-methyl-5...

journal_title：Journal of neurochemistry

authors： Maksay G

更新日期：1996-07-01 00:00:00

abstract：:The thalamic synapses relay peripheral sensory information to the cortex, and constitute an important part of the thalamocortical network that generates oscillatory activities responsible for different vigilance (sleep and wakefulness) states. However, the modulation of thalamic synaptic transmission by potential slee...

journal_title：Journal of neurochemistry

authors： Yang YC,Hu CC,Huang CS,Chou PY

更新日期：2014-03-01 00:00:00

abstract：:Ethanol provides neuroprotection following ischemia/reperfusion. This study assessed ethanol's effect on hyperglycolysis and NADPH oxidase (NOX) activation. Adult, male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h. Three sets of experiments were conducted to determine ethanol's...

journal_title：Journal of neurochemistry

authors： Kochanski R,Peng C,Higashida T,Geng X,Hüttemann M,Guthikonda M,Ding Y

更新日期：2013-07-01 00:00:00

abstract：:Previous studies have indicated that the brains of DBA/2J (D2) mice have a more heavily myelinated CNS than those of C57BL/6J (B6) at postnatal days 17-21. However, the amount of myelin in the brains of F1 (B6 X D2) hybrids is even higher than in their parental strains. To investigate further factors involved in regul...

journal_title：Journal of neurochemistry

authors： Sato C,Yu RK

更新日期：1987-10-01 00:00:00

abstract：:The possibilities of interference by glycerophosphoryl ethanolamine (GPE) in the estimation of taurine levels in cerebral cortex, midbrain, cerebellum, medullapons, and spinal cord of developing human fetal brain regions were eliminated by hydrolyzing tissue extracts with 6 M HCl. Cysteic acid thus produced was separa...

journal_title：Journal of neurochemistry

authors： Datta SC

更新日期：1988-04-01 00:00:00

abstract：:Previously used methods of comparing amperometric spike characteristics from two separate groups of cells have entailed pooling all the values for a spike characteristic from each group of cells and then statistically comparing the two samples. Although this approach has indicated that there are significant difference...

journal_title：Journal of neurochemistry

authors： Colliver TL,Hess EJ,Pothos EN,Sulzer D,Ewing AG

更新日期：2000-03-01 00:00:00

abstract：:The mechanisms of injury-induced apoptosis of neurons within the spinal cord are poorly understood. In this study, we show that spinal cord injury (SCI) induces endoplasmic reticulum stress revealed by the activation of an unbalanced unfolded protein response (UPR). Using a weight-drop contusion model of SCI, the UPR ...

journal_title：Journal of neurochemistry

authors： Penas C,Guzmán MS,Verdú E,Forés J,Navarro X,Casas C

更新日期：2007-08-01 00:00:00

abstract：:Choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, I.U.B. 2.3.1.6) activity and total protein content in visual and extra-visual areas were compared in normal Long-Evans rats and in rats subjected to complete light-deprivation for 21 days from birth. The enzyme activity and the protein content in the ...

journal_title：Journal of neurochemistry

authors： Maletta GJ,Timiras PS

更新日期：1968-08-01 00:00:00

abstract：:Memory performance varies over a 24-h day/night cycle. While the detailed underlying mechanisms are yet unknown, recent evidence suggests that in the mouse hippocampus, rhythmic phosphorylation of mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate response element-binding protein (CREB) are cen...

journal_title：Journal of neurochemistry

authors： Rawashdeh O,Jilg A,Maronde E,Fahrenkrug J,Stehle JH

更新日期：2016-09-01 00:00:00

abstract：:A protein that binds vesamicol has been purified from a soluble fraction of the Torpedo electric organ homogenate that does not contain synaptic vesicles. The purified vesamicol-binding protein (VBP) has a molecular mass of 470 kDa composed of 30- and 24-kDa subunits. Chemical deglycosylation yielded a single, heterog...

journal_title：Journal of neurochemistry

authors： Hicks BW,Rogers GA,Parsons SM

更新日期：1991-08-01 00:00:00

abstract：:N-Copine is a novel protein with two C2 domains. Its expression is brain specific and up-regulated by neuronal activity such as kainate stimulation and tetanus stimulation evoking hippocampal CA1 long-term potentiation. We examined the localization and subcellular distribution of N-copine in mouse brain. In situ hybri...

journal_title：Journal of neurochemistry

authors： Nakayama T,Yaoi T,Kuwajima G

更新日期：1999-01-01 00:00:00

abstract：:The recycling of synaptic vesicles in nerve terminals involves multiple steps, underlies all aspects of synaptic transmission, and is a key to understanding the basis of synaptic plasticity. The development of styryl dyes as fluorescent molecules that label recycling synaptic vesicles has revolutionized the way in whi...

journal_title：Journal of neurochemistry

authors： Cousin MA,Robinson PJ

更新日期：1999-12-01 00:00:00

abstract：:The uptake of glutamate and other acidic amino acids into barnacle single muscle fibres has been characterized. The uptake of glutamate consists of two components, one Na-independent and one Na-dependent. The Na-dependent uptake is saturable (half-maximal at 250 microM external glutamate) and is inhibited by a variety...

journal_title：Journal of neurochemistry

authors： Revest PA,Baker PF

更新日期：1988-01-01 00:00:00

abstract：:We have correlated myelin membrane structure with biochemical composition in the CNS and PNS of a phylogenetic series of animals, including elasmobranchs, teleosts, amphibians, and mammals. X-ray diffraction patterns were recorded from freshly dissected, unfixed tissue and used to determine the thicknesses of the liqu...

journal_title：Journal of neurochemistry

authors： Kirschner DA,Inouye H,Ganser AL,Mann V

更新日期：1989-11-01 00:00:00

abstract：:Beta-amyloid peptides (A beta) are deposited in an aggregated fibrillar form in both diffuse and senile plaques in the brains of patients with Alzheimer's disease. The neurotoxicity of A beta in cultured neurons is dependent on its aggregation state, but the factors contributing to aggregation and fibril formation are...

journal_title：Journal of neurochemistry

authors： Du Y,Bales KR,Dodel RC,Liu X,Glinn MA,Horn JW,Little SP,Paul SM

更新日期：1998-03-01 00:00:00

abstract：:The activity-dependent fusion, retrieval and recycling of synaptic vesicles is essential for the maintenance of neurotransmission. Until relatively recently it was believed that most mutations in genes that were essential for this process would be incompatible with life, because of this fundamental role. However, an e...

journal_title：Journal of neurochemistry

authors： Bonnycastle K,Davenport EC,Cousin MA

更新日期：2020-05-07 00:00:00

abstract：:Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP (cAMP), a molecule involved in inflammation, is down-regulated after TBI. To determine the mechanism by which cAMP is down-regulated after TBI, we determined wh...

journal_title：Journal of neurochemistry

authors： Oliva AA Jr,Kang Y,Furones C,Alonso OF,Bruno O,Dietrich WD,Atkins CM

更新日期：2012-12-01 00:00:00

abstract：:The RNA integrity number (RIN) is often considered to be a critical measure of the quality of postmortem human brains. However, it has been suggested that RINs do not necessarily reflect the availability of intact mRNA. Using the Agilent bioanalyzer and qRT-PCR, we explored whether RINs provide a meaningful way of ass...

journal_title：Journal of neurochemistry

authors： Sonntag KC,Tejada G,Subburaju S,Berretta S,Benes FM,Woo TU

更新日期：2016-07-01 00:00:00

abstract：:The nervous system is frequently the site of symptomatic toxicity of antineoplastic agents. However, there is limited information about the differential vulnerability of neurons, astrocytes and glioma cells. We have analyzed the effects of four chemotherapeutic drugs (lomustine, cisplatin, topotecan and vincristine) o...

journal_title：Journal of neurochemistry

authors： Wick A,Wick W,Hirrlinger J,Gerhardt E,Dringen R,Dichgans J,Weller M,Schulz JB

更新日期：2004-12-01 00:00:00