Insulin-like growth factor binding protein-1 activates integrin-mediated intracellular signaling and migration in oligodendrocytes.

abstract：:Previous studies have shown that phorbol esters and lithium each stimulate the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary tumor cell line AtT20/D16-16. Pretreatment with either lithium or phorbol ester desensitizes the cells to subsequent stimulation by phorbol ester. An early consequenc...

journal_title：Journal of neurochemistry

authors： Zatz M,Mahan LC,Reisine T

更新日期：1987-01-01 00:00:00

abstract：:HNK-1 antibody reactive sulfoglucuronyl carbohydrate (SGC) and SSEA-1 antibody reactive Lewis X (Lex) epitope are expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and have been implicated in cell-cell recognition, neurite outgrowth, and/or neuronal migration during development. ...

journal_title：Journal of neurochemistry

authors： Chou DK,Henion TR,Jungalwala FB

更新日期：2003-08-01 00:00:00

abstract：:The effect of cerebral hypoxia-ischemia (HI) on levels and tyrosine phosphorylation of the NMDA receptor was examined in 7- (P7) and 21 (P21)-day-old rats. Unilateral HI was administered by ligation of the right common carotid artery and exposure to an atmosphere of 8% O2/92% N2 for 2 (P7) or 1.5 (P21) h. This duratio...

journal_title：Journal of neurochemistry

authors： Gurd JW,Bissoon N,Beesley PW,Nakazawa T,Yamamoto T,Vannucci SJ

更新日期：2002-08-01 00:00:00

abstract：:Recent studies have highlighted the role of mitochondria in dendritic protrusion growth and plasticity. However, the detailed mechanisms that mitochondria regulate dendritic filopodia morphogenesis remain elusive. Cyclophilin D (CypD, gene name: Ppif) controls the opening of mitochondrial permeability transition pore....

journal_title：Journal of neurochemistry

authors： Sui S,Tian J,Gauba E,Wang Q,Guo L,Du H

更新日期：2018-08-01 00:00:00

abstract：:A major hallmark of mutant superoxide dismutase (SOD1)-linked familial amyotrophic lateral sclerosis is SOD1-immunopositive inclusions found within motor neurons. The mechanism by which SOD1 becomes aggregated, however, remains unclear. In this study, we aimed to investigate the role of nitrosative stress and S-nitros...

journal_title：Journal of neurochemistry

authors： Chen X,Zhang X,Li C,Guan T,Shang H,Cui L,Li XM,Kong J

更新日期：2013-01-01 00:00:00

abstract：:The endocannabinoid anandamide (N-arachidonoylethanolamine) and other bioactive long-chain N-acylethanolamines are thought to be formed from their corresponding N-acylphosphatidylethanolamines by a specific phospholipase D (NAPE-PLD) in the brain as well as other tissues. However, regional distribution of NAPE-PLD in ...

journal_title：Journal of neurochemistry

authors： Morishita J,Okamoto Y,Tsuboi K,Ueno M,Sakamoto H,Maekawa N,Ueda N

更新日期：2005-08-01 00:00:00

abstract：:The myelin-deficient (mld) mouse is an autosomal recessive mutant characterized by hypomyelination of the CNS due to reduced expression of the myelin basic protein (MBP) gene. In the mld mutant, the MBP gene is duplicated in tandem. One gene is intact, but a large portion is inverted upstream of the other copy, and it...

journal_title：Journal of neurochemistry

authors： Okano H,Aruga J,Nakagawa T,Shiota C,Mikoshiba K

更新日期：1991-02-01 00:00:00

abstract：:Suicide and depression are associated with an increased density of alpha2-adrenoceptors (radioligand receptor binding) in specific regions of the human brain. The function of these inhibitory receptors involves various regulatory proteins (Gi coupling proteins and G protein-coupled receptor kinases, GRKs), which work ...

journal_title：Journal of neurochemistry

authors： García-Sevilla JA,Escribá PV,Ozaita A,La Harpe R,Walzer C,Eytan A,Guimón J

更新日期：1999-01-01 00:00:00

abstract：:Kainate receptors (KARs) modulate synaptic transmission at both pre-synaptic and post-synaptic sites. The overlap in the distribution of KA-2 and GluR6/7 subunits in several brain regions suggests the co-assembly of these subunits in native KARs. The molecular mechanisms that control the assembly and surface expressio...

journal_title：Journal of neurochemistry

authors： Gallyas F Jr,Ball SM,Molnar E

更新日期：2003-09-01 00:00:00

abstract：:The amygdala has been implicated in the neuronal sequelae of stress, although little is known about the neurochemical mechanisms underlying amygdala transmission. In vivo microdialysis was employed to measure extracellular levels of dopamine in the basolateral nucleus of the amygdala in awake rats. Once it was establi...

journal_title：Journal of neurochemistry

authors： Inglis FM,Moghaddam B

更新日期：1999-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) and oxidative stress have long been linked to cell death of neurons in many neurodegenerative conditions. However, the exact molecular mechanisms triggered by oxidative stress in neurodegeneration are at present unclear. In the current work we have used the human neuroblastoma SH-SY5Y cel...

journal_title：Journal of neurochemistry

authors： Sanvicens N,Gómez-Vicente V,Messeguer A,Cotter TG

更新日期：2006-08-01 00:00:00

abstract：:Cationic amino acids are transported from blood into brain by a saturable carrier at the blood-brain barrier (BBB). The transport properties of this carrier were examined in the rat using an in situ brain perfusion technique. Influx into brain via this system was found to be sodium independent and followed Michaelis-M...

journal_title：Journal of neurochemistry

authors： Stoll J,Wadhwani KC,Smith QR

更新日期：1993-05-01 00:00:00

abstract：:Hypoxic preconditioning (HP) 24 h before hypoxic-ischemic (HI) injury confers significant neuroprotection in neonatal rat brain. Recent studies have shown that the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K) intracellular signaling pathways play a role in the induction of tolerance...

journal_title：Journal of neurochemistry

authors： Jones NM,Bergeron M

更新日期：2004-04-01 00:00:00

abstract：:The content of 1,2-diacylglycerol (DAG) was determined in sciatic nerves from normal and streptozotocin-induced diabetic rats. In nerves frozen in situ, DAG content was reduced 22% in the proximal region and 77% in the distal region of diabetic nerve, principally because of the loss of associated fat. DAG levels in fr...

journal_title：Journal of neurochemistry

authors： Zhu X,Eichberg J

更新日期：1990-09-01 00:00:00

abstract：:The monoamines dopamine, norepinephrine, epinephrine, and serotonin and their major metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxy-4-hydroxyphenylethylene glycol, and 5-hydroxyindoleacetic acid were measured in the CNS of the rat during development from fetal day 18 to young adult. The catech...

journal_title：Journal of neurochemistry

authors： Herregodts P,Velkeniers B,Ebinger G,Michotte Y,Vanhaelst L,Hooghe-Peters E

更新日期：1990-09-01 00:00:00

abstract：:Although 3,4-dihydroxyphenylethylamine (dopamine, DA) and vasoactive intestinal peptide (VIP) have been reported to stimulate adenylate cyclase activity in the rabbit retina, possible interactions between VIP-sensitive and DA-sensitive adenylate cyclase systems have not been previously investigated. To elucidate the i...

journal_title：Journal of neurochemistry

authors： Pachter JA,Lam DM

更新日期：1986-01-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are known to occur following acute seizure activity but their contribution during epileptogenesis is largely unknown. The goal of this study was to determine the extent of mitochondrial oxidative stress, changes to redox status, and mitochondrial DNA (mtDNA) damage during...

journal_title：Journal of neurochemistry

authors： Waldbaum S,Liang LP,Patel M

更新日期：2010-12-01 00:00:00

abstract：:The glutamate (Glu) terminals in rat neostriatum were removed by a unilateral frontal decortication. One to two weeks later the effects of insulin-induced hypoglycemia on the steady-state levels of amino acids [Glu, glutamine (Gln), aspartate (Asp), gamma-aminobutyric acid (GABA), taurine] and energy metabolites (gluc...

journal_title：Journal of neurochemistry

authors： Engelsen B,Westerberg E,Fonnum F,Wieloch T

更新日期：1986-11-01 00:00:00

abstract：:Real-time alterations in intracellular Ca2+ ([Ca2+]i) were monitored in fluo-3-loaded cerebellar granule neurons (CGNs) exposed to the brevetoxin PbTx-1. [Ca2+]i was measured using a fluorescent plate reader (FLIPR), which measures simultaneously the mean intracellular Ca2+ change in a population of cultured cells in ...

journal_title：Journal of neurochemistry

authors： Berman FW,Murray TF

更新日期：2000-04-01 00:00:00

abstract：:Leptin, the obese gene product, was reported to stimulate prolactin (PRL) secretion, but the neuroendocrine mechanism underlying this hormonal response is largely unknown. Thus, in this study we examined the involvement of several important PRL regulators in the leptin-induced PRL secretion in male rats. Compared with...

journal_title：Journal of neurochemistry

authors： Watanobe H,Schiöth HB,Izumi J

更新日期：2003-04-01 00:00:00

abstract：:Using antiphosphotyrosine antibodies, we have investigated protein phosphorylation in mouse brain during development in intact animals and in reaggregated cerebral cultures. Under basal conditions, in vivo and in vitro, the levels of two main phosphoproteins, of Mr 120,000 and 180,000 (pp180), increased with developme...

journal_title：Journal of neurochemistry

authors： Girault JA,Chamak B,Bertuzzi G,Tixier H,Wang JK,Pang DT,Greengard P

更新日期：1992-02-01 00:00:00

abstract：:We investigated the regulatory pathways responsible for agonist-induced internalization and down-regulation of G(q) protein-coupled histamine H(1)-receptors in Chinese hamster ovary cells. Histamine-induced internalization and down-regulation of H(1)-receptors were detected as the loss of [(3)H]mepyramine binding site...

journal_title：Journal of neurochemistry

authors： Hishinuma S,Komazaki H,Fukui H,Shoji M

更新日期：2010-05-01 00:00:00

abstract：:CNS myelin was isolated from the spinal cord of the African lungfish Protopterus dolloi. Its proteins consisted of (1) two basic proteins (16,000 and 18,500 apparent Mr) that reacted with anti-human CNS myelin basic protein antibodies and (2) a major protein (29,000 apparent Mr) that stained with concanavalin A-horser...

journal_title：Journal of neurochemistry

authors： Waehneldt TV,Matthieu JM,Jeserich G

更新日期：1986-05-01 00:00:00

abstract：:Neuromodulation is a fundamental process in the brain that regulates synaptic transmission, neuronal network activity and behavior. Emerging evidence demonstrates that astrocytes, a major population of glial cells in the brain, play previously unrecognized functions in neuronal modulation. Astrocytes can detect the le...

journal_title：Journal of neurochemistry

authors： Fellin T

更新日期：2009-02-01 00:00:00

abstract：:We investigated the mechanism of increases in cyclic GMP levels in bovine superior cervical ganglion (SCG) in response to muscarinic receptor stimulation. Acetylcholine increased cyclic GMP levels in SCG. This increase was inhibited by NG-methyl-L-arginine (NMA), and the inhibition was reversed by L-arginine. Soluble ...

journal_title：Journal of neurochemistry

authors： Sheng H,Gagne GD,Matsumoto T,Miller MF,Förstermann U,Murad F

更新日期：1993-09-01 00:00:00

abstract：:Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down-regulation by antidepressants of the noradrenergic cyclic AMP-generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade ...

journal_title：Journal of neurochemistry

authors： Janowsky A,Steranka LR,Gillespie DD,Sulser F

更新日期：1982-07-01 00:00:00

abstract：:In cerebellar granule cells, the mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) cascade mediates multiple functions, including proliferation, differentiation, and survival. In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pi...

journal_title：Journal of neurochemistry

authors： Obara Y,Horgan AM,Stork PJ

更新日期：2007-04-01 00:00:00

abstract：:Dopamine neurons have been suggested to use glutamate as a cotransmitter. To identify the basis of such a phenotype, we have examined the expression of the three recently identified vesicular glutamate transporters (VGLUT1-3) in postnatal rat dopamine neurons in culture. We found that the majority of isolated dopamine...

journal_title：Journal of neurochemistry

authors： Dal Bo G,St-Gelais F,Danik M,Williams S,Cotton M,Trudeau LE

更新日期：2004-03-01 00:00:00

abstract：:Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To detect amyloid fibrils, fluorophores with high sensitivity and better efficiency coupled with the low toxicity are in high demand even to date. In this pursuit,...

journal_title：Journal of neurochemistry

authors： Pravin N,Kumar R,Tripathi S,Kumar P,Mohite GM,Navalkar A,Panigrahi R,Singh N,Gadhe LG,Manchanda S,Shimozawa M,Nilsson P,Johansson J,Kumar A,Maji SK,Shanmugam M

更新日期：2020-08-04 00:00:00

abstract：:Several members of the tetrahydroisoquinoline (TIQ) family of monoamine alkaloids can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell death in Parkinson's disease (PD). Using enantiomeric-selective high-performance liquid chromatography with electrochem...

journal_title：Journal of neurochemistry

authors： DeCuypere M,Lu Y,Miller DD,LeDoux MS

更新日期：2008-12-01 00:00:00