Cortical regulation of subcortical dopamine release: mediation via the ventral tegmental area.

abstract：:The activities of the three major catecholamine-synthesizing enzymes were determined in brain tissue pellets dissected from 500-micrometers thick horizontal sections of rat lower brainstem. The rostrocaudal distributions of the three enzymatic activities were generally not parallel, suggesting differences in the respe...

journal_title：Journal of neurochemistry

authors： Chamba G,Denoroy L,Renaud B

更新日期：1982-08-01 00:00:00

abstract：:Here, we examined whether amyloid-beta (Abeta) protein participates in cell death and retinal function using three types of transgenic (Tg) mice in vivo [human mutant amyloid precursor protein (APP) Tg (Tg 2576) mice, mutant presenilin-1 (PS-1) knock-in mice, and APP/PS-1 double Tg mice]. ELISA revealed that the insol...

journal_title：Journal of neurochemistry

authors： Shimazawa M,Inokuchi Y,Okuno T,Nakajima Y,Sakaguchi G,Kato A,Oku H,Sugiyama T,Kudo T,Ikeda T,Takeda M,Hara H

更新日期：2008-10-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is involved in many aspects of neuronal biology and hippocampal physiology. Status epilepticus (SE) is a condition in which prolonged seizures lead to neuronal degeneration. SE-induced in rodents serves as a model of Temporal Lobe Epilepsy with hippocampal sclerosis, the most f...

journal_title：Journal of neurochemistry

authors： Unsain N,Montroull LE,Mascó DH

更新日期：2009-10-01 00:00:00

abstract：:Neural transplantation is an experimental treatment for Parkinson's disease. Widespread clinical application of the grafting technique is hampered by a relatively poor survival (around 10%) of implanted embryonic dopamine neurones. Earlier animal studies have indicated that a large proportion of the grafted cells die ...

journal_title：Journal of neurochemistry

authors： Emgård M,Hallin U,Karlsson J,Bahr BA,Brundin P,Blomgren K

更新日期：2003-09-01 00:00:00

abstract：:G protein-coupled receptors are important regulators of cellular signaling processes. Within the large family of rhodopsin-like receptors, those binding to biogenic amines form a discrete subgroup. Activation of biogenic amine receptors leads to transient changes of intracellular Ca²⁺-([Ca²⁺](i)) or 3',5'-cyclic adeno...

journal_title：Journal of neurochemistry

authors： Balfanz S,Jordan N,Langenstück T,Breuer J,Bergmeier V,Baumann A

更新日期：2014-04-01 00:00:00

abstract：:The release of gamma-aminobutyric acid (GABA) was studied in slices of the head of the rabbit caudate nucleus. The slices were preincubated with [3H]GABA and then superfused. Aminooxyacetic acid was present throughout. Both the tritium in the slices and that in the superfusate consisted practically entirely of [3H]GAB...

journal_title：Journal of neurochemistry

authors： Limberger N,Späth L,Starke K

更新日期：1986-04-01 00:00:00

abstract：:Recent studies suggest that the function of the blood-brain barrier (BBB) is not static under normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing thinking about CNS function, and neurodegenerative disease in particular, is neurocentric excluding the impact of factors outside th...

journal_title：Journal of neurochemistry

authors： Carvey PM,Hendey B,Monahan AJ

更新日期：2009-10-01 00:00:00

abstract：:Optimal neuronal activity requires that supporting cells provide both efficient nutrient delivery and waste disposal. The incomplete processing of engulfed waste by their lysosomes can lead to accumulation of residual material and compromise their support of neurons. As most degradative lysosomal enzymes function best...

journal_title：Journal of neurochemistry

authors： Guha S,Baltazar GC,Tu LA,Liu J,Lim JC,Lu W,Argall A,Boesze-Battaglia K,Laties AM,Mitchell CH

更新日期：2012-08-01 00:00:00

abstract：:Stimulated dopamine overflow has been measured with in vivo voltammetry in the caudate-putamen and nucleus accumbens. Overflow was induced by electrical stimulation of the medial forebrain bundle with 120 1-ms, 300-microA, biphasic pulses at frequencies between 10 and 60 Hz. Overflow was measured with a Nafion-coated,...

journal_title：Journal of neurochemistry

authors： May LJ,Wightman RM

更新日期：1989-09-01 00:00:00

abstract：:Acetyltransferase enzymatic activity was detected and measured in homogenates obtained from intact nerve fibers and their saparate cellular components, in the tropical squid Sepioteuthis sepioidea. The levels of acetylcholine synthesis were determined in pooled samples of whole stellar nerve, intact giant nerve fiber,...

journal_title：Journal of neurochemistry

authors： Heumann R,Villegas J,Herzfeld DW

更新日期：1981-02-01 00:00:00

abstract：:The normal cellular prion protein (PrP(C)) is a glycoprotein with two highly conserved potential N-linked glycosylation sites. All prion diseases, whether inherited, infectious or sporadic, are believed to share the same pathogenic mechanism that is based on the conversion of the normal cellular prion protein (PrP(C))...

journal_title：Journal of neurochemistry

authors： Goh AX,Li C,Sy MS,Wong BS

更新日期：2007-02-01 00:00:00

abstract：:Primary astrocyte cultures from neonatal rat brains show uptake of [3H]norepinephrine ([3H]NE). This uptake has a high-affinity component with an apparent Km of approximately 3 X 10(-7) M. At 10(-7) M [3H]NE both the initial rate of uptake and steady-state content of [3H]NE is inhibited by up to 95% by omission of ext...

journal_title：Journal of neurochemistry

authors： Kimelberg HK,Pelton EW 2nd

更新日期：1983-05-01 00:00:00

abstract：:Kindling induces long-term adaptations in neuronal function that lead to a decreased threshold for induction of seizures. In the present study, the influence of amygdala kindling on levels of mRNA for the immediate-early genes (IEGs) c-fos, c-jun, and NGF1-A were examined both before and after an acute electroconvulsi...

journal_title：Journal of neurochemistry

authors： Duman RS,Craig JS,Winston SM,Deutch AY,Hernandez TD

更新日期：1992-11-01 00:00:00

abstract：:Nerve growth factor (NGF) is a trophic and survival factor for cholinergic neurons, and it induces the expression of several genes that are essential for synthesis and storage of acetylcholine (ACh), specifically choline acetyltransferase, vesicular ACh transporter (VAChT), and choline transporter. We have found previ...

journal_title：Journal of neurochemistry

authors： Madziar B,Shah S,Brock M,Burke R,Lopez-Coviella I,Nickel AC,Cakal EB,Blusztajn JK,Berse B

更新日期：2008-12-01 00:00:00

abstract：:Dystrobrevin binding protein-1 (dysbindin-1), a candidate gene for schizophrenia, modulates cognition, synaptic plasticity and frontocortical circuitry and interacts with glutamatergic and dopaminergic transmission. Loss of dysbindin-1 modifies cellular trafficking of dopamine (DA) D2 receptors to increase cell surfac...

journal_title：Journal of neurochemistry

authors： Schmieg N,Rocchi C,Romeo S,Maggio R,Millan MJ,Mannoury la Cour C

更新日期：2016-03-01 00:00:00

abstract：:GABA(A) receptors are the major inhibitory neurotransmitter receptors in the brain. Some of them are targets of benzodiazepines that are widely used in clinical practice for their sedative/hypnotic, anxiolytic, muscle relaxant and anticonvulsant effects. In order to rationally separate these different drug actions, we...

journal_title：Journal of neurochemistry

authors： Tan KR,Baur R,Charon S,Goeldner M,Sigel E

更新日期：2009-12-01 00:00:00

abstract：:Primary rat fibroblasts genetically modified to express Drosophila choline acetyltransferase (dChAT) synthesize and release acetylcholine (ACh) in vitro. The ACh produced from the transduced fibroblasts was found to be enhanced by increasing amounts of choline chloride in the culture media. These dChAT-expressing cell...

journal_title：Journal of neurochemistry

authors： Fisher LJ,Schinstine M,Salvaterra P,Dekker AJ,Thal L,Gage FH

更新日期：1993-10-01 00:00:00

abstract：:Extracellular adenosine in the brain, which modulates various physiological and pathological processes, fluctuates in a complicated manner that reflects the circadian cycle, neuronal activity, metabolism, and disease states. The dynamics of extracellular adenosine in the brain are not fully understood, largely because...

journal_title：Journal of neurochemistry

authors： Yamashiro K,Fujii Y,Maekawa S,Morita M

更新日期：2017-01-01 00:00:00

abstract：:The protein kinases and protein phosphatases that act on tyrosine hydroxylase in vivo have not been established. Bovine adrenal chromaffin cells were permeabilized with digitonin and incubated with [gamma-32P]ATP, in the presence or absence of 10 microM Ca2+, 1 microM cyclic AMP, 1 microM phorbol dibutyrate, or variou...

journal_title：Journal of neurochemistry

authors： Gonçalves CA,Hall A,Sim AT,Bunn SJ,Marley PD,Cheah TB,Dunkley PR

更新日期：1997-12-01 00:00:00

abstract：:The efficacy of funnel-freezing of rat brain to inactivate metabolic processes and preserve in vivo tissue glucose concentration was validated by comparing the results obtained by funnel-freezing with those obtained with freeze-blowing of brain. The arterial plasma glucose level was clamped at 9 mM in halothane-anesth...

journal_title：Journal of neurochemistry

authors： Mies G,Cruz N,Sokoloff L

更新日期：1991-05-01 00:00:00

abstract：:Gs alpha, the GTP-binding protein that mediates receptor stimulation of adenylyl cyclase, exists in small (Gs alpha-S) and large (Gs alpha-L) molecular forms. Previous work has established that these Gs alpha isoforms are products of alternatively spliced Gs alpha pre-mRNA. The present work examined the splicing patte...

journal_title：Journal of neurochemistry

authors： Granneman JG,Bannon MJ

更新日期：1991-09-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) have been implicated in membrane-cytoskeletal events underlying cell adhesion, migration, secretion, and phagocytosis. In BV-2 microglial cells, lipopolysaccharide (LPS) elicited a dose-dependent increase in mRNA of both MRP (sixfo...

journal_title：Journal of neurochemistry

authors： Sunohara JR,Ridgway ND,Cook HW,Byers DM

更新日期：2001-08-01 00:00:00

abstract：:Intracellular protein inclusions in Alzheimer's disease and progressive supranuclear palsy contain UBB+1, a variant ubiquitin. UBB+1 is able block the 26S proteasome in cell lines. Proteasome inhibition by drug action has previously been shown to induce a heat-shock response and render protection against stress. We in...

journal_title：Journal of neurochemistry

authors： Hope AD,de Silva R,Fischer DF,Hol EM,van Leeuwen FW,Lees AJ

更新日期：2003-07-01 00:00:00

abstract：:Agmatine (decarboxylated arginine) was originally identified in the CNS as an imidazoline receptor ligand. Further studies demonstrated that agmatine antagonizes NMDA receptors and inhibits nitric oxide synthase. Intrathecally administered agmatine inhibits opioid tolerance and hyperalgesia evoked by inflammation, ner...

journal_title：Journal of neurochemistry

authors： Goracke-Postle CJ,Overland AC,Riedl MS,Stone LS,Fairbanks CA

更新日期：2007-09-01 00:00:00

abstract：:Developmental profiles were determined for the activities of eight enzymes involved in fatty acid beta-oxidation in rat brain. The enzymes studied were the palmitoyl-CoA, octanoyl-CoA, butyryl-CoA, glutaryl-CoA, and 3-hydroxyacyl-CoA dehydrogenases, the enoyl-CoA hydratase (crotonase), and the C4- and C10-thiolases. W...

journal_title：Journal of neurochemistry

authors： Reichmann H,Maltese WA,DeVivo DC

更新日期：1988-08-01 00:00:00

abstract：:Parkinson's disease is a debilitating neurodegenerative disease characterized by loss of midbrain dopaminergic neurons. These neurons are particularly sensitive to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which causes parkinsonian ...

journal_title：Journal of neurochemistry

authors： Chu CT,Zhu JH,Cao G,Signore A,Wang S,Chen J

更新日期：2005-09-01 00:00:00

abstract：:Prolonged stress affects homeostasis in various organs and induces stress-associated disorders. We examined the cellular changes of pituitary gland under the continuous stress condition using a rat model in which rats were kept in a cage filled with water to a height of 1.5 cm for up to 5 days. Among the pituitary hor...

journal_title：Journal of neurochemistry

authors： Ogawa T,Shishioh-Ikejima N,Konishi H,Makino T,Sei H,Kiryu-Seo S,Tanaka M,Watanabe Y,Kiyama H

更新日期：2009-06-01 00:00:00

abstract：:delta 1-Pyrroline, 5-methyl-delta 1-pyrroline, and 5,5-dimethyl-delta 1-pyrroline have been identified as substances metabolized to gamma-aminobutyric acid (GABA), 4-aminopentanoic acid (methylGABA), and 4-amino-4-methylpentanoic acid (dimethylGABA), respectively. An enzyme system residing in the soluble fraction of r...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA,Nayar MS,Stogniew M,Rao KG

更新日期：1982-04-01 00:00:00

abstract：:To evaluate the role of various growth factors in naturally occurring cell death during development of the neural retina, we examined the effects of such factors on the nuclear morphology and the size of DNA in cultured chick embryonic neural retina cells. Basic fibroblast growth factor (bFGF) increased internucleosom...

journal_title：Journal of neurochemistry

authors： Yokoyama Y,Ozawa S,Seyama Y,Namiki H,Hayashi Y,Kaji K,Shirama K,Shioda M,Kano K

更新日期：1997-05-01 00:00:00