Acetylcholine synthesis in the Schwann cell and axon in the giant nerve fiber of the squid.

Abstract:

:Acetyltransferase enzymatic activity was detected and measured in homogenates obtained from intact nerve fibers and their saparate cellular components, in the tropical squid Sepioteuthis sepioidea. The levels of acetylcholine synthesis were determined in pooled samples of whole stellar nerve, intact giant nerve fiber, extruded axoplasm, axoplasm-free giant nerve fiber sheaths, and small nerve fibers. The values found per mg of protein for the axoplasm-free sheaths are about 3-9 times those of the extruded axoplasm, and comparable to those found for the intact giant nerve fiber. These experimental findings settle the question of whether the Schwann cells of the giant nerve fiber of S. sepiodea, under physiological conditions, contain acetyltransferase activity and are able to synthesize acetylcholine.

journal_name

J Neurochem

authors

Heumann R,Villegas J,Herzfeld DW

doi

10.1111/j.1471-4159.1981.tb01654.x

subject

Has Abstract

pub_date

1981-02-01 00:00:00

pages

765-8

issue

2

eissn

0022-3042

issn

1471-4159

journal_volume

36

pub_type

杂志文章
  • The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?

    abstract::EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Although, in the adult, EAAC1/EAAT3 exhibits a rather low expressi...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审

    doi:10.1111/j.1471-4159.2006.03978.x

    authors: Nieoullon A,Canolle B,Masmejean F,Guillet B,Pisano P,Lortet S

    更新日期:2006-08-01 00:00:00

  • Identification of an ectokinase activity in cerebellar granule primary neuronal cultures.

    abstract::Primary neuronal cultures from 8-day-old rat cerebellum were incubated in the presence of exogenously added 16 nM [gamma-32P]ATP. Phosphorylation of a 45-kDa endogenous protein was detected within 1 min and increased linearly for approximately 20 min. Unlike what was seen with [gamma-32P]ATP, in the presence of [32P]o...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1994.63062028.x

    authors: Volonté C,Merlo D,Ciotti MT,Calissano P

    更新日期:1994-12-01 00:00:00

  • Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions.

    abstract::The identification of a hexanucleotide repeat expansion in a non-coding region of C9orf72 as a major cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) drastically changed the field of research on both of these conditions. Yet, despite the vast amount of work aimed at elucidating the m...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审

    doi:10.1111/jnc.13623

    authors: Todd TW,Petrucelli L

    更新日期:2016-08-01 00:00:00

  • Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays.

    abstract::One of the most striking features of neurons in the mature peripheral nervous system is their ability to survive and to regenerate their axons following axonal injury. To perform a comprehensive survey of the molecular mechanisms that underlie peripheral nerve regeneration, we analyzed a cDNA library derived from the ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2002.01060.x

    authors: Kubo T,Yamashita T,Yamaguchi A,Hosokawa K,Tohyama M

    更新日期:2002-09-01 00:00:00

  • Development of sodium channel protein during chemically induced differentiation of neuroblastoma cells.

    abstract::We have previously shown that the [3H]saxitoxin binding site of the sodium channel is expressed independently of the [125I]scorpion toxin binding site in chick muscle cultures and in rat brain. In the present work, we studied the development of the sodium channel protein during chemically induced differentiation of N1...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1987.tb05656.x

    authors: Baumgold J,Spector I

    更新日期:1987-04-01 00:00:00

  • Activation of Rho GTPases by synaptic transmission in the hippocampus.

    abstract::Ras-related GTPases of the Rho family, such as RhoA and RhoB, are well-characterised mediators of morphological change in peripheral tissues via their effects on the actin cytoskeleton. We tested the hypothesis that Rho family GTPases are involved in synaptic transmission in the CA1 region of the hippocampus. We show ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2003.02102.x

    authors: O'Kane EM,Stone TW,Morris BJ

    更新日期:2003-12-01 00:00:00

  • Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells.

    abstract::Monoamine oxidases (MAOs) are mitochondrial enzymes which control the levels of neurotransmitters in the brain and dietary amines in peripheral tissues via oxidative deamination. MAO has also been implicated in cell signalling. In this study, we describe the MAO-A isoform as functional in apoptosis induced by staurosp...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2007.04921.x

    authors: Fitzgerald JC,Ufer C,De Girolamo LA,Kuhn H,Billett EE

    更新日期:2007-12-01 00:00:00

  • Reduction in glial fibrillary acidic protein mRNA abundance induced by (-)-deprenyl and other monoamine oxidase B inhibitors in C6 glioma cells.

    abstract::Gliosis is commonly observed in the CNS following tissue damage, and it also occurs in aging and in many neurodegenerative diseases. Glial fibrillary acidic protein (GFAP) accumulation is a prominent feature of astrocytic gliosis. An inhibition or delay in GFAP synthesis could mitigate scar formation and thus reduce t...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1993.tb13660.x

    authors: Li XM,Qi J,Juorio AV,Boulton AA

    更新日期:1993-10-01 00:00:00

  • Effects of chronic hypoxia on Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells.

    abstract::Microfluorimetric measurements of intracellular calcium ion concentration [Ca(2+)](i) were employed to examine the effects of chronic hypoxia (2.5% O(2), 24 h) on Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells. Activation of muscarinic receptors evoked rises in [Ca(2+)](i) which wer...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2001.00620.x

    authors: Smith IF,Boyle JP,Vaughan PF,Pearson HA,Peers C

    更新日期:2001-11-01 00:00:00

  • Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures.

    abstract::Glial cells secrete proinflammatory mediators in the brain in response to exogenous stimuli such as infection and injury. Previously, we documented that systemic maternal lipopolysaccharide (LPS)-exposure at embryonic gestation day 18 causes oligodendrocyte (OL)-injury/hypomyelination in the developing brain which can...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2007.05199.x

    authors: Paintlia MK,Paintlia AS,Khan M,Singh I,Singh AK

    更新日期:2008-05-01 00:00:00

  • Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats.

    abstract::Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), and what are its underlying mechanisms. In this study, we investigated the efficacy of tamoxifen ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2009.06077.x

    authors: Tian DS,Liu JL,Xie MJ,Zhan Y,Qu WS,Yu ZY,Tang ZP,Pan DJ,Wang W

    更新日期:2009-06-01 00:00:00

  • Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response.

    abstract::The mechanisms of injury-induced apoptosis of neurons within the spinal cord are poorly understood. In this study, we show that spinal cord injury (SCI) induces endoplasmic reticulum stress revealed by the activation of an unbalanced unfolded protein response (UPR). Using a weight-drop contusion model of SCI, the UPR ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2007.04671.x

    authors: Penas C,Guzmán MS,Verdú E,Forés J,Navarro X,Casas C

    更新日期:2007-08-01 00:00:00

  • Ca2(+)-surrogate action of Pb2+ on acetylcholine release from rat brain synaptosomes.

    abstract::The effect of lead ions on the release of acetylcholine (ACh) was investigated in intact and digitonin-permeabilized rat cerebrocortical synaptosomes that had been prelabeled with [3H]choline. Release of ACh was inferred from the release of total 3H label or by determination of [3H]ACh. Application of 1 microM Pb2+ to...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1991.tb08187.x

    authors: Shao Z,Suszkiw JB

    更新日期:1991-02-01 00:00:00

  • Gallium-67 as a potential marker for aluminium transport in rat brain: implications for Alzheimer's disease.

    abstract::Evidence of a link between aluminium and Alzheimer's disease, parkinsonism-dementia of Guam, and dialysis encephalopathy raises questions regarding the role of this element in the pathogenesis of these conditions. Therefore, we have investigated the use of gallium-67 (67Ga) as a marker for brain uptake of aluminium. T...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1990.tb08846.x

    authors: Pullen RG,Candy JM,Morris CM,Taylor G,Keith AB,Edwardson JA

    更新日期:1990-07-01 00:00:00

  • Muscular dystrophy in mdx mice despite lack of neuronal nitric oxide synthase.

    abstract::Neuronal nitric oxide synthase (nNOS) is a component of the dystrophin complex in skeletal muscle. The absence of dystrophin protein in Duchenne muscular dystrophy and in mdx mouse causes a redistribution of nNOS from the plasma membrane to the cytosol in muscle cells. Aberrant nNOS activity in the cytosol can induce ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1998.71020784.x

    authors: Chao DS,Silvagno F,Bredt DS

    更新日期:1998-08-01 00:00:00

  • Concentration and in vivo synthesis of cholecystokinin in subcortical regions of the rat brain.

    abstract::The in vivo biosynthesis of cholecystokinin (CCK) in subcortical regions of the rat brain was studied by intracisternal pulse injections of [35S]methionine. The rats were killed 1.0 or 1.5 h after the injection. Subcortical CCK extracted in boiling water and acetic acid was immunoabsorbed by an antiserum specific for ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1980.tb06290.x

    authors: Goltermann NR,Rehfeld JF,Petersen HR

    更新日期:1980-08-01 00:00:00

  • Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships.

    abstract::The (R) and (S) forms of 5-amino-2-hydroxyvaleric acid (2-OH-DAVA) and 5-amino-4-hydroxyvaleric acid (4-OH-DAVA) were designed as structural hybrids of the 4-aminobutyric acidB (GABAB) agonist (R)-(-)-4-amino-3-hydroxybutyric acid [(R)-(-)-3-OH-GABA] and the GABAB antagonist 5-aminovaleric acid (DAVA). (S)-(-)-2-OH-DA...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1992.tb09374.x

    authors: Kristiansen U,Hedegaard A,Herdeis C,Lund TM,Nielsen B,Hansen JJ,Falch E,Hjeds H,Krogsgaard-Larsen P

    更新日期:1992-03-01 00:00:00

  • Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival.

    abstract::Rho family GTPases promote the survival of certain neuronal populations. However, pro-survival and pro-death signaling pathways regulated downstream of Rho GTPases are largely unknown. Cerebellar granule neurons (CGNs) exposed to Clostridium difficile toxin B (ToxB), a monoglucosyltransferase that specifically inhibit...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2006.03802.x

    authors: Loucks FA,Le SS,Zimmermann AK,Ryan KR,Barth H,Aktories K,Linseman DA

    更新日期:2006-05-01 00:00:00

  • A monoclonal antibody raised against plasma membrane of cholinergic nerve terminals of the Torpedo inhibits choline acetyltransferase activity and acetylcholine release.

    abstract::Monoclonal antibodies were raised against the synaptosomal plasma membranes (SPMs) purified from the electric organ of the Torpedo. One antibody that reacts preferentially with SPMs rather than with other membrane fractions isolated from this tissue was previously found to inhibit hydrophilic and amphiphilic choline-O...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1989.tb08533.x

    authors: Eder-Colli L,Briand PA,Pellegrinelli N,Dunant Y

    更新日期:1989-11-01 00:00:00

  • SNARE proteins--why so many, why so few?

    abstract::Both trafficking and secretion critically depend on accurate and specific membrane recognition and fusion. A key step in these processes is the assembly of a complex consisting of a small number of proteins, i.e., the exocytic core complex. In nerve terminals, this set consists of VAMP and synaptotagmin, which reside ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审

    doi:10.1046/j.1471-4159.1997.69051781.x

    authors: Linial M

    更新日期:1997-11-01 00:00:00

  • Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex.

    abstract::Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects on the neurochemical profile of the frontal cortex. A mouse mod...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.14116

    authors: Corcoba A,Gruetter R,Do KQ,Duarte JMN

    更新日期:2017-09-01 00:00:00

  • Glioma cells survival depends both on fatty acid oxidation and on functional carnitine transport by SLC22A5.

    abstract::Gliomas are the most common primary malignant brain tumor in adults, but current treatment for glioblastoma multiforme (GBM) is insufficient. Even though glucose is the primary energetic substrate of glioma cells, they are capable of using fatty acids to generate energy. Fatty acid oxidation (FAO) in mitochondria requ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.15124

    authors: Juraszek B,Czarnecka-Herok J,Nałęcz KA

    更新日期:2020-07-12 00:00:00

  • Effects of muscarinic agonists and depolarizing agents on inositol monophosphate accumulation in the rabbit vagus nerve.

    abstract::The effects of muscarinic agonists and depolarizing agents on inositol phospholipid hydrolysis in the rabbit vagus nerve were assessed by the measurement of [3H]inositol monophosphate production in nerves that had been preincubated with [3H]inositol. After 1 h of drug action, carbachol, oxotremorine, and arecoline inc...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1992.tb09392.x

    authors: Sierro CD,Vitus J,Dunant Y

    更新日期:1992-08-01 00:00:00

  • Interspecies comparison of brain ganglioside patterns studied by two-dimensional thin-layer chromatography.

    abstract::Brain gangliosides from four vertebrate classes (fish, amphibia, aves, and mammalia) were studied by patterns generated with the use of two-dimensional thin-layer chromatography. In an effort to retain possible alkalilabile gangliosides, samples were not base-hydrolyzed. Resultant chromatograms revealed complex patter...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1981.tb04490.x

    authors: Hunter GD,Wiegant VM,Dunn AJ

    更新日期:1981-10-01 00:00:00

  • Regulation of prostaglandin E2 receptor binding activity in porcine temporal cortex by protein phosphorylation.

    abstract::Regulation of prostaglandin (PG) E2 receptors was investigated in a 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate-solubilized fraction from the synaptic membrane of porcine temporal cortex. The fraction was preincubated with exogenous protein kinases, and then the binding of PGE2 was measured. PGE2 binding...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1991.tb08291.x

    authors: Morii H,Tanemura M,Watanabe Y

    更新日期:1991-10-01 00:00:00

  • Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism.

    abstract::Recent etiological study in twins (Tanner et al. 1999) strongly suggests that environmental factors play an important role in typical, non-familial Parkinson's disease (PD), beginning after age 50. Epidemiological risk factor analyses of typical PD cases have identified several neurotoxicants, including MPP(+) (the ac...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2001.00096.x

    authors: Chun HS,Gibson GE,DeGiorgio LA,Zhang H,Kidd VJ,Son JH

    更新日期:2001-02-01 00:00:00

  • Alternative polyadenylation and miR-34 family members regulate tau expression.

    abstract::Tau pathologically aggregates in Alzheimer's disease, and evidence suggests that reducing tau expression may be safe and beneficial for the prevention or treatment of this disease. We sought to examine the role of the 3'-untranslated region (3'-UTR) of human tau mRNA in regulating tau expression. Tau expresses two 3'-...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.12437

    authors: Dickson JR,Kruse C,Montagna DR,Finsen B,Wolfe MS

    更新日期:2013-12-01 00:00:00

  • The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro.

    abstract::Axonal degeneration is a key component of many neurodegenerative diseases. Injured axons undergo a program of self-destruction termed Wallerian degeneration that is an active, well-regulated process. The pathways leading to axon fragmentation are uncharacterized, but experiments with wld(s) mutant mice led to the disc...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2009.06002.x

    authors: Press C,Milbrandt J

    更新日期:2009-04-01 00:00:00

  • The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection.

    abstract::Latanoprost was first developed for use in glaucoma therapy as an ocular hypotensive agent targeting the prostaglandin F2α (FP) receptor. Subsequently, latanoprost showed a neuroprotective effect, an additional pharmacological action. However, although it is well-known that latanoprost exerts an ocular hypotensive eff...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.13902

    authors: Yamamoto K,Sato K,Yukita M,Yasuda M,Omodaka K,Ryu M,Fujita K,Nishiguchi KM,Machida S,Nakazawa T

    更新日期:2017-02-01 00:00:00

  • Pre-synaptic nicotinic and D receptors functionally interact on dopaminergic nerve endings of rat and mouse nucleus accumbens.

    abstract::The existence of pre-synaptic auto- and hetero receptors which modulate neurotransmitter release is well documented. Emerging evidence show that in some cases these pre-synaptic receptors may also cross-talk with each other. The aim of the present work was to investigate whether acetylcholine receptors (nAChRs) and do...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2009.05933.x

    authors: Grilli M,Zappettini S,Zoli M,Marchi M

    更新日期:2009-03-01 00:00:00