Restraint stress increases neuroinflammation independently of amyloid β levels in amyloid precursor protein/PS1 transgenic mice.

abstract：:The role of neuroactive steroids and GABA(A) receptors in the generation of spontaneous spike-and-wave discharges (SWDs) was investigated in the WAG/Rij rat model of absence epilepsy. The plasma, cerebrocortical, and thalamic concentrations of the progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5a...

journal_title：Journal of neurochemistry

authors： Pisu MG,Mostallino MC,Dore R,Mura ML,Maciocco E,Russo E,De Sarro G,Serra M

更新日期：2008-09-01 00:00:00

abstract：:The molecular forms of angiotensin converting enzyme (ACE; EC 3.4.15.1) in preparations of pig brain cortical microvessels and striatal synaptosomal membranes have been identified by immunoelectrophoretic blot analysis. The cortical microvessels contained only the endothelial form of the enzyme, Mr 180,000, which comi...

journal_title：Journal of neurochemistry

authors： Williams TA,Hooper NM,Turner AJ

更新日期：1991-07-01 00:00:00

abstract：:Cerebral cortex tissue was obtained at autopsy from neonatal Poll Hereford calves with clinically confirmed maple syrup urine disease (MSUD), neonatal Holstein-Friesian calves with clinically confirmed citrullinemia, and matched controls. From this, synaptosomes were prepared for studies of neurotransmitter amino acid...

journal_title：Journal of neurochemistry

authors： Dodd PR,Williams SH,Gundlach AL,Harper PA,Healy PJ,Dennis JA,Johnston GA

更新日期：1992-08-01 00:00:00

abstract：:Brain homogenate, cerebral microvessels, and endothelial cells (ECs) were prepared from 15-18-week-old human fetuses and analyzed biochemically for the presence of elements of the cholinergic system [acetylcholinesterase (AChE), choline acetyltransferase (ChAT), and butyrylcholinesterase]. The ECs were cultured, and t...

journal_title：Journal of neurochemistry

authors： Kasa P,Pakaski M,Joó F,Lajtha A

更新日期：1991-06-01 00:00:00

abstract：:Overexpression of gp120, the major coat protein of the HIV-1 virus, in central glial cells, or treatment of neurons with gp120 in culture, produces apoptotic neuronal death. Here we demonstrate that CEP-1347 (KT7515), an inhibitor of mixed lineage kinase 3 (MLK3), an upstream activator of JNK, inhibits gp120IIIB-induc...

journal_title：Journal of neurochemistry

authors： Bodner A,Maroney AC,Finn JP,Ghadge G,Roos R,Miller RJ

更新日期：2002-09-01 00:00:00

abstract：:cDNAs have been cloned that encode the chicken (Gallus domesticus) gamma-aminobutyric acidA receptor gamma 1 subunit, the mature sequence of which shares 90, 79, and 69% identity with those of the rat gamma 1, gamma 2, and gamma 3 subunits, respectively. In situ hybridization reveals that there are pronounced differen...

journal_title：Journal of neurochemistry

authors： Glencorse TA,Darlison MG,Barnard EA,Bateson AN

更新日期：1993-12-01 00:00:00

abstract：:Depletion of glutathione in the substantia nigra is one of the earliest changes observed in Parkinson's disease (PD) and could initiate dopaminergic neuronal degeneration. Nevertheless, experimental glutathione depletion does not result in preferential toxicity to dopaminergic neurons either in vivo or in vitro. Moreo...

journal_title：Journal of neurochemistry

authors： Nakamura K,Wright DA,Wiatr T,Kowlessur D,Milstien S,Lei XG,Kang UJ

更新日期：2000-06-01 00:00:00

abstract：:Dermorphin and its Hyp6 analogue are opiate-like heptapeptides originally discovered in frog skin and characterized by the presence of a D-Ala2 residue in their sequence. They were assayed for their capacity to compete with [3H]Leu-enkephalin for binding to opioid receptors in membranes of neuroblastoma x glioma hybri...

journal_title：Journal of neurochemistry

authors： Glaser T,Hübner K,de Castiglione R,Hamprecht B

更新日期：1981-12-01 00:00:00

abstract：:We have used thapsigargin (TG), a specific, irreversible inhibitor of endoplasmic reticulum (ER) Ca(2+)-ATPases, and caffeine, an agonist of the ryanodine receptor, to study the effect of emptying of ER calcium stores on protein synthesis in neuronal cells. TG at 1 microM caused a permanent inhibition of protein synth...

journal_title：Journal of neurochemistry

authors： Paschen W,Doutheil J,Gissel C,Treiman M

更新日期：1996-10-01 00:00:00

abstract：:Glial cells are currently viewed as active partners of neurons in synapse formation. The close proximity of astrocytes to the synaptic cleft suggests that these cells might be potential targets for neuronal-released molecules although this issue has been less addressed. Here, we evaluated the role of the excitatory ne...

journal_title：Journal of neurochemistry

authors： Romão LF,Sousa Vde O,Neto VM,Gomes FC

更新日期：2008-07-01 00:00:00

abstract：:The activities of choline acetyltransferase (CAT) and glutamic acid decarboxylase (GAD), markers of cholinergic and GABAergic terminals, were measured in growing and adult Gunn rats, which possess an autosomal recessive gene for jaundice or kernicterus. In the olfactory tubercle, hippocampus, neostriatum, thalamus, an...

journal_title：Journal of neurochemistry

authors： Ohno T

更新日期：1981-10-01 00:00:00

abstract：:Rat and mouse CNS neurofilament proteins (NFPs) were characterized and compared, in terms of electrophoretic properties on polyacrylamide gels and by peptide mapping, with one another and with other co-purifying lower-molecular-weight CNS proteins, including alpha and beta tubulin. NFPs were partially purified by modi...

journal_title：Journal of neurochemistry

authors： Brown BA,Nixon RA,Strocchi P,Marotta CA

更新日期：1981-01-01 00:00:00

abstract：:In human fetal spinal cord (HFSC), six additional microtubule-associated protein-2 (MAP-2) transcripts are generated by alternative splicing of two recently described exons, exon 8 and exon 13. The following three translated proteins are detected by western blot analysis: MAP-2b expressing exon 8 (MAP-2b + 8; MAP-2a),...

journal_title：Journal of neurochemistry

authors： Kalcheva N,Weidenheim KM,Kress Y,Shafit-Zagardo B

更新日期：1997-01-01 00:00:00

abstract：:A previous report has described the presence of t-[35S]-butylbicyclophosphorothionate binding sites and GABA-gated Cl- flux in the human neuroblastoma IMR-32 cell line. We now report the further characterisation of this binding site and, even more important, the identification of the GABAA receptor alpha 3 sub-unit ex...

journal_title：Journal of neurochemistry

authors： Noble PJ,Anderson SM,De Souza RJ,Cross AJ,Stephenson FA

更新日期：1993-08-01 00:00:00

abstract：:Exogenously administered estrogens can enhance the rate of increase of glucose 6-phosphate dehydrogenase activity in rat extensor digitorum longus muscles following denervation. In this communication, we report that the effect of denervation on glucose 6-phosphate dehydrogenase activity is modified by variations in en...

journal_title：Journal of neurochemistry

authors： Schaerf FW,Patz T,Max SR

更新日期：1982-06-01 00:00:00

abstract：:Parkinson's disease is a common neurodegenerative disorder with a mainly sporadic aetiology, although a number of monogenic familiar forms are known. Most of the motor symptoms are due to selective depletion of dopaminergic, neuromelanin-containing neurones of the substantia nigra pars compacta. Neuromelanin is the da...

journal_title：Journal of neurochemistry

authors： Fasano M,Bergamasco B,Lopiano L

更新日期：2006-02-01 00:00:00

abstract：:Synaptosomal-associated protein of 25 kDa (SNAP-25) is thought to play a key role in vesicle exocytosis and in the control of transmitter release. However, the precise mechanisms of action as well as the regulation of SNAP-25 remain unclear. Here we show by immunoprecipitation that activation of protein kinase C (PKC)...

journal_title：Journal of neurochemistry

authors： Genoud S,Pralong W,Riederer BM,Eder L,Catsicas S,Muller D

更新日期：1999-04-01 00:00:00

abstract：:The contribution of neuromelanin (NM) to the pathogenesis of Parkinson's disease (PD) has long been suspected. In particular, a correlation has been reported between the estimated cell loss in the mesencephalic dopaminergic cell groups and the percentage of NM-pigmented neurons in these cell groups. To test whether th...

journal_title：Journal of neurochemistry

authors： Kastner A,Hirsch EC,Lejeune O,Javoy-Agid F,Rascol O,Agid Y

更新日期：1992-09-01 00:00:00

abstract：:The carbohydrate content of human brain glycoproteins was studied during development from the age of 12 fetal weeks to 8 postnatal months. The concentration of all the glycoprotein monosaccharides increased with age. The total amount of glycoprotein monosaccharides per lipid-free dry tissue increased by about 150% fro...

journal_title：Journal of neurochemistry

authors： Korpeinen T,Mononen I,Krusius T,Järnefelt J

更新日期：1982-12-01 00:00:00

abstract：:Perilymph, which bathes the sensory cells of the cochlea, was collected from guinea pigs exposed to noise and analyzed via two cation-exchange HPLC procedures with fluorescence detection, resolving 51 and 81 primary-amine compounds, respectively, at a sensitivity limit of 0.1 pmol relative to leucine. During a first p...

journal_title：Journal of neurochemistry

authors： Drescher MJ,Drescher DG,Medina JE

更新日期：1983-08-01 00:00:00

abstract：:Synaptic scaffolding molecule (S-SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin. Here, we identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated wit...

journal_title：Journal of neurochemistry

authors： Hirabayashi S,Nishimura W,Iida J,Kansaku A,Kishida S,Kikuchi A,Tanaka N,Hata Y

更新日期：2004-07-01 00:00:00

abstract：:D-serine is a co-agonist of NMDA receptor (NMDAR) and plays important roles in synaptic plasticity mechanisms. Serine racemase (SR) is a brain-enriched enzyme that converts L-serine to D-serine. SR interacts with the protein interacting with C-kinase 1 (PICK1), which is known to direct protein kinase C (PKC) to its ta...

journal_title：Journal of neurochemistry

authors： Vargas-Lopes C,Madeira C,Kahn SA,Albino do Couto I,Bado P,Houzel JC,De Miranda J,de Freitas MS,Ferreira ST,Panizzutti R

更新日期：2011-01-01 00:00:00

abstract：:Stem cell-based approaches provide hope as a potential therapy for neurodegenerative diseases and stroke. One of the major scientific hurdles for stem cell therapy is the poor survival rate of the newly formed or transplanted neural stem cells. In this study, we found that low-dose treatment with the Heat shock protei...

journal_title：Journal of neurochemistry

authors： Wang G,Krishnamurthy K,Tangpisuthipongsa D

更新日期：2011-05-01 00:00:00

abstract：:Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects on the neurochemical profile of the frontal cortex. A mouse mod...

journal_title：Journal of neurochemistry

authors： Corcoba A,Gruetter R,Do KQ,Duarte JMN

更新日期：2017-09-01 00:00:00

abstract：:The mature form of Alzheimer's beta-amyloid precursor protein (APP) is phosphorylated specifically at Thr(668) in neurons. In mature neurons, phosphorylated APP is detected in neurites, with dephosphorylated APP being found mostly in the cell body. In vitro, active cyclin-dependent kinase 5 (Cdk5) phosphorylated the c...

journal_title：Journal of neurochemistry

authors： Iijima K,Ando K,Takeda S,Satoh Y,Seki T,Itohara S,Greengard P,Kirino Y,Nairn AC,Suzuki T

更新日期：2000-09-01 00:00:00

abstract：:cDNAs encoding four isoforms of the human NMDA receptor (NMDAR) NMDAR2C (hNR2C-1, -2, -3, and -4) have been isolated and characterized. The overall identity of the deduced amino acid sequences of human and rat NR2C-1 is 89.0%. The sequences of the rat and human carboxyl termini (Gly925-Val1,236) are encoded by differe...

journal_title：Journal of neurochemistry

authors： Daggett LP,Johnson EC,Varney MA,Lin FF,Hess SD,Deal CR,Jachec C,Lu CC,Kerner JA,Landwehrmeyer GB,Standaert DG,Young AB,Harpold MM,Veliçelebi G

更新日期：1998-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common type of dementia among elderly people. Amyloid beta (Aβ) peptides in extracellular Aβ plaques, produced from the amyloid precursor protein (APP) via sequential processing by β- and γ-secretases, impair hippocampal synaptic plastic...

journal_title：Journal of neurochemistry

authors： Kuwabara Y,Ishizeki M,Watamura N,Toba J,Yoshii A,Inoue T,Ohshima T

更新日期：2014-08-01 00:00:00

abstract：:α-Synuclein causes Parkinson's disease if mutated or aberrantly produced in neurons. α-Synuclein-lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N-terminal amino acids dramatically reduced lipid bindi...

journal_title：Journal of neurochemistry

authors： Vamvaca K,Lansbury PT Jr,Stefanis L

更新日期：2011-10-01 00:00:00

abstract：:As a result of the identification, pharmacological characterization, and localization of the cannabinoid receptor in the CNS, the existence of an endogenous ligand for this receptor can be hypothesized. Following the premise that such a substance could have the properties of a neuromodulator being stored in intracellu...

journal_title：Journal of neurochemistry

authors： Evans DM,Johnson MR,Howlett AC

更新日期：1992-02-01 00:00:00

abstract：:Previous evidence has suggested that brain catecholamine levels are important in the regulation of central angiotensin II receptors. In the present study, the effects of norepinephrine and 3,4-dihydroxyphenylethylamine (dopamine) on angiotensin II receptor regulation in neuronal cultures from rat hypothalamus and brai...

journal_title：Journal of neurochemistry

authors： Sumners C,Watkins LL,Raizada MK

更新日期：1986-10-01 00:00:00