Abstract:
:The mature form of Alzheimer's beta-amyloid precursor protein (APP) is phosphorylated specifically at Thr(668) in neurons. In mature neurons, phosphorylated APP is detected in neurites, with dephosphorylated APP being found mostly in the cell body. In vitro, active cyclin-dependent kinase 5 (Cdk5) phosphorylated the cytoplasmic domain of APP at Thr(668). Treatment of mature neurons with an antisense oligonucleotide to Cdk5 suppressed Cdk5 expression and significantly diminished the level of phosphorylated APP. The expression of APP was unaffected in antisense-treated neurons. These results indicate that in neurons APP is phosphorylated by Cdk5, and that this may play a role in its localization.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Iijima K,Ando K,Takeda S,Satoh Y,Seki T,Itohara S,Greengard P,Kirino Y,Nairn AC,Suzuki Tdoi
10.1046/j.1471-4159.2000.0751085.xkeywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1085-91issue
3eissn
0022-3042issn
1471-4159journal_volume
75pub_type
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journal_title:Journal of neurochemistry
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Journal of neurochemistry
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journal_title:Journal of neurochemistry
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1046/j.1471-4159.1995.65041562.x
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journal_title:Journal of neurochemistry
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.1991.tb08287.x
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
abstract::Synapsin I, a prominent phosphoprotein in nerve terminals, is proposed to modulate exocytosis by interaction with the cytoplasmic surface of small synaptic vesicles and cytoskeletal elements in a phosphorylation-dependent manner. Tetanus toxin (TeTx), a potent inhibitor of neurotransmitter release, attenuated the depo...
journal_title:Journal of neurochemistry
pub_type: 杂志文章
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