Increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in Huntington's disease: evidence for an overactive dopaminergic brain transmission.

abstract：:Treatment with phorbol esters such as 12-O-tetradecanoylphorbol acetate (TPA) rapidly enhances [3H]norepinephrine secretion from digitonin-permeabilized adrenal chromaffin cells. When TPA treatment was prolonged for several hours, a second distinct enhancing effect was observed. This later enhancement was most promine...

journal_title：Journal of neurochemistry

authors： Bittner MA,Holz RW

更新日期：1990-01-01 00:00:00

abstract：:The proposed structural protein of peripheral nerve myelin, P0, has been shown to have several covalent modifications. In addition to being glycosylated, sulfated, and acylated, P0 is phosphorylated, with the intracellular site of this latter addition being in question. By employing nerve injury models that exhibit di...

journal_title：Journal of neurochemistry

authors： Brunden KR,Poduslo JF

更新日期：1987-12-01 00:00:00

abstract：:Dopamine (DA)-producing neurons in the ventral midbrain are generated from a specified neuronal lineage and form selective axonal pathways that mediate multiple CNS functions. Expression of the gene encoding tyrosine hydroxylase (TH), which is a key enzyme of catecholamine biosynthesis, is regulated during the develop...

journal_title：Journal of neurochemistry

authors： Matsushita N,Okada H,Yasoshima Y,Takahashi K,Kiuchi K,Kobayashi K

更新日期：2002-07-01 00:00:00

abstract：:RIC-3 enhances the functional expression of certain nicotinic acetylcholine receptors (nAChRs) in vertebrates and invertebrates and increases the availability of functional receptors in cultured cells and Xenopus laevis oocytes. Maximal activity of RIC-3 may be cell-type dependent, so neither mammalian nor invertebrat...

journal_title：Journal of neurochemistry

authors： Bennett HM,Lees K,Harper KM,Jones AK,Sattelle DB,Wonnacott S,Wolstenholme AJ

更新日期：2012-12-01 00:00:00

abstract：:An important step in the cascade leading to neuronal cell death is degradation of laminin and other components of the brain extracellular matrix by microglia-derived proteases. Excitotoxic cell death of murine hippocampal neurones in vivo can be prevented by inhibitors of tissue plasminogen activator (tPA) or by inhib...

journal_title：Journal of neurochemistry

authors： Campbell SJ,Finlay M,Clements JM,Wells G,Miller KM,Perry VH,Anthony DC

更新日期：2004-06-01 00:00:00

abstract：:Several mechanisms are thought to be involved in the progressive decline in neurons of the substantia nigra pars compacta (SNpc) that leads to Parkinson's disease (PD). Neurotoxin 6-hydroxydopamine (6-OHDA), which induces parkinsonian symptoms in experimental animals, is thought to be formed endogenously in patients w...

journal_title：Journal of neurochemistry

authors： Barkats M,Millecamps S,Bilang-Bleuel A,Mallet J

更新日期：2002-07-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is a major pathological feature of Alzheimer's disease and related disorders. Human cerebrovascular smooth muscle (HCSM) cells, which are intimately associated with CAA, have been used as an in vitro model system to investigate pathologic interactions with amyloid beta protein (A beta...

journal_title：Journal of neurochemistry

authors： Jung SS,Zhang W,Van Nostrand WE

更新日期：2003-06-01 00:00:00

abstract：:Fever is thought to be mediated by leukocytic pyrogen (LP), a polypeptide synthesized by phagocytic leukocytes and which is responsible for the upwards resetting of the hypothalamic thermostat. In an attempt to study the effects of LP directly on brain tissue, purified human LP was incubated with rabbit brain slices i...

journal_title：Journal of neurochemistry

authors： Dinarello CA,Bernheim HA

更新日期：1981-09-01 00:00:00

abstract：:Inducible expression of the group-I metabotropic glutamate receptor (mGlu1alpha) in Chinese hamster ovary cells allows for the study of receptor density dependent effects. However, expression levels attainable with this system are lower than those reported for various brain regions and achieved by conventional (consti...

journal_title：Journal of neurochemistry

authors： Nash MS,Selkirk JV,Gaymer CE,Challiss RA,Nahorski SR

更新日期：2001-06-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), an n-3 fatty acid, is rapidly deposited during the period of rapid brain development. The influence of n-3 fatty acid deficiency on learning performance in adult rats over two generations was investigated. Rats were fed either an n-3 fatty acid-adequate (n-3 Adq) or -deficient (n-3 Def) die...

journal_title：Journal of neurochemistry

authors： Moriguchi T,Greiner RS,Salem N Jr

更新日期：2000-12-01 00:00:00

abstract：:Glycerol phosphate dehydrogenase (GPDH), glucose-6-phosphate dehydrogenase (G6PDH), and lactate dehydrogenase (LDH) activities were determined in oligodendrocytes, neurons, and astrocytes isolated from the brains of developing rats. The activity of each enzyme was significantly lower in both neurons and astrocytes tha...

journal_title：Journal of neurochemistry

authors： Cammer W,Snyder DS,Zimmerman TR Jr,Farooq M,Norton WT

更新日期：1982-02-01 00:00:00

abstract：:Long-chain polyunsaturated (n-3) fatty acids have been reported to influence the efficiency of membrane receptors, transporters and enzymes. Because the brain is particularly rich in docosahexaenoic acid (DHA, 22:6 n-3), the present study addresses the question of whether the 22:6 n-3 fatty acid deficiency induces dis...

journal_title：Journal of neurochemistry

authors： Ximenes da Silva A,Lavialle F,Gendrot G,Guesnet P,Alessandri JM,Lavialle M

更新日期：2002-06-01 00:00:00

abstract：:Aberrant production of amyloid-beta peptides by processing of the beta-amyloid precursor protein leads to the formation of characteristic extracellular protein deposits which are thought to be the cause of Alzheimer's disease. Therefore, inhibiting the key enzymes responsible for amyloid-beta peptide generation, beta-...

journal_title：Journal of neurochemistry

authors： Beher D,Wrigley JD,Owens AP,Shearman MS

更新日期：2002-08-01 00:00:00

abstract：:To further analyze the action of copper on brain synaptic mechanisms, the brain dipeptide carnosine (beta-alanyl-L-histidine) was tested in Xenopus laevis oocytes expressing the rat P2X4 or P2X7 receptors. Ten micromolar copper halved the currents evoked by ATP in both receptors; co-application of carnosine plus coppe...

journal_title：Journal of neurochemistry

authors： Coddou C,Villalobos C,González J,Acuña-Castillo C,Loeb B,Huidobro-Toro JP

更新日期：2002-02-01 00:00:00

abstract：:(R)-[3H]Tomoxetine is a radioligand that binds to the norepinephrine (NE) uptake site with high affinity but also binds to a second, lower-affinity site. The goal of the present study was to identify the nature of this low-affinity site by comparing the binding properties of (R)-[3H]tomoxetine with those of (R/S)-[3H]...

journal_title：Journal of neurochemistry

authors： Gehlert DR,Schober DA,Gackenheimer SL

更新日期：1995-06-01 00:00:00

abstract：:[3H]Strychnine binding to rat pons + medulla membranes was used as a measure of glycine receptors or glycine receptor-coupled chloride channels in vitro. A series of compounds structurally related to 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP), which previously were shown to antagonize glycine responses in c...

journal_title：Journal of neurochemistry

authors： Braestrup C,Nielsen M,Krogsgaard-Larsen P

更新日期：1986-09-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) concentration in CSF is potentially a diagnostic and therapeutic target for Alzheimer's disease (AD). The purpose of this study was to clarify the elimination mechanism of human Aβ(1-40) [hAβ (1-40)] from CSF. After intracerebroventricular (ICV) administration, [(125) I]hAβ(1-40) was eliminated ...

journal_title：Journal of neurochemistry

authors： Fujiyoshi M,Tachikawa M,Ohtsuki S,Ito S,Uchida Y,Akanuma S,Kamiie J,Hashimoto T,Hosoya K,Iwatsubo T,Terasaki T

更新日期：2011-08-01 00:00:00

abstract：:The synaptosomal metabolism of glutamine was studied under in vitro conditions that simulate depolarization in vivo. With [2-15N]glutamine as precursor, the [glutamine]i was diminished in the presence of veratridine or 50 mM KCl, but the total amounts of [15N]glutamate and [15N]aspartate formed were either equal to th...

journal_title：Journal of neurochemistry

authors： Erecińska M,Zaleska MM,Nelson D,Nissim I,Yudkoff M

更新日期：1990-06-01 00:00:00

abstract：:Altered aquaporin-4 (AQP4) expression has been reported in brain edema, tumors, muscular dystrophy, and neuromyelitis optica. However, the plasma membrane organization of AQP4 and its interaction with proteins such as the dystrophin-associated protein complex are not well understood. In this study, we used sucrose den...

journal_title：Journal of neurochemistry

authors： Nicchia GP,Cogotzi L,Rossi A,Basco D,Brancaccio A,Svelto M,Frigeri A

更新日期：2008-06-01 00:00:00

abstract：:The effects of treatment of brain membranes with diethyl pyrocarbonate (DEP), a histidine-modifying reagent, on the binding of 3H-labeled Ro 15-4513 (ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]- [1,4]benzodiazepine-3-carboxylate) and [3H]diazepam were compared. DEP pretreatment produced a dose-dependent...

journal_title：Journal of neurochemistry

authors： Uusi-Oukari M

更新日期：1992-08-01 00:00:00

abstract：:The zinc-finger transcription factor Yin Yang 1 (YY1) is a multifunctional protein that plays a critical role in embryonic development. Although it has been shown to play a role in eye development, its expression in the retina was not previously described. Here, we investigated YY1 expression in chicken tissues and we...

journal_title：Journal of neurochemistry

authors： Bernard M,Voisin P

更新日期：2008-05-01 00:00:00

abstract：:We recently reported that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in cultured bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+,K+-ATPase, synergistically induced a gradual secretion of catecholamines from the cells. The effect on catecholamine release was specific f...

journal_title：Journal of neurochemistry

authors： Tanaka T,Yokohama H,Negishi M,Hayashi H,Ito S,Hayaishi O

更新日期：1990-01-01 00:00:00

abstract：:Presynaptic receptors modulating the release of acetylcholine (ACh) were studied in fetal septal neurons cultured in a growth medium to which various drugs were added from day 3 in vitro (DIV 3) to DIV 14. The influence of these drugs on the function of the presynaptic muscarinic (M-) autoreceptor was determined at DI...

journal_title：Journal of neurochemistry

authors： Ehret A,Birthelmer A,Rutz S,Riegert C,Rothmaier AK,Jackisch R

更新日期：2007-08-01 00:00:00

abstract：:2,4,5-Trihydroxyphenylalanine (TOPA) oxidizes in solution to form a quinone derivative that is a non-N-methyl-D-aspartate agonist and neurotoxin. Although pathways have been postulated for the formation of both TOPA and TOPA quinone from closely related catecholamines, the generation of these compounds has not been co...

journal_title：Journal of neurochemistry

authors： Newcomer TA,Palmer AM,Rosenberg PA,Aizenman E

更新日期：1993-09-01 00:00:00

abstract：:Although the involvement of both endogenous opioid and serotonergic systems in modulation of pain and emotion was suggested, the neurochemical interaction between these systems in the brain has not previously been studied directly. Herein, the effects of the local application of serotonin (5-HT) and fluoxetine (a 5-HT...

journal_title：Journal of neurochemistry

authors： Zangen A,Nakash R,Yadid G

更新日期：1999-12-01 00:00:00

abstract：:Cerebral endothelial cells form the selective permeability barrier between brain and blood by virtue of their impermeable tight junctions and the presence of specific carrier systems. These specialized properties of brain capillaries are reflected in the presence of proteins that are not found in other capillaries of ...

journal_title：Journal of neurochemistry

authors： Risau W,Dingler A,Albrecht U,Dehouck MP,Cecchelli R

更新日期：1992-02-01 00:00:00

abstract：:We report on the expression of ionotropic glutamate receptor subunits in primary neuronal cultures from rat cortex, hippocampus and cerebellum and of metabotropic glutamate (mGlu) receptor subtypes in these neuronal cultures as well as in cortical astroglial cultures. We found that the NMDA receptor (NR) subunits NR1,...

journal_title：Journal of neurochemistry

authors： Janssens N,Lesage AS

更新日期：2001-06-01 00:00:00

abstract：:Recently, in the course of our search for the prostacyclin receptor in the brain, we found a novel subtype, designated as IP2, which was finely discriminated by use of the specific ligand (15R)-16-m-tolyl-17,18,19,20-tetranorisocarbacyclin (15R-TIC) and specifically localized in the rostral part of the brain. In the p...

journal_title：Journal of neurochemistry

authors： Watanabe Y,Matsumura K,Takechi H,Kato K,Morii H,Björkman M,Långström B,Noyori R,Suzuki M,Watanabe Y

更新日期：1999-06-01 00:00:00

abstract：:Synaptic plasma membranes (SPM) and synaptic junctions (SJ) were isolated from the cortices of rats varying in age between 5 and 28 days. Gel electrophoresis of SPM and SJ indicated a marked increase in the concentration of the "PSD protein" (M. W. 52,000) with development. The biosynthesis of glycoproteins was measur...

journal_title：Journal of neurochemistry

authors： Fu SC,Cruz TF,Gurd JW

更新日期：1981-04-01 00:00:00

abstract：:Choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, I.U.B. 2.3.1.6) activity and total protein content in visual and extra-visual areas were compared in normal Long-Evans rats and in rats subjected to complete light-deprivation for 21 days from birth. The enzyme activity and the protein content in the ...

journal_title：Journal of neurochemistry

authors： Maletta GJ,Timiras PS

更新日期：1968-08-01 00:00:00