Abstract：
:Kainate receptors (KARs) have been described as modulators of synaptic transmission at different synapses. However, this role of KARs has not been well characterized in the amygdala. We have explored the effect of kainate receptor activation at the synapse established between fibers originating at medial geniculate nucleus and the principal cells in the lateral amygdala. We have observed an inhibition of evoked excitatory postsynaptic currents (eEPSCs) amplitude after a brief application of KARs agonists KA and ATPA. Paired-pulse recordings showed a clear pair pulse facilitation that was enhanced after KA or ATPA application. When postsynaptic cells were loaded with BAPTA, the depression of eEPSC amplitude observed after the perfusion of KAR agonists was not prevented. We have also observed that the inhibition of the eEPSCs by KARs agonists was prevented by protein kinase A but not by protein kinase C inhibitors. Taken together our results indicate that KARs present at this synapse are pre-synaptic and their activation mediate the inhibition of glutamate release through a mechanism that involves the activation of protein kinase A.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Negrete-Díaz JV,Duque-Feria P,Andrade-Talavera Y,Carrión M,Flores G,Rodríguez-Moreno Adoi
10.1111/j.1471-4159.2012.07665.xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
36-43issue
1eissn
0022-3042issn
1471-4159journal_volume
121pub_type
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