Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells.

abstract：:Chandipura virus (CHPV; genus Vesiculovirus, family Rhabdoviridae) induces neuronal death through the Fas-mediated extrinsic apoptosis pathway. What propels this apoptosis remains unclear, although oxysterols have been reported to be key players in neurodegeneration. In our study of CHPV-infected brain samples, we obs...

journal_title：Journal of neurochemistry

authors： Ghosh S,Mukherjee S,Basu A

更新日期：2015-10-01 00:00:00

abstract：:Type 1 cannabinoid receptor (CB1) is expressed in different neuronal populations in the mammalian brain. In particular, CB1 on GABAergic or glutamatergic neurons exerts different functions and display different pharmacological properties in vivo. This suggests the existence of neuron-type specific signalling pathways ...

journal_title：Journal of neurochemistry

authors： Steindel F,Lerner R,Häring M,Ruehle S,Marsicano G,Lutz B,Monory K

更新日期：2013-03-01 00:00:00

abstract：:Bone fracture at the acute stage of stroke exacerbates stroke injury by increasing neuroinflammation. We hypothesize that activation of α-7 nicotinic acetylcholine receptor (α-7 nAchR) attenuates neuroinflammation and oxidative stress, and reduces brain injury in mice with bone fracture and stroke. Permanent middle ce...

journal_title：Journal of neurochemistry

authors： Han Z,Li L,Wang L,Degos V,Maze M,Su H

更新日期：2014-11-01 00:00:00

abstract：:We have analyzed brain coated vesicles and synaptic plasma membrane for the presence of the plasma membrane proteolipid protein. Coated vesicles were isolated from calf brain gray matter with a final purification on Sephacryl S-1000 and reisolated twice by chromatography to ensure homogeneity. Fractions were analyzed ...

journal_title：Journal of neurochemistry

authors： Sapirstein VS,Nolan C,Stern R,Ciocci M,Masur SK

更新日期：1988-09-01 00:00:00

abstract：:Acute nicotine administration stimulated [3H]norepinephrine ([3H]NE) release from cultured fetal locus coeruleus (LC) cells. The effect was concentration dependent, with an EC50 of 0.9 microM, and was abolished by removal of calcium from, or addition of tetrodotoxin (500 nM) to, the assay buffer. Other nicotinic recep...

journal_title：Journal of neurochemistry

authors： Gallardo KA,Leslie FM

更新日期：1998-02-01 00:00:00

abstract：:The effectiveness of intranasal drug administration to stimulate central neuronal systems is well known from drug addiction and has also been considered as an alternative pharmacokinetic approach to treat brain disorders such as Parkinson's disease. In the present study, the possible neurochemical effects of intranasa...

journal_title：Journal of neurochemistry

authors： De Souza Silva MA,Mattern C,Häcker R,Nogueira PJ,Huston JP,Schwarting RK

更新日期：1997-01-01 00:00:00

abstract：:This study examined the hypothesis that chronic ethanol consumption results in significant abnormalities in both the dopaminergic and the serotonergic system of aged rats. Levels of dopamine (DA), serotonin [5-hydroxytryptamine (5-HT)], 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindole-3-acetic acid (5-HIAA)...

journal_title：Journal of neurochemistry

authors： Woods JM,Druse MJ

更新日期：1996-05-01 00:00:00

abstract：:We recently reported that by postnatal day 40 the activity of sn-glycerol-3-phosphate dehydrogenase (GPDH) was significantly depressed in the cerebellum of genetic-hypothyroid mutant mice. This mutant mouse-GPDH combination was used in the present study to define the critical time period during which thyroid hormone (...

journal_title：Journal of neurochemistry

authors： Sugisaki T,Noguchi T

更新日期：1992-12-01 00:00:00

abstract：:Tanycytes are glial cells in the hypothalamus that are functionally part of the blood-brain barrier. They can sense nutrients and metabolites in the circulation such as glucose, then signal to neuronal systems to influence ingestive behaviour and energy storage, and ultimately affect body weight. The complex structure...

journal_title：Journal of neurochemistry

authors： Ebling FJP

更新日期：2020-11-09 00:00:00

abstract：:In an established rat model of penetrating ballistic-like brain injury (PBBI), arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase) activity was significantly reduced at the ipsilateral site of injury, but unaffected at the contralateral site or in sham controls. In addition, the ARSB substrate chondroitin 4-sulf...

journal_title：Journal of neurochemistry

authors： Bhattacharyya S,Zhang X,Feferman L,Johnson D,Tortella FC,Guizzetti M,Tobacman JK

更新日期：2015-08-01 00:00:00

abstract：:Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to the daily changes of their environment. These clocks generate self-sustained oscillations at the cellular, tissue, and behavioral level. The rhythm-generating mechanism is based on a gene expressi...

journal_title：Journal of neurochemistry

authors： Srikanta SB,Cermakian N

更新日期：2020-07-27 00:00:00

abstract：:The present paper describes the isolation and characterization of a clone of hybrid myelomas (3-E7) secreting a mouse monoclonal antibody to beta-endorphin. An examination of its specificity against a series of human beta-lipotropin fragments and other opioid peptides revealed that the N-terminus portion of beta-endor...

journal_title：Journal of neurochemistry

authors： Gramsch C,Meo T,Riethmüller G,Herz A

更新日期：1983-05-01 00:00:00

abstract：:pros-Methylimidazoleacetic acid (p-MIAA; 1-methylimidazole-5-acetic acid), an isomer of the histamine metabolite, tele-methylimidazoleacetic acid (t-MIAA), is present in brain and CSF. Its relationship to histamine synthesis and catabolism was assessed in brains of rats. p-MIAA distribution in brain regions was hetero...

journal_title：Journal of neurochemistry

authors： Prell GD,Khandelwal JK,Hough LB,Green JP

更新日期：1989-02-01 00:00:00

abstract：:It is necessary for the cell-cycle machinery of neurons to be suppressed to promote differentiation and maintenance of their terminally differentiated state. Reactivation of the cell cycle in response to neurotoxic insults leads to neuronal cell death and some cell-cycle-related proteins contribute to the process. p27...

journal_title：Journal of neurochemistry

authors： Jaiswal S,Sharma P

更新日期：2017-02-01 00:00:00

abstract：:This study examined the respective influences of cannabinoid type-1 (CB1) receptors expressed either in forebrain GABAergic neurons, in cortical glutamatergic neurons, or in astrocytes on the turnover rates of the endocannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabin...

journal_title：Journal of neurochemistry

authors： Belluomo I,Matias I,Pernègre C,Marsicano G,Chaouloff F

更新日期：2015-04-01 00:00:00

abstract：:Glutamate or a related excitatory amino acid is thought to be the major excitatory neurotransmitter of hippocampal afferents, intrinsic neurons, and efferents. We have used an autoradiographic technique to investigate the status of excitatory amino acid receptors in the hippocampal formation of patients dying with dem...

journal_title：Journal of neurochemistry

authors： Greenamyre JT,Penney JB,D'Amato CJ,Young AB

更新日期：1987-02-01 00:00:00

abstract：:Prenatal and early postnatal periods are important for brain development and neural function. Neonatal insults such as hypoxia-ischemia (HI) causes prolonged neural and metabolic dysregulation, affecting central nervous system maturation. There is evidence that brain hypometabolism could increase the risk of adult-ons...

journal_title：Journal of neurochemistry

authors： Durán-Carabali LE,Kawa Odorcyk F,Greggio S,Teribele Venturin G,Farias Sanches E,Garcia Schu G,Soares Carvalho A,Avila Pedroso T,de Sá Couto-Pereira N,Costa da Costa J,Dalmaz C,Rigon Zimmer E,Netto CA

更新日期：2020-10-23 00:00:00

abstract：:Voltage-gated sodium channels (VGSC) are involved in the generation of action potentials in neurons. Brevetoxins (PbTx) are potent allosteric enhancers of VGSC function and are associated with the periodic 'red tide' blooms. Using PbTx-2 as a probe, we have characterized the effects of activation of VGSC on Ca(2+) dyn...

journal_title：Journal of neurochemistry

authors： Dravid SM,Baden DG,Murray TF

更新日期：2004-05-01 00:00:00

abstract：:The myelin-deficient (mld) mouse is an autosomal recessive mutant characterized by hypomyelination of the CNS due to reduced expression of the myelin basic protein (MBP) gene. In the mld mutant, the MBP gene is duplicated in tandem. One gene is intact, but a large portion is inverted upstream of the other copy, and it...

journal_title：Journal of neurochemistry

authors： Okano H,Aruga J,Nakagawa T,Shiota C,Mikoshiba K

更新日期：1991-02-01 00:00:00

abstract：:The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine-synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the ...

journal_title：Journal of neurochemistry

authors： Sacchetti P,Mitchell TR,Granneman JG,Bannon MJ

更新日期：2001-03-01 00:00:00

abstract：:The possibilities of interference by glycerophosphoryl ethanolamine (GPE) in the estimation of taurine levels in cerebral cortex, midbrain, cerebellum, medullapons, and spinal cord of developing human fetal brain regions were eliminated by hydrolyzing tissue extracts with 6 M HCl. Cysteic acid thus produced was separa...

journal_title：Journal of neurochemistry

authors： Datta SC

更新日期：1988-04-01 00:00:00

abstract：:Currently, the underlying mechanisms and the specific cell types associated with Japanese encephalitis-associated leukocyte trafficking are not understood. Brain microvascular endothelial cells represent a functional barrier and could play key roles in leukocyte central nervous system trafficking. We found that cultur...

journal_title：Journal of neurochemistry

authors： Lai CY,Ou YC,Chang CY,Pan HC,Chang CJ,Liao SL,Su HL,Chen CJ

更新日期：2012-10-01 00:00:00

abstract：:Environment-induced relapse is a major concern in drug addiction because of the strong associations formed between drug reward and environment. Cocaine-conditioned place preference is an ideal experimental tool to examine adaptations in the molecular pathways that are activated upon re-exposure to an environment previ...

journal_title：Journal of neurochemistry

authors： Tropea TF,Kosofsky BE,Rajadhyaksha AM

更新日期：2008-08-01 00:00:00

abstract：:Activation of integrin receptors in neurons can promote cell survival and synaptic plasticity, but the underlying signal transduction pathway(s) is unknown. We report that integrin signaling prevents apoptosis of embryonic hippocampal neurons by a mechanism involving integrin-linked kinase (ILK) that activates Akt kin...

journal_title：Journal of neurochemistry

authors： Gary DS,Milhavet O,Camandola S,Mattson MP

更新日期：2003-02-01 00:00:00

abstract：:This study investigated the temporal expression and cell subtype distribution of activated caspase-3 following cortical impact-induced traumatic brain injury in rats. The animals were killed and examined for protein expression of the proteolytically active subunit of caspase-3, p18, at intervals from 6 h to 14 days af...

journal_title：Journal of neurochemistry

authors： Beer R,Franz G,Srinivasan A,Hayes RL,Pike BR,Newcomb JK,Zhao X,Schmutzhard E,Poewe W,Kampfl A

更新日期：2000-09-01 00:00:00

abstract：:The FE65 adaptor protein family was identified in two-hybrid screens as proteins that bind the cytoplasmic domain of the amyloid precursor protein (APP). Studies have shown that FE65 binding to APP modulates APP processing. Increased levels of alpha-secretase derived secreted APP (APPsalpha) and beta-amyloid (Abeta) w...

journal_title：Journal of neurochemistry

authors： Guénette SY,Chang Y,Hyman BT,Tanzi RE,Rebeck GW

更新日期：2002-08-01 00:00:00

abstract：:Microglia, macrophage-like cells in the CNS, are multifunctional cells; they play an important role in removal of dead cells or their remnants by phagocytosis in the CNS degeneration and are one of important cells in the CNS cytokine network to produce and respond to a variety of cytokines. The functions of microglia ...

journal_title：Journal of neurochemistry

authors： Sawada M,Suzumura A,Hosoya H,Marunouchi T,Nagatsu T

更新日期：1999-04-01 00:00:00

abstract：:ε4 allele of ApoE is the strongest genetic risk factor for late onset Alzheimer's disease (AD). Supplementation of ApoE proteins or mimetics has been pursued for drug developments against AD. A very low-density lipoprotein (HDL) mimetic peptide 4F was shown to alleviate AD-related deficits in APP transgenic mice, and ...

journal_title：Journal of neurochemistry

authors： Wang W,Zhu X

更新日期：2018-12-01 00:00:00

abstract：:The specific opioid receptor antagonist naloxone attenuates the behavioral and neurochemical effects of amphetamine. Furthermore, the amphetamine-induced increase in locomotor activity is attenuated by intracisternally administered naltrindole, a selective delta-opioid receptor antagonist, but not by the irreversible ...

journal_title：Journal of neurochemistry

authors： Schad CA,Justice JB Jr,Holtzman SG

更新日期：1996-12-01 00:00:00

abstract：:Drosophila melanogaster homogenates incubated with tritiated 5-hydroxytryptophan, 5-hydroxytryptamine, or N-acetylserotonin have the ability of converting them into labelled indolamines, including melatonin. All these compounds were characterized by two-dimensional thin-layer chromatography by comparison with nonradio...

journal_title：Journal of neurochemistry

authors： Finocchiaro L,Callebert J,Launay JM,Jallon JM

更新日期：1988-02-01 00:00:00