Nicotine-stimulated release of [3H]norepinephrine from fetal rat locus coeruleus cells in culture.

abstract：:The synaptosomal metabolism of glutamine was studied under in vitro conditions that simulate depolarization in vivo. With [2-15N]glutamine as precursor, the [glutamine]i was diminished in the presence of veratridine or 50 mM KCl, but the total amounts of [15N]glutamate and [15N]aspartate formed were either equal to th...

journal_title：Journal of neurochemistry

authors： Erecińska M,Zaleska MM,Nelson D,Nissim I,Yudkoff M

更新日期：1990-06-01 00:00:00

abstract：:The myelin-deficient (mld) mouse is an autosomal recessive mutant characterized by hypomyelination of the CNS due to reduced expression of the myelin basic protein (MBP) gene. In the mld mutant, the MBP gene is duplicated in tandem. One gene is intact, but a large portion is inverted upstream of the other copy, and it...

journal_title：Journal of neurochemistry

authors： Okano H,Aruga J,Nakagawa T,Shiota C,Mikoshiba K

更新日期：1991-02-01 00:00:00

abstract：:Overexpression of gp120, the major coat protein of the HIV-1 virus, in central glial cells, or treatment of neurons with gp120 in culture, produces apoptotic neuronal death. Here we demonstrate that CEP-1347 (KT7515), an inhibitor of mixed lineage kinase 3 (MLK3), an upstream activator of JNK, inhibits gp120IIIB-induc...

journal_title：Journal of neurochemistry

authors： Bodner A,Maroney AC,Finn JP,Ghadge G,Roos R,Miller RJ

更新日期：2002-09-01 00:00:00

abstract：:By using a 125I-calmodulin overlay assay, three major high-affinity calmodulin-binding proteins, showing apparent molecular masses of 135, 60, and 50 kDa, have been detected in purified nuclear fractions isolated from rat neurons. It has been shown that after extraction of the nuclei with nucleases and high salt, all ...

journal_title：Journal of neurochemistry

authors： Pujol MJ,Bosser R,Vendrell M,Serratosa J,Bachs O

更新日期：1993-04-01 00:00:00

abstract：:Fused in sarcoma (FUS) is a ubiquitously expressed RNA/DNA-binding protein that plays different roles in the cell. FUS pathology has been reported in neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in FUS have also been linked to a subset of familial ALS. FUS...

journal_title：Journal of neurochemistry

authors： Arenas A,Kuang L,Zhang J,Kingren MS,Zhu H

更新日期：2020-12-22 00:00:00

abstract：:In spite of biochemical and autoradiographic evidence for glucocorticoid binding sites in the spinal cord (SC), events occurring after the preliminary step of hormone binding were not studied. In this investigation, we have examined the transformation (activation) of the cytosolic receptor coupled to [3H]dexamethasone...

journal_title：Journal of neurochemistry

authors： Ortí E,Tornello S,De Nicola AF

更新日期：1985-12-01 00:00:00

abstract：:A diverse group of neurodegenerative diseases - including progressive supranuclear palsy (PSP), corticobasal degeneration and Alzheimer's disease among others, collectively referred to as tauopathies - are characterized by progressive, age-dependent intracellular formations of misfolded protein aggregates that play ke...

journal_title：Journal of neurochemistry

authors： Pasinetti GM,Ksiezak-Reding H,Santa-Maria I,Wang J,Ho L

更新日期：2010-09-01 00:00:00

abstract：:To examine the effect of cocaine on the brain histamine neuron system, histamine levels and histamine N-methyltransferase activity in the rat brain were measured after the administration of cocaine. Moreover, we examined the effect of L-histidine on cocaine-induced wheel-running behavior. The administration of cocaine...

journal_title：Journal of neurochemistry

authors： Ito C,Onodera K,Sakurai E,Sato M,Watanabe T

更新日期：1997-08-01 00:00:00

abstract：:PK 11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide] is a new ligand for the "peripheral-type" benzodiazepine binding sites, chemically unrelated to benzodiazepines. It displaces with a very high potency (IC50 congruent to 10(-9) M) [3H]-RO5-4864 (a benzodiazepine which specifically labe...

journal_title：Journal of neurochemistry

authors： Benavides J,Quarteronet D,Imbault F,Malgouris C,Uzan A,Renault C,Dubroeucq MC,Gueremy C,Le Fur G

更新日期：1983-12-01 00:00:00

abstract：:Synapsin I, a prominent phosphoprotein in nerve terminals, is proposed to modulate exocytosis by interaction with the cytoplasmic surface of small synaptic vesicles and cytoskeletal elements in a phosphorylation-dependent manner. Tetanus toxin (TeTx), a potent inhibitor of neurotransmitter release, attenuated the depo...

journal_title：Journal of neurochemistry

authors： Presek P,Jessen S,Dreyer F,Jarvie PE,Findik D,Dunkley PR

更新日期：1992-10-01 00:00:00

abstract：:We investigated changes in the extracellular levels of acetylcholine (ACh) following local application of serotonergic agents to the dorsal hippocampus of freely moving rats by means of perfusion using a microdialysis technique. Perfusion of serotonin (5-HT; 10 microM, for 30 min at a rate of 3 microliters/min), disso...

journal_title：Journal of neurochemistry

authors： Izumi J,Washizuka M,Miura N,Hiraga Y,Ikeda Y

更新日期：1994-05-01 00:00:00

abstract：:Rho kinase (ROCK) may play an important role in regulating biological events of cells, including proliferation, differentiation and survival/death. Blockade of ROCK promotes axonal regeneration and neuron survival in vivo and in vitro, thereby exhibiting potential clinical applications in spinal cord damage and stroke...

journal_title：Journal of neurochemistry

authors： Ding J,Li QY,Wang X,Sun CH,Lu CZ,Xiao BG

更新日期：2010-09-01 00:00:00

abstract：:It is well established that ischemia-induced release of glutamate and the subsequent activation of post-synaptic glutamate receptors are important processes involved in the development of ischemic neuronal damage. Moderate intraischemic hypothermia attenuates glutamate release and confers protection from ischemic dama...

journal_title：Journal of neurochemistry

authors： Busto R,Globus MY,Neary JT,Ginsberg MD

更新日期：1994-09-01 00:00:00

abstract：:A simple and rapid method for preparation of enriched neurofilament protein from mammalian peripheral nerve or spinal cord is described. Tissue extracts from guinea pig nerve or spinal cord are fractionated by ammonium sulfate fractionation, chromatography on Sepharofe 4B, and precipitation with ethanol. Molecular exc...

journal_title：Journal of neurochemistry

authors： Shecket G,Lasek RJ

更新日期：1980-12-01 00:00:00

abstract：:This study describes the effect of signalling through muscarinic acetylcholine receptors on two transcription factors implicated in long-term synaptic plasticity and memory formation, EGR1 and the cyclic AMP response element binding protein (CREB). In SK-N-SH neuroblastoma cells, treatment with the cholinergic agonist...

journal_title：Journal of neurochemistry

authors： Greenwood JM,Dragunow M

更新日期：2002-07-01 00:00:00

abstract：:Liver fatty acid-binding protein (FABP1, L-FABP) has high affinity for and enhances uptake of arachidonic acid (ARA, C20:4, n-6) which, when esterified to phospholipids, is the requisite precursor for synthesis of endocannabinoids (EC) such as arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG). The brain...

journal_title：Journal of neurochemistry

authors： Martin GG,Chung S,Landrock D,Landrock KK,Huang H,Dangott LJ,Peng X,Kaczocha M,Seeger DR,Murphy EJ,Golovko MY,Kier AB,Schroeder F

更新日期：2016-08-01 00:00:00

abstract：:In the human fetus, obtained postmortem at estimated gestational ages of 8-22 weeks, biochemical activities of cortical choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were comparable to those of adult brain tissue. In contrast cholinergic receptor binding, including muscarinic M1 and M2 subtypes (mea...

journal_title：Journal of neurochemistry

authors： Perry EK,Smith CJ,Atack JR,Candy JM,Johnson M,Perry RH

更新日期：1986-10-01 00:00:00

abstract：:We examined the effects of orally administered 5'-cytidinediphosphocholine (CDP-choline) on arterial plasma choline and cytidine levels and on brain phospholipid composition in rats. Animals receiving a single oral dose of 100, 250, or 500 mg/kg showed peak plasma choline levels 6-8 h after drug administration (from 1...

journal_title：Journal of neurochemistry

authors： López-Coviella I,Agut J,Savci V,Ortiz JA,Wurtman RJ

更新日期：1995-08-01 00:00:00

abstract：:Myelinogenesis in developing rats was studied following chronic dosing with triethyl tin (TET), at a level of 1.0 mg TET/kg body wt/day. Experiments included starved controls with body weights depressed by 17 to 40% to equal those of the TET-treated groups. Rats at ages of 16, 21, and 30 days showed decreases relative...

journal_title：Journal of neurochemistry

authors： Blaker WD,Krigman MR,Thomas DJ,Mushak P,Morell P

更新日期：1981-01-01 00:00:00

abstract：:Leucine and beta-(+/-)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) stimulated, in a dose-dependent manner, reductive amination of 2-oxoglutarate in rat brain synaptosomes treated with Triton X-100. The concentration dependence curves were sigmoid, with 10-15-fold stimulations at 15 mM leucine (or BCH); oxidat...

journal_title：Journal of neurochemistry

authors： Erecińska M,Nelson D

更新日期：1990-04-01 00:00:00

abstract：:The stimulatory effect of cysteine sulfinic acid on cyclic AMP formation was examined in slices from three different regions of guinea pig brain. The inhibitory effect of taurine on the stimulated formation of cyclic AMP was also studied. Cysteine sulfinic acid (1--10 mM) greatly increased the cyclic AMP level in stri...

journal_title：Journal of neurochemistry

authors： Baba A,Lee E,Tatsuno T,Iwata H

更新日期：1982-05-01 00:00:00

abstract：:The function of membrane phospholipids (PL) in the regulation of gamma-aminobutyric acid (GABA) transport and GABA carrier binding has been investigated in organized cultures of rat cerebral cortex. The cellular lipid composition has been changed by growing the cells in a delipidated nutrient solution or by short-term...

journal_title：Journal of neurochemistry

authors： Giesing M,Gerken U,Kastrup H

更新日期：1985-03-01 00:00:00

abstract：:Increasing evidence suggests that glucagon-like peptide-1 (GLP-1), an incretin hormone of current interest in type 2 diabetes, is neuroprotective in both cell culture and animal models. To characterize the neuroprotective properties of GLP-1 and associated underlying mechanisms, we over-expressed the GLP-1 receptor (G...

journal_title：Journal of neurochemistry

authors： Li Y,Tweedie D,Mattson MP,Holloway HW,Greig NH

更新日期：2010-06-01 00:00:00

abstract：:The overflows of 3,4-dihydroxyphenylalanine, dopamine, noradrenaline, and 3,4-dihydroxyphenylglycol in canine portal vein superfused in vitro were studied before, during, and after depolarization of sympathetic nerve endings. The four compounds were separated from superfusate and from tissue on Sep-Pak C-18 cartridges...

journal_title：Journal of neurochemistry

authors： Hunter LW,Rorie DK,Tyce GM

更新日期：1992-09-01 00:00:00

abstract：:Ischemic postconditioning is increasingly being investigated as a therapeutic approach for cerebral ischemia. However, the majority of studies are focused on the acute protection of neurons per se. Whether and how postconditioning affects multiple cells in the recovering neurovascular unit remains to be fully elucidat...

journal_title：Journal of neurochemistry

authors： Esposito E,Hayakawa K,Ahn BJ,Chan SJ,Xing C,Liang AC,Kim KW,Arai K,Lo EH

更新日期：2018-07-01 00:00:00

abstract：:The objective of the present study was to assess metabolic changes in the neocortex and hippocampus of well-oxygenated or moderately hypoxic rats in which fluorothyl-induced seizures were sustained for 5 or 20 min, or which were allowed recovery periods of 5, 15, or 45 min following cessation of 20-min seizure activit...

journal_title：Journal of neurochemistry

authors： Folbergrová J,Ingvar M,Nevander G,Siesjö BK

更新日期：1985-05-01 00:00:00

abstract：:There is much evidence to suggest that G protein coupled receptors exist as oligomers but the relevance to their function is unclear. We have, therefore, examined the binding of the radiolabelled agonist [(3)H]NPA to membranes of CHO cells expressing the D(2) dopamine receptor in dissociation rate experiments. When [(...

journal_title：Journal of neurochemistry

authors： Kara E,Lin H,Strange PG

更新日期：2010-03-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is involved in many aspects of neuronal biology and hippocampal physiology. Status epilepticus (SE) is a condition in which prolonged seizures lead to neuronal degeneration. SE-induced in rodents serves as a model of Temporal Lobe Epilepsy with hippocampal sclerosis, the most f...

journal_title：Journal of neurochemistry

authors： Unsain N,Montroull LE,Mascó DH

更新日期：2009-10-01 00:00:00

abstract：:Evidence that glucagon-like peptide-1 (GLP-1) (7-36) amide functions as a novel neuropeptide prompted us to study the gene expression of its receptor in rat brain. Northern blot analysis showed transcripts of similar size in RINm5F cells, hypothalamus, and brain-stem. First-strand cDNA was prepared by using RNA from h...

journal_title：Journal of neurochemistry

authors： Alvarez E,Roncero I,Chowen JA,Thorens B,Blázquez E

更新日期：1996-03-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons. Recent studies have revealed that AhR activity in central neurons depends on the NMDA receptor. In this study, we investigated how the neuronal activity influence AhR-mediated dioxin-respon...

journal_title：Journal of neurochemistry

authors： Lin CH,Juan SH,Wang CY,Sun YY,Chou CM,Chang SF,Hu SY,Lee WS,Lee YH

更新日期：2008-03-01 00:00:00