Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity.

abstract：:Chromogranin A and two other proteins (A1 and A2) of the soluble proteins of bovine chromaffin granules were isolated by extraction from polyacrylamide gels after electrophoresis. The carbohydrate content of these proteins was 5%, with galactose, N-acetylgalactosamine, and sialic acid as the main sugars. Membranes of ...

journal_title：Journal of neurochemistry

authors： Fischer-Colbrie R,Schachinger M,Zangerle R,Winkler H

更新日期：1982-03-01 00:00:00

abstract：:Synaptosomes (vesicles of nerve endings) isolated from rabbit brain were studied as a model system for the uptake of inorganic phosphate. The phosphate uptake showed a sodium-dependent, saturable component with a Kt of 0.29 mM. The sodium-dependent component was larger at pH 6 than at pH 7.4 or 8. Application of potas...

journal_title：Journal of neurochemistry

authors： Salamin A,Deshusses J,Straub RW

更新日期：1981-12-01 00:00:00

abstract：:Using antiphosphotyrosine antibodies, we have investigated protein phosphorylation in mouse brain during development in intact animals and in reaggregated cerebral cultures. Under basal conditions, in vivo and in vitro, the levels of two main phosphoproteins, of Mr 120,000 and 180,000 (pp180), increased with developme...

journal_title：Journal of neurochemistry

authors： Girault JA,Chamak B,Bertuzzi G,Tixier H,Wang JK,Pang DT,Greengard P

更新日期：1992-02-01 00:00:00

abstract：:Carnitine is known to accumulate in brain, therefore transport of carnitine through the blood-brain barrier was studied in an in vitro system using bovine brain capillary endothelial cells (BBCEC) grown on filter inserts in a co-culture system with glial cells. Long-term exposure of BBCEC to carnitine resulted in a hi...

journal_title：Journal of neurochemistry

authors： Berezowski V,Miecz D,Marszałek M,Bröer A,Bröer S,Cecchelli R,Nałecz KA

更新日期：2004-11-01 00:00:00

abstract：:Rat glioma X mouse neuroblastoma hybrid neurotumor cells (NG108-15), synchronized by amino acid deprivation, showed a cell-cycle-dependent peak of activity of a ganglioside N-acetylgalactosaminyl transferase 14-24 h following release from the cell cycle block (S/G2 phase). Maximal expression of two typical lysosomal h...

journal_title：Journal of neurochemistry

authors： Scheideler MA,Lockney MW,Dawson G

更新日期：1984-04-01 00:00:00

abstract：:The genetic defect in Friedreich's ataxia (FRDA) is the expansion of a GAA·TCC triplet in the first intron of the FXN gene, which encodes the mitochondrial protein frataxin. Previous studies have established that the repeats reduce transcription of this essential gene, with a concomitant decrease in frataxin protein i...

journal_title：Journal of neurochemistry

authors： Gottesfeld JM,Rusche JR,Pandolfo M

更新日期：2013-08-01 00:00:00

abstract：:We have investigated the effects of fetal hypophysectomy (HX) with or without thyroxine (T4)replacement on the plasma concentrations of free methionine-enkephalin (free Met-Enk), noradrenaline, and adrenaline in late gestation sheep fetus. Plasma adrenaline concentrations were significantly higher in intact fetal shee...

journal_title：Journal of neurochemistry

authors： Simonetta G,Young IR,McMillen IC

更新日期：1994-10-01 00:00:00

abstract：:The effects of phorbol esters were investigated on the survival of chick sympathetic neurons in a serum-free culture medium. The protein kinase C activator phorbol 12,13-dibutyrate (PDB) supported about 40% of the plated sympathetic neurons. This number was comparable to that supported by nerve growth factor (NGF). A ...

journal_title：Journal of neurochemistry

authors： Wakade AR,Wakade TD,Malhotra RK,Bhave SV

更新日期：1988-09-01 00:00:00

abstract：:Rat cerebral cortex synaptosomes were exposed in superfusion to various depolarizing stimuli and the release of somatostatin-like immunoreactivity (SRIF-LI) was measured by means of a radioimmunoassay procedure. High KCl (9-50 mM) concentration dependently evoked SRIF-LI release; the evoked overflow reached a plateau ...

journal_title：Journal of neurochemistry

authors： Bonanno G,Parodi B,Cafaggi S,Raiteri M

更新日期：1991-10-01 00:00:00

abstract：:The cannabinoid type 2 (CB2) receptor plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s disease and is therefore a very promising target for therapeutic approaches as well as for imaging. Based on the literature, we id...

journal_title：Journal of neurochemistry

authors： Mu L,Bieri D,Slavik R,Drandarov K,Müller A,Cermak S,Weber M,Schibli R,Krämer SD,Ametamey SM

更新日期：2013-09-01 00:00:00

abstract：:The neuronal protein B-50 may be involved in diverse functions including neural development, axonal regeneration, neural plasticity, and synaptic transmission. The rat B-50 sequence contains 226 amino acids which include 14 Ser and 14 Thr residues, all putative sites for phosphorylation by calcium/phospholipid-depende...

journal_title：Journal of neurochemistry

authors： Coggins PJ,Zwiers H

更新日期：1989-12-01 00:00:00

abstract：:This study investigates the functioning of synaptosomal ouabain-sensitive Na+ -K+ -ATPase in cold-induced edema. During vasogenic brain edema development, the enzyme affinities for Na+ and K+ are progressively decreased paralleling the increase in the tissue water content, whereas maximal velocity of the reaction is n...

journal_title：Journal of neurochemistry

authors： Averet N,Rigoulet M,Cohadon F

更新日期：1984-01-01 00:00:00

abstract：:Post-traumatic immune suppression renders individuals with spinal cord injury (SCI) susceptible to infection. Normally, proper immune function is regulated by collaboration between the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and involves the controlled release of glucocorticoids ...

journal_title：Journal of neurochemistry

authors： Lucin KM,Sanders VM,Popovich PG

更新日期：2009-09-01 00:00:00

abstract：:msec7-1, a mammalian homologue of yeast sec7p, is known as a GDP/GTP exchange factor (GEF) for the ADP ribosylation factor (ARF) family of small GTPases. Here, we report that msec7-1 overexpression in cultured Aplysia neurons leads to an extensive neuritogenesis in a GEF activity-dependent manner through the modulatio...

journal_title：Journal of neurochemistry

authors： Huh M,Han JH,Lim CS,Lee SH,Kim S,Kim E,Kaang BK

更新日期：2003-04-01 00:00:00

abstract：:Prolonged hypoxia exerts profound effects on cell function, and has been associated with increased production of amyloid beta peptides (A beta Ps) of Alzheimer's disease. Here, we have investigated the effects of chronic hypoxia (2.5% O2, 24 h) on capacitative Ca2+ entry (CCE) in primary cultures of rat type-I cortica...

journal_title：Journal of neurochemistry

authors： Smith IF,Plant LD,Boyle JP,Skinner RA,Pearson HA,Peers C

更新日期：2003-06-01 00:00:00

abstract：:We examined the effects of chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid (3-NP) in doses ranging from 12 to 16 mg/kg/day for 30 days on striatal cytoarchitecture in rats. Administration of 3-NP at a dose of 16 mg/kg/day resulted in large lesions with a central necrotic core that was ...

journal_title：Journal of neurochemistry

authors： Wüllner U,Young AB,Penney JB,Beal MF

更新日期：1994-11-01 00:00:00

abstract：:Neuroimage analysis in alcoholic corpus callosum (CC) suggests that microstructural abnormalities are higher in the genu followed by the body and the splenium. Molecular mechanisms underlying these dysmorphologys are still unclear. Protein expression was performed using the CC body samples [(nine controls, seven uncom...

journal_title：Journal of neurochemistry

authors： Kashem MA,Etages HD,Kopitar-Jerala N,McGregor IS,Matsumoto I

更新日期：2009-07-01 00:00:00

abstract：:We examined the effects of orally administered 5'-cytidinediphosphocholine (CDP-choline) on arterial plasma choline and cytidine levels and on brain phospholipid composition in rats. Animals receiving a single oral dose of 100, 250, or 500 mg/kg showed peak plasma choline levels 6-8 h after drug administration (from 1...

journal_title：Journal of neurochemistry

authors： López-Coviella I,Agut J,Savci V,Ortiz JA,Wurtman RJ

更新日期：1995-08-01 00:00:00

abstract：:The contents of cystathionine and taurine, as well as cystathionine beta-synthase activity in various regions of the brains of normal and DL-propargylglycine-treated rats, were measured. The content of cystathionine in each region of brain increased gradually from 0.5 mg to 20 mg/200 g body weight in relation to the d...

journal_title：Journal of neurochemistry

authors： Kodama H,Ikeda H,Awata S,Nakayama K

更新日期：1985-04-01 00:00:00

abstract：:Inhibition of the mitochondrial electron transport chain (ETC) ultimately limits ATP production and depletes cellular ATP. However, the individual complexes of the ETC in brain mitochondria need to be inhibited by approximately 50% before causing significant depression of ATP synthesis. Moreover, the ETC is the key si...

journal_title：Journal of neurochemistry

authors： Jacobson J,Duchen MR,Hothersall J,Clark JB,Heales SJ

更新日期：2005-10-01 00:00:00

abstract：:CYP46A1 is a neuron-specific cytochrome P450 that plays a pivotal role in maintaining cholesterol homeostasis in the CNS. However, the molecular mechanisms underlying human CYP46A1 expression are still poorly understood, partly because of the lack of a cellular model that expresses high levels of CYP46A1. Our previous...

journal_title：Journal of neurochemistry

authors： Milagre I,Nunes MJ,Castro-Caldas M,Moutinho M,Gama MJ,Rodrigues E

更新日期：2012-01-01 00:00:00

abstract：:A naturally occurring point mutation (R231H) within one of the major 3gamma-binding surface (switch II region) on the a subunit of Gs (alpha(s)) has previously been found to disrupt receptor-mediated activation of Gs. The disruption caused by mutating this conserved residue may be a general phenomenon for all a subuni...

journal_title：Journal of neurochemistry

authors： Ho MK,Yung LY,Wong YH

更新日期：1999-11-01 00:00:00

abstract：:Intraperitoneal injection of the cyclic imine 1-piperideine in mice resulted in measurable quantities of 5-aminopentanoic acid in brain. 5-Aminopentanoic acid is a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. 5-Aminopentanoic acid formed in the periphery was ruled out as the sourc...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA

更新日期：1985-09-01 00:00:00

abstract：:The extracellular concentrations of amino acids in the hippocampal CA1 field and striatum of conscious freely moving rats were monitored simultaneously by in vivo brain microdialysis using HPLC with electrochemical detection. Under basal conditions, aspartate, glutamate, glutamine, glycine, taurine, and alanine were d...

journal_title：Journal of neurochemistry

authors： Shibanoki S,Kogure M,Sugahara M,Ishikawa K

更新日期：1993-11-01 00:00:00

abstract：:By using two structurally unrelated hydrogen sulfide (H2 S) donors 5-(4-methoxyphenyl) -3H-1, 2-dithiole-3-thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2 S protected blood-brain barrier (BBB) integrity following middle cerebral artery occlusion (MCAO). ICR mice underwent MCAO and received H...

journal_title：Journal of neurochemistry

authors： Wang Y,Jia J,Ao G,Hu L,Liu H,Xiao Y,Du H,Alkayed NJ,Liu CF,Cheng J

更新日期：2014-06-01 00:00:00

abstract：:The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y(12) by extracellular ATP. We recently showed that P2Y(12) stimulation by ATP induces microglial process extension in collagen gels. In the present study, we found that a P2Y(12) agonis...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Sanagi T,Nakamura Y,Suzuki E,Inoue K,Kohsaka S

更新日期：2012-04-01 00:00:00

abstract：:A mass fragmentographic method for the determination of trace amounts of amino acid neurotransmitter candidates from brain perfusates is described. The analytical procedure includes the measurements of glycine, beta-alanine, gamma-aminobutyric acid, proline, aspartic acid, and glutamic acid; alpha-alanine, leucine, an...

journal_title：Journal of neurochemistry

authors： Wolfensberger M,Amsler U

更新日期：1982-02-01 00:00:00

abstract：:In heterologous expression systems, dopamine transporter (DAT) cell-surface localization is reduced after relatively prolonged exposure to d-amphetamine (AMPH) or dopamine (DA), suggesting a role for substrate-mediated regulation of transporter function. Here, we investigated whether brief, repeated periods of substra...

journal_title：Journal of neurochemistry

authors： Gulley JM,Doolen S,Zahniser NR

更新日期：2002-10-01 00:00:00

abstract：:The effects of acute and chronic administration of buspirone, a serotonin 5-HT1A agonist, on the 5-HT synthesis rates in various rat brain structures were investigated using alpha-[14C]methyl-L-tryptophan (alpha-[14C]MTrp) and an autoradiographic method. In the acute treatment study, buspirone (10 mg/kg) was injected ...

journal_title：Journal of neurochemistry

authors： Okazawa H,Yamane F,Blier P,Diksic M

更新日期：1999-05-01 00:00:00

abstract：:Nicotine has been shown to stimulate neurotransmitter release from brain tissue by acting on presynaptic receptors. In this study, the ability of nicotine pretreatment to produce functional desensitization was investigated in rat striatal synaptosomes in which the release of [3H]dopamine was measured with an in vitro ...

journal_title：Journal of neurochemistry

authors： Rowell PP,Hillebrand JA

更新日期：1994-08-01 00:00:00