Effect of cocaine on the histaminergic neuron system in the rat brain.

abstract：:The technique of intracerebral dialysis in combination with a sensitive and specific radioenzymatic method was used for recovery and quantification of endogenous extracellular acetylcholine from the striata of freely moving rats. A thin dialysis tube was inserted transversally through the caudate nuclei, and the tube ...

journal_title：Journal of neurochemistry

authors： Consolo S,Wu CF,Fiorentini F,Ladinsky H,Vezzani A

更新日期：1987-05-01 00:00:00

abstract：:We report that a subtoxic dose of the succinate dehydrogenase (SDH) inhibitor malonate greatly enhances the neurotoxicity of three different excitatory amino acid agonists: N-methyl-D-aspartate (NMDA), S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (S-AMPA), and L-glutamate. In male Sprague-Dawley rats, in...

journal_title：Journal of neurochemistry

authors： Greene JG,Greenamyre JT

更新日期：1995-05-01 00:00:00

abstract：:L-DOPA-induced dyskinesia (LID) is among the motor complications that arise in Parkinson's disease (PD) patients after a prolonged treatment with L-DOPA. To this day, transcriptome analysis has been performed in a rat model of LID [Neurobiol. Dis., 17 (2004), 219] but information regarding the proteome is still lackin...

journal_title：Journal of neurochemistry

authors： Valastro B,Dekundy A,Krogh M,Lundblad M,James P,Danysz W,Quack G,Cenci MA

更新日期：2007-08-01 00:00:00

abstract：:Topiramate (TPM) is a structurally novel broad-spectrum anticonvulsant known to modulate the activity of several ligand- and voltage-gated ion channels in neurons. These include an inhibitory effect on the AMPA and kainate subtypes of glutamate receptors, mixed modulatory effects (usually positive) on some types of GA...

journal_title：Journal of neurochemistry

authors： Angehagen M,Ben-Menachem E,Shank R,Rönnbäck L,Hansson E

更新日期：2004-01-01 00:00:00

abstract：:Chronic cocaine use in humans and animal models is known to lead to pronounced alterations in glutamatergic function in brain regions associated with reinforcement. Previous studies have examined ionotropic glutamate receptor (iGluR) subunit protein level changes following acute and chronic experimenter-administered c...

journal_title：Journal of neurochemistry

authors： Tang W,Wesley M,Freeman WM,Liang B,Hemby SE

更新日期：2004-05-01 00:00:00

abstract：:The zinc-finger transcription factor Yin Yang 1 (YY1) is a multifunctional protein that plays a critical role in embryonic development. Although it has been shown to play a role in eye development, its expression in the retina was not previously described. Here, we investigated YY1 expression in chicken tissues and we...

journal_title：Journal of neurochemistry

authors： Bernard M,Voisin P

更新日期：2008-05-01 00:00:00

abstract：:Glutamine is a primary precursor for the biosynthesis of the neurotransmitters glutamate and gamma-aminobutyric acid. It is proposed that glutamine, synthesized and released by astrocytes, is transported into the neuron for subsequent conversion to neurotransmitters. To provide a more complete characterization of this...

journal_title：Journal of neurochemistry

authors： Tamarappoo BK,Raizada MK,Kilberg MS

更新日期：1997-03-01 00:00:00

abstract：:Accumulation of misfolded proteins and alterations in the ubiquitin-proteasome pathway are associated with various neurodegenerative conditions of the CNS and PNS. Aggregates containing ubiquitin and peripheral myelin protein 22 (PMP22) have been observed in the Trembler J mouse model of Charcot-Marie-Tooth disease ty...

journal_title：Journal of neurochemistry

authors： Fortun J,Li J,Go J,Fenstermaker A,Fletcher BS,Notterpek L

更新日期：2005-03-01 00:00:00

abstract：:Adenosine uptake by cerebral smooth muscle cells is a carrier-mediated process. The Km value for adenosine uptake is 10.0 microM and the Vmax is 0.95 nmol/min-mg cell protein. This uptake system is inhibited by the adenosine analog 2-chloroadenosine at low adenosine concentrations. These results prove the existence of...

journal_title：Journal of neurochemistry

authors： Beck DW,Vinters HV,Moore SA,Hart MN,Cancilla PA

更新日期：1983-10-01 00:00:00

abstract：:After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane bindin...

journal_title：Journal of neurochemistry

authors： Meffre D,Delespierre B,Gouézou M,Leclerc P,Vinson GP,Schumacher M,Stein DG,Guennoun R

更新日期：2005-06-01 00:00:00

abstract：:There is great interest in soy isoflavones as alternatives to endogenous estrogens not only in hormonal pathologies, but also in inflammatory, neurodegenerative diseases, and pain. We investigated the effect of the isoflavone genistein on neuropathic pain. Genistein binds estrogen receptors (ER) with higher affinity f...

journal_title：Journal of neurochemistry

authors： Valsecchi AE,Franchi S,Panerai AE,Sacerdote P,Trovato AE,Colleoni M

更新日期：2008-10-01 00:00:00

abstract：:The Coffin-Lowry syndrome, a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene. To further investigate RSK2 (90-kDa ribosomal S6 kinase) implication in cognitive processes, a mrsk2_KO mouse has previously been generated as an animal model of Coffin-...

journal_title：Journal of neurochemistry

authors： Marques Pereira P,Gruss M,Braun K,Foos N,Pannetier S,Hanauer A

更新日期：2008-12-01 00:00:00

abstract：:The protein kinase v-akt murine thymoma viral oncogene homolog (AKT) gene family comprises three human homologs that phosphorylate and inactivate glycogen synthase kinase 3beta (GSK3beta). Studies have reported the genetic association of AKT1 with schizophrenia. Additionally, decreased AKT1 protein expression and the ...

journal_title：Journal of neurochemistry

authors： Ide M,Ohnishi T,Murayama M,Matsumoto I,Yamada K,Iwayama Y,Dedova I,Toyota T,Asada T,Takashima A,Yoshikawa T

更新日期：2006-10-01 00:00:00

abstract：:Expression of the carboxyl-terminal fragment (CT) of the beta-amyloid precursor protein (APP) in transgenic animals has been linked with neurotoxicity. However, it remains to be clarified whether the neurotoxicity is caused by beta-amyloid proteins (A betas) derived from CT or by CT itself. To study the in vivo neurot...

journal_title：Journal of neurochemistry

authors： Song DK,Won MH,Jung JS,Lee JC,Kang TC,Suh HW,Huh SO,Paek SH,Kim YH,Kim SH,Suh YH

更新日期：1998-08-01 00:00:00

abstract：:White matter infarct induces demyelination and brain dysfunction. We previously reported that transplantation of brain microvascular endothelial cells improved the behavioral outcome and promoted remyelination by increasing the number of oligodendrocyte precursor cells in the rat model of white matter infarct. In this...

journal_title：Journal of neurochemistry

authors： Xu B,Kurachi M,Shimauchi-Ohtaki H,Yoshimoto Y,Ishizaki Y

更新日期：2020-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with worldwide prevalence. Its clinical manifestation involves the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs). NFTs occur in brain tissues as a result of both Aβ agglomeration and Tau phosphory...

journal_title：Journal of neurochemistry

authors： Jha NK,Jha SK,Kar R,Nand P,Swati K,Goswami VK

更新日期：2019-07-01 00:00:00

abstract：:Capsaicin receptors are expressed in primary sensory neurons and excited by heat and protons. We examined the inflammation-induced changes of the level of VR1 capsaicin receptor mRNA in sensory neurons and the sensitivity of primary afferents to capsaicin. Carrageenan treatment induced axonal transport of VR1 mRNA, bu...

journal_title：Journal of neurochemistry

authors： Tohda C,Sasaki M,Konemura T,Sasamura T,Itoh M,Kuraishi Y

更新日期：2001-03-01 00:00:00

abstract：:The oxidation of differentially labelled glucose, pyruvate and glutamate in brain slices from rats aged 20 days to 26 months has been studied and the partition of the glucose used into the glycolytic-tricarboxylic acid cycle pathway, the pentose phosphate pathway and the glutamate-GABA shunt has been calculated. Over ...

journal_title：Journal of neurochemistry

authors： Zubairu S,Hothersall JS,El-Hassan A,McLean P,Greenbaum AL

更新日期：1983-07-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is a major pathological feature of Alzheimer's disease and related disorders. Human cerebrovascular smooth muscle (HCSM) cells, which are intimately associated with CAA, have been used as an in vitro model system to investigate pathologic interactions with amyloid beta protein (A beta...

journal_title：Journal of neurochemistry

authors： Jung SS,Zhang W,Van Nostrand WE

更新日期：2003-06-01 00:00:00

abstract：:The functions of cellular prion protein (PrP(C)) are under intense debate and PrP(C) loss of function has been implicated in the pathology of prion diseases. Neuronal PrP(C) engagement with stress-inducible protein-1 and laminin (LN) plays a key role in cell survival and differentiation. The present study evaluated wh...

journal_title：Journal of neurochemistry

authors： Lima FR,Arantes CP,Muras AG,Nomizo R,Brentani RR,Martins VR

更新日期：2007-12-01 00:00:00

abstract：:G-protein coupled receptors may mediate their effects on neuronal growth and differentiation through activation of extracellular signal-regulated kinases 1/2 (ERK1/2), often elicited by transactivation of growth factor receptor tyrosine kinases. This elaborate signaling process includes inducible formation and traffic...

journal_title：Journal of neurochemistry

authors： Asimaki O,Leondaritis G,Lois G,Sakellaridis N,Mangoura D

更新日期：2011-03-01 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative condition characterized by pathology in the brain and peripheral tissues. Hyperactivity of the innate immune system, due in part to NFκB pathway dysregulation, is an early and active component of HD. Evidence suggests targeting immune disruption may slow disease progres...

journal_title：Journal of neurochemistry

authors： Dobson L,Träger U,Farmer R,Hayardeny L,Loupe P,Hayden MR,Tabrizi SJ

更新日期：2016-06-01 00:00:00

abstract：:We have shown recently that the presence of albumin in astrocytes triggers the synthesis and release of oleic acid, which behaves as a neurotrophic factor for neurons. Thus, oleic acid promotes axonal growth together with the expression of the axonal growth-associated protein, GAP-43. Here we attempted to elucidate wh...

journal_title：Journal of neurochemistry

authors： Rodríguez-Rodríguez RA,Tabernero A,Velasco A,Lavado EM,Medina JM

更新日期：2004-03-01 00:00:00

abstract：:A sensitive enzyme-linked immunosorbent assay (ELISA) for nerve growth factor (NGF) has been developed. The sensitivity of this assay (0.1 pg/well) permits the quantification of endogenous immunoreactive NGF in the peripheral nervous system and the CNS. Studies on the regulatory mechanisms involved in NGF production i...

journal_title：Journal of neurochemistry

authors： Weskamp G,Otten U

更新日期：1987-06-01 00:00:00

abstract：:To examine the correlation between the structure of Bcl-2 and its inhibitory function of c-Jun N-terminal kinase (JNK) and caspase activity, we established a dopaminergic neuronal cell line, MN9D overexpressing Bcl-2 (MN9D/Bcl-2) or its structural mutants. The mutants comprised a point mutation in the BH1 (G145A; MN9D...

journal_title：Journal of neurochemistry

authors： Choi WS,Yoon SY,Chang II,Choi EJ,Rhim H,Jin BK,Oh TH,Krajewski S,Reed JC,Oh YJ

更新日期：2000-04-01 00:00:00

abstract：:The mouse myelin proteolipid protein (PLP) gene has been studied in normal and jimpymsd mice. Potential upstream regulatory regions of the normal gene have been cloned and mapped, but when these regions were studied in jimpymsd mice by Southern blots, no alterations were observed, relative to the normal gene. To asses...

journal_title：Journal of neurochemistry

authors： Macklin WB,Gardinier MV,Obeso ZO,King KD,Wight PA

更新日期：1991-01-01 00:00:00

abstract：:Tubulin tyrosine ligase catalyzes the reversible addition of tyrosine to the C-terminus of tubulin alpha chains. By using ligase and carboxypeptidase A in conjunction, we have previously shown that brain cytoplasmic tubulin exists in three forms: 15-40% already has C-terminal tyrosine, another 10-30% can accept additi...

journal_title：Journal of neurochemistry

authors： Nath J,Flavin M

更新日期：1980-09-01 00:00:00

abstract：:We have proposed that a very early step in the pathogenesis of idiopathic Parkinson's disease is the elevated translocation of L-cysteine into neuromelanin-pigmented dopaminergic neurons in the substantia nigra. This influx of L-cysteine was proposed to divert the normal neuromelanin pathway by scavenging dopamine-o-q...

journal_title：Journal of neurochemistry

authors： Li H,Shen XM,Dryhurst G

更新日期：1998-11-01 00:00:00

abstract：:Huntington's disease is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. This expansion produces a mutant form of the huntingtin protein, which contains an elongated polyglutamine stretch at its amino-terminus. Mutant huntingtin may adopt an aberrant, aggr...

journal_title：Journal of neurochemistry

authors： Roscic A,Baldo B,Crochemore C,Marcellin D,Paganetti P

更新日期：2011-10-01 00:00:00

abstract：:In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, and the amyloid deposits in the walls of pial and parenchymal blood vessels are mainly composed of amyloid beta-peptides. In the prese...

journal_title：Journal of neurochemistry

authors： Ghersi-Egea JF,Gorevic PD,Ghiso J,Frangione B,Patlak CS,Fenstermacher JD

更新日期：1996-08-01 00:00:00