Effects of chronic ethanol consumption and aging on dopamine, serotonin, and metabolites.

abstract：:Ammonia, amino acids (AA), and middle molecules (MM) have been implicated in the pathogenesis of experimentally induced acute hepatic coma in the pig. Hemodialysis (HD) using either a low- (Cuprophan = CU) or a high-permeability (polyacrylonitrile = AN 69) membrane has demonstrated the role of MM. Selective hemodialys...

journal_title：Journal of neurochemistry

authors： Denis J,Delorme ML,Boschat M,Nordlinger B,Opolon P

更新日期：1983-01-01 00:00:00

abstract：:Rats were submitted to a series of 10 daily electroconvulsive shocks (ECS). A first group of animals was killed 1 day after the last seizure and a second group 30 days later. Tyrosine hydroxylase (TH) activity was measured using an in vitro assay in the nucleus caudatus, anterior cortex, amygdala, substantia nigra, ve...

journal_title：Journal of neurochemistry

authors： Leviel V,Fayada C,Guibert B,Chaminade M,Machek G,Mallet J,Biguet NF

更新日期：1990-03-01 00:00:00

abstract：:The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have alpha 6, alpha 1, gamma 2S, gamma 2L, and...

journal_title：Journal of neurochemistry

authors： Khan ZU,Gutierrez A,De Blas AL

更新日期：1994-07-01 00:00:00

abstract：:Acute nicotine administration stimulated [3H]norepinephrine ([3H]NE) release from cultured fetal locus coeruleus (LC) cells. The effect was concentration dependent, with an EC50 of 0.9 microM, and was abolished by removal of calcium from, or addition of tetrodotoxin (500 nM) to, the assay buffer. Other nicotinic recep...

journal_title：Journal of neurochemistry

authors： Gallardo KA,Leslie FM

更新日期：1998-02-01 00:00:00

abstract：:Existence of microtubule cytoskeleton at the membrane and submembranous regions, referred as 'membrane tubulin' has remained controversial for a long time. Since we reported physical and functional interaction of Transient Receptor Potential Vanilloid Sub Type 1 (TRPV1) with microtubules and linked the importance of T...

journal_title：Journal of neurochemistry

authors： Goswami C

更新日期：2012-10-01 00:00:00

abstract：:The major component of the amyloid deposition that characterizes Alzheimer's disease is the 4-kDa beta A4 protein, which is derived from a much larger amyloid protein precursor (APP). A procedure for the complete purification of APP from human brain is described. The same amino terminal sequence of APP was found in tw...

journal_title：Journal of neurochemistry

authors： Moir RD,Martins RN,Bush AI,Small DH,Milward EA,Rumble BA,Multhaup G,Beyreuther K,Masters CL

更新日期：1992-10-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative condition characterized by pathology in the brain and peripheral tissues. Hyperactivity of the innate immune system, due in part to NFκB pathway dysregulation, is an early and active component of HD. Evidence suggests targeting immune disruption may slow disease progres...

journal_title：Journal of neurochemistry

authors： Dobson L,Träger U,Farmer R,Hayardeny L,Loupe P,Hayden MR,Tabrizi SJ

更新日期：2016-06-01 00:00:00

abstract：:Primary rat fibroblasts genetically modified to express Drosophila choline acetyltransferase (dChAT) synthesize and release acetylcholine (ACh) in vitro. The ACh produced from the transduced fibroblasts was found to be enhanced by increasing amounts of choline chloride in the culture media. These dChAT-expressing cell...

journal_title：Journal of neurochemistry

authors： Fisher LJ,Schinstine M,Salvaterra P,Dekker AJ,Thal L,Gage FH

更新日期：1993-10-01 00:00:00

abstract：:Oligodendroglial cell death in the myelin proteolipid protein (PLP) mutants can be partially rescued by the environment factor(s) supplied by the wild-type cells in vivo and in vitro. It is possible that the presence of PLP or DM-20 results in secretion of a factor or factors in the CNS influencing oligodendrocyte dev...

journal_title：Journal of neurochemistry

authors： Nakao J,Yamada M,Kagawa T,Kim SU,Miyao Y,Shimizu K,Mikoshiba K,Ikenaka K

更新日期：1995-06-01 00:00:00

abstract：:Previous in vitro studies have shown that group III metabotropic glutamate receptors (mGluRs) regulate synaptic glutamate release. The present study used microdialysis to characterize this regulation in vivo in rat nucleus accumbens. Reverse dialysis of the group III mGluR agonist l-(+)-2-amino-4-phosphonobutyric acid...

journal_title：Journal of neurochemistry

authors： Xi ZX,Shen H,Baker DA,Kalivas PW

更新日期：2003-12-01 00:00:00

abstract：:The glycogen content of primary cultured astrocytes was approximately doubled by incubation with 1 mM L-glutamate or L-aspartate. Other amino acids and excitatory neurotransmitters were without effect. The increase in glycogen level was not blocked by the glutamate receptor antagonist kynurenic acid but was completely...

journal_title：Journal of neurochemistry

authors： Swanson RA,Yu AC,Chan PH,Sharp FR

更新日期：1990-02-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:[3H]Ouabain binding was studied in sections of rabbit somatosensory cortex by quantitative autoradiography and in rabbit brain microsomal membranes using a conventional filtration assay. KD values of 8-12 nM for specific high-affinity binding of [3H]ouabain were found by both methods. High-affinity binding was not uni...

journal_title：Journal of neurochemistry

authors： Antonelli MC,Baskin DG,Garland M,Stahl WL

更新日期：1989-01-01 00:00:00

abstract：:Electrical stimulation of an ascending path of the locus ceruleus-norepinephrine system was used to elicit release of norepinephrine at noradrenergic terminal fields of the rat thalamus. Overflow into the extracellular fluid space was measured by fast in vivo chronoamperometry. At pretreated carbon fibers, the electro...

journal_title：Journal of neurochemistry

authors： Ghasemzadeh MB,Capella P,Mitchell K,Adams RN

更新日期：1993-02-01 00:00:00

abstract：:The unique modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) is tightly associated with nervous system development and plasticity. The prevailing view that this large carbohydrate polymer acts as an anti-adhesive factor seems straightforward at first sight. However, during almost 25...

journal_title：Journal of neurochemistry

authors： Hildebrandt H,Mühlenhoff M,Weinhold B,Gerardy-Schahn R

更新日期：2007-11-01 00:00:00

abstract：:Mutations in the free radical-scavenging enzyme copper/zinc superoxide dismutase (Cu/Zn-SOD) are associated with neuronal death in humans and mice. Here, we examine the effects of human wild-type (WT SOD) and mutant (Gly93 --> Ala; G93A) Cu/Zn-SOD enzyme on the fate of postnatal midbrain neurons. One-week-old cultures...

journal_title：Journal of neurochemistry

authors： Mena MA,Khan U,Togasaki DM,Sulzer D,Epstein CJ,Przedborski S

更新日期：1997-07-01 00:00:00

abstract：:Cationic amino acids are transported from blood into brain by a saturable carrier at the blood-brain barrier (BBB). The transport properties of this carrier were examined in the rat using an in situ brain perfusion technique. Influx into brain via this system was found to be sodium independent and followed Michaelis-M...

journal_title：Journal of neurochemistry

authors： Stoll J,Wadhwani KC,Smith QR

更新日期：1993-05-01 00:00:00

abstract：:Specific antisera were raised against the A and B chains of glycoprotein III. Immunoblotting revealed that in adrenal medulla both chains migrate very closely together in two-dimensional electrophoresis. Both chains with slightly differing molecular sizes are found in several endocrine tissues and in brain, kidney, li...

journal_title：Journal of neurochemistry

authors： Laslop A,Steiner HJ,Egger C,Wolkersdorfer M,Kapelari S,Hogue-Angeletti R,Erickson JD,Fischer-Colbrie R,Winkler H

更新日期：1993-10-01 00:00:00

abstract：:NMDA receptors are potentiated by phosphorylation in a subunit- and kinase-specific manner. Both native and recombinant NMDA receptors are inhibited by behaviorally relevant concentrations of ethanol. Whether the phosphorylation state of individual subunits modulates the ethanol sensitivity of these receptors is not k...

journal_title：Journal of neurochemistry

authors： Anders DL,Blevins T,Sutton G,Swope S,Chandler LJ,Woodward JJ

更新日期：1999-04-01 00:00:00

abstract：:Syntaxin, a protein required for the docking of synaptic vesicles, may be involved in the manifestation of synaptic plasticity. The possible involvement of syntaxin in epileptogenesis was investigated by assessing the expression levels of syntaxin1B/GR33 mRNA by in situ hybridization at different stages of hippocampal...

journal_title：Journal of neurochemistry

authors： Kamphuis W,Smirnova T,Hicks A,Hendriksen H,Mallet J,Lopes da Silva FH

更新日期：1995-11-01 00:00:00

abstract：:We have correlated myelin membrane structure with biochemical composition in the CNS and PNS of a phylogenetic series of animals, including elasmobranchs, teleosts, amphibians, and mammals. X-ray diffraction patterns were recorded from freshly dissected, unfixed tissue and used to determine the thicknesses of the liqu...

journal_title：Journal of neurochemistry

authors： Kirschner DA,Inouye H,Ganser AL,Mann V

更新日期：1989-11-01 00:00:00

abstract：:Dietary n-6 polyunsaturated fatty acid (PUFA) deprivation in rodents reduces brain arachidonic acid (20:4n-6) concentration and 20:4n-6-preferring cytosolic phospholipase A(2) (cPLA(2) -IVA) and cyclooxygenase (COX)-2 expression, while increasing brain docosahexaenoic acid (DHA, 22:6n-3) concentration and DHA-selectiv...

journal_title：Journal of neurochemistry

authors： Igarashi M,Kim HW,Chang L,Ma K,Rapoport SI

更新日期：2012-03-01 00:00:00

abstract：:The objective of the present study was to assess metabolic changes in the neocortex and hippocampus of well-oxygenated or moderately hypoxic rats in which fluorothyl-induced seizures were sustained for 5 or 20 min, or which were allowed recovery periods of 5, 15, or 45 min following cessation of 20-min seizure activit...

journal_title：Journal of neurochemistry

authors： Folbergrová J,Ingvar M,Nevander G,Siesjö BK

更新日期：1985-05-01 00:00:00

abstract：:Electrophorus electroplax microsomes were examined for Ca2+- and Mg2+-dependent ATPase activity. In addition to the previously reported low-affinity ATPase, a high-affinity (Ca2+,Mg2+)-ATPase was found. At low ATP and Mg2+ concentrations (200 microM or less), the high-affinity (Ca2+,Mg2+)-ATPase exhibits an activity o...

journal_title：Journal of neurochemistry

authors： Amende LM,Chock SP,Albers RW

更新日期：1983-04-01 00:00:00

abstract：:Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and plays an important, phosphorylation-dependent role in the modulation...

journal_title：Journal of neurochemistry

authors： Sosa LJ,Malter JS,Hu J,Bustos Plonka F,Oksdath M,Nieto Guil AF,Quiroga S,Pfenninger KH

更新日期：2016-06-01 00:00:00

abstract：:Serotonin-1A (5-HT(1A) receptors in the dorsal raphe nucleus (DRN) function as somatodendritic autoreceptors, and therefore play a critical role in controlling serotonergic cell firing and serotonergic neurotransmission. We hypothesized that a decrease in the capacity of 5-HT(1A) receptors to activate G proteins was a...

journal_title：Journal of neurochemistry

authors： Rossi DV,Burke TF,McCasland M,Hensler JG

更新日期：2008-05-01 00:00:00

abstract：:Copper/zinc-superoxide dismutase (CuZn-SOD) transgenic mice overexpress the gene for human CuZn-SOD. To assess the effects of the overexpression of CuZn-SOD on the brain scavenging systems, we have measured the activities of manganese-SOD (Mn-SOD), catalase, and glutathione peroxidase (GSH-Px) in various regions of th...

journal_title：Journal of neurochemistry

authors： Przedborski S,Jackson-Lewis V,Kostic V,Carlson E,Epstein CJ,Cadet JL

更新日期：1992-05-01 00:00:00

abstract：:Acute seizures and other stimuli that increase neuronal activity cause a rapid induction of the immediate-early genes c-fos and c-jun, also referred to as nuclear proto-oncogenes, in the nervous system. In the present study, rats were administered one or more electroconvulsive seizures (ECS) and the responsiveness of ...

journal_title：Journal of neurochemistry

authors： Winston SM,Hayward MD,Nestler EJ,Duman RS

更新日期：1990-06-01 00:00:00

abstract：:3,4-Dihydroxyphenylethylamine (dopamine) D2 receptor agonists, including BHT 920 and bromocriptine, and the potassium channel opener minoxidil share the property of hyperpolarizing the plasma membrane by activating voltage-dependent potassium channels. These drugs were tested for their ability to inhibit the cyclic AM...

journal_title：Journal of neurochemistry

authors： Memo M,Pizzi M,Belloni M,Benarese M,Spano P

更新日期：1992-11-01 00:00:00