Serotonin-1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline.

abstract：:Voltage-gated sodium channels (VGSC) are involved in the generation of action potentials in neurons. Brevetoxins (PbTx) are potent allosteric enhancers of VGSC function and are associated with the periodic 'red tide' blooms. Using PbTx-2 as a probe, we have characterized the effects of activation of VGSC on Ca(2+) dyn...

journal_title：Journal of neurochemistry

authors： Dravid SM,Baden DG,Murray TF

更新日期：2004-05-01 00:00:00

abstract：:Levels of multidrug efflux transporter P-glycoprotein (P-gp) on endothelial cells lining brain blood vessels are important for limiting access of many compounds to the brain. In vivo studies have indicated that ischaemia-reperfusion that generates reactive oxygen species also increases P-gp levels in brain endothelial...

journal_title：Journal of neurochemistry

authors： Robertson SJ,Kania KD,Hladky SB,Barrand MA

更新日期：2009-10-01 00:00:00

abstract：:The ontogeny of chick brain and heart ventricle calcium antagonist binding sites was determined, using [3H]nitrendipine ([3H]NDP), as the ligand. The binding of [3H]NDP to adult heart and brain was kinetically very similar, with the former displaying a KD of 0.28 +/- 0.02 nM and a Bmax of 138 +/- 17 fmol/mg protein, a...

journal_title：Journal of neurochemistry

authors： Marangos PJ,Sperelakis N,Patel J

更新日期：1984-05-01 00:00:00

abstract：:Previous studies have demonstrated opposing roles for adenosine A1 and A2A receptors in the modulation of extracellular levels of glutamate and dopamine in the striatum. In the present study, acute systemic administration of motor-activating doses of the A2A receptor antagonist MSX-3 significantly decreased extracellu...

journal_title：Journal of neurochemistry

authors： Quarta D,Ferré S,Solinas M,You ZB,Hockemeyer J,Popoli P,Goldberg SR

更新日期：2004-03-01 00:00:00

abstract：:Functional activation of NMDA receptors requires co-activation of glutamate- and glycine-binding sites. D-serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin-induced conditioned place avoidance (F-CPA) behavioral model and whole-cell patch-clamp...

journal_title：Journal of neurochemistry

authors： Ren WH,Guo JD,Cao H,Wang H,Wang PF,Sha H,Ji RR,Zhao ZQ,Zhang YQ

更新日期：2006-03-01 00:00:00

abstract：:The neurotoxic metabolite of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium, selectively accumulates in dopaminergic neurons via the dopamine reuptake system. Consequently, nontoxic radiolabeled MPTP analogs may be potentially useful for visualizing catecholaminergic neurons in vivo. ...

journal_title：Journal of neurochemistry

authors： Efange SM,Mash D,Hefti F,Kung HF,Billings J

更新日期：1989-08-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative movement disorder. The histopathology of Parkinson's disease comprises proteinaceous inclusions known as Lewy bodies, which contains aggregated α-synuclein. Cathepsin D (CD) is a lysosomal protease previously demonstrated to cleave α-synuclein and decrease its toxicity in bot...

journal_title：Journal of neurochemistry

authors： Crabtree D,Dodson M,Ouyang X,Boyer-Guittaut M,Liang Q,Ballestas ME,Fineberg N,Zhang J

更新日期：2014-03-01 00:00:00

abstract：:We have examined the binding of the adenosine agonist radioligands [3N]N6-cyclohexyladenosine ([3H]CHA) and [3H]5'-N-ethylcarboxamidoadenosine ([3H]NECA) to membranes prepared from postmortem human pineal glands. The results showed that the A-1-specific ligand CHA did not bind to membranes. By contrast, [3H]NECA, a no...

journal_title：Journal of neurochemistry

authors： Reynaud D,Gharib A,Lagarde M,Sarda N

更新日期：1990-10-01 00:00:00

abstract：:In cerebellar granule cells, the mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) cascade mediates multiple functions, including proliferation, differentiation, and survival. In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pi...

journal_title：Journal of neurochemistry

authors： Obara Y,Horgan AM,Stork PJ

更新日期：2007-04-01 00:00:00

abstract：:We identified, by affinity chromatography, two putative binding proteins for the presynaptic snake venom toxin taipoxin. We have previously characterized one of these proteins [neuronal pentraxin (NP)] as a neuronally secreted protein with homology to acute-phase proteins. Here we report the identification of the seco...

journal_title：Journal of neurochemistry

authors： Dodds D,Schlimgen AK,Lu SY,Perin MS

更新日期：1995-05-01 00:00:00

abstract：:The roles of two subtypes of corticotrophin-releasing factor (CRF) receptor in corticostriatal synaptic plasticity under cocaine withdrawal condition were examined in this study. Neither the resting membrane potential and input resistance of striatal neurons nor the long-term potentiation (LTP) of corticostriatal slic...

journal_title：Journal of neurochemistry

authors： Guan X,Wang L,Chen CL,Guan Y,Li S

更新日期：2010-11-01 00:00:00

abstract：:The glutamine cycle has been proposed as a pathway in which glutamine synthesized in glia provides substrate for synthesis of the neurotransmitters glutamate and GABA as they are lost from neurons. To test whether GABA may regulate this pathway, the effect of elevated GABA on the glial enzyme glutamine synthetase was ...

journal_title：Journal of neurochemistry

authors： Waniewski RA,Martin DL

更新日期：1995-07-01 00:00:00

abstract：:Several neurodegenerative disorders are associated with evidence of inflammation, one feature of which is increased activation of microglia, the most likely cellular source of inflammatory cytokines like interleukin-1beta. It is now recognized that interaction of microglia with other cells contributes to maintenance o...

journal_title：Journal of neurochemistry

authors： Lyons A,Lynch AM,Downer EJ,Hanley R,O'Sullivan JB,Smith A,Lynch MA

更新日期：2009-09-01 00:00:00

abstract：:The characteristics of the serotonin (5-HT) output in the dorsal and median raphe nuclei of the rat were studies using in vivo microdialysis. The basal output of 5-HT increased after KCl was added to the perfusion fluid. In contrast, neither the omission of calcium ions nor the addition of 0.5 microM tetrodotoxin affe...

journal_title：Journal of neurochemistry

authors： Adell A,Carceller A,Artigas F

更新日期：1993-05-01 00:00:00

abstract：:The effects of short- and long-chain fatty acids on the cerebromicrovascular (Na+ + K+)-ATPase were investigated using specific [3H]ouabain binding to the enzyme. Specific binding increased linearly with total microvessel protein (37-110 micrograms) and was time-dependent with maximum binding obtained by 10 min. Arach...

journal_title：Journal of neurochemistry

authors： Caspers ML,Grammas P

更新日期：1988-04-01 00:00:00

abstract：:The motor signs of Parkinson's disease have been partly attributed to an overinhibition of the external globus pallidus (GP) that results from hyperactivity of striatopallidal GABA/enkephalinergic neurons. The goals of this study were to measure basal levels of extracellular fluid GABA in the GP of normal cats, 1-meth...

journal_title：Journal of neurochemistry

authors： Schroeder JA,Schneider JS

更新日期：2002-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotectiv...

journal_title：Journal of neurochemistry

authors： Tapia-Rojas C,Inestrosa NC

更新日期：2018-02-01 00:00:00

abstract：:The release of gamma-aminobutyric acid (GABA) was studied in slices of the head of the rabbit caudate nucleus. The slices were preincubated with [3H]GABA and then superfused. Aminooxyacetic acid was present throughout. Both the tritium in the slices and that in the superfusate consisted practically entirely of [3H]GAB...

journal_title：Journal of neurochemistry

authors： Limberger N,Späth L,Starke K

更新日期：1986-04-01 00:00:00

abstract：:Biomarkers in CSF can offer improved diagnostic accuracy for Alzheimer's disease (AD). The present study investigated whether the glycoprotein and putative tumor suppressor Dickkopf homolog 3 (Dkk-3) is secreted into CSF and evaluated its applicability as a diagnostic marker for AD. Using our highly specific immunoenz...

journal_title：Journal of neurochemistry

authors： Zenzmaier C,Marksteiner J,Kiefer A,Berger P,Humpel C

更新日期：2009-07-01 00:00:00

abstract：:Mutations in copper/zinc superoxide dismutase (SOD1) account for 10-20% of a familial form of amyotrophic lateral sclerosis (ALS). A common feature of SOD1 mutants is abnormal aggregation of the aberrant SOD1 in neurons and glia. We now report that in ALS transgenic mouse models the constitutively expressed heat shock...

journal_title：Journal of neurochemistry

authors： Liu J,Shinobu LA,Ward CM,Young D,Cleveland DW

更新日期：2005-05-01 00:00:00

abstract：:We studied the formation of early endosomes in differentiating oligodendrocytes and type-2 astrocytes, which are derived from common precursor cells in rat neonates, using fluorescent analogues of lactosylceramide (LacCer) and sulfatide labeled with 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene++ +-3-pentano...

journal_title：Journal of neurochemistry

authors： Watanabe R,Asakura K,Rodriguez M,Pagano RE

更新日期：1999-10-01 00:00:00

abstract：:Muscarinic receptors mediate metabotropic actions of acetylcholine in the CNS and PNS and autocrine functions of acetylcholine in non-neuronal systems. Because of the lack of highly selective muscarinic ligands, the precise location, functional role, and roles in various diseases of the five muscarinic receptor subtyp...

journal_title：Journal of neurochemistry

authors： Servent D,Fruchart-Gaillard C

更新日期：2009-06-01 00:00:00

abstract：:Somatostatin (SS) and neuropeptide Y (NPY) are coproduced in a subpopulation of neurons that are selectively resistant to NMDA neurotoxicity. We have previously reported that quinolinic acid (QUIN), an NMDA receptor agonist, augments SS mRNA in cultured fetal rat cortical neurons. This study examines coregulation of S...

journal_title：Journal of neurochemistry

authors： Patel YC,Liu JL,Warszynska A,Kent G,Papachristou DN,Patel SC

更新日期：1995-09-01 00:00:00

abstract：:The activities of choline acetyltransferase (CAT) and glutamic acid decarboxylase (GAD), markers of cholinergic and GABAergic terminals, were measured in growing and adult Gunn rats, which possess an autosomal recessive gene for jaundice or kernicterus. In the olfactory tubercle, hippocampus, neostriatum, thalamus, an...

journal_title：Journal of neurochemistry

authors： Ohno T

更新日期：1981-10-01 00:00:00

abstract：:The incorporation of radioactive precursors into gangliosides and other glycolipids, glycoproteins, and total lipids has been studied in rat pheochromocytoma PC12 cells. Starting with the same PC12 cell pool, cultures displaying different degrees of neuritic expression in response to nerve growth factor (NGF) and comb...

journal_title：Journal of neurochemistry

authors： Katoh-Semba R,Skaper SD,Varon S

更新日期：1986-02-01 00:00:00

abstract：:In vivo microdialysis was used to determine the extent to which ionotropic glutamate receptors in the ventral tegmental area (VTA) regulate dopamine release in the nucleus accumbens. Coapplication of 2-amino-5-phosphonopentanoic acid (AP5; 200 microM) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 50 microM) to the V...

journal_title：Journal of neurochemistry

authors： Taber MT,Das S,Fibiger HC

更新日期：1995-09-01 00:00:00

abstract：:The technique of intracerebral dialysis in combination with a sensitive and specific radioenzymatic method was used for recovery and quantification of endogenous extracellular acetylcholine from the striata of freely moving rats. A thin dialysis tube was inserted transversally through the caudate nuclei, and the tube ...

journal_title：Journal of neurochemistry

authors： Consolo S,Wu CF,Fiorentini F,Ladinsky H,Vezzani A

更新日期：1987-05-01 00:00:00

abstract：:Dystonia musculorum (dt) mice suffer from a severe sensory neuropathy caused by mutations in the gene encoding the cytoskeletal cross-linker protein dystonin/bullous pemphigoid antigen 1 (Bpag1). Loss of function of dystonin/Bpag1 within neurons leads to a loss in the maintenance of cytoskeletal organization and to th...

journal_title：Journal of neurochemistry

authors： De Repentigny Y,Deschênes-Furry J,Jasmin BJ,Kothary R

更新日期：2003-08-01 00:00:00

abstract：:Glutamate receptors belonging to the subclass specifically activated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) were solubilized from rat forebrain membranes with Triton X-100 and partially purified through a series of three chromatographic steps. Specific [3H]AMPA binding increased 30-60-fold ...

journal_title：Journal of neurochemistry

authors： Bahr BA,Vodyanoy V,Hall RA,Suppiramaniam V,Kessler M,Sumikawa K,Lynch G

更新日期：1992-11-01 00:00:00

abstract：:The beta-amyloid peptide (Abeta) is considered responsible for the pathogenesis of Alzheimer's disease. Despite the magnitude of reports describing a neurotoxic role of extracellular Abeta, the role for intracellular Abeta (iAbeta) has not been elucidated. We previously demonstrated that in rat pheochromocytoma cells ...

journal_title：Journal of neurochemistry

authors： Arvanitis DN,Ducatenzeiler A,Ou JN,Grodstein E,Andrews SD,Tendulkar SR,Ribeiro-da-Silva A,Szyf M,Cuello AC

更新日期：2007-10-01 00:00:00