Tanycytes: Gateway to the hungry brain: An Editorial for "The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway" on https://doi.org/10.1111/jnc.15188.

abstract：:Microglial activation can lead to microglial apoptosis, which may serve to remove highly reactive and possibly neurotoxic microglia. However the loss of microglia may have consequences for future recovery, protection and repair. P53, a nuclear phosphoprotein transcription factor, is critical for activating the express...

journal_title：Journal of neurochemistry

authors： Davenport CM,Sevastou IG,Hooper C,Pocock JM

更新日期：2010-01-01 00:00:00

abstract：:Autism is a behaviorally defined neurodevelopmental disorder and among its symptoms are disturbances in face and emotional processing. Emerging evidence demonstrates abnormalities in the GABAergic (gamma-aminobutyric acid) system in autism, which likely contributes to these deficits. GABA(B) receptors play an importan...

journal_title：Journal of neurochemistry

authors： Oblak AL,Gibbs TT,Blatt GJ

更新日期：2010-09-01 00:00:00

abstract：:Female mice are more susceptible to apolipoprotein E (apoE4)-induced cognitive deficits than male mice. These deficits can be antagonized by stimulating androgen receptors (ARs). To determine the role of AR in the cognitive effects of apoE4, we backcrossed mutant mice with a naturally occurring defect in the AR [testi...

journal_title：Journal of neurochemistry

authors： Rizk-Jackson A,Robertson J,Raber J

更新日期：2008-04-01 00:00:00

abstract：:Recently, we described estrogen and agonists of the G-protein coupled estrogen receptor GPR30 to induce protein kinase C (PKC)ε-dependent pain sensitization. PKCε phosphorylates the ion channel transient receptor potential, vanilloid subclass I (TRPV1) close to a novel microtubule-TRPV1 binding site. We now modeled th...

journal_title：Journal of neurochemistry

authors： Goswami C,Kuhn J,Dina OA,Fernández-Ballester G,Levine JD,Ferrer-Montiel A,Hucho T

更新日期：2011-06-01 00:00:00

abstract：:Ischemia, anoxia, and hypoxia of the brain have been shown to inhibit protein synthesis in the central nervous system. To obtain data on the changes in DNA-dependent RNA and DNA polymerase as they pertain specifically to neurons and glia, nuclear enriched neuronal and glial fractions were prepared, by sucrose-gradient...

journal_title：Journal of neurochemistry

authors： Gottlieb M,Chavko M,Marsala J

更新日期：1981-07-01 00:00:00

abstract：:Haptoglobin (Hp) binds hemoglobin (Hb) with high affinity and provides the primary defense against its toxicity after intravascular hemolysis. Neurons are exposed to extracellular Hb after CNS hemorrhage, and a therapeutic effect of Hp via Hb sequestration has been hypothesized. In this study, we tested the hypothesis...

journal_title：Journal of neurochemistry

authors： Chen-Roetling J,Regan RF

更新日期：2016-11-01 00:00:00

abstract：:Inhibition of the mitochondrial electron transport chain (ETC) ultimately limits ATP production and depletes cellular ATP. However, the individual complexes of the ETC in brain mitochondria need to be inhibited by approximately 50% before causing significant depression of ATP synthesis. Moreover, the ETC is the key si...

journal_title：Journal of neurochemistry

authors： Jacobson J,Duchen MR,Hothersall J,Clark JB,Heales SJ

更新日期：2005-10-01 00:00:00

abstract：:Although pharmacological stimulation of a wide variety of transmitter receptors triggers phosphoinositide (PI) turnover, little is known about the type of synaptic activity required to activate this system. To investigate this question, we have used primary cultures of embryonic cortical neurons, which develop functio...

journal_title：Journal of neurochemistry

authors： Murphy TH,Wright DD,Baraban JM

更新日期：1992-12-01 00:00:00

abstract：:The NMDA receptor/channel has been shown to be inhibited by ethanol in the clinically relevant range 25-100 mM. We studied heteromeric assemblies (NR1b/NR2) of the NMDA receptor, expressed in oocytes, to address three questions regarding this inhibition, and discovered the following: (1) The inhibition was nearly equi...

journal_title：Journal of neurochemistry

authors： Chu B,Anantharam V,Treistman SN

更新日期：1995-07-01 00:00:00

abstract：:Although the excitatory action of GABA has been shown to activate the expression of brain-derived neurotrophic factor (BDNF), its molecular mechanisms remain unclear. Using cultured rat cortical cells, we here demonstrated that GABA induced Bdnf mRNA expression mainly via L-type voltage-dependent Ca(2+) channels (L-VD...

journal_title：Journal of neurochemistry

authors： Fukuchi M,Kirikoshi Y,Mori A,Eda R,Ihara D,Takasaki I,Tabuchi A,Tsuda M

更新日期：2014-10-01 00:00:00

abstract：:Highly purified human serum cholinesterase (EC 3.1.1.8, also known as pseudocholinesterase and butyrylcholinesterase) had peptidase activity toward substance P. Digestion of substance P was monitored by high performance liquid chromatography, which separated three product peptides. The cleavages occurred sequentially....

journal_title：Journal of neurochemistry

authors： Lockridge O

更新日期：1982-07-01 00:00:00

abstract：:The metabolic pathway of inositol phospholipids represents a series of synthetic and hydrolytic reactions with inositol as a by-product. Hence, the rate of [3H]inositol release from prelabeled phospholipids can be used as a reflection of activity of this pathway. In the frog sympathetic ganglion prelabeled with [3H]in...

journal_title：Journal of neurochemistry

authors： Rubio R,Bencherif M,Berne RM

更新日期：1989-03-01 00:00:00

abstract：:Increasing evidence suggests that glucagon-like peptide-1 (GLP-1), an incretin hormone of current interest in type 2 diabetes, is neuroprotective in both cell culture and animal models. To characterize the neuroprotective properties of GLP-1 and associated underlying mechanisms, we over-expressed the GLP-1 receptor (G...

journal_title：Journal of neurochemistry

authors： Li Y,Tweedie D,Mattson MP,Holloway HW,Greig NH

更新日期：2010-06-01 00:00:00

abstract：:Three different transcripts of the homeodomain gene termed pituitary homeobox (Ptx) 2 (Pitx2/Brx/Rieg/Solurshin/Arp) were cloned from different species encoding proteins belonging to the paired-like family of homeodomain proteins. Ptx2a (324 amino acids), Ptx2b (271 amino acids), and Ptx2c (318 amino acids) share the ...

journal_title：Journal of neurochemistry

authors： Smidt MP,Cox JJ,van Schaick HS,Coolen M,Schepers J,van der Kleij AM,Burbach JP

更新日期：2000-11-01 00:00:00

abstract：:Two monoclonal antibodies that recognize Alzheimer's neurofibrillary tangles (ANTs), AD10 and AB18, have been characterized by immunoblotting against human and calf spinal cord neurofilament (NF) and calf brain microtubule preparations. Both antibodies bind to the 200-kilodalton (kd) (NF-H) and 160-kd (NF-M) but not t...

journal_title：Journal of neurochemistry

authors： Ksiezak-Reding H,Yen SH

更新日期：1987-02-01 00:00:00

abstract：:The protein kinase C γ (PKCγ) undergoes multistep activation and participates in various cellular processes in Purkinje cells. Perturbations in its phosphorylation state, conformation or localization can disrupt kinase signalling, such as in spinocerebellar ataxia type 14 (SCA14) that is caused by missense mutations i...

journal_title：Journal of neurochemistry

authors： Jezierska J,Goedhart J,Kampinga HH,Reits EA,Verbeek DS

更新日期：2014-03-01 00:00:00

abstract：:Angiotensin (Ang)-converting enzyme (ACE) 2 cleaves Ang-II into the vasodilator peptide Ang-(1-7), thus acting as a pivotal element in balancing the local effects of these peptides. ACE2 has been identified in various tissues and is supposed to be a modulator of cardiovascular function. Decreases in ACE2 expression an...

journal_title：Journal of neurochemistry

authors： Xia H,Lazartigues E

更新日期：2008-12-01 00:00:00

abstract：:The inhibitory effect of an adenosine analogue, R-N6-phenylisopropyl adenosine (R-PIA), of the cholinergic agonist carbachol, and of morphine on 3H efflux from [3H]choline-labeled field-stimulated rat hippocampal slices was compared with that produced by two inhibitors of N- and L-type Ca2+ channels, omega-conotoxin (...

journal_title：Journal of neurochemistry

authors： Fredholm BB

更新日期：1990-04-01 00:00:00

abstract：:We have previously shown that prolonged exposure to neurotrophins induces oxidative neuronal death. In the present study, we further examined the cascades involved in neurotrophin-4/5 (NT-4/5)-induced neuronal death. Exposure of mature cortical cultures for 48 h to NT-4/5 induced neuronal death through TrkB activation...

journal_title：Journal of neurochemistry

authors： Choi SY,Hwang JJ,Koh JY

更新日期：2004-02-01 00:00:00

abstract：:Electrical stimulation of an ascending path of the locus ceruleus-norepinephrine system was used to elicit release of norepinephrine at noradrenergic terminal fields of the rat thalamus. Overflow into the extracellular fluid space was measured by fast in vivo chronoamperometry. At pretreated carbon fibers, the electro...

journal_title：Journal of neurochemistry

authors： Ghasemzadeh MB,Capella P,Mitchell K,Adams RN

更新日期：1993-02-01 00:00:00

abstract：:Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce A beta production by functionally inhibiting gamma-secretase, the activity responsible for the carboxy-terminal cleavage required for A beta production. These mo...

journal_title：Journal of neurochemistry

authors： Dovey HF,John V,Anderson JP,Chen LZ,de Saint Andrieu P,Fang LY,Freedman SB,Folmer B,Goldbach E,Holsztynska EJ,Hu KL,Johnson-Wood KL,Kennedy SL,Kholodenko D,Knops JE,Latimer LH,Lee M,Liao Z,Lieberburg IM,Motter RN,

更新日期：2001-01-01 00:00:00

abstract：:The neuronal nitric oxide (NO) synthase generates NO from arginine. NO mediates its physiological effects mainly by stimulating the synthesis of cyclic GMP. We have investigated the role of the arginine availability on the NMDA-induced cyclic GMP accumulation in immature rat brain slices. The effect of NMDA was blocke...

journal_title：Journal of neurochemistry

authors： Grima G,Cuénod M,Pfeiffer S,Mayer B,Do KQ

更新日期：1998-11-01 00:00:00

abstract：:F2-isoprostanes (F2-IsoPs) are well-established sensitive and specific markers of oxidative stress in vivo. Isofurans (IsoFs) are also products of lipid peroxidation, but in contrast to F2-IsoPs, their formation is favored when oxygen tension is increased in vitro or in vivo. Mitochondrial dysfunction in Parkinson's d...

journal_title：Journal of neurochemistry

authors： Fessel JP,Hulette C,Powell S,Roberts LJ 2nd,Zhang J

更新日期：2003-05-01 00:00:00

abstract：:We report that a subtoxic dose of the succinate dehydrogenase (SDH) inhibitor malonate greatly enhances the neurotoxicity of three different excitatory amino acid agonists: N-methyl-D-aspartate (NMDA), S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (S-AMPA), and L-glutamate. In male Sprague-Dawley rats, in...

journal_title：Journal of neurochemistry

authors： Greene JG,Greenamyre JT

更新日期：1995-05-01 00:00:00

abstract：:Intracerebral administration of [3H]arachidonic acid ([3H]ArA) into 19-20-day-old rat embryos, resulted in a rapid incorporation of label into brain lipids. One hour after injection, 55.6 +/- 8.2, 18.0 +/- 3.4, and 13.7 +/- 1.3% of the total radioactivity was associated with phosphatidylcholine, phosphatidylinositol, ...

journal_title：Journal of neurochemistry

authors： Kunievsky B,Bazan NG,Yavin E

更新日期：1992-11-01 00:00:00

abstract：:Endogenous cannabinoid receptor ligands (endocannabinoids) may rescue neurons from glutamate excitotoxicity. As these substances also accumulate in cultured immature neurons following neuronal damage, elevated endocannabinoid concentrations may be interpreted as a putative neuroprotective response. However, it is not ...

journal_title：Journal of neurochemistry

authors： Hansen HH,Schmid PC,Bittigau P,Lastres-Becker I,Berrendero F,Manzanares J,Ikonomidou C,Schmid HH,Fernández-Ruiz JJ,Hansen HS

更新日期：2001-09-01 00:00:00

abstract：:Previous studies examining age differences in membrane fluidity and cholesterol content have reported on the average or total change in membrane structure, respectively. However, a membrane consists of an exofacial leaflet and a cytofacial leaflet that differ in fluidity and cholesterol distribution. The purpose of th...

journal_title：Journal of neurochemistry

authors： Igbavboa U,Avdulov NA,Schroeder F,Wood WG

更新日期：1996-04-01 00:00:00

abstract：:Effects of protein kinase C on protein stability and activity of rat AANAT were investigated in vitro and in vivo. When COS-7 cells transfected with AANAT cDNA were treated with phorbol 12-myristate 13-acetate (PMA), both the activity and protein level of AANAT were increased. These effects of PMA were blocked by GF10...

journal_title：Journal of neurochemistry

authors： Choi BH,Chae HD,Park TJ,Oh J,Lim J,Kang SS,Ha H,Kim KT

更新日期：2004-07-01 00:00:00

abstract：:Perhaps the most reproducible early event induced by the interaction of amyloid beta peptide (A beta) with the cell is the inhibition of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. We recently demonstrated that cytotoxic amyloid peptides such as A beta and human amylin inhibi...

journal_title：Journal of neurochemistry

authors： Liu Y,Schubert D

更新日期：1998-12-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases have been implicated in multiple responses to extracellular stimuli. In this study we show that MAP kinase activity is enhanced after a KCl pulse. This activation correlates with an increased tyrosine phosphorylation of a 42-kDa protein as determined by antiphosphotyrosine immun...

journal_title：Journal of neurochemistry

authors： Baron C,Benes C,Van Tan H,Fagard R,Roisin MP

更新日期：1996-03-01 00:00:00