HDL mimetic peptides affect apolipoprotein E metabolism: equal supplement or functional enhancer?: An Editorial for 'High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary

abstract：:The nucleoside transporter of cerebral microvessels and choroid plexus was identified and characterized using [3H]nitrobenzylthioinosine (NBMPR) as a specific probe. [3H]NBMPR bound reversibly and with high affinity to a single specific site in particulate fractions of cerebral microvessels, choroid plexus, and cerebr...

journal_title：Journal of neurochemistry

authors： Kalaria RN,Harik SI

更新日期：1986-12-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors labelled with tritiated agonists are reduced in the cerebral cortex in Alzheimer's disease (AD), but to date it has not been demonstrated which nicotinic receptor subunits contribute to this deficit. In the present study, autopsy tissue from the temporal cortex of 14 AD cases...

journal_title：Journal of neurochemistry

authors： Martin-Ruiz CM,Court JA,Molnar E,Lee M,Gotti C,Mamalaki A,Tsouloufis T,Tzartos S,Ballard C,Perry RH,Perry EK

更新日期：1999-10-01 00:00:00

abstract：:Rat cerebellar granule cells differentiated in culture were fed [1-(3)H]sphingosine, allowing the metabolic radiolabelling of all cell sphingolipids and phosphatidylethanolamine. A detergent-insoluble sphingolipid-enriched membrane fraction, containing about 60% of cell sphingolipids, but only trace amounts of phospha...

journal_title：Journal of neurochemistry

authors： Prinetti A,Prioni S,Chigorno V,Karagogeos D,Tettamanti G,Sonnino S

更新日期：2001-09-01 00:00:00

abstract：:We developed a rapid and sensitive radioimmunohistochemical method for the quantification of tyrosine hydroxylase (TH) at both the anatomical and cellular level. Coronal tissue sections from fresh-frozen rat brains were incubated in the presence of a TH monoclonal antibody. The reaction was revealed with a 35S-labeled...

journal_title：Journal of neurochemistry

authors： Blanchard V,Raisman-Vozari R,Savasta M,Hirsch E,Javoy-Agid F,Feuerstein C,Agid Y

更新日期：1993-08-01 00:00:00

abstract：:Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate changes in blood kynurenine pathway metabolites, as well as markers of inflammation and oxidative stress in HD patients and healthy controls. Results showed tha...

journal_title：Journal of neurochemistry

authors： Stoy N,Mackay GM,Forrest CM,Christofides J,Egerton M,Stone TW,Darlington LG

更新日期：2005-05-01 00:00:00

abstract：:Glial uptake of neurotransmitter glutamate (GLU) from the extracellular fluid was studied in vivo in rat brain by (13)C NMR and microdialysis combined with gas-chromatography/mass-spectrometry. Brain GLU C5 was (13)C enriched by intravenous [2,5-(13)C]glucose infusion, followed by [(12)C]glucose infusion to chase (13)...

journal_title：Journal of neurochemistry

authors： Kanamori K,Ross BD,Kondrat RW

更新日期：2002-11-01 00:00:00

abstract：:We investigated the effects of 17beta-estradiol, an estrogen, on [(3)H]norepinephrine ([(3)H]NE) secretion in PC12 cells. Pretreatment with 17beta-estradiol reduced 70 mM K(+)-induced [(3)H]NE secretion in a concentration-dependent manner with a half-maximal inhibitory concentration (IC(50)) of 2 +/- 1 microM. The 70 ...

journal_title：Journal of neurochemistry

authors： Kim YJ,Hur EM,Park TJ,Kim KT

更新日期：2000-06-01 00:00:00

abstract：:In developing CNS D1 dopamine receptor-imaging agents with improved specificity and longer brain retention, an iodinated D1 ligand was synthesized. In vitro and in vivo radiolabeling studies of a new iodinated benzazepine, TISCH [7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine], an a...

journal_title：Journal of neurochemistry

authors： Billings JJ,Kung MP,Chumpradit S,Mozley D,Alavi A,Kung HF

更新日期：1992-01-01 00:00:00

abstract：:In complex tissues where multiple subtypes of nicotinic acetylcholine receptors (nAChRs) are expressed, immunohistochemistry has been the most popular tool for investigation of nAChR subunit distribution. However, recent studies with nAChR subunit knockout mice demonstrated that a large panel of antibodies is unsuitab...

journal_title：Journal of neurochemistry

authors： Shelukhina IV,Kryukova EV,Lips KS,Tsetlin VI,Kummer W

更新日期：2009-05-01 00:00:00

abstract：:Beta-amyloid accumulates in cerebral deposits in Alzheimer's disease, so to test the correlation between the neurotoxic and fibrillogenic capacity of beta-amyloid, we synthesized a peptide homologous to fragment 25-35 of beta-amyloid (beta25-35) and amidated at the C-terminus (beta25-35-NH2). As the amidation strongly...

journal_title：Journal of neurochemistry

authors： Forloni G,Lucca E,Angeretti N,Della Torre P,Salmona M

更新日期：1997-11-01 00:00:00

abstract：:It is well-known that the extracellular concentration of calcium affects neuronal excitability and synaptic transmission. Less is known about the physiological concentration of extracellular calcium in the brain. In electrophysiological brain slice experiments, the artificial cerebrospinal fluid traditionally contains...

journal_title：Journal of neurochemistry

authors： Forsberg M,Seth H,Björefeldt A,Lyckenvik T,Andersson M,Wasling P,Zetterberg H,Hanse E

更新日期：2019-05-01 00:00:00

abstract：:In human fetal spinal cord (HFSC), six additional microtubule-associated protein-2 (MAP-2) transcripts are generated by alternative splicing of two recently described exons, exon 8 and exon 13. The following three translated proteins are detected by western blot analysis: MAP-2b expressing exon 8 (MAP-2b + 8; MAP-2a),...

journal_title：Journal of neurochemistry

authors： Kalcheva N,Weidenheim KM,Kress Y,Shafit-Zagardo B

更新日期：1997-01-01 00:00:00

abstract：:Cross-talk between cannabinoid CB1 and serotonin 5-HT receptors in rat cerebellar membranes was investigated using radioligand binding. In competition against the CB1 antagonist, [3 H]SR141716A, the agonist, WIN 55,212-2 yielded a biphasic isotherm. The majority of binding was to a high-affinity state that was signifi...

journal_title：Journal of neurochemistry

authors： Devlin MG,Christopoulos A

更新日期：2002-03-01 00:00:00

abstract：:A Ca2+- and calmodulin-dependent protein kinase was purified from rat brain cytosol fraction to apparent homogeneity at approximately 800-fold and with a 5% yield. The purified enzyme had a molecular weight of 640,000 as determined by gel filtration analysis on Sephacryl S-300 and a sedimentation coefficient of 15.3 S...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Yamamoto H,Matsui K,Higashi K,Miyamoto E

更新日期：1982-12-01 00:00:00

abstract：:The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken beta-actin promoter. In...

journal_title：Journal of neurochemistry

authors： Oyama F,Sawamura N,Kobayashi K,Morishima-Kawashima M,Kuramochi T,Ito M,Tomita T,Maruyama K,Saido TC,Iwatsubo T,Capell A,Walter J,Grünberg J,Ueyama Y,Haass C,Ihara Y

更新日期：1998-07-01 00:00:00

abstract：:The glutamate receptor 2 (GluR2) subunit determines many of the functional properties of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate subtype of glutamate receptor. The roles of untranslated regions (UTRs) in mRNA stability, transport, or translation are increasingly recognized. The 3' end of the GluR2 tra...

journal_title：Journal of neurochemistry

authors： Irier HA,Shaw R,Lau A,Feng Y,Dingledine R

更新日期：2009-04-01 00:00:00

abstract：:Calcium influx into SH-SY5Y human neuroblastoma cells after ionophore treatment or transient permeabilization in calcium-containing medium increased ALZ-50 immunoreactivity markedly. This increase was prevented by inhibitors active against calpain or against protein kinase C (PKC), suggesting that both of these enzyme...

journal_title：Journal of neurochemistry

authors： Shea TB,Spencer MJ,Beermann ML,Cressman CM,Nixon RA

更新日期：1996-04-01 00:00:00

abstract：:Genetic factors and nerve injury-induced changes of gene expression in sensory neurons are potential contributors to tactile allodynia, a neuropathic pain state manifested as hypersensitivity to innocuous mechanical stimulation. To uncover genes relevant to neuropathic allodynia, we analyzed gene expression profiles i...

journal_title：Journal of neurochemistry

authors： Valder CR,Liu JJ,Song YH,Luo ZD

更新日期：2003-11-01 00:00:00

abstract：:Enzymes considered to be markers for neurons (angiotensin converting enzyme, thermolysin-like metalloendopeptidase, alanine aminopeptidase, and glutamate-oxaloacetate transaminase), glia (glutamine synthetase, pyruvate carboxylase, and beta-glucuronidase), and endothelial cells (alkaline phosphatase and plasminogen ac...

journal_title：Journal of neurochemistry

authors： Butterworth J

更新日期：1986-08-01 00:00:00

abstract：:The double C2 (Doc2) family is characterized by an N-terminal Munc13-1-interacting domain and C-terminal tandem C2 domains, and it comprises three isoforms, Doc2alpha, Doc2beta, and Doc2gamma, in humans and mice. Doc2alpha, the best-characterized, brain-specific isoform, exhibits Ca(2+)-dependent phospholipid-binding ...

journal_title：Journal of neurochemistry

authors： Sato M,Mori Y,Matsui T,Aoki R,Oya M,Yanagihara Y,Fukuda M,Tsuboi T

更新日期：2010-07-01 00:00:00

abstract：:We investigated the molecular mechanism underlying the ganglioside-induced initiation of the assembly of wild and hereditary variant-type amyloid beta-proteins, including Arctic-, Dutch-, and Flemish-type amyloid beta-proteins. We monitored the assembly of amyloid beta-protein by thioflavin-T assay, western blotting a...

journal_title：Journal of neurochemistry

authors： Yamamoto N,Matsuzaki K,Yanagisawa K

更新日期：2005-11-01 00:00:00

abstract：:Tubulin tyrosine ligase catalyzes the reversible addition of tyrosine to the C-terminus of tubulin alpha chains. By using ligase and carboxypeptidase A in conjunction, we have previously shown that brain cytoplasmic tubulin exists in three forms: 15-40% already has C-terminal tyrosine, another 10-30% can accept additi...

journal_title：Journal of neurochemistry

authors： Nath J,Flavin M

更新日期：1980-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of neurofibrillary tangles and amyloid plaques in the brain of patients. To study plaque formation, we report on further quantitative and qualitative analysis of human and mouse amyloid beta peptides (Abeta) from brain extracts of transgenic mice overexpressing the Lo...

journal_title：Journal of neurochemistry

authors： Pype S,Moechars D,Dillen L,Mercken M

更新日期：2003-02-01 00:00:00

abstract：:Rat glioma X mouse neuroblastoma hybrid neurotumor cells (NG108-15), synchronized by amino acid deprivation, showed a cell-cycle-dependent peak of activity of a ganglioside N-acetylgalactosaminyl transferase 14-24 h following release from the cell cycle block (S/G2 phase). Maximal expression of two typical lysosomal h...

journal_title：Journal of neurochemistry

authors： Scheideler MA,Lockney MW,Dawson G

更新日期：1984-04-01 00:00:00

abstract：:To identify the transductional mechanisms responsible for the neuroprotective effect of nitric oxide (NO) during ischemic preconditioning (IPC), we investigated the effects of this gaseous mediator on mitochondrial Mn-superoxide dismutase (Mn-SOD) expression and activity. In addition, the possible involvement of Ras/e...

journal_title：Journal of neurochemistry

authors： Scorziello A,Santillo M,Adornetto A,Dell'aversano C,Sirabella R,Damiano S,Canzoniero LM,Renzo GF,Annunziato L

更新日期：2007-11-01 00:00:00

abstract：:The ubiquitous second messenger cyclic GMP (cGMP) is synthesized by soluble guanylate cyclases in response to nitric oxide (NO) and degraded by phosphodiesterases (PDE). We studied the homeostasis of cGMP in living thalamic neurons by using the genetically encoded fluorescence resonance energy transfer sensor Cygnet, ...

journal_title：Journal of neurochemistry

authors： Hepp R,Tricoire L,Hu E,Gervasi N,Paupardin-Tritsch D,Lambolez B,Vincent P

更新日期：2007-09-01 00:00:00

abstract：:The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-aspartate content increases rapidly from 1 year to approximately 35 y...

journal_title：Journal of neurochemistry

authors： Man EH,Fisher GH,Payan IL,Cadilla-Perezrios R,Garcia NM,Chemburkar R,Arends G,Frey WH 2nd

更新日期：1987-02-01 00:00:00

abstract：:Beta-amyloid peptides play a major role in the pathogenesis of Alzheimer's disease (AD). Therefore, preventing beta-amyloid formation by inhibition of the beta site amyloid precursor protein-cleaving enzyme (BACE) 1 is considered as a potential strategy to treat AD. Cholinergic mechanisms have been shown to control am...

journal_title：Journal of neurochemistry

authors： Zuchner T,Schliebs R,Perez-Polo JR

更新日期：2005-10-01 00:00:00

abstract：:Methyl CpG binding protein 2 (MeCP2) binds to methylated DNA and acts as a transcriptional repressor. Mutations of human MECP2 gene lead to Rett syndrome, a severe neural developmental disorder. Here, we report that the MeCP2 protein can be modified by covalent linkage to small ubiquitin-like modifier (SUMO) and SUMOy...

journal_title：Journal of neurochemistry

authors： Cheng J,Huang M,Zhu Y,Xin YJ,Zhao YK,Huang J,Yu JX,Zhou WH,Qiu Z

更新日期：2014-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been suggested to act as cellular messengers that mediate signal transduction cascades in various cell types. However, little is known about their role in this capacity in the nervous system. We have begun to investigate the role of ROS, and that of nitric oxide (NO), in mediating mi...

journal_title：Journal of neurochemistry

authors： Kanterewicz BI,Knapp LT,Klann E

更新日期：1998-03-01 00:00:00