Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

abstract：:The effects of treatment of brain membranes with diethyl pyrocarbonate (DEP), a histidine-modifying reagent, on the binding of 3H-labeled Ro 15-4513 (ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]- [1,4]benzodiazepine-3-carboxylate) and [3H]diazepam were compared. DEP pretreatment produced a dose-dependent...

journal_title：Journal of neurochemistry

authors： Uusi-Oukari M

更新日期：1992-08-01 00:00:00

abstract：:Glial glutamate transporter-1 (GLT-1) is the predominant subtype of glutamate transporters which are responsible for the homeostasis of extracellular glutamate. Our previous studies have shown that up-regulation in GLT-1 protein expression matches brain ischemic tolerance induced by cerebral ischemic preconditioning (...

journal_title：Journal of neurochemistry

authors： Liu AJ,Hu YY,Li WB,Xu J,Zhang M

更新日期：2011-10-01 00:00:00

abstract：:Glutamate receptor (GluR) δ1 is widely expressed in the developing forebrain, whereas GluRδ2 is selectively expressed in cerebellar Purkinje cells. Recently, we found that trans-synaptic interaction of postsynaptic GluRδ2 and pre-synaptic neurexins (NRXNs) through cerebellin precursor protein (Cbln) 1 mediates excitat...

journal_title：Journal of neurochemistry

authors： Yasumura M,Yoshida T,Lee SJ,Uemura T,Joo JY,Mishina M

更新日期：2012-06-01 00:00:00

abstract：:The kappa-opioid receptor agonists including U-50,488H and dynorphin A (1-17) in ranges of 0.1-100 nM inhibited the hydrolysis of GTP to GDP (P(i) release) inherent in GTP-binding proteins (G proteins) in guinea pig cerebellar membranes. U-50,488H inhibited only high-affinity GTPase activity, not low-affinity activity...

journal_title：Journal of neurochemistry

authors： Ueda H,Misawa H,Fukushima N,Katada T,Ui M,Satoh M

更新日期：1996-02-01 00:00:00

abstract：:Long-chain polyunsaturated (n-3) fatty acids have been reported to influence the efficiency of membrane receptors, transporters and enzymes. Because the brain is particularly rich in docosahexaenoic acid (DHA, 22:6 n-3), the present study addresses the question of whether the 22:6 n-3 fatty acid deficiency induces dis...

journal_title：Journal of neurochemistry

authors： Ximenes da Silva A,Lavialle F,Gendrot G,Guesnet P,Alessandri JM,Lavialle M

更新日期：2002-06-01 00:00:00

abstract：:We reported earlier that adenine nucleotides and adenosine inhibit acetylcholine-induced catecholamine secretion from bovine adrenal medulla chromaffin cells. In this article, we used an adenosine analogue, N6-L-phenylisopropyladenosine (PIA), to study the mechanism underlying inhibition of catecholamine secretion by ...

journal_title：Journal of neurochemistry

authors： Chern YJ,Bott M,Chu PJ,Lin YJ,Kao LS,Westhead EW

更新日期：1992-10-01 00:00:00

abstract：:The ability of activated glia to affect cerebral vascular tone has been evaluated using an in vitro experimental system in which basilar arteries were incubated with glial cultures activated by treatment with lipopolysaccharide (LPS). Vascular tone was measured with an isometric myograph. Contraction in response to hi...

journal_title：Journal of neurochemistry

authors： Chisari M,Salomone S,Laureanti F,Copani A,Sortino MA

更新日期：2004-12-01 00:00:00

abstract：:Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employ...

journal_title：Journal of neurochemistry

authors： Baidanoff FM,Plano SA,Doctorovich F,Suárez SA,Golombek DA,Chiesa JJ

更新日期：2014-04-01 00:00:00

abstract：:At 0 degrees C, when Na+ was the only cation present in the incubation medium, increasing the Na+ concentration from 3 to 10 mM enhanced the affinity of [3H]1-[2-(++di-phenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperaz ine [( 3H]GBR 12783) for the specific binding site present in rat striatal membranes without affect...

journal_title：Journal of neurochemistry

authors： Bonnet JJ,Benmansour S,Vaugeois JM,Costentin J

更新日期：1988-03-01 00:00:00

abstract：:One of the fundamental goals of lipidomics research is to identify the linkage of an individual gene with a given lipidome, thereby revealing the role of that gene in lipid metabolism, transport, and homeostasis. In this study, we have identified four apolipoprotein E (apoE)-induced alterations in the lipidome of mous...

journal_title：Journal of neurochemistry

authors： Cheng H,Jiang X,Han X

更新日期：2007-04-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:Melanocortin-4 receptors (MC4 R) are unique among G-protein-coupled receptors (GPCRs) as they have endogenous ligands that can exhibit inverse agonistic properties in the case of elevated basal activity. It is known that the constitutive activity of GPCRs strongly affects the ligand-dependent physiological responses, ...

journal_title：Journal of neurochemistry

authors： Link R,Veiksina S,Tahk MJ,Laasfeld T,Paiste P,Kopanchuk S,Rinken A

更新日期：2020-05-01 00:00:00

abstract：:The purpose of the present study was to clarify the expression, transport properties and regulation of ATP-binding cassette G2 (ABCG2) transporter at the rat blood-brain barrier (BBB). The rat homologue of ABCG2 (rABCG2) was cloned from rat brain capillary fraction. In rABCG2-transfected HEK293 cells, rABCG2 was detec...

journal_title：Journal of neurochemistry

authors： Hori S,Ohtsuki S,Tachikawa M,Kimura N,Kondo T,Watanabe M,Nakashima E,Terasaki T

更新日期：2004-08-01 00:00:00

abstract：:Rarefaction of the dendritic tree leading to neuronal dysfunction is a hallmark of many neurodegenerative diseases and we have shown previously that heat shock protein B5 (HspB5)/αB-crystallin is able to increase dendritic complexity in vitro. The aim of this study was to investigate if this effect is also present in ...

journal_title：Journal of neurochemistry

authors： Bartelt-Kirbach B,Wiegreffe C,Birk S,Baur T,Moron M,Britsch S,Golenhofen N

更新日期：2020-11-21 00:00:00

abstract：:Extracts of rat tissues were subjected to ultracentrifugation on linear density gradients of sucrose (5-20%) and fractions of these gradients were analyzed for acetylcholinesterase (AChE) activity. Most of the AChE activity in extracts of vagus nerve was found to sediment at 10S. However, 16S AChE, previously thought ...

journal_title：Journal of neurochemistry

authors： Skau KA,Brimijoin S

更新日期：1980-11-01 00:00:00

abstract：:Tetanus and botulinum toxins bind and are internalized at the neuromuscular junction. Botulinum neurotoxins (BoNTs) enter the cytosol at the motor nerve terminal; tetanus neurotoxin (TeNT) proceeds retroaxonally inside the motor axon to reach the spinal cord inhibitory interneurons. Although the major target of BoNTs ...

journal_title：Journal of neurochemistry

authors： Verderio C,Coco S,Rossetto O,Montecucco C,Matteoli M

更新日期：1999-07-01 00:00:00

abstract：:Pumiliotoxins (PTX) A, B, and 251D, members of a new class of indolizidine alkaloids isolated from the skin of poison frogs of the family Dendrobatidae, inhibit Ca2+-ATPase activity in sarcoplasmic reticulum vesicles from frog and rat hind-limb muscles. PTX-B and PTX-A appear to be relatively specific inhibitors of Ca...

journal_title：Journal of neurochemistry

authors： Tamburini R,Albuquerque EX,Daly JW,Kauffman FC

更新日期：1981-09-01 00:00:00

abstract：:Lipid precursors ([2-3H]glycerol for phospholipids and [3H]acetate for cholesterol) were injected into the L-5 dorsal root ganglion of adult rats. At various times, animals were killed, the ganglion and consecutive 5-mm segments of sciatic nerve were dissected, and lipids were extracted and analyzed by TLC. Individual...

journal_title：Journal of neurochemistry

authors： Toews AD,Saunders BF,Blaker WD,Morell P

更新日期：1983-02-01 00:00:00

abstract：:We assessed the functional expression of the norepinephrine (NE) transporter (NET) in cultured rat cortical astrocytes. Specific [3H]NE uptake increased in a time-dependent manner, and this uptake involves temperature- and Na+-sensitive mechanisms. The Na+-dependent [3H]NE uptake was saturable, and the Km for the proc...

journal_title：Journal of neurochemistry

authors： Inazu M,Takeda H,Matsumiya T

更新日期：2003-01-01 00:00:00

abstract：:L-Aspartate N-acetyltransferase, a nervous system enzyme that mediates the synthesis of N-acetyl-L-aspartic acid, has been characterized. In the presence of acetyl-CoA, L-aspartate was acetylated 10-fold more efficiently than L-glutamate, and the acetylation of aspartylglutamate was not detectable. Within the nervous ...

journal_title：Journal of neurochemistry

authors： Truckenmiller ME,Namboodiri MA,Brownstein MJ,Neale JH

更新日期：1985-11-01 00:00:00

abstract：:Frame-shifted amyloid precursor protein (APP(+1)), which has a truncated out-of-frame C-terminus, accumulates in the neuropathological hallmarks of patients with Alzheimer's disease pathology. To study a possible involvement of APP(+1) in the pathogenesis of Alzheimer's disease, we expressed APP695 and APP(+1) in the ...

journal_title：Journal of neurochemistry

authors： van Dijk R,Fischer DF,Sluijs JA,Sonnemans MA,Hobo B,Mercken L,Mann DM,Hol EM,van Leeuwen FW

更新日期：2004-08-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD-1 gene product, ataxin-3. Ataxin-3 is degraded by the proteasome. However, the precise mechanism of ataxin-3 degradation remains to be elucidated. In this st...

journal_title：Journal of neurochemistry

authors： Wang H,Jia N,Fei E,Wang Z,Liu C,Zhang T,Fan J,Wu M,Chen L,Nukina N,Zhou J,Wang G

更新日期：2007-06-01 00:00:00

abstract：:GD3 synthase (Sial-T2) is a key enzyme of ganglioside synthesis that, in concert with GM2 synthase (GalNAc-T), regulates the ratio of a- and b-pathway gangliosides. In this work, we study the sub-Golgi location of an epitope-tagged version of chicken Sial-T2 transfected to CHO-K1 cells. The expressed protein was enzym...

journal_title：Journal of neurochemistry

authors： Daniotti JL,Martina JA,Giraudo CG,Zurita AR,Maccioni HJ

更新日期：2000-04-01 00:00:00

abstract：:Protein biosynthesis in the retina and fast axonal transport along the optic pathway were studied in rabbits in which diabetes had been experimentally induced. Retinal protein biosynthesis and axonal transport were significantly reduced in the diabetic rabbits, and the reduction was correlated to the severity of the d...

journal_title：Journal of neurochemistry

authors： Chihara E

更新日期：1981-07-01 00:00:00

abstract：:Ammonia is responsible for cerebral edema associated with acute liver failure, but the role of the vasogenic mechanism has been a matter of dispute. Here, we tested the hypothesis that ammonia induces changes in blood-brain barrier (BBB) permeability by a mechanism coupled to oxidative/nitrosative stress (ONS) evoked ...

journal_title：Journal of neurochemistry

authors： Skowrońska M,Zielińska M,Wójcik-Stanaszek L,Ruszkiewicz J,Milatovic D,Aschner M,Albrecht J

更新日期：2012-04-01 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative condition characterized by pathology in the brain and peripheral tissues. Hyperactivity of the innate immune system, due in part to NFκB pathway dysregulation, is an early and active component of HD. Evidence suggests targeting immune disruption may slow disease progres...

journal_title：Journal of neurochemistry

authors： Dobson L,Träger U,Farmer R,Hayardeny L,Loupe P,Hayden MR,Tabrizi SJ

更新日期：2016-06-01 00:00:00

abstract：:The specific binding of L-[3H]glutamate was investigated in the presence and the absence of sodium ions in freshly prepared membranes from rat hippocampus. Sodium ions were found to have a biphasic effect; low concentrations induced a marked inhibition of the binding (in the range 0.5-5.0 mM), whereas higher concentra...

journal_title：Journal of neurochemistry

authors： Baudry M,Lynch G

更新日期：1981-03-01 00:00:00

abstract：:The pivotal role for voltage-sensitive calcium channels in initiating synaptic transmitter release is undisputed, but it is only partly known to what extent the different subtypes contribute in vivo. Their importance for the dendritic release of dopamine has not been investigated in vivo previously. To evaluate compre...

journal_title：Journal of neurochemistry

authors： Bergquist F,Jonason J,Pileblad E,Nissbrandt H

更新日期：1998-04-01 00:00:00

abstract：:Serotonin-1A (5-HT(1A) receptors in the dorsal raphe nucleus (DRN) function as somatodendritic autoreceptors, and therefore play a critical role in controlling serotonergic cell firing and serotonergic neurotransmission. We hypothesized that a decrease in the capacity of 5-HT(1A) receptors to activate G proteins was a...

journal_title：Journal of neurochemistry

authors： Rossi DV,Burke TF,McCasland M,Hensler JG

更新日期：2008-05-01 00:00:00

abstract：:The effects of long-term treatment with imipramine or mirtazapine, two antidepressant drugs with different mechanisms of action, on the response of cortical dopaminergic neurons to foot-shock stress or to the anxiogenic drug FG7142 were evaluated in freely moving rats. As expected, foot shock induced a marked increase...

journal_title：Journal of neurochemistry

authors： Dazzi L,Spiga F,Pira L,Ladu S,Vacca G,Rivano A,Jentsch JD,Biggio G

更新日期：2001-02-01 00:00:00