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Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia.

Abstract：

:Microglia, macrophage-like cells in the CNS, are multifunctional cells; they play an important role in removal of dead cells or their remnants by phagocytosis in the CNS degeneration and are one of important cells in the CNS cytokine network to produce and respond to a variety of cytokines. The functions of microglia are regulated by inhibitory cytokines. We have reported the expression of interleukin (IL)-10, one of the inhibitory cytokines, and its receptor in mouse microglia; therefore, IL-10 may affect microglial functions. In this study, we investigated the effects of IL-10 on purified microglia in culture. IL-10 inhibited lipopolysaccharide-induced IL-1beta and tumor necrosis factor-alpha production, lysosomal enzyme activity, and superoxide anion production in a dose-dependent manner, but did not affect granulocyte/ macrophage colony-stimulating factor-dependent proliferation of microglia. IL-10 also decreased the expression of both IL-6 receptor and lipopolysaccharide-induced IL-2 receptor but not IL-4 receptor on microglia as measured by flow cytometric analysis with an indirect immunofluorescence technique. IL-10 also decreased mRNA expression of IL-2 and IL-6 cytokine receptors. These results suggest that IL-10 is a unique and potent inhibitory factor in the CNS cytokine network involved in decreasing the expression of cytokine receptors as well as cytokine production by microglia.

journal_name

J Neurochem

journal_title

Journal of neurochemistry

authors

Sawada M,Suzumura A,Hosoya H,Marunouchi T,Nagatsu T

doi

10.1046/j.1471-4159.1999.721466.x

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

1466-71

issue

4

eissn

0022-3042

issn

1471-4159

journal_volume

72

pub_type

杂志文章

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