Kinetics of the mechanism of action of monoamine oxidase in the regulation of Na+,K+-ATPase activity in rat brain.

abstract：:When isolated myelin membranes were ADP-ribosylated by [32P]NAD+ either in the absence of toxin (by the membrane ADP-ribosyltransferase) or in the presence of cholera toxin, the same proteins were ADP-ribosylated in both cases and myelin basic protein (MBP) was the major radioactive product. Therefore, cholera toxin w...

journal_title：Journal of neurochemistry

authors： Boulias C,Moscarello MA

更新日期：1994-07-01 00:00:00

abstract：:Sequential 31P and 1H nuclear magnetic resonance spectra were measured for neonatal piglets (n = 7) to determine the relationship between brain intracellular pH (pHi), lactate, and phosphorylated energy metabolites during partial ischemia. Simultaneous determinations of arterial and cerebral venous blood gases, pH, O2...

journal_title：Journal of neurochemistry

authors： Corbett RJ,Laptook AR,Nunnally RL,Hassan A,Jackson J

更新日期：1988-11-01 00:00:00

abstract：:Using nuclear reaction 6Li(n, alpha)3H and dielectric detectors, we have studied the distribution of Li in the brain of adult mice, following Li treatment of the animals. Two strains of animals were used in parallel: "quaking" dysmyelinating mutants and normally myelinated controls. The distribution appeared to be sha...

journal_title：Journal of neurochemistry

authors： Heurteaux C,Baumann N,Lachapelle F,Wissocq JC,Thellier M

更新日期：1986-04-01 00:00:00

abstract：:The aggravating effect of hyperglycemia on ischemic brain injury can be mimicked in a model of in vitro ischemia (IVI) using murine hippocampal slice cultures. Using this model, we found that the damage in the CA1 region following IVI in the absence or presence of 40 mm glucose (hyperglycemia) is highly temperature de...

journal_title：Journal of neurochemistry

authors： Rytter A,Cardoso CM,Johansson P,Cronberg T,Hansson MJ,Mattiasson G,Elmér E,Wieloch T

更新日期：2005-11-01 00:00:00

abstract：:Type 1 cannabinoid receptor (CB1) is expressed in different neuronal populations in the mammalian brain. In particular, CB1 on GABAergic or glutamatergic neurons exerts different functions and display different pharmacological properties in vivo. This suggests the existence of neuron-type specific signalling pathways ...

journal_title：Journal of neurochemistry

authors： Steindel F,Lerner R,Häring M,Ruehle S,Marsicano G,Lutz B,Monory K

更新日期：2013-03-01 00:00:00

abstract：:The beta-amyloid peptide (Abeta) is considered responsible for the pathogenesis of Alzheimer's disease. Despite the magnitude of reports describing a neurotoxic role of extracellular Abeta, the role for intracellular Abeta (iAbeta) has not been elucidated. We previously demonstrated that in rat pheochromocytoma cells ...

journal_title：Journal of neurochemistry

authors： Arvanitis DN,Ducatenzeiler A,Ou JN,Grodstein E,Andrews SD,Tendulkar SR,Ribeiro-da-Silva A,Szyf M,Cuello AC

更新日期：2007-10-01 00:00:00

abstract：:We show that the expression of the gene encoding glial fibrillary acidic protein (GFAP) gene is affected by at least three cis-acting elements. A positive regulatory element that is located between nucleotides -1,631 and -1,479 can confer cell type-specific expression on a heterologous gene. A second regulatory elemen...

journal_title：Journal of neurochemistry

authors： Sarkar S,Cowan NJ

更新日期：1991-08-01 00:00:00

abstract：:The ATP-dependent glutamate uptake system in synaptic vesicles prepared from mouse cerebellum was characterized, and the levels of glutamate uptake were investigated in the cerebellar mutant mice, staggerer and weaver, whose main defect is the loss of cerebellar granule cells, and the nervous mutant, whose main defect...

journal_title：Journal of neurochemistry

authors： Fischer-Bovenkerk C,Kish PE,Ueda T

更新日期：1988-10-01 00:00:00

abstract：:The glycogen content of primary cultured astrocytes was approximately doubled by incubation with 1 mM L-glutamate or L-aspartate. Other amino acids and excitatory neurotransmitters were without effect. The increase in glycogen level was not blocked by the glutamate receptor antagonist kynurenic acid but was completely...

journal_title：Journal of neurochemistry

authors： Swanson RA,Yu AC,Chan PH,Sharp FR

更新日期：1990-02-01 00:00:00

abstract：:Oxidative stress has been shown to play a role in aging and in neurodegenerative disorders. Some of the consequences of oxidative stress are DNA base modifications, lipid peroxidation, and protein modifications such as formation of carbonyls and nitrotyrosine. These events may play a role in apoptosis, another factor ...

journal_title：Journal of neurochemistry

authors： Kaufmann JA,Bickford PC,Taglialatela G

更新日期：2001-02-01 00:00:00

abstract：:PCR was used to isolate identical partial cDNA clones encoding a serotonin 5-HT3 receptor subunit from rat nodose and superior cervical ganglia. The amino acid sequence predicted from these clones, extending from the putative transmembrane domain I to the stop codon, demonstrated a 93% homology with the 5-HT3 receptor...

journal_title：Journal of neurochemistry

authors： Miquel MC,Emerit MB,Gingrich JA,Nosjean A,Hamon M,el Mestikawy S

更新日期：1995-08-01 00:00:00

abstract：:Electrophorus electroplax microsomes were examined for Ca2+- and Mg2+-dependent ATPase activity. In addition to the previously reported low-affinity ATPase, a high-affinity (Ca2+,Mg2+)-ATPase was found. At low ATP and Mg2+ concentrations (200 microM or less), the high-affinity (Ca2+,Mg2+)-ATPase exhibits an activity o...

journal_title：Journal of neurochemistry

authors： Amende LM,Chock SP,Albers RW

更新日期：1983-04-01 00:00:00

abstract：:During development, neurons extend axons toward their appropriate synaptic targets to establish functional neuronal connections. The growth cone, a highly motile structure at the tip of the axon, is capable of recognizing extracellular guidance cues and translating them into directed axon outgrowth through modulation ...

journal_title：Journal of neurochemistry

authors： Duquette PM,Lamarche-Vane N

更新日期：2020-02-01 00:00:00

abstract：:By using a 125I-calmodulin overlay assay, three major high-affinity calmodulin-binding proteins, showing apparent molecular masses of 135, 60, and 50 kDa, have been detected in purified nuclear fractions isolated from rat neurons. It has been shown that after extraction of the nuclei with nucleases and high salt, all ...

journal_title：Journal of neurochemistry

authors： Pujol MJ,Bosser R,Vendrell M,Serratosa J,Bachs O

更新日期：1993-04-01 00:00:00

abstract：:SUMOylation is a post-translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein-protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation...

journal_title：Journal of neurochemistry

authors： Henley JM,Seager R,Nakamura Y,Talandyte K,Nair J,Wilkinson KA

更新日期：2020-06-15 00:00:00

abstract：:Abstract Huntingtin is a large, multi-domain protein of unknown function in the brain. An abnormally elongated polyglutamine stretch in its N-terminus causes Huntington's disease (HD), a progressive neurodegenerative disorder. Huntingtin has been proposed to play a functional role in membrane trafficking via proteins ...

journal_title：Journal of neurochemistry

authors： Suopanki J,Götz C,Lutsch G,Schiller J,Harjes P,Herrmann A,Wanker EE

更新日期：2006-02-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression was analyzed in PC12 cells. PC12 cells transfected with a PACAP promoter-luciferase reporter construct were utilized to investigate the effects of PACAP, either alone or in combination with nerve growth factor (NGF), on PACAP transcriptional re...

journal_title：Journal of neurochemistry

authors： Hashimoto H,Hagihara N,Koga K,Yamamoto K,Shintani N,Tomimoto S,Mori W,Koyama Y,Matsuda T,Baba A

更新日期：2000-02-01 00:00:00

abstract：:The nuclear mitochondrial and synaptosomal fractions of rat brain were each found to contain some 25-30% of the total aldehyde dehydrogenase activity. The cytoplasmic fraction had a very low total aldehyde dehydrogenase activity. There were differences in the distribution of the activity when different aldehydes were ...

journal_title：Journal of neurochemistry

authors： Koivula T,Turner AJ,Huttunen M,Koivusalo M

更新日期：1981-06-01 00:00:00

abstract：:alpha-Conotoxins interact with nicotinic acetylcholine receptors (nAChRs) and acetylcholine-binding proteins (AChBPs) at the sites for agonists/competitive antagonists. alpha-Conotoxins blocking muscle-type or alpha7 nAChRs compete with alpha-bungarotoxin. However, alpha-conotoxin ImII, a close homolog of the alpha7 n...

journal_title：Journal of neurochemistry

authors： Kasheverov IE,Zhmak MN,Fish A,Rucktooa P,Khruschov AY,Osipov AV,Ziganshin RH,D'hoedt D,Bertrand D,Sixma TK,Smit AB,Tsetlin VI

更新日期：2009-11-01 00:00:00

abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

journal_title：Journal of neurochemistry

authors： Shields SM,Vernon PJ,Kelly PT

更新日期：1984-12-01 00:00:00

abstract：:Bradykinin, a mediator of inflammation, is produced in the brain during trauma and stroke. It is thought to open the blood-brain barrier, although the mechanism is unclear. We have investigated, therefore, the effect of bradykinin on the expression of interleukin-6 (IL-6), a putative modulator of the blood-brain barri...

journal_title：Journal of neurochemistry

authors： Schwaninger M,Sallmann S,Petersen N,Schneider A,Prinz S,Libermann TA,Spranger M

更新日期：1999-10-01 00:00:00

abstract：:This study investigated possible D1/D2 interactions in rat and bovine striatal tissue by examining the effects of D2 antagonists on the action of dopamine at D1 dopamine receptors. In addition, the extent to which D2 antagonists may induce an agonist low-affinity state of the D1 receptor was evaluated in comparison wi...

journal_title：Journal of neurochemistry

authors： Farrell CB,Lawlor M,Dunne A,O'Boyle KM

更新日期：1995-09-01 00:00:00

abstract：:We have examined cyclic GMP concentrations, guanylate cyclase activities, and cyclic GMP phosphodiesterase (PDE) activities in developing retinas of congenic mice with different allelic combinations at the retinal degeneration (rd) and retinal degeneration slow (rds) loci. Although guanylate cyclase activities were fo...

journal_title：Journal of neurochemistry

authors： Fletcher RT,Sanyal S,Krishna G,Aguirre G,Chader GJ

更新日期：1986-04-01 00:00:00

abstract：:Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated in affected neurons of Alzheimer disease brain. This hyperphosphorylated tau can be dephosphorylated at some of the abnormal phosphorylated sites by purified protein phosphatase-1, 2A, and 2B in vitro. In the present study, we have dev...

journal_title：Journal of neurochemistry

authors： Gong CX,Shaikh S,Wang JZ,Zaidi T,Grundke-Iqbal I,Iqbal K

更新日期：1995-08-01 00:00:00

abstract：:α-Synuclein causes Parkinson's disease if mutated or aberrantly produced in neurons. α-Synuclein-lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N-terminal amino acids dramatically reduced lipid bindi...

journal_title：Journal of neurochemistry

authors： Vamvaca K,Lansbury PT Jr,Stefanis L

更新日期：2011-10-01 00:00:00

abstract：:Since emotional stress elicits brain activation, mitochondria should be a key component of stressed brain response. However, few studies have focused on mitochondria functioning in these conditions. In this work, we aimed to determine the effects of an acute restraint stress on rat brain mitochondrial functions, with ...

journal_title：Journal of neurochemistry

authors： Batandier C,Poulet L,Hininger I,Couturier K,Fontaine E,Roussel AM,Canini F

更新日期：2014-11-01 00:00:00

abstract：:Kainate receptors (KARs) modulate synaptic transmission at both pre-synaptic and post-synaptic sites. The overlap in the distribution of KA-2 and GluR6/7 subunits in several brain regions suggests the co-assembly of these subunits in native KARs. The molecular mechanisms that control the assembly and surface expressio...

journal_title：Journal of neurochemistry

authors： Gallyas F Jr,Ball SM,Molnar E

更新日期：2003-09-01 00:00:00

abstract：:The deficits in Alzheimer disease (AD) stem at least partly from neurotoxic beta-amyloid peptides generated from the amyloid precursor protein (APP). APP may also be cleaved intracellularly at Asp664 to yield a second neurotoxic peptide, C31. Previously, we showed that cleavage of APP at the C-terminus is required for...

journal_title：Journal of neurochemistry

authors： Nguyen TV,Galvan V,Huang W,Banwait S,Tang H,Zhang J,Bredesen DE

更新日期：2008-02-01 00:00:00

abstract：:Tau pathologically aggregates in Alzheimer's disease, and evidence suggests that reducing tau expression may be safe and beneficial for the prevention or treatment of this disease. We sought to examine the role of the 3'-untranslated region (3'-UTR) of human tau mRNA in regulating tau expression. Tau expresses two 3'-...

journal_title：Journal of neurochemistry

authors： Dickson JR,Kruse C,Montagna DR,Finsen B,Wolfe MS

更新日期：2013-12-01 00:00:00

abstract：:To enable us to study expression of tyrosine hydroxylase [TH; tyrosine 3-monooxygenase; L-tyrosine tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] as a measure of dopaminergic neuron function in future experiments, methods were developed to quantify TH mRNA levels in cultures of dopaminergic...

journal_title：Journal of neurochemistry

authors： Beck KD,Knusel B,Pasinetti G,Michel PP,Zawadzka H,Goldstein M,Hefti F

更新日期：1991-08-01 00:00:00