SUMOylation of synaptic and synapse-associated proteins: An update.

abstract：:It is well-known that the extracellular concentration of calcium affects neuronal excitability and synaptic transmission. Less is known about the physiological concentration of extracellular calcium in the brain. In electrophysiological brain slice experiments, the artificial cerebrospinal fluid traditionally contains...

journal_title：Journal of neurochemistry

authors： Forsberg M,Seth H,Björefeldt A,Lyckenvik T,Andersson M,Wasling P,Zetterberg H,Hanse E

更新日期：2019-05-01 00:00:00

abstract：:A targeted neuropharmacological, (1)H/(13)C NMR spectroscopy and multivariate statistical approach was used to examine the effects of exogenous GABA and ligands at the GABA(A) receptor family on brain metabolism in the Guinea pig cortical tissue slice. All ligands at GABA(A) receptors generated metabolic patterns whic...

journal_title：Journal of neurochemistry

authors： Nasrallah FA,Griffin JL,Balcar VJ,Rae C

更新日期：2009-01-01 00:00:00

abstract：:In this review, we discuss the poorly explored role of calcium/calmodulin-dependent protein kinase II (CaMKII) in memory maintenance, and its influence on memory destabilization. After a brief review on CaMKII and memory destabilization, we present critical pieces of evidence suggesting that CaMKII activity increases ...

journal_title：Journal of neurochemistry

authors： Vigil FA,Giese KP

更新日期：2018-10-01 00:00:00

abstract：:The present study aims to investigate the role of extracellular glutamate and NMDA receptor stimulation in the neuronal death induced by a transient exposure to H2O2 of cultured neurons originating from mouse cerebral cortex. Most of the neuronal loss following a transient exposure to H2O2 of cortical neurons results ...

journal_title：Journal of neurochemistry

authors： Mailly F,Marin P,Israël M,Glowinski J,Prémont J

更新日期：1999-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) released from the activated microglia upon neurotropic virus infection may exacerbate the neuronal damage. Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs over-expressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JE...

journal_title：Journal of neurochemistry

authors： Mukherjee S,Akbar I,Kumari B,Vrati S,Basu A,Banerjee A

更新日期：2019-05-01 00:00:00

abstract：:The metabolism of the positron-emitting compound [18F]6-fluoro-L-3,4-dihydroxyphenylalanine (*F-DOPA) was studied in carbidopa-pretreated male hooded rats. Thirty minutes following carbidopa administration (5 mg/kg i.p.), animals received *F-DOPA (500 micrograms/kg; specific activity, 175-230 Ci/mol) as an intrajugula...

journal_title：Journal of neurochemistry

authors： Cumming P,Boyes BE,Martin WR,Adam M,Grierson J,Ruth T,McGeer EG

更新日期：1987-02-01 00:00:00

abstract：:Acetylcholine is a key neurotransmitter of the inner ear efferent system. In this study, we identify two novel nAChR subunits in the inner ear: α1 and γ, encoded by Chrna1 and Chrng, respectively. In situ hybridization shows that the messages of these two subunits are present in vestibular and cochlear hair cells duri...

journal_title：Journal of neurochemistry

authors： Scheffer D,Sage C,Plazas PV,Huang M,Wedemeyer C,Zhang DS,Chen ZY,Elgoyhen AB,Corey DP,Pingault V

更新日期：2007-12-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00

abstract：:We have investigated the effects of fetal hypophysectomy (HX) with or without thyroxine (T4)replacement on the plasma concentrations of free methionine-enkephalin (free Met-Enk), noradrenaline, and adrenaline in late gestation sheep fetus. Plasma adrenaline concentrations were significantly higher in intact fetal shee...

journal_title：Journal of neurochemistry

authors： Simonetta G,Young IR,McMillen IC

更新日期：1994-10-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is a peptide neurotransmitter that has been implicated in drug reward and reinforcement. CART mRNA and peptide expression are highly concentrated in several compartments of the mesolimbic reward pathway. Several lines of evidence suggest that CART peptides may contr...

journal_title：Journal of neurochemistry

authors： Salinas A,Wilde JD,Maldve RE

更新日期：2006-04-01 00:00:00

abstract：:An important step in the cascade leading to neuronal cell death is degradation of laminin and other components of the brain extracellular matrix by microglia-derived proteases. Excitotoxic cell death of murine hippocampal neurones in vivo can be prevented by inhibitors of tissue plasminogen activator (tPA) or by inhib...

journal_title：Journal of neurochemistry

authors： Campbell SJ,Finlay M,Clements JM,Wells G,Miller KM,Perry VH,Anthony DC

更新日期：2004-06-01 00:00:00

abstract：:Induction of the prodynorphin gene occurs in a tissue-specific manner following different physiological stimuli. Using electrophoretic mobility shift assays, we studied the relative activity of the five major regulatory sites in the rat prodynorphin promoter. Prodynorphin cyclic AMP-responsive element 2 (DynCRE2), Dyn...

journal_title：Journal of neurochemistry

authors： Carrión AM,Mellström B,Luckman SM,Naranjo JR

更新日期：1998-03-01 00:00:00

abstract：:Exposure of bovine chromaffin cells in primary culture to 0.01-1 microM reserpine caused a dose- and time-dependent increase in intracellular levels of the amidated enkephalin peptide metorphamide. Maximal levels (approximately 800% of control) were obtained at 0.1 microM reserpine and increased levels were apparent b...

journal_title：Journal of neurochemistry

authors： Eiden LE,Zamir N

更新日期：1986-05-01 00:00:00

abstract：:Repeated intermittent treatment with amphetamine (AMPH) induces both neurite outgrowth and enhanced AMPH-stimulated dopamine (DA) release in PC12 cells. We investigated the role of protein kinases in the induction of these AMPH-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein ki...

journal_title：Journal of neurochemistry

authors： Park YH,Kantor L,Guptaroy B,Zhang M,Wang KK,Gnegy ME

更新日期：2003-12-01 00:00:00

abstract：:Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

journal_title：Journal of neurochemistry

authors： Wade JV,Samson FE,Nelson SR,Pazdernik TL

更新日期：1987-08-01 00:00:00

abstract：:Microsomal fractions isolated from rat corpus striatum catalyze the oxidation of thiobenzamide to the sulfoxide. The rate of thiobenzamide sulfoxidation is 6.9 +/- 4.8 nmol(min)-1 (mg microsomal protein)-1. The reaction is inhibited by an excess of sulfur- and nitrogen-containing substrates for the microsomal flavin-c...

journal_title：Journal of neurochemistry

authors： Duffel MW,Gillespie SG

更新日期：1984-05-01 00:00:00

abstract：:The contents of cystathionine and taurine, as well as cystathionine beta-synthase activity in various regions of the brains of normal and DL-propargylglycine-treated rats, were measured. The content of cystathionine in each region of brain increased gradually from 0.5 mg to 20 mg/200 g body weight in relation to the d...

journal_title：Journal of neurochemistry

authors： Kodama H,Ikeda H,Awata S,Nakayama K

更新日期：1985-04-01 00:00:00

abstract：:Imprinting in chicks is a form of juvenile learning that has been used to study the basic cellular mechanisms of learning and memory. The forebrain area mediorostral neostriatum/hyperstriatum ventrale (MNH) is a center for acoustic imprinting. Electrophysiological and pharmacological behavioral studies in the MNH have...

journal_title：Journal of neurochemistry

authors： Gruss M,Braun K

更新日期：1996-03-01 00:00:00

abstract：:Prolonged stress affects homeostasis in various organs and induces stress-associated disorders. We examined the cellular changes of pituitary gland under the continuous stress condition using a rat model in which rats were kept in a cage filled with water to a height of 1.5 cm for up to 5 days. Among the pituitary hor...

journal_title：Journal of neurochemistry

authors： Ogawa T,Shishioh-Ikejima N,Konishi H,Makino T,Sei H,Kiryu-Seo S,Tanaka M,Watanabe Y,Kiyama H

更新日期：2009-06-01 00:00:00

abstract：:The proinflammatory cytokine interleukin 1beta (IL-1beta), acting at IL-1R1 receptors, affects neuronal signaling under both physiological and pathophysiological conditions. The molecular mechanism of the rapid synaptic actions of IL-1beta in neurons is not known. We show here that within minutes of IL-1beta exposure,...

journal_title：Journal of neurochemistry

authors： Davis CN,Tabarean I,Gaidarova S,Behrens MM,Bartfai T

更新日期：2006-09-01 00:00:00

abstract：:Mutations within the amyloid-beta (Abeta) domain of the amyloid precursor protein (APP) typically generate hemorrhagic strokes and vascular amyloid angiopathy. In contrast, the Arctic mutation (APP E693G) results in Alzheimer's disease. Little is known about the pathologic mechanisms that result from the Arctic mutati...

journal_title：Journal of neurochemistry

authors： Sahlin C,Lord A,Magnusson K,Englund H,Almeida CG,Greengard P,Nyberg F,Gouras GK,Lannfelt L,Nilsson LN

更新日期：2007-05-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) in the brain striatum has recently been shown to bind at a putatively vesicular site labeled by [3H]tyramine ([3H]TY). Whereas in the rat and mouse striatum MPP+ antagonized TY binding competitively, in the cerebellum there was a mixed-type antagonism, which sugges...

journal_title：Journal of neurochemistry

authors： Vaccari A,Saba PL,Gessa GL,Del Zompo M

更新日期：1993-02-01 00:00:00

abstract：:The turnover rate of gamma-aminobutyric acid (GABA) in the rat striatum was estimated by measuring its accumulation after inhibition of GABA-transaminase (GABA-T) with gabaculine. Intrastriatal injections of 100 micrograms gabaculine induced a rapid and complete inhibition of GABA-T. GABA accumulation was linear with ...

journal_title：Journal of neurochemistry

authors： Giorgi O,Meek JL

更新日期：1984-01-01 00:00:00

abstract：:Using ligand binding techniques, we studied beta-adrenergic receptor subtypes in brains obtained at autopsy from seven histologically normal controls and seven histopathologically verified cases with Alzheimer-type dementia (ATD). Inhibition of [3H]dihydroalprenolol [( 3H]DHA) binding by the selective beta 1 antagonis...

journal_title：Journal of neurochemistry

authors： Shimohama S,Taniguchi T,Fujiwara M,Kameyama M

更新日期：1987-04-01 00:00:00

abstract：:The activity-dependent fusion, retrieval and recycling of synaptic vesicles is essential for the maintenance of neurotransmission. Until relatively recently it was believed that most mutations in genes that were essential for this process would be incompatible with life, because of this fundamental role. However, an e...

journal_title：Journal of neurochemistry

authors： Bonnycastle K,Davenport EC,Cousin MA

更新日期：2020-05-07 00:00:00

abstract：:We have assessed the expression, molecular identification and functional role of Na+ channels (Na(v)) in carotid bodies (CB) obtained from normoxic and chronically hypoxic adult rats. Veratridine evoked release of catecholamines (CA) from an in vitro preparation of intact CBs obtained from normoxic animals, the respon...

journal_title：Journal of neurochemistry

authors： Caceres AI,Obeso A,Gonzalez C,Rocher A

更新日期：2007-07-01 00:00:00

abstract：:The Review "The malleable brain: plasticity of neural circuits and behavior - A review from students to students" has been written by a group of students following the International Society for Neurochemistry and Journal of Neurochemistry Flagship School. Comprehensively written by students for students, it provides b...

journal_title：Journal of neurochemistry

authors： Schulz JB,Hausmann L

更新日期：2017-09-01 00:00:00

abstract：:Gs alpha, the GTP-binding protein that mediates receptor stimulation of adenylyl cyclase, exists in small (Gs alpha-S) and large (Gs alpha-L) molecular forms. Previous work has established that these Gs alpha isoforms are products of alternatively spliced Gs alpha pre-mRNA. The present work examined the splicing patte...

journal_title：Journal of neurochemistry

authors： Granneman JG,Bannon MJ

更新日期：1991-09-01 00:00:00

abstract：:Protein aggregation is a common feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. How protein aggregates are formed and contribute to neurodegeneration, however, is not clear. Mutation of Ubiquilin 2 (UBQLN2) has recently been linked to ...

journal_title：Journal of neurochemistry

authors： Xia Y,Yan LH,Huang B,Liu M,Liu X,Huang C

更新日期：2014-04-01 00:00:00

abstract：:Chronic exposure to the pesticide rotenone induces a selective degeneration of nigrostriatal dopaminergic neurons and reproduces the features of Parkinson's disease in experimental animals. This action is thought to be relevant to its inhibition of the mitochondrial complex I, but the precise mechanism of this suppres...

journal_title：Journal of neurochemistry

authors： Moon Y,Lee KH,Park JH,Geum D,Kim K

更新日期：2005-06-01 00:00:00