Intragenic sequences affect the expression of the gene encoding glial fibrillary acidic protein.

Abstract:

:We show that the expression of the gene encoding glial fibrillary acidic protein (GFAP) gene is affected by at least three cis-acting elements. A positive regulatory element that is located between nucleotides -1,631 and -1,479 can confer cell type-specific expression on a heterologous gene. A second regulatory element is located between nucleotides -97 and -80. The third is a negative regulatory element that is located within the first intron of the gene. Deletion of this element activates GFAP expression in HeLa cells, and affects promoter function in glioma cells.

journal_name

J Neurochem

authors

Sarkar S,Cowan NJ

doi

10.1111/j.1471-4159.1991.tb03799.x

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

675-84

issue

2

eissn

0022-3042

issn

1471-4159

journal_volume

57

pub_type

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