Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes.

abstract：:Acidosis is a universal response of tissue to ischemia. In the brain, severe acidosis has been linked to worsening of cerebral infarction. However, milder acidosis can have protective effects. As part of our investigations of the therapeutic window in our neuronal tissue culture model of ischemia, we investigated the ...

journal_title：Journal of neurochemistry

authors： Vornov JJ,Thomas AG,Jo D

更新日期：1996-12-01 00:00:00

abstract：:A dramatic loss of glutamate transport has been observed in sporadic amyotrophic lateral sclerosis and has been postulated to contribute to the disease. Experimentally, this hypothesis was corroborated by mimicking the chronic loss of glutamate transport in postnatal rat spinal cord organotypic cultures through the us...

journal_title：Journal of neurochemistry

authors： Rothstein JD,Kuncl RW

更新日期：1995-08-01 00:00:00

abstract：:P25alpha is a protein normally expressed in oligodendrocytes and subcellular relocalization of p25alpha occurs in multiple system atrophy, Parkinson's disease and Lewy body dementia along with ectopic expression in neurons. Moreover, it accumulates in Lewy body inclusions with aggregated alpha-synuclein and is a poten...

journal_title：Journal of neurochemistry

authors： Kleinnijenhuis AJ,Hedegaard C,Lundvig D,Sundbye S,Issinger OG,Jensen ON,Jensen PH

更新日期：2008-07-01 00:00:00

abstract：:Previous studies from this laboratory have shown that synthesis of GT3, the precursor of c series gangliosides, occurs in proximal Golgi compartments, as has been shown for the synthesis of GM3 and GD3, the precursors of a and b series gangliosides, respectively. In this work we studied whether the synthesis of GM3, G...

journal_title：Journal of neurochemistry

authors： Rosales Fritz VM,Maxzúd MK,Maccioni HJ

更新日期：1996-10-01 00:00:00

abstract：:The activities of the three major catecholamine-synthesizing enzymes were determined in brain tissue pellets dissected from 500-micrometers thick horizontal sections of rat lower brainstem. The rostrocaudal distributions of the three enzymatic activities were generally not parallel, suggesting differences in the respe...

journal_title：Journal of neurochemistry

authors： Chamba G,Denoroy L,Renaud B

更新日期：1982-08-01 00:00:00

abstract：:A previous report has described the presence of t-[35S]-butylbicyclophosphorothionate binding sites and GABA-gated Cl- flux in the human neuroblastoma IMR-32 cell line. We now report the further characterisation of this binding site and, even more important, the identification of the GABAA receptor alpha 3 sub-unit ex...

journal_title：Journal of neurochemistry

authors： Noble PJ,Anderson SM,De Souza RJ,Cross AJ,Stephenson FA

更新日期：1993-08-01 00:00:00

abstract：:Although the involvement of both endogenous opioid and serotonergic systems in modulation of pain and emotion was suggested, the neurochemical interaction between these systems in the brain has not previously been studied directly. Herein, the effects of the local application of serotonin (5-HT) and fluoxetine (a 5-HT...

journal_title：Journal of neurochemistry

authors： Zangen A,Nakash R,Yadid G

更新日期：1999-12-01 00:00:00

abstract：:The extracellular matrix (ECM) is important for both structural integrity and functions of the brain. Matrix metalloproteinases (MMPs) play major roles in ECM-remodeling under both physiological and pathological conditions. Reversion-inducing cysteine-rich protein with Kazal motifs (Reck) is a membrane-anchored MMP-re...

journal_title：Journal of neurochemistry

authors： Wang H,Imamura Y,Ishibashi R,Chandana EP,Yamamoto M,Noda M

更新日期：2010-10-01 00:00:00

abstract：:This study investigated mRNA expression and protein localization of equilibrative and concentrative nucleoside transporters (ENTs, CNTs) in primary cultures of rat brain endothelial cells (RBEC) and rat choroid plexus epithelial cells (RCPEC). Reverse transcriptase PCR analysis revealed that RBEC and RCPEC contained m...

journal_title：Journal of neurochemistry

authors： Redzic ZB,Biringer J,Barnes K,Baldwin SA,Al-Sarraf H,Nicola PA,Young JD,Cass CE,Barrand MA,Hladky SB

更新日期：2005-09-01 00:00:00

abstract：:Cerebral microvessels isolated from perfused, adult murine brain produce a compound with the chromatographic properties of a monohydroxyeicosatetraenoic acid when incubated with arachidonic acid or stimulated with calcium ionophore A23187. The formation of this arachidonic acid metabolite is not reduced in the presenc...

journal_title：Journal of neurochemistry

authors： Moore SA,Figard PH,Spector AA,Hart MN

更新日期：1989-08-01 00:00:00

abstract：:The extracellular regulated kinases (ERK) 1 and ERK2 are members of mitogen-activated protein (MAP) kinase family that play an important role in transducing extracellular signals to the nucleus and have been implicated in a broad spectrum of biological responses. To test the hypothesis that MAP kinases may be involved...

journal_title：Journal of neurochemistry

authors： Dwivedi Y,Rizavi HS,Roberts RC,Conley RC,Tamminga CA,Pandey GN

更新日期：2001-05-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) receptor (PAC1R) is a class B Gprotein-coupled receptor (GPCR) that is widely expressed in the human body and is involved in neuronal differentiation. As class B GPCRs are known to form heterocomplexes with family members, we hypothesized that PAC1R mediates neuro...

journal_title：Journal of neurochemistry

authors： Ke R,Lok SIS,Singh K,Chow BKC,Lee LTO

更新日期：2020-10-20 00:00:00

abstract：:Methylphenidate (MPD) was found to inhibit competitively the striatal dopamine transporter (DAT) and bind at sites on the DAT in common with both cocaine (a non-substrate site ligand) and amphetamine (a substrate site ligand). Some methylphenidate analogues modified on the aromatic ring and/or at the nitrogen were tes...

journal_title：Journal of neurochemistry

authors： Wayment HK,Deutsch H,Schweri MM,Schenk JO

更新日期：1999-03-01 00:00:00

abstract：:Astrocytes can either exacerbate or ameliorate secondary degeneration at sites of injury in the CNS but the contextual basis for eliciting these opposing phenotypes is poorly understood. In this study, we demonstrate that the two major cytokines produced by Th1 and Th2 cells, interferon-gamma (IFN-gamma), and interleu...

journal_title：Journal of neurochemistry

authors： Garg SK,Kipnis J,Banerjee R

更新日期：2009-03-01 00:00:00

abstract：:U-78518F, a 21-aminosteroid from the novel family of lipid peroxidation inhibitors (lazaroids), increased survival of dopamine (DA) neurons in mesencephalic cell cultures incubated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP+). Protection against DA neuron death occurred with increasing concentrations of U-78...

journal_title：Journal of neurochemistry

authors： Sanchez-Ramos JR,Song S,Mash DC,Weiner WJ

更新日期：1992-01-01 00:00:00

abstract：:The present study aims to investigate the role of extracellular glutamate and NMDA receptor stimulation in the neuronal death induced by a transient exposure to H2O2 of cultured neurons originating from mouse cerebral cortex. Most of the neuronal loss following a transient exposure to H2O2 of cortical neurons results ...

journal_title：Journal of neurochemistry

authors： Mailly F,Marin P,Israël M,Glowinski J,Prémont J

更新日期：1999-09-01 00:00:00

abstract：:The incorporation of radioactive phosphate into proteins of both normal and regenerating ganglia of the sympathetic nervous system of the rat is reported. The incorporation reactions were carried out in vitro by incubating homogenates of excised ganglia with [gamma-32P]ATP under various conditions. It was found that i...

journal_title：Journal of neurochemistry

authors： Watterson JG,Good R,Moses E,Hearn MT,Austin L

更新日期：1989-06-01 00:00:00

abstract：:The regulation of glial and neuronal Na+-dependent glutamate/aspartate transporters is of interest because abnormal glutamate transport may be responsible for certain neurological diseases. Because expression of the Wnt-1 protooncogene results in induction of the glial-type glutamate transporter GLAST in PC12 neuron-l...

journal_title：Journal of neurochemistry

authors： Palos TP,Zheng S,Howard BD

更新日期：1999-09-01 00:00:00

abstract：:Neurosecretory terminals (neurosecretosomes, NSS) were isolated from rat neurohypophyses. High [K+]o or veratridine stimulated secretion of vasopressin and oxytocin by up to approximately 100-fold. Stimulated secretion was dependent on calcium and temperature, and could be elicited from NSS maintained in culture for 4...

journal_title：Journal of neurochemistry

authors： Payza K,Russell JT

更新日期：1991-08-01 00:00:00

abstract：:Recently, a tyrosine hydroxylase (TH)-expressing CNS-derived cell line, CAD, was obtained that is capable of undergoing reversible morphological differentiation. The isolation of the CAD line allowed us to ask whether different DNA regulatory elements direct TH transcription when cells are growing and undifferentiated...

journal_title：Journal of neurochemistry

authors： Lazaroff M,Qi Y,Chikaraishi DM

更新日期：1998-07-01 00:00:00

abstract：:Glycine and GABA are likely co-transmitters in the spinal cord. Their possible interactions in presynaptic terminals have, however, not been investigated. We studied the effects of glycine on GABA release using superfused mouse spinal cord synaptosomes. Glycine concentration dependently elicited [(3)H]GABA release whi...

journal_title：Journal of neurochemistry

authors： Raiteri L,Raiteri M,Bonanno G

更新日期：2001-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized pathologically by motor neuron degeneration and associated with aggregation of RNA-binding proteins. TATA-binding protein-associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, and clearance of these...

journal_title：Journal of neurochemistry

authors： Choi HJ,Joo Cha S,Do HA,Kim HJ,Lee JW,Kim K

更新日期：2020-09-11 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the extracellular levels of taurine and on excitability in the dentate gyrus were studied in anesthetized rats by the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode with Krebs-Ringer-bicarbonate or GABA solutions. Amino acid contents in pe...

journal_title：Journal of neurochemistry

authors： Lerma J,Herranz AS,Herreras O,Muñoz D,Solís JM,del Río RM,Delgado JM

更新日期：1985-03-01 00:00:00

abstract：:Administration of kainate or pentylenetetrazole increased c-fos, c-jun, junB, and junD mRNA levels in rat brain in a dose-dependent manner. Kainate increased these mRNA levels predominantly in the hippocampus, and pentylenetetrazole was more effective in the cortex. Adrenalectomy (3 days) was used to eliminate endogen...

journal_title：Journal of neurochemistry

authors： Li X,Song L,Kolasa K,Jope RS

更新日期：1992-06-01 00:00:00

abstract：:The transmission of pain signalling involves the cytoskeleton, but mechanistically this is poorly understood. We recently demonstrated that the capsaicin receptor TRPV1, a non-selective cation channel expressed by nociceptors that is capable of detecting multiple pain-producing stimuli, directly interacts with the tub...

journal_title：Journal of neurochemistry

authors： Goswami C,Dreger M,Otto H,Schwappach B,Hucho F

更新日期：2006-01-01 00:00:00

abstract：:Our previous work demonstrated that immunoproteasome is up-regulated in the retina and brain in response to injury that does not involve an inflammatory response (J. Neurochem. 2008; 106:158). These results suggest additional non-immune functions for the immunoproteasome in the cellular stress response pathway. The pr...

journal_title：Journal of neurochemistry

authors： Hussong SA,Kapphahn RJ,Phillips SL,Maldonado M,Ferrington DA

更新日期：2010-06-01 00:00:00

abstract：:After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane bindin...

journal_title：Journal of neurochemistry

authors： Meffre D,Delespierre B,Gouézou M,Leclerc P,Vinson GP,Schumacher M,Stein DG,Guennoun R

更新日期：2005-06-01 00:00:00

abstract：:The proinflammatory cytokine interleukin 1beta (IL-1beta), acting at IL-1R1 receptors, affects neuronal signaling under both physiological and pathophysiological conditions. The molecular mechanism of the rapid synaptic actions of IL-1beta in neurons is not known. We show here that within minutes of IL-1beta exposure,...

journal_title：Journal of neurochemistry

authors： Davis CN,Tabarean I,Gaidarova S,Behrens MM,Bartfai T

更新日期：2006-09-01 00:00:00

abstract：:In the present study, by means of genetic, biochemical, morphological, and electrophysiological approaches, the role of large-conductance voltage- and Ca(2+)-dependent K(+) channels (BK channels) in the release of excitatory and non-excitatory neurotransmitters at hippocampal and non-hippocampal sites has been investi...

journal_title：Journal of neurochemistry

authors： Martire M,Barrese V,D'Amico M,Iannotti FA,Pizzarelli R,Samengo I,Viggiano D,Ruth P,Cherubini E,Taglialatela M

更新日期：2010-10-01 00:00:00

abstract：:The nicotinic acetylcholine receptor (AChR) exhibits at least four different conformational states varying in affinity for agonists such as acetylcholine (ACh). Photoaffinity labeling has been previously used to elucidate the topography of the AChR. However, to date, the photosensitive probes used to explore the choli...

journal_title：Journal of neurochemistry

authors： Kotzyba-Hibert F,Kessler P,Zerbib V,Bogen C,Snetkov V,Takeda K,Goeldner M,Hirth C

更新日期：1996-12-01 00:00:00