Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture.

abstract：:The I1-imidazoline receptor (I1R) is a proposed target for drug action relevant to blood pressure and glucose control. The imidazoline receptor antisera-selected (IRAS) gene, also known as Nischarin, has several characteristics of an I1R. To test the contribution of IRAS to I1R binding capacity and cell-signaling func...

journal_title：Journal of neurochemistry

authors： Sun Z,Chang CH,Ernsberger P

更新日期：2007-04-01 00:00:00

abstract：:Previous work from our laboratory points to plasma free tryptophan being a useful predictor of brain tryptophan concentration in many circumstances. Other work, in particular various studies on the acute effects of food intake, has emphasized the roles of plasma total tryptophan and of plasma large neutral amino acids...

journal_title：Journal of neurochemistry

authors： Sarna GS,Kantamaneni BD,Curzon G

更新日期：1985-05-01 00:00:00

abstract：:Myelination, during both normal development and with respect to disorders of myelination, is commonly studied by morphological and/or biochemical techniques that assay as their end-points the extent of myelination. The rate of myelination is potentially a more useful parameter, but it is difficult and time-consuming t...

journal_title：Journal of neurochemistry

authors： Muse ED,Jurevics H,Toews AD,Matsushima GK,Morell P

更新日期：2001-01-01 00:00:00

abstract：:It has been established that neurosteroids can either inhibit or enhance GABA(A) receptor activity. Although GABA is the main inhibitory neurotransmitter in the mammalian retina, the effects of neurosteroids on retinal GABAergic activity have not been investigated. The aim of this work was to study the neurochemical a...

journal_title：Journal of neurochemistry

authors： Jaliffa CO,Howard S,Hoijman E,Salido E,Sarmiento MI,Arias P,Rosenstein RE

更新日期：2005-09-01 00:00:00

abstract：:The neurotransmitter glutamate, once released into the synaptic cleft, is largely recycled by the glutamate-glutamine cycle, which involves uptake into astrocytes, conversion into glutamine and subsequent release of glutamine from astrocytes as a precursor for neuroneal glutamate synthesis. We analysed glutamine efflu...

journal_title：Journal of neurochemistry

authors： Deitmer JW,Bröer A,Bröer S

更新日期：2003-10-01 00:00:00

abstract：:The metabolism and blood-brain transport of choline (Ch) were investigated in perfused canine brain under control conditions and for 60 min after inhibition of brain cholinesterases by the organophosphorus (OP) compounds soman (pinacolylmethylphosphonofluoridate). Ch and acetylcholine (ACh) in blood and brain samples ...

journal_title：Journal of neurochemistry

authors： Drewes LR,Singh AK

更新日期：1988-03-01 00:00:00

abstract：:Apolipoprotein E (apoE) plays a crucial role in lipid transport in circulation and the brain. The apoE4 isoform is a major risk factor for Alzheimer's disease (AD). ApoE4 is more susceptible to proteolysis than other apoE isoforms and apoE4 fragments have been found in brains of AD patients. These apoE4 fragments have...

journal_title：Journal of neurochemistry

authors： Dafnis I,Stratikos E,Tzinia A,Tsilibary EC,Zannis VI,Chroni A

更新日期：2010-11-01 00:00:00

abstract：:For a long time, prolyl endopeptidase (PEP) was believed to inactivate neuropeptides in the extracellular space. However, reports on the intracellular activity of PEP suggest additional, as yet unidentified, physiological functions for this enzyme. Here, we demonstrate using biochemical methods of subcellular fraction...

journal_title：Journal of neurochemistry

authors： Schulz I,Zeitschel U,Rudolph T,Ruiz-Carrillo D,Rahfeld JU,Gerhartz B,Bigl V,Demuth HU,Rossner S

更新日期：2005-08-01 00:00:00

abstract：:The neurotoxic properties of the dietary excitotoxins beta-N-methylamino-L-alanine and beta-N-oxalylamino-L-alanine have been studied in rat cerebellar granule cells and compared with those of glutamate. Glutamate caused dose-dependent death of cerebellar granule cells after a 30-min exposure when viability was assess...

journal_title：Journal of neurochemistry

authors： Staton PC,Bristow DR

更新日期：1997-10-01 00:00:00

abstract：:To investigate regulation of D2 receptor (D2R) gene expression by protein kinases, we evaluated effects of constitutively active MAPK kinase kinase (MEKK), Ca2+/calmodulin-dependent protein kinase (CaMK) II, CaMKIV and cyclic AMP-dependent protein kinase (PKA) on D2R promoter activity using luciferase reporter gene as...

journal_title：Journal of neurochemistry

authors： Takeuchi Y,Miyamoto E,Fukunaga K

更新日期：2002-11-01 00:00:00

abstract：:We have identified two genes from the parasitic nematode Haemonchus contortus, Hco-unc-49B and Hco-unc-49C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis revealed that this channel has properties similar to those of the UNC-49 channel from the free-living nematode Caenorhabditis el...

journal_title：Journal of neurochemistry

authors： Siddiqui SZ,Brown DD,Rao VT,Forrester SG

更新日期：2010-06-01 00:00:00

abstract：:The possibility that the mechanism of lead neurotoxicity may be at the level of transcription was investigated in PC12 cells. In electrophoretic mobility gel shift assays Pb2+ was found to increase activator protein-1 complex (AP-1) DNA binding activity in PC12 cells; the increase was time- and concentration-dependent...

journal_title：Journal of neurochemistry

authors： Chakraborti T,Kim KA,Goldstein GG,Bressler JP

更新日期：1999-07-01 00:00:00

abstract：:Optimal neuronal activity requires that supporting cells provide both efficient nutrient delivery and waste disposal. The incomplete processing of engulfed waste by their lysosomes can lead to accumulation of residual material and compromise their support of neurons. As most degradative lysosomal enzymes function best...

journal_title：Journal of neurochemistry

authors： Guha S,Baltazar GC,Tu LA,Liu J,Lim JC,Lu W,Argall A,Boesze-Battaglia K,Laties AM,Mitchell CH

更新日期：2012-08-01 00:00:00

abstract：:We have cloned Caenorhabditis elegans lev-8 and demonstrated that it encodes a novel nicotinic acetylcholine receptor (nAChR) subunit (previously designated ACR-13), which has functional roles in body wall and uterine muscles as part of a levamisole-sensitive receptor. LEV-8 is an alpha subunit and is the first to be ...

journal_title：Journal of neurochemistry

authors： Towers PR,Edwards B,Richmond JE,Sattelle DB

更新日期：2005-04-01 00:00:00

abstract：:In this study, we have investigated the effect of mivazerol, [3-(1H-imidazol-4-yl)methyl-1]-2-hydroxy-benzamide hydrochloride, a new alpha2-agonist lacking hypotensive properties and a potential anti-ischemic drug, on the evoked release of norepinephrine, aspartate, and glutamate in tissue preparations from hippocampu...

journal_title：Journal of neurochemistry

authors： El Tamer A,Prokopenko I,Wülfert E,Hanin I

更新日期：1996-08-01 00:00:00

abstract：:Oligodendrocytes are glial cells responsible for the synthesis and maintenance of myelin in the central nervous system (CNS). Oligodendrocytes are vulnerable to damage occurring in a variety of neurological diseases. Understanding oligodendrocyte biology is crucial for the dissemination of de- and remyelination mechan...

journal_title：Journal of neurochemistry

authors： Dumont D,Noben JP,Moreels M,Vanderlocht J,Hellings N,Vandenabeele F,Lambrichts I,Stinissen P,Robben J

更新日期：2007-07-01 00:00:00

abstract：:Potassium-induced depolarization of synaptoneurosomes prepared from rat telencephalon was found to increase [3H]amino-3-hydroxy-5-methylisoxazole-4-propionate ([3H]AMPA) binding to the AMPA receptor. The effect required the presence of calcium because it was blocked by the calcium chelator EGTA but was not blocked by ...

journal_title：Journal of neurochemistry

authors： Bernard J,Massicotte G,Baudry M

更新日期：1992-01-01 00:00:00

abstract：:Chromogranin A and two other proteins (A1 and A2) of the soluble proteins of bovine chromaffin granules were isolated by extraction from polyacrylamide gels after electrophoresis. The carbohydrate content of these proteins was 5%, with galactose, N-acetylgalactosamine, and sialic acid as the main sugars. Membranes of ...

journal_title：Journal of neurochemistry

authors： Fischer-Colbrie R,Schachinger M,Zangerle R,Winkler H

更新日期：1982-03-01 00:00:00

abstract：:Transcriptional responses to growth factor and G protein-coupled receptors were compared in PC12 cells using retroviral luciferase reporters. In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP ...

journal_title：Journal of neurochemistry

authors： Minneman KP,Lee D,Zhong H,Berts A,Abbott KL,Murphy TJ

更新日期：2000-06-01 00:00:00

abstract：:Calmodulin (CaM)-dependent enzymes, such as CaM-dependent phosphodiesterase (CaM-PDE), CaM-dependent protein phosphatase (CN), and CaM-dependent protein kinase II (CaM kinase II), are found in high concentrations in differentiated mammalian neurons. In order to determine whether neuroblastoma cells express these CaM-d...

journal_title：Journal of neurochemistry

authors： Pennypacker KR,Kincaid RL,Polli JW,Billingsley ML

更新日期：1989-05-01 00:00:00

abstract：:Mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17). Functionally, about half of the known mutations increase the alternative mRNA splicing of exon 10 of the tau gene, resulting in the overproduction of tau isoforms with four microtubule-binding repeats. The other...

journal_title：Journal of neurochemistry

authors： Yoshida H,Crowther RA,Goedert M

更新日期：2002-02-01 00:00:00

abstract：:Dibutyryl cyclic AMP (dBcAMP) is known to induce maturation and differentiation in astrocytes. As myo-inositol is an important osmoregulator in astrocytes, we examined the effects of maturation and biochemical differentiation on the kinetic properties of myo-inositol transport. Treatment of astrocytes with dBcAMP sign...

journal_title：Journal of neurochemistry

authors： Isaacks RE,Bender AS,Reuben JS,Kim CY,Shi YF,Norenberg MD

更新日期：1999-07-01 00:00:00

abstract：:Sequential 31P and 1H nuclear magnetic resonance spectra were measured for neonatal piglets (n = 7) to determine the relationship between brain intracellular pH (pHi), lactate, and phosphorylated energy metabolites during partial ischemia. Simultaneous determinations of arterial and cerebral venous blood gases, pH, O2...

journal_title：Journal of neurochemistry

authors： Corbett RJ,Laptook AR,Nunnally RL,Hassan A,Jackson J

更新日期：1988-11-01 00:00:00

abstract：:Perhaps the most reproducible early event induced by the interaction of amyloid beta peptide (A beta) with the cell is the inhibition of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. We recently demonstrated that cytotoxic amyloid peptides such as A beta and human amylin inhibi...

journal_title：Journal of neurochemistry

authors： Liu Y,Schubert D

更新日期：1998-12-01 00:00:00

abstract：:Protein synthesis in the brain is known to be affected by a wide range of treatments. The detailed analysis of the mechanisms that are involved would be facilitated by the development of cell-free translation systems derived from brain tissue. To date, brain cell-free systems have not been fully characterized to demon...

journal_title：Journal of neurochemistry

authors： Cosgrove JW,Brown IR

更新日期：1981-03-01 00:00:00

abstract：:Using optical imaging of retinal ganglion cell (RGC) calcium dynamics in living intact retinal wholemount preparations, we tested whether RGCs in an experimental rat glaucoma model were more sensitive to exogenously applied glutamate as a result of deficient glutamate clearance mechanisms. In contrast to post-natal ra...

journal_title：Journal of neurochemistry

authors： Hartwick AT,Zhang X,Chauhan BC,Baldridge WH

更新日期：2005-08-01 00:00:00

abstract：:The multifunctional protein high mobility group box 1 (HMGB1) is expressed in hippocampus and cerebellum of adult mouse brain. Our aim was to determine whether HMGB1 affects glutamatergic transmission by monitoring neurotransmitter release from glial (gliosomes) and neuronal (synaptosomes) re-sealed subcellular partic...

journal_title：Journal of neurochemistry

authors： Pedrazzi M,Raiteri L,Bonanno G,Patrone M,Ledda S,Passalacqua M,Milanese M,Melloni E,Raiteri M,Pontremoli S,Sparatore B

更新日期：2006-11-01 00:00:00

abstract：:This paper describes the interaction of neurotensin with mouse neuroblastoma N1E115 cells. Neurotensin binding sites are undetectable in nondifferentiated neuroblastoma cells. They appear during cell differentiation in the presence of a low serum concentration and dimethyl sulfoxide, and reach a maximal level after 50...

journal_title：Journal of neurochemistry

authors： Poustis C,Mazella J,Kitabgi P,Vincent JP

更新日期：1984-04-01 00:00:00

abstract：:Latanoprost was first developed for use in glaucoma therapy as an ocular hypotensive agent targeting the prostaglandin F2α (FP) receptor. Subsequently, latanoprost showed a neuroprotective effect, an additional pharmacological action. However, although it is well-known that latanoprost exerts an ocular hypotensive eff...

journal_title：Journal of neurochemistry

authors： Yamamoto K,Sato K,Yukita M,Yasuda M,Omodaka K,Ryu M,Fujita K,Nishiguchi KM,Machida S,Nakazawa T

更新日期：2017-02-01 00:00:00

abstract：:Members of the protein kinase D (PKD) family of serine/threonine kinases are known to exert diverse roles in neuronal stress responses. Here, we show the transient activation and nuclear translocation of endogenous PKD upon oxidative stress induced by H2 O2 treatment in primary neuronal cultures. Using pharmacological...

journal_title：Journal of neurochemistry

authors： Liliom H,Tárnok K,Ábrahám Z,Rácz B,Hausser A,Schlett K

更新日期：2017-09-01 00:00:00