Effect of dibutyryl cyclic AMP on the kinetics of myo-inositol transport in cultured astrocytes.

abstract：:The distribution of type I calmodulin-sensitive adenylyl cyclase in bovine and rat tissues was examined by northern blot analysis and in situ hybridization. Northern blot analysis using poly(A)(+)-selected RNA from various bovine tissues indicated that mRNA for type I adenylyl cyclase was found only in brain, retina, ...

journal_title：Journal of neurochemistry

authors： Xia Z,Choi EJ,Wang F,Blazynski C,Storm DR

更新日期：1993-01-01 00:00:00

abstract：:Androgens affect cognitive processes in both humans and animals. The effects of androgens may be limited to certain cognitive domains, specifically spatial memory, but this hypothesis remains elusive. Here, we tested castrated and sham-operated mice in various behavioral tasks to ask whether androgens affect multiple ...

journal_title：Journal of neurochemistry

authors： Benice TS,Raber J

更新日期：2009-08-01 00:00:00

abstract：:Increasing evidence suggests that proteasome inhibition plays a causal role in promoting the neurodegeneration and neuron death observed in multiple disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). The ability of severe and acute inhibition of proteasome function to induce neuron death and n...

journal_title：Journal of neurochemistry

authors： Ding Q,Dimayuga E,Martin S,Bruce-Keller AJ,Nukala V,Cuervo AM,Keller JN

更新日期：2003-07-01 00:00:00

abstract：:The brain-specific protein p42IP4, also called centaurin-alpha1, specifically binds phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. Here, we investigate the interaction of p42IP4/centaurin-alpha1 with nardilysin (NRDc), a member of the M16 family of z...

journal_title：Journal of neurochemistry

authors： Stricker R,Chow KM,Walther D,Hanck T,Hersh LB,Reiser G

更新日期：2006-07-01 00:00:00

abstract：:The purpose of this study was to assess and compare the toxicity of beta-amyloid (Abeta) on primary cortical and mesencephalic neurons cultured with and without microglia in order to determine the mechanism underlying microglia-mediated Abeta-induced neurotoxicity. Incubation of cortical or mesencephalic neuron-enrich...

journal_title：Journal of neurochemistry

authors： Qin L,Liu Y,Cooper C,Liu B,Wilson B,Hong JS

更新日期：2002-11-01 00:00:00

abstract：:The nuclear mitochondrial and synaptosomal fractions of rat brain were each found to contain some 25-30% of the total aldehyde dehydrogenase activity. The cytoplasmic fraction had a very low total aldehyde dehydrogenase activity. There were differences in the distribution of the activity when different aldehydes were ...

journal_title：Journal of neurochemistry

authors： Koivula T,Turner AJ,Huttunen M,Koivusalo M

更新日期：1981-06-01 00:00:00

abstract：:To investigate the role of the retinoblastoma protein pRB in neuronal differentiation, we have measured the accumulation of hypophosphorylated pRB in PC12 cells stimulated by nerve growth factor (NGF). NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cy...

journal_title：Journal of neurochemistry

authors： Li H,Kawasaki H,Nishida E,Hattori S,Nakamura S

更新日期：1996-06-01 00:00:00

abstract：:Neuromelanin is a dark brown pigment present at high concentrations in dopaminergic neurones of the human substantia nigra (SN). Early electron microscopic examinations of neuromelanin fine structure revealed a significant neutral lipid component; however, the identity of this lipid has remained unknown. Here we show ...

journal_title：Journal of neurochemistry

authors： Fedorow H,Pickford R,Hook JM,Double KL,Halliday GM,Gerlach M,Riederer P,Garner B

更新日期：2005-02-01 00:00:00

abstract：:A diphtheria toxin-neurotrophin-4/5 (NT-4/5) chimera (DAB389-NT4), in which the native receptor binding domain of diphtheria toxin was replaced with a synthetic gene encoding rat NT-4/5, was expressed, refolded, and purified. This fusion toxin has a deduced molecular mass of 60,163 and is formed by joining the first 3...

journal_title：Journal of neurochemistry

authors： Negro A,Skaper SD

更新日期：1997-02-01 00:00:00

abstract：:Mutations in the presenilin 1 (PS1) gene are associated with autosomal dominant, early-onset, familial Alzheimer's disease and result in increased release of the hyperaggregatable 42-amino acid form of the amyloid beta-peptide (A(beta)42). To determine which subcellular compartments are potential source(s) of released...

journal_title：Journal of neurochemistry

authors： Petanceska SS,Seeger M,Checler F,Gandy S

更新日期：2000-05-01 00:00:00

abstract：:Damage or stress in many organelles may trigger apoptosis by several not yet fully elucidated mechanisms. A cell death pathway is induced by endoplasmic reticulum (ER) stress elicited by the unfolded protein response and/or by aberrant Ca(2+) signalling. Reticulon-1C (RTN-1C) belongs to the reticulon family, neuroendo...

journal_title：Journal of neurochemistry

authors： Di Sano F,Fazi B,Tufi R,Nardacci R,Piacentini M

更新日期：2007-07-01 00:00:00

abstract：:In complex tissues where multiple subtypes of nicotinic acetylcholine receptors (nAChRs) are expressed, immunohistochemistry has been the most popular tool for investigation of nAChR subunit distribution. However, recent studies with nAChR subunit knockout mice demonstrated that a large panel of antibodies is unsuitab...

journal_title：Journal of neurochemistry

authors： Shelukhina IV,Kryukova EV,Lips KS,Tsetlin VI,Kummer W

更新日期：2009-05-01 00:00:00

abstract：:A reversed-phase HPLC system was used to concentrate and separate components of substance P-like immunoreactivity (SP-LI) from human CSF. When CSF was injected and fractions collected, no SP-LI could be detected by radioimmunoassay (RIA) at the retention time of SP or SP-sulfoxide. Instead, SP-LI was detected in later...

journal_title：Journal of neurochemistry

authors： Toresson G,Brodin E,Wahlström A,Bertilsson L

更新日期：1988-06-01 00:00:00

abstract：:To investigate the regulatory effects of somatodendritic D2 receptors on the terminal's extracellular dopamine (DA) concentration, a D2 antagonist (eticlopride) was infused directly into the ventral tegmental area via a microdialysis probe in chloral hydrate-anesthetized rats. Extracellular DA changes in both the nucl...

journal_title：Journal of neurochemistry

authors： Chen NN,Pan WH

更新日期：2000-06-01 00:00:00

abstract：:Experimental evidence suggests that magnesium plays a role in the pathophysiological sequelae of brain injury. The present study examined the variation of blood ionized and total magnesium, as well as potassium, sodium, and ionized calcium, after experimental fluid percussion brain injury in rats. Blood ionized magnes...

journal_title：Journal of neurochemistry

authors： Bareyre FM,Saatman KE,Helfaer MA,Sinson G,Weisser JD,Brown AL,McIntosh TK

更新日期：1999-07-01 00:00:00

abstract：:Membrane vesicles, showing a 21 +/- 2-fold enrichment in the activity of 5'-nucleotidase and a 11 +/- 4-fold enrichment in the activity of angiotensin-converting enzyme relative to homogenate, were prepared from the myenteric plexus-containing longitudinal muscle layer of guinea pig ileum. Incubation of the vesicles w...

journal_title：Journal of neurochemistry

authors： Nau R,Schäfer G,Deacon CF,Cole T,Agoston DV,Conlon JM

更新日期：1986-09-01 00:00:00

abstract：:The metabolism of the positron-emitting compound [18F]6-fluoro-L-3,4-dihydroxyphenylalanine (*F-DOPA) was studied in carbidopa-pretreated male hooded rats. Thirty minutes following carbidopa administration (5 mg/kg i.p.), animals received *F-DOPA (500 micrograms/kg; specific activity, 175-230 Ci/mol) as an intrajugula...

journal_title：Journal of neurochemistry

authors： Cumming P,Boyes BE,Martin WR,Adam M,Grierson J,Ruth T,McGeer EG

更新日期：1987-02-01 00:00:00

abstract：:The effect of vigabatrin (gamma-vinyl-gamma-aminobutyric acid), a new anticonvulsant drug, on the transmitter amino acids in rat cisternal CSF was studied. CSF was collected through a permanently implanted polyethylene cannula from freely moving rats at 5, 24, 48, and 96 h after administration of 1,000 mg/kg of vigaba...

journal_title：Journal of neurochemistry

authors： Halonen T,Pitkänen A,Riekkinen PJ

更新日期：1990-12-01 00:00:00

abstract：:Niemann Pick type C (NPC1) is a rare fatal hereditary cholesterol storage disease associated with a massive Purkinje cells loss. The mechanisms leading to neurodegeneration are still poorly understood. Different laboratories pointed to hypersensitivity to cytotoxic effects of statins (HMG-CoA reductase inhibitors) in ...

journal_title：Journal of neurochemistry

authors： Marschalek N,Albert F,Afshordel S,Meske V,Eckert GP,Ohm TG

更新日期：2015-04-01 00:00:00

abstract：:Taurine is the abundant sulfur-containing beta-amino acid in brain where it exerts a neuroprotective effect. Although it is known that the blood-brain barrier (BBB) mediates taurine transport, the regulation of taurine transport have not been clarified yet. A conditionally immortalized rat brain capillary endothelial ...

journal_title：Journal of neurochemistry

authors： Kang YS,Ohtsuki S,Takanaga H,Tomi M,Hosoya K,Terasaki T

更新日期：2002-12-01 00:00:00

abstract：:We examined the effects of chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid (3-NP) in doses ranging from 12 to 16 mg/kg/day for 30 days on striatal cytoarchitecture in rats. Administration of 3-NP at a dose of 16 mg/kg/day resulted in large lesions with a central necrotic core that was ...

journal_title：Journal of neurochemistry

authors： Wüllner U,Young AB,Penney JB,Beal MF

更新日期：1994-11-01 00:00:00

abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

journal_title：Journal of neurochemistry

authors： Shields SM,Vernon PJ,Kelly PT

更新日期：1984-12-01 00:00:00

abstract：:The concentration of dopamine (DA) in the synaptic cleft in the mouse striatum in vivo was estimated from the competition between the synaptic DA and the 3H-labelled DA D2 receptor agonists N-n-propylnorapomorphine (NPA) or N,N-diethyl-N'-[(3 alpha, 4a alpha, 10 beta)-1,2,3,4,4a,5,10,10a-octahydro- 7-hydroxyl-1-propyl...

journal_title：Journal of neurochemistry

authors： Ross SB

更新日期：1991-01-01 00:00:00

abstract：:Transgenic Huntington's disease (HD) mice, expressing exon 1 of the HD gene with an expanded CAG repeat, are totally resistant to striatal lesion induced by excessive NMDA receptor activation. We now show that striatal lesions induced by the mitochondrial toxin malonate are reduced by 70-80% in transgenic HD mice comp...

journal_title：Journal of neurochemistry

authors： Hansson O,Castilho RF,Korhonen L,Lindholm D,Bates GP,Brundin P

更新日期：2001-08-01 00:00:00

abstract：:Evidence that glucagon-like peptide-1 (GLP-1) (7-36) amide functions as a novel neuropeptide prompted us to study the gene expression of its receptor in rat brain. Northern blot analysis showed transcripts of similar size in RINm5F cells, hypothalamus, and brain-stem. First-strand cDNA was prepared by using RNA from h...

journal_title：Journal of neurochemistry

authors： Alvarez E,Roncero I,Chowen JA,Thorens B,Blázquez E

更新日期：1996-03-01 00:00:00

abstract：:Lipid precursors ([2-3H]glycerol for phospholipids and [3H]acetate for cholesterol) were injected into the L-5 dorsal root ganglion of adult rats. At various times, animals were killed, the ganglion and consecutive 5-mm segments of sciatic nerve were dissected, and lipids were extracted and analyzed by TLC. Individual...

journal_title：Journal of neurochemistry

authors： Toews AD,Saunders BF,Blaker WD,Morell P

更新日期：1983-02-01 00:00:00

abstract：:Previous evidence has suggested that brain catecholamine levels are important in the regulation of central angiotensin II receptors. In the present study, the effects of norepinephrine and 3,4-dihydroxyphenylethylamine (dopamine) on angiotensin II receptor regulation in neuronal cultures from rat hypothalamus and brai...

journal_title：Journal of neurochemistry

authors： Sumners C,Watkins LL,Raizada MK

更新日期：1986-10-01 00:00:00

abstract：:We developed a rapid and sensitive radioimmunohistochemical method for the quantification of tyrosine hydroxylase (TH) at both the anatomical and cellular level. Coronal tissue sections from fresh-frozen rat brains were incubated in the presence of a TH monoclonal antibody. The reaction was revealed with a 35S-labeled...

journal_title：Journal of neurochemistry

authors： Blanchard V,Raisman-Vozari R,Savasta M,Hirsch E,Javoy-Agid F,Feuerstein C,Agid Y

更新日期：1993-08-01 00:00:00

abstract：:Heterozygous CB1 receptor knockout mice were used to examine the effect of reduced CB1 receptor density on G-protein activation in membranes prepared from four brain regions: cerebellum, hippocampus, striatum/globus pallidus (striatum/GP) and cingulate cortex. Results showed that CB1 receptor levels were approximately...

journal_title：Journal of neurochemistry

authors： Selley DE,Rorrer WK,Breivogel CS,Zimmer AM,Zimmer A,Martin BR,Sim-Selley LJ

更新日期：2001-05-01 00:00:00

abstract：:The specific opioid receptor antagonist naloxone attenuates the behavioral and neurochemical effects of amphetamine. Furthermore, the amphetamine-induced increase in locomotor activity is attenuated by intracisternally administered naltrindole, a selective delta-opioid receptor antagonist, but not by the irreversible ...

journal_title：Journal of neurochemistry

authors： Schad CA,Justice JB Jr,Holtzman SG

更新日期：1996-12-01 00:00:00