gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish.

abstract：:[3H]Spiroperidol binding to homogenates of rat striatum is saturable and shows either monophasic or biphasic saturation isotherms under specified conditions. In poorly washed membrane fragment preparations, saturation isotherms of [3H]spiroperidol binding are monophasic, revealing an apparently homogeneous set of site...

journal_title：Journal of neurochemistry

authors： Andorn AC,Maguire ME

更新日期：1980-11-01 00:00:00

abstract：:Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), and what are its underlying mechanisms. In this study, we investigated the efficacy of tamoxifen ...

journal_title：Journal of neurochemistry

authors： Tian DS,Liu JL,Xie MJ,Zhan Y,Qu WS,Yu ZY,Tang ZP,Pan DJ,Wang W

更新日期：2009-06-01 00:00:00

abstract：:Tryptic digestion of tyrosine hydroxylase (TH) isolated from rat adrenal glands labeled with 32Pi produced five phosphopeptides. Based on the correspondence of these phosphopeptides with those identified in TH from rat pheochromocytoma cells, four phosphorylation sites (Ser8, Ser19, Ser31, and Ser40) were inferred. Fi...

journal_title：Journal of neurochemistry

authors： Haycock JW,Wakade AR

更新日期：1992-01-01 00:00:00

abstract：:The effects of treatment of brain membranes with diethyl pyrocarbonate (DEP), a histidine-modifying reagent, on the binding of 3H-labeled Ro 15-4513 (ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]- [1,4]benzodiazepine-3-carboxylate) and [3H]diazepam were compared. DEP pretreatment produced a dose-dependent...

journal_title：Journal of neurochemistry

authors： Uusi-Oukari M

更新日期：1992-08-01 00:00:00

abstract：:This review summarizes the latest advances that have been made to elucidate the somatostatinergic system in respect to somatostatin receptor evolution, the development of receptor agonists/antagonists, receptor regulation, signal transduction, effects on cell proliferation, receptor-receptor or receptor-protein intera...

journal_title：Journal of neurochemistry

authors： Olias G,Viollet C,Kusserow H,Epelbaum J,Meyerhof W

更新日期：2004-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive decline. Amyloid plaque deposits consisting specifically of beta-amyloid peptides that have formed fibrils displaying beta-pleated sheet conformation are associated with activated microglia and astrocytes, are colocalized with C...

journal_title：Journal of neurochemistry

authors： Zhou J,Fonseca MI,Pisalyaput K,Tenner AJ

更新日期：2008-09-01 00:00:00

abstract：:The activities of the three major catecholamine-synthesizing enzymes were determined in brain tissue pellets dissected from 500-micrometers thick horizontal sections of rat lower brainstem. The rostrocaudal distributions of the three enzymatic activities were generally not parallel, suggesting differences in the respe...

journal_title：Journal of neurochemistry

authors： Chamba G,Denoroy L,Renaud B

更新日期：1982-08-01 00:00:00

abstract：:Recent evidence supports the emerging hypothesis that the amyloid-β precursor protein C-terminal fragments (APP-CTFs) and dysregulations in both their qualitative and quantitative productions may actively and directly contribute to the neuronal toxicity in early phases of Alzheimer's disease (AD). These new findings r...

journal_title：Journal of neurochemistry

authors： Mosser S,Gerber H,Fraering PC

更新日期：2020-08-05 00:00:00

abstract：:Iron, an essential element for all cells of the body, including those of the brain, is transported bound to transferrin in the blood and the general extracellular fluid of the body. The demonstration of transferrin receptors on brain capillary endothelial cells (BCECs) more than 20 years ago provided the evidence for ...

journal_title：Journal of neurochemistry

authors： Moos T,Rosengren Nielsen T,Skjørringe T,Morgan EH

更新日期：2007-12-01 00:00:00

abstract：:We investigated, using adult (2-month-old) and senescent (12- and 24-month-old) rats, the effects of aging on the relationship between the alpha 1-adrenergic coupling system and the membrane viscosity of the cerebral cortex. There was no age-related difference in the KD values of [3H]prazosin binding on the membranes....

journal_title：Journal of neurochemistry

authors： Miyamoto A,Araiso T,Koyama T,Ohshika H

更新日期：1990-07-01 00:00:00

abstract：:Neural injury due to ischemia and related insults is thought to involve the action of excitatory amino acids at N-methyl-D-aspartate receptors, which results in the influx of extracellular Ca2+ and the generation of nitric oxide. Because ethanol inhibits physiologic responses to excitatory amino acids, we examined its...

journal_title：Journal of neurochemistry

authors： Lustig HS,von Brauchitsch KL,Chan J,Greenberg DA

更新日期：1992-12-01 00:00:00

abstract：:Effects of protein kinase C on protein stability and activity of rat AANAT were investigated in vitro and in vivo. When COS-7 cells transfected with AANAT cDNA were treated with phorbol 12-myristate 13-acetate (PMA), both the activity and protein level of AANAT were increased. These effects of PMA were blocked by GF10...

journal_title：Journal of neurochemistry

authors： Choi BH,Chae HD,Park TJ,Oh J,Lim J,Kang SS,Ha H,Kim KT

更新日期：2004-07-01 00:00:00

abstract：:The delta-opioid receptor is known to regulate multiple effectors in various tissues. When expressed in human embryonic kidney 293 cells, the cloned delta-opioid receptor inhibited cyclic AMP (cAMP) accumulation in response to the delta-selective agonist [D-Pen2,D-Pen5]-enkephalin. The inhibitory response of [D-Pen2,D...

journal_title：Journal of neurochemistry

authors： Tsu RC,Chan JS,Wong YH

更新日期：1995-06-01 00:00:00

abstract：:Incubation of beta-endorphin with cytosolic and particulate fractions of rat brain resulted in the formation of several peptides, including gamma-endorphin [beta-endorphin-(1-17)] and beta-endorphin-(18-31), indicating the presence of enzyme activity cleaving the Leu17-Phe18 bond of beta-endorphin. An assay for this L...

journal_title：Journal of neurochemistry

authors： Lebouille JL,Hendriks RW,Soeter NM,Burbach JP

更新日期：1989-06-01 00:00:00

abstract：:The effect of 6-aminonicotinamide (6AN) treatment on the activities of alternative pathways of glucose metabolism in 20-day-old rat brain was evaluated by measurements of yields of 14CO2 from glucose labeled with 14C on carbons 1, 2, 3 + 4, or 6 and uniformly labeled glucose, and from the incorporation of 14C from spe...

journal_title：Journal of neurochemistry

authors： Hothersall JS,Zubairu S,McLean P,Greenbaum AL

更新日期：1981-12-01 00:00:00

abstract：:beta-nerve growth factor (NGF) was modified by biotinylation via carboxyl group substitution (C-bio-NGF) using biotin hydrazide and the coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide, under reaction conditions that yielded an average of 3 biotin additions per NGF subunit. NGF was also biotinylated thr...

journal_title：Journal of neurochemistry

authors： Rosenberg MB,Hawrot E,Breakefield XO

更新日期：1986-02-01 00:00:00

abstract：:5-Hydroxytryptamine2 (5-HT2) receptor antagonists have been shown to interfere with the stimulation of striatal dopamine synthesis and release produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA). To localize the receptors responsible for the attenuation of MDMA-induced release, 5-HT2 receptor...

journal_title：Journal of neurochemistry

authors： Schmidt CJ,Sullivan CK,Fadayel GM

更新日期：1994-04-01 00:00:00

abstract：:Five muscarinic receptor genes (m1-m5) that encode distinct muscarinic receptor subtypes have been cloned. Because of their structural homology and pharmacological similarity, ligand binding probes currently available do not clearly distinguish among the subtypes. To obtain a clear distribution within the CNS of molec...

journal_title：Journal of neurochemistry

authors： Wei J,Walton EA,Milici A,Buccafusco JJ

更新日期：1994-09-01 00:00:00

abstract：:Impairment of cognitive functions including hippocampus-dependent spatial learning and memory affects nearly half of the aged population. Age-related cognitive decline is associated with synaptic dysfunction that occurs in the absence of neuronal cell loss, suggesting that impaired neuronal signaling and plasticity ma...

journal_title：Journal of neurochemistry

authors： Vanguilder HD,Bixler GV,Sonntag WE,Freeman WM

更新日期：2012-04-01 00:00:00

abstract：:Phosphorylation of G protein-coupled receptors is considered an important step during their desensitization. In SK-N-BE cells, recently presented as a pertinent model for the studies of the human delta-opioid receptor, pretreatment with the opioid agonist etorphine increased time-dependently the rate of phosphorylatio...

journal_title：Journal of neurochemistry

authors： Hasbi A,Polastron J,Allouche S,Stanasila L,Massotte D,Jauzac P

更新日期：1998-05-01 00:00:00

abstract：:ATP transport to synaptic vesicles from rat brain has been studied using the fluorescent substrate analogue 1,N6-ethenoadenosine 5'-triphosphate (epsilon-ATP). The increase in intravesicular concentration was time dependent for the first 30 min, epsilon-ATP being the most abundant nucleotide. The complexity of the sat...

journal_title：Journal of neurochemistry

authors： Gualix J,Pintor J,Miras-Portugal MT

更新日期：1999-09-01 00:00:00

abstract：:We report that a subtoxic dose of the succinate dehydrogenase (SDH) inhibitor malonate greatly enhances the neurotoxicity of three different excitatory amino acid agonists: N-methyl-D-aspartate (NMDA), S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (S-AMPA), and L-glutamate. In male Sprague-Dawley rats, in...

journal_title：Journal of neurochemistry

authors： Greene JG,Greenamyre JT

更新日期：1995-05-01 00:00:00

abstract：:Intracerebral administration of [3H]arachidonic acid ([3H]ArA) into 19-20-day-old rat embryos, resulted in a rapid incorporation of label into brain lipids. One hour after injection, 55.6 +/- 8.2, 18.0 +/- 3.4, and 13.7 +/- 1.3% of the total radioactivity was associated with phosphatidylcholine, phosphatidylinositol, ...

journal_title：Journal of neurochemistry

authors： Kunievsky B,Bazan NG,Yavin E

更新日期：1992-11-01 00:00:00

abstract：:Exogenously added sialyl cholesterol (SC) induced neuritogenesis and accumulated in the nuclear fraction of a mouse neuroblastoma cell line, Neuro2a, as reported elsewhere. To clarify the significance of nuclear SC, we examined the structure of chromatin and its transcriptional level. The chromatin of SC-treated cells...

journal_title：Journal of neurochemistry

authors： Yamashita T,Tsuji S

更新日期：1992-04-01 00:00:00

abstract：:Capillaries in vertebrate brain have unique permeability properties that make up the blood-brain barrier (BBB). Although it is known that capillaries are innervated by nerve endings of intracerebral origin and that brain capillary function is likely acutely regulated by neuronal inputs, the possible mechanisms of neur...

journal_title：Journal of neurochemistry

authors： Pardridge WM,Yang J,Eisenberg J

更新日期：1985-10-01 00:00:00

abstract：:To investigate the role of the retinoblastoma protein pRB in neuronal differentiation, we have measured the accumulation of hypophosphorylated pRB in PC12 cells stimulated by nerve growth factor (NGF). NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cy...

journal_title：Journal of neurochemistry

authors： Li H,Kawasaki H,Nishida E,Hattori S,Nakamura S

更新日期：1996-06-01 00:00:00

abstract：:Aggregate-prone mutant proteins, such as α-synuclein and huntingtin, play a prominent role in the pathogenesis of various neurodegenerative disorders; thus, it has been hypothesized that reducing the aggregate-prone proteins may be a beneficial therapeutic strategy for these neurodegenerative disorders. Here, we ident...

journal_title：Journal of neurochemistry

authors： Shen W,Henry AG,Paumier KL,Li L,Mou K,Dunlop J,Berger Z,Hirst WD

更新日期：2014-06-01 00:00:00

abstract：:The Ret receptor tyrosine kinase is the common signaling receptor for the glial cell line-derived neurotrophic factor (GDNF) family ligands. The Met918Thr mutation leads to constitutive activation of Ret and is responsible for dominantly inherited cancer syndrome MEN2B. Previously, we found that the mice carrying the ...

journal_title：Journal of neurochemistry

authors： Mijatovic J,Patrikainen O,Yavich L,Airavaara M,Ahtee L,Saarma M,Piepponen TP

更新日期：2008-06-01 00:00:00

abstract：:Reactive oxygen species are believed to play a crucial role in situations where dopamine neurons die, such as in Parkinson's disease or during intracerebral transplantation of embryonic mesencephalic tissue. The present study was designed to address the question whether, and to what extent, the glutathione redox syste...

journal_title：Journal of neurochemistry

authors： Grasbon-Frodl EM,Andersson A,Brundin P

更新日期：1996-10-01 00:00:00

abstract：:Dibutyryl cyclic AMP (dBcAMP) is known to induce maturation and differentiation in astrocytes. As myo-inositol is an important osmoregulator in astrocytes, we examined the effects of maturation and biochemical differentiation on the kinetic properties of myo-inositol transport. Treatment of astrocytes with dBcAMP sign...

journal_title：Journal of neurochemistry

authors： Isaacks RE,Bender AS,Reuben JS,Kim CY,Shi YF,Norenberg MD

更新日期：1999-07-01 00:00:00