Nuclear sialyl cholesterol causes changes in the structure of chromatin and its transcription level followed by the promotion of neuritogenesis.

abstract：:Sodium-dependent, high-affinity glutamate transport is generally assumed to limit the toxicity of glutamate in vivo and in vitro, but there is very little direct evidence to support this hypothesis. In the present study, the effects of the specific uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate on the toxicity...

journal_title：Journal of neurochemistry

authors： Robinson MB,Djali S,Buchhalter JR

更新日期：1993-12-01 00:00:00

abstract：:Read the highlighted article 'Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies' on page 645. ...

journal_title：Journal of neurochemistry

authors： Jaber SM,Polster BM

更新日期：2017-02-01 00:00:00

abstract：:Rat-1 fibroblasts were transduced to express Drosophila choline acetyltransferase. The presence of an active enzyme in these cells (Rat-1/dChAT) was confirmed using various methods. Rat-1/dChAT fibroblasts released acetylcholine (ACh) into the culture medium. Moreover, intra- and extracellular levels of ACh could be i...

journal_title：Journal of neurochemistry

authors： Schinstine M,Rosenberg MB,Routledge-Ward C,Friedmann T,Gage FH

更新日期：1992-06-01 00:00:00

abstract：:The effect of tumor necrosis factor-alpha (TNF-alpha) on neuronal viability has been investigated in the SK-N-BE neuroblastoma cell line. These cells undergo differentiation upon chronic treatment with retinoic acid. Exposure of SK-N-BE cells to TNF-alpha produced a proliferative response in undifferentiated cells, wh...

journal_title：Journal of neurochemistry

authors： Condorelli F,Sortino MA,Stella AM,Canonico PL

更新日期：2000-09-01 00:00:00

abstract：:The Coffin-Lowry syndrome, a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene. To further investigate RSK2 (90-kDa ribosomal S6 kinase) implication in cognitive processes, a mrsk2_KO mouse has previously been generated as an animal model of Coffin-...

journal_title：Journal of neurochemistry

authors： Marques Pereira P,Gruss M,Braun K,Foos N,Pannetier S,Hanauer A

更新日期：2008-12-01 00:00:00

abstract：:Adult rat cerebral cortex slices when incubated in media in increasing K+ concentrations, from 3 to 20 mM ("physiological" conditions), exhibited an increase of Ki+ and a decrease of Nai+ and Cli-. This phenomenon appeared at 30 days postnatally, which is fairly late during development. Over 20 mM-K+ ("pathological" c...

journal_title：Journal of neurochemistry

authors： Grisar T,Franck G

更新日期：1981-05-01 00:00:00

abstract：:Astrocytes can either exacerbate or ameliorate secondary degeneration at sites of injury in the CNS but the contextual basis for eliciting these opposing phenotypes is poorly understood. In this study, we demonstrate that the two major cytokines produced by Th1 and Th2 cells, interferon-gamma (IFN-gamma), and interleu...

journal_title：Journal of neurochemistry

authors： Garg SK,Kipnis J,Banerjee R

更新日期：2009-03-01 00:00:00

abstract：:Brain inflammation includes microglial activation and enhanced production of diffusible chemical mediators, including prostaglandin E2. Prostaglandin E2 is generally considered a proinflammatory molecule, but it also promotes neuronal survival and down-regulates some aspects of microglial activation. It remains unknow...

journal_title：Journal of neurochemistry

authors： Caggiano AO,Kraig RP

更新日期：1998-06-01 00:00:00

abstract：:The photic regulation of heme oxygenase (HO) activity was examined in the golden hamster retina. This enzymatic activity was significantly higher at midday than at midnight. When the hamsters were placed under constant darkness for 48 h and killed at subjective day or at subjective night, the differences in HO activit...

journal_title：Journal of neurochemistry

authors： Sacca GB,Sáenz DA,Jaliffa CO,Minces L,Keller Sarmiento MI,Rosenstein RE

更新日期：2003-04-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) activity was measured in microvessels prepared from cerebral cortices of 4-week-old spontaneously hypertensive rats (SHR). The Vmax value of the ACE activity in the cerebral microvessels of SHR was lower than that of Wistar Kyoto controls of the same age by 25% without difference in...

journal_title：Journal of neurochemistry

authors： Kobayashi H,Wada A,Izumi F,Take K,Magnoni MS

更新日期：1985-04-01 00:00:00

abstract：:Nicotinic cholinergic receptor binding sites labeled by [3H]acetylcholine were measured in the cerebral cortices, thalami, striata, and hypothalami of rats lesioned by intraventricular injection of either 6-hydroxydopamine or 5, 7-dihydroxytryptamine. In addition, [3H]acetylcholine binding sites were measured in the c...

journal_title：Journal of neurochemistry

authors： Schwartz RD,Lehmann J,Kellar KJ

更新日期：1984-05-01 00:00:00

abstract：:The human NMDAR2D subunit was cloned, and the pharmacological properties of receptors resulting from injection of transcripts encoding human NMDAR1A and NMDAR2D subunits in Xenopus oocytes were characterized by profiling NMDA receptor agonists and antagonists. We found that glutamate, NMDA, glycine, and D-serine were ...

journal_title：Journal of neurochemistry

authors： Hess SD,Daggett LP,Deal C,Lu CC,Johnson EC,Veliçelebi G

更新日期：1998-03-01 00:00:00

abstract：:Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures. The extracellular signal-regulated kinase (ERK) signaling cascade is activated by M(1) mAChR and is elevated during status epi...

journal_title：Journal of neurochemistry

authors： Berkeley JL,Decker MJ,Levey AI

更新日期：2002-07-01 00:00:00

abstract：:An early biochemical change in the Parkinsonian substantia nigra (SN) is reduction in total glutathione (GSH + GSSG) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex I activity, dopamine loss, and cell death. We have demonstrated using dopaminergic PC12 cell lines genetically enginee...

journal_title：Journal of neurochemistry

authors： Hsu M,Srinivas B,Kumar J,Subramanian R,Andersen J

更新日期：2005-03-01 00:00:00

abstract：:The nuclear mitochondrial and synaptosomal fractions of rat brain were each found to contain some 25-30% of the total aldehyde dehydrogenase activity. The cytoplasmic fraction had a very low total aldehyde dehydrogenase activity. There were differences in the distribution of the activity when different aldehydes were ...

journal_title：Journal of neurochemistry

authors： Koivula T,Turner AJ,Huttunen M,Koivusalo M

更新日期：1981-06-01 00:00:00

abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

journal_title：Journal of neurochemistry

authors： Shields SM,Vernon PJ,Kelly PT

更新日期：1984-12-01 00:00:00

abstract：:An enzyme-linked immunoadsorbent assay (ELISA) for neurofilament protein was utilised to quantify the effect of exogenous ganglioside on neurite regeneration in cultures of dorsal root ganglion neurones. In contrast to nerve growth factor (NGF), ganglioside GM1 (100 micrograms/ml) failed to support neuronal survival a...

journal_title：Journal of neurochemistry

authors： Doherty P,Dickson JG,Flanigan TP,Walsh FS

更新日期：1985-04-01 00:00:00

abstract：:The objective of this study was to examine the role of dopamine (DA) receptors in the nucleus accumbens (ACB) in controlling feedback regulation of mesolimbic somatodendritic DA release in the ventral tegmental area (VTA) of Wistar rats using ipsilateral dual-probe in vivo microdialysis. Perfusion of the ACB for 60 mi...

journal_title：Journal of neurochemistry

authors： Rahman S,McBride WJ

更新日期：2000-02-01 00:00:00

abstract：:The purpose of the present study was to clarify the expression, transport properties and regulation of ATP-binding cassette G2 (ABCG2) transporter at the rat blood-brain barrier (BBB). The rat homologue of ABCG2 (rABCG2) was cloned from rat brain capillary fraction. In rABCG2-transfected HEK293 cells, rABCG2 was detec...

journal_title：Journal of neurochemistry

authors： Hori S,Ohtsuki S,Tachikawa M,Kimura N,Kondo T,Watanabe M,Nakashima E,Terasaki T

更新日期：2004-08-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) promotes the survival of various neuronal populations and thus shows potential in the treatment of neurodegenerative disease. However, BDNF is not pharmacokinetically optimal for use as a therapeutic agent. As a step toward the development of low-molecular-weight BDNF-like drug...

journal_title：Journal of neurochemistry

authors： O'Leary PD,Hughes RA

更新日期：1998-04-01 00:00:00

abstract：:Histamine stimulates cyclic AMP accumulation in astrocyte-enriched and neuronal primary cultures from rat brain in the presence of the phosphodiesterase inhibitor isobutylmethylxanthine. The response in the astrocyte cultures (Emax = 304 +/- 44% over basal, EC50 = 43 +/- 5 microM) was much higher than in neuronal cult...

journal_title：Journal of neurochemistry

authors： Agulló L,Picatoste F,García A

更新日期：1990-11-01 00:00:00

abstract：:We have developed a novel competitive method to select from a phage display library a single chain Fv which is able to mimic the alpha-bungarotoxin binding site of the muscle nicotinic receptor. The single chain Fv was selected from a large synthetic library using alpha-bungarotoxin-coated magnetic beads. Toxin-bound ...

journal_title：Journal of neurochemistry

authors： Bracci L,Pini A,Lozzi L,Lelli B,Battestin P,Spreafico A,Bernini A,Niccolai N,Neri P

更新日期：2001-07-01 00:00:00

abstract：:Protein synthesis in the brain is known to be affected by a wide range of treatments. The detailed analysis of the mechanisms that are involved would be facilitated by the development of cell-free translation systems derived from brain tissue. To date, brain cell-free systems have not been fully characterized to demon...

journal_title：Journal of neurochemistry

authors： Cosgrove JW,Brown IR

更新日期：1981-03-01 00:00:00

abstract：:The effects of chronic treatment with the specific, mechanism-based, irreversible inhibitors of 4-aminobutyrate aminotransferase (EC 2.6.1.19; GABA transaminase), ethanolamine O-sulphate (EOS), and 4-aminohexenoate [vigabatrin; gamma-vinyl-GABA (GVG)] on the extracellular concentrations of GABA in the hippocampus have...

journal_title：Journal of neurochemistry

authors： Qume M,Whitton PS,Fowler LJ

更新日期：1995-05-01 00:00:00

abstract：:The anti-diabetic drug and peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, rosiglitazone, alters astrocyte activation; however, its mechanism remains less-known. We hypothesized participation of epidermal growth factor receptor (EGFR), known to control astrocyte reactivity. We first detected that ros...

journal_title：Journal of neurochemistry

authors： Kushwaha R,Mishra J,Gupta AP,Gupta K,Vishwakarma J,Chattopadhyay N,Gayen JR,Kamthan M,Bandyopadhyay S

更新日期：2019-06-01 00:00:00

abstract：:Patients with cancer cachexia often suffer from psychiatric disorders. In the present study, we investigated the changes in monoaminergic activities in the brain in tumor-bearing mice with reference to the development of cachexia. Two clones, clone-5 (noncachectic clone) and clone-20 (cachectic clone), derived from th...

journal_title：Journal of neurochemistry

authors： Uomoto M,Nishibori M,Nakaya N,Takeuchi Y,Iwagaki H,Tanaka N,Saeki K

更新日期：1998-01-01 00:00:00

abstract：:Enzymes considered to be markers for neurons (angiotensin converting enzyme, thermolysin-like metalloendopeptidase, alanine aminopeptidase, and glutamate-oxaloacetate transaminase), glia (glutamine synthetase, pyruvate carboxylase, and beta-glucuronidase), and endothelial cells (alkaline phosphatase and plasminogen ac...

journal_title：Journal of neurochemistry

authors： Butterworth J

更新日期：1986-08-01 00:00:00

abstract：:The L1- and F11-like axonal glycoproteins, implicated in neurite outgrowth and fasciculation, are members of the Ig superfamily comprising multiple fibronectin type III-like domains. Their Ig-like and fibronectin type III-related domains are likely to be composed of seven beta-strands arranged in two opposing beta-she...

journal_title：Journal of neurochemistry

authors： Brümmendorf T,Rathjen FG

更新日期：1993-10-01 00:00:00

abstract：:We previously showed that Nuclear Factor kappaB (NF-kappaB) inactivation in astrocytes leads to improved functional recovery following spinal cord injury (SCI). This correlated with reduced expression of pro-inflammatory mediators and chondroitin sulfate proteoglycans, and increased white matter preservation. Hence we...

journal_title：Journal of neurochemistry

authors： Brambilla R,Hurtado A,Persaud T,Esham K,Pearse DD,Oudega M,Bethea JR

更新日期：2009-07-01 00:00:00

abstract：:In this review, we discuss the poorly explored role of calcium/calmodulin-dependent protein kinase II (CaMKII) in memory maintenance, and its influence on memory destabilization. After a brief review on CaMKII and memory destabilization, we present critical pieces of evidence suggesting that CaMKII activity increases ...

journal_title：Journal of neurochemistry

authors： Vigil FA,Giese KP

更新日期：2018-10-01 00:00:00