Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.

abstract：:Microelectrophoretic methods were used to study the effects on cat spinal neurones of a number of compounds structurally related to the gamma-aminobutyric acid (GABA) agonists muscimol, THIP, and isoguvacine. While N-methylmuscimol was an agonist at bicuculline methochloride-sensitive GABA receptors, somewhat weaker t...

journal_title：Journal of neurochemistry

authors： Krogsgaard-Larsen P,Hjeds H,Curtis DR,Leah JD,Peet MJ

更新日期：1982-11-01 00:00:00

abstract：:Total polyribosomes were isolated from the brains of 16-20 day C57BL/6 mice, four neurological mutants (qk/qk, shi/shi, mld/mld, and jp/Y), and four heterozygote or littermate controls (qk/+, shil/+, mld, and jp littermates) and translated in a homologous, cell-free system. No differences were observed among the nine ...

journal_title：Journal of neurochemistry

authors： Campagnoni AT,Campagnoni CW,Bourre JM,Jacque C,Baumann N

更新日期：1984-03-01 00:00:00

abstract：:In this study, we describe a novel form of anti-homeostatic plasticity produced after culturing spinal neurons with strychnine, but not bicuculline or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Strychnine caused a large increase in network excitability, detected as spontaneous synaptic currents and calcium transient...

journal_title：Journal of neurochemistry

authors： Carrasco MA,Castro PA,Sepulveda FJ,Cuevas M,Tapia JC,Izaurieta P,van Zundert B,Aguayo LG

更新日期：2007-03-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) is a component of the dystrophin complex in skeletal muscle. The absence of dystrophin protein in Duchenne muscular dystrophy and in mdx mouse causes a redistribution of nNOS from the plasma membrane to the cytosol in muscle cells. Aberrant nNOS activity in the cytosol can induce ...

journal_title：Journal of neurochemistry

authors： Chao DS,Silvagno F,Bredt DS

更新日期：1998-08-01 00:00:00

abstract：:Intrastriatal microdialysis was used to administer muscarinic drugs in freely moving rats for 40 min at a flow rate of 2 microl/min. Administration of the nonselective agonist pilocarpine at 10 mM increased striatal dopamine release and decreased extracellular GABA and glutamate overflow. Perfusion with the muscarinic...

journal_title：Journal of neurochemistry

authors： Smolders I,Bogaert L,Ebinger G,Michotte Y

更新日期：1997-05-01 00:00:00

abstract：:Adrenomedullary chromaffin cells represent an excellent model to study the molecular events linked to exocytosis, because they use the same type of SNAREs for vesicle docking and fusion as neurons. In these cells, both in the intact tissue and in isolated cells in culture, syntaxin-1 and SNAP-25 are present in the pla...

journal_title：Journal of neurochemistry

authors： López-Font I,Torregrosa-Hetland CJ,Villanueva J,Gutiérrez LM

更新日期：2010-09-01 00:00:00

abstract：:The role of serotonin (5-HT)1B receptors in the mechanism of action of selective serotonin re-uptake inhibitors (SSRI) was studied by using intracerebral in vivo microdialysis in conscious, freely moving wild-type and 5-HT1B receptor knockout (KO 5-HT1B) mice in order to compare the effects of chronic administration o...

journal_title：Journal of neurochemistry

authors： Gardier AM,David DJ,Jego G,Przybylski C,Jacquot C,Durier S,Gruwez B,Douvier E,Beauverie P,Poisson N,Hen R,Bourin M

更新日期：2003-07-01 00:00:00

abstract：:During CNS injury and diseases, nitric oxide (NO) is released at a high flux rate leading to formation of peroxynitrite (ONOO(*)) and other reactive nitrogenous species, which nitrate tyrosines of proteins to form 3-nitrotyrosine (3NY), leading to cell death. Previously, we have found that motor neurons exposed to low...

journal_title：Journal of neurochemistry

authors： Bishop A,Gooch R,Eguchi A,Jeffrey S,Smallwood L,Anderson J,Estevez AG

更新日期：2009-04-01 00:00:00

abstract：:Bone fracture at the acute stage of stroke exacerbates stroke injury by increasing neuroinflammation. We hypothesize that activation of α-7 nicotinic acetylcholine receptor (α-7 nAchR) attenuates neuroinflammation and oxidative stress, and reduces brain injury in mice with bone fracture and stroke. Permanent middle ce...

journal_title：Journal of neurochemistry

authors： Han Z,Li L,Wang L,Degos V,Maze M,Su H

更新日期：2014-11-01 00:00:00

abstract：:Studies performed over the past several years have provided evidence that phosphorylation of proteins is important in the regulation of neurotransmitter release. In this study, it is shown that rabphilin-3A is present in cerebellar granule cells as a phosphoprotein, by using 32P-labeling of cerebellar granule cells, i...

journal_title：Journal of neurochemistry

authors： Fykse EM

更新日期：1998-10-01 00:00:00

abstract：:Methamphetamine causes persistent damage to dopamine nerve endings of the striatum. Repeated, intermittent treatment of mice with low doses of methamphetamine leads to the development of tolerance to its neurotoxic effects. The mechanisms underlying tolerance are not understood but clearly involve more than alteration...

journal_title：Journal of neurochemistry

authors： Thomas DM,Kuhn DM

更新日期：2005-02-01 00:00:00

abstract：:Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To detect amyloid fibrils, fluorophores with high sensitivity and better efficiency coupled with the low toxicity are in high demand even to date. In this pursuit,...

journal_title：Journal of neurochemistry

authors： Pravin N,Kumar R,Tripathi S,Kumar P,Mohite GM,Navalkar A,Panigrahi R,Singh N,Gadhe LG,Manchanda S,Shimozawa M,Nilsson P,Johansson J,Kumar A,Maji SK,Shanmugam M

更新日期：2020-08-04 00:00:00

abstract：:Antibodies raised against the synthetic peptide NH2-QKSDDDYEDYASNKTC-COOH (gamma 2 1-15 Cys), which corresponds to the N-terminal amino acid sequence with a C-terminal cysteine of the human gamma 2 subunit of the gamma-aminobutyric acidA (GABAA) receptor, were used to study the quantitative immunoprecipitation of agon...

journal_title：Journal of neurochemistry

authors： Duggan MJ,Pollard S,Stephenson FA

更新日期：1992-01-01 00:00:00

abstract：:Acetyl-L-carnitine (ALCAR) is an endogenous metabolic intermediate that facilitates the influx and efflux of acetyl groups across the mitochondrial inner membrane. Exogenously administered ALCAR has been used as a nutritional supplement and also as an experimental drug with reported neuroprotective properties and effe...

journal_title：Journal of neurochemistry

authors： Scafidi S,Fiskum G,Lindauer SL,Bamford P,Shi D,Hopkins I,McKenna MC

更新日期：2010-08-01 00:00:00

abstract：:The polypeptide composition and glycosylation of soluble isoforms of neural cell adhesion molecule (NCAM) in developing rat brain, CSF, and plasma were characterized. Soluble NCAM in rat brain consisted of several glycosylated isoforms. The degree of glycosylation was developmentally regulated. After desialylation, fo...

journal_title：Journal of neurochemistry

authors： Krog L,Olsen M,Dalseg AM,Roth J,Bock E

更新日期：1992-09-01 00:00:00

abstract：:Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a s...

journal_title：Journal of neurochemistry

authors： Sztriha L,Joó F,Dux L,Böti Z

更新日期：1987-07-01 00:00:00

abstract：:Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post-traumatic stress and anxiety disorders. Neurotransmitter release is triggered, in part, by activation of nicotinic acetylcholine receptors (nAChRs). However, despite decades of use as a model system ...

journal_title：Journal of neurochemistry

authors： Hone AJ,Rueda-Ruzafa L,Gordon TJ,Gajewiak J,Christensen S,Dyhring T,Albillos A,McIntosh JM

更新日期：2020-07-01 00:00:00

abstract：:The effect of glucose concentration on the in vitro release of histamine (HA) was examined, using two different preparations of the mouse hypothalamus. The HA and tele-methylhistamine released from whole blocks of the hypothalamus into the medium linearly increased during 2-h incubation in normal Krebs-Ringer bicarbon...

journal_title：Journal of neurochemistry

authors： Nishibori M,Oishi R,Itoh Y,Saeki K

更新日期：1986-12-01 00:00:00

abstract：:Maternal separation (MS) is known to affect hippocampal function such as learning and memory, yet the molecular mechanism remains unknown. We hypothesized that these impairments are attributed to abnormities of neural circuit formation by MS, and focused on brain-derived neurotrophic factor (BDNF) as key factor becaus...

journal_title：Journal of neurochemistry

authors： Ohta KI,Suzuki S,Warita K,Kaji T,Kusaka T,Miki T

更新日期：2017-04-01 00:00:00

abstract：:To evaluate the ability of ependymal, microglial and oligodendroglial cells to degrade leucine, the presence of 3-methylcrotonyl-CoA carboxylase (MCC) was investigated in cultures of these cells. MCC is a biotin-containing heterodimeric enzyme that is specific for the irreversible part of the leucine catabolic pathway...

journal_title：Journal of neurochemistry

authors： Murín R,Verleysdonk S,Rapp M,Hamprecht B

更新日期：2006-06-01 00:00:00

abstract：:Muscarinic receptors are the predominant cholinergic receptors in the central and peripheral nervous systems. Recently, activation of muscarinic receptors was found to elicit pigment granule dispersion in retinal pigment epithelium isolated from bluegill fish. Pigment granule movement in retinal pigment epithelium is ...

journal_title：Journal of neurochemistry

authors： Phatarpekar PV,Durdan SF,Copeland CM,Crittenden EL,Neece JD,García DM

更新日期：2005-12-01 00:00:00

abstract：:The content of the tryptophan metabolites quinolinic acid (QUIN), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) was measured in various brain areas of rats bearing a portocaval anastomosis (PCA) for 4 weeks, using mass fragmentography or HPLC. In these animals, the content of the excitotoxic comp...

journal_title：Journal of neurochemistry

authors： Moroni F,Lombardi G,Carlà V,Pellegrini D,Carassale GL,Cortesini C

更新日期：1986-03-01 00:00:00

abstract：:Mechanical transection of the nigrostriatal dopamine pathway at the medial forebrain bundle (MFB) results in the delayed degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). We have previously demonstrated that c-Jun activation is an obligate component of neuronal death in this model. Her...

journal_title：Journal of neurochemistry

authors： Crocker SJ,Hayley SP,Smith PD,Mount MP,Lamba WR,Callaghan SM,Slack RS,Park DS

更新日期：2006-01-01 00:00:00

abstract：:HNK-1 antibody reactive sulfoglucuronyl carbohydrate (SGC) and SSEA-1 antibody reactive Lewis X (Lex) epitope are expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and have been implicated in cell-cell recognition, neurite outgrowth, and/or neuronal migration during development. ...

journal_title：Journal of neurochemistry

authors： Chou DK,Henion TR,Jungalwala FB

更新日期：2003-08-01 00:00:00

abstract：:Amyloid beta (Aβ) peptide is the major constituent of the extracellular amyloid plaques deposited in the brains of Alzheimer's disease patients and is central to the pathogenic pathway causing this disease. The identity of the neurotoxic Aβ species remains elusive. We previously reported that Aβ toxicity correlates st...

journal_title：Journal of neurochemistry

authors： Jana MK,Cappai R,Pham CL,Ciccotosto GD

更新日期：2016-02-01 00:00:00

abstract：:Subcortical ischemic vascular cognitive impairment (SIVCI) is the most preventable form of cognitive dysfunction. There is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI. Currently, there are no curative pharmaceutical treatments for vascular dementia; how...

journal_title：Journal of neurochemistry

authors： Dao E,Hsiung GR,Liu-Ambrose T

更新日期：2018-03-01 00:00:00

abstract：:Binding of DL-alpha-[3H]amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid ([3H]AMPA) to lysed rat brain membranes in the presence of potassium thiocyanate resulted in curvilinear Scatchard plots that could be resolved by regression analysis into a large low-affinity component and a small high-affinity component. Sol...

journal_title：Journal of neurochemistry

authors： Hall RA,Kessler M,Lynch G

更新日期：1992-12-01 00:00:00

abstract：:Existence of microtubule cytoskeleton at the membrane and submembranous regions, referred as 'membrane tubulin' has remained controversial for a long time. Since we reported physical and functional interaction of Transient Receptor Potential Vanilloid Sub Type 1 (TRPV1) with microtubules and linked the importance of T...

journal_title：Journal of neurochemistry

authors： Goswami C

更新日期：2012-10-01 00:00:00

abstract：:Neurodegenerative diseases such as Alzheimer's disease (AD) are characterized by an abnormal aggregation of misfolded beta-sheet rich proteins such as β-amyloid (Aβ). Various ubiquitously expressed molecular chaperones control the correct folding of cellular proteins and prevent the accumulation of harmful species. We...

journal_title：Journal of neurochemistry

authors： Hoshino A,Helwig M,Rezaei S,Berridge C,Eriksen JL,Lindberg I

更新日期：2014-02-01 00:00:00

abstract：:Antisilencer or antirepressor elements have been described, thus far, for only a few eukaryotic genes and were identified by their ability not to augment gene expression per se but to override repression mediated via negative transcription regulatory elements. Here we report the first case of antisilencing for a neura...

journal_title：Journal of neurochemistry

authors： Dobretsova A,Wight PA

更新日期：1999-06-01 00:00:00