Calcium/calmodulin-dependent kinase II and memory destabilization: a new role in memory maintenance.

abstract：:A method has been developed for the simultaneous in vivo measurement of local rates for methionine incorporation into cerebral protein in the rat. It is based on the use of L-[35S]methionine as a tracer for reflecting the bidirectional exchange of methionine between plasma and brain and its incorporation into cerebral...

journal_title：Journal of neurochemistry

authors： Lestage P,Gonon M,Lepetit P,Vitte PA,Debilly G,Rossatto C,Lecestre D,Bobillier P

更新日期：1987-02-01 00:00:00

abstract：:The binding of a series of glycosylated beta-galactosidases to a fraction rich in synaptic membrane of bovine brain was examined. beta-galactosidase modified with p-aminophenyl beta-D-galactopyranoside (beta-D-Gal beta-gal) was found the most effective in binding to synaptic membrane, followed by that modified with be...

journal_title：Journal of neurochemistry

authors： Naoi M,Nagatsu T

更新日期：1986-02-01 00:00:00

abstract：:The effect of a unilateral perinatal hypoxic-ischemic brain injury on dopamine D1 and D2 receptors and uptake sites was investigated in rats by using in vitro quantitative binding autoradiography, 2-3 weeks after the insult. We observed significant decreases in the Bmax and KD for [3H]SCH 23390-labeled D1 and in the B...

journal_title：Journal of neurochemistry

authors： Przedborski S,Kostic V,Jackson-Lewis V,Cadet JL,Burke RE

更新日期：1991-12-01 00:00:00

abstract：:Quinolinic acid (QUIN), an excitotoxic compound present in the mammalian CNS and periphery, has been hypothetically linked to human neurodegenerative disorders such as Huntington's disease and epilepsy. Quinolinic acid phosphoribosyltransferase (QPRT), the catabolic enzyme of QUIN, is found in the CNS and peripheral o...

journal_title：Journal of neurochemistry

authors： Foster AC,Schwarcz R

更新日期：1985-07-01 00:00:00

abstract：:Carnitine is known to accumulate in brain, therefore transport of carnitine through the blood-brain barrier was studied in an in vitro system using bovine brain capillary endothelial cells (BBCEC) grown on filter inserts in a co-culture system with glial cells. Long-term exposure of BBCEC to carnitine resulted in a hi...

journal_title：Journal of neurochemistry

authors： Berezowski V,Miecz D,Marszałek M,Bröer A,Bröer S,Cecchelli R,Nałecz KA

更新日期：2004-11-01 00:00:00

abstract：:Prostaglandin E2 (PGE2 ) plays crucial roles in managing microglial activation through the prostanoid EP2 receptor, a PGE2 receptor subtype. In this study, we report that PGE2 enhances interferon-γ (IFN-γ)-induced nitric oxide production in microglia. IFN-γ increased the release of nitrite, a metabolite of nitric oxid...

journal_title：Journal of neurochemistry

authors： Nagano T,Nishiyama R,Sanada A,Mutaguchi Y,Ioku A,Umeki H,Kishimoto S,Yamanaka D,Kimura SH,Takemura M

更新日期：2017-02-01 00:00:00

abstract：:The changes in activity of phospholipid methyltransferase I and [3H]S-adenosyl-L-homocysteine ([3H]SAH) binding were determined in cortical membrane preparations from newborn rats and rats 1, 2, and 8 months old. The activity of phospholipid methyltransferase I and the [3H]SAH binding were significantly greater (respe...

journal_title：Journal of neurochemistry

authors： Gharib A,Rey C,Fonlupt P,Sarda N,Pacheco H

更新日期：1985-07-01 00:00:00

abstract：:Recent studies suggest that the chemotactic G protein-coupled receptor formyl-peptide-receptor-like-1 (FPRL1) or the scavenger receptor MARCO (macrophage receptor with collagenous structure) plays an essential role in the inflammatory response of host defense mechanisms and neurodegenerative disorders such as Alzheime...

journal_title：Journal of neurochemistry

authors： Brandenburg LO,Konrad M,Wruck CJ,Koch T,Lucius R,Pufe T

更新日期：2010-05-01 00:00:00

abstract：:The extracellular matrix (ECM) is important for both structural integrity and functions of the brain. Matrix metalloproteinases (MMPs) play major roles in ECM-remodeling under both physiological and pathological conditions. Reversion-inducing cysteine-rich protein with Kazal motifs (Reck) is a membrane-anchored MMP-re...

journal_title：Journal of neurochemistry

authors： Wang H,Imamura Y,Ishibashi R,Chandana EP,Yamamoto M,Noda M

更新日期：2010-10-01 00:00:00

abstract：:To enable us to study expression of tyrosine hydroxylase [TH; tyrosine 3-monooxygenase; L-tyrosine tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] as a measure of dopaminergic neuron function in future experiments, methods were developed to quantify TH mRNA levels in cultures of dopaminergic...

journal_title：Journal of neurochemistry

authors： Beck KD,Knusel B,Pasinetti G,Michel PP,Zawadzka H,Goldstein M,Hefti F

更新日期：1991-08-01 00:00:00

abstract：:Ras-GAP SH3-domain-binding protein, G3BP, is an important component in the assembly of stress granules (SGs), which are cytoplasmic aggregates assembled following translational stress. To assess the physiological function of G3BP, we generated viable G3bp1-knockout (KO) mice, which demonstrated behavioral defects link...

journal_title：Journal of neurochemistry

authors： Martin S,Zekri L,Metz A,Maurice T,Chebli K,Vignes M,Tazi J

更新日期：2013-04-01 00:00:00

abstract：:Release-regulating heterocarriers exist on brain nerve endings. We have investigated in this study the mechanisms involved in the neurotransmitter release evoked by GABA heterocarrier activation. GABA increased the basal release of [3H]acetylcholine and [3H]noradrenaline from rat hippocampal synaptosomes and of [3H]do...

journal_title：Journal of neurochemistry

authors： Fassio A,Bonanno G,Fontana G,Usai C,Marchi M,Raiteri M

更新日期：1996-04-01 00:00:00

abstract：:HPLC analysis of guanidinium hydrochloride extracts of neonatal and adult rat brain revealed a polypeptide that is present in high concentration in the immature nervous system, but whose levels decline dramatically in the adult. This polypeptide has been isolated and its complete amino acid sequence determined by gas-...

journal_title：Journal of neurochemistry

authors： Lugo DI,Chen SC,Hall AK,Ziai R,Hempstead JL,Morgan JI

更新日期：1991-02-01 00:00:00

abstract：:We have shown previously that N-(4-hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid derivative, induces neuronal differentiation in cultured human retinal pigment epithelial (RPE) cells [Chen et al., J. Neurochem., 84 (2003), 972]. We asked the question whether the mitogen-activated protein kinase (MAPK) ...

journal_title：Journal of neurochemistry

authors： Samuel W,Kutty RK,Sekhar S,Vijayasarathy C,Wiggert B,Redmond TM

更新日期：2008-07-01 00:00:00

abstract：:Previously, we reported a modest but significant reduction in the concentration of neuropeptide Y in frontal cortices from victims of suicide relative to age-matched natural or accidental death control subjects. The reduction in neuropeptide Y appeared to be greatest in a subgroup of victims of suicide for which there...

journal_title：Journal of neurochemistry

authors： Ordway GA,Stockmeier CA,Meltzer HY,Overholser JC,Jaconetta S,Widdowson PS

更新日期：1995-10-01 00:00:00

abstract：:We investigated, using adult (2-month-old) and senescent (12- and 24-month-old) rats, the effects of aging on the relationship between the alpha 1-adrenergic coupling system and the membrane viscosity of the cerebral cortex. There was no age-related difference in the KD values of [3H]prazosin binding on the membranes....

journal_title：Journal of neurochemistry

authors： Miyamoto A,Araiso T,Koyama T,Ohshika H

更新日期：1990-07-01 00:00:00

abstract：:Hippocampus mossy fibre terminals activate CA3 pyramidal neurons via two distinct mechanisms, both quantal and glutamatergic: (i) rapid excitatory transmission in response to afferent action potentials and (ii) delayed and prolonged release following nicotinic receptor activation. These processes were analysed here us...

journal_title：Journal of neurochemistry

authors： Bancila V,Cordeiro JM,Bloc A,Dunant Y

更新日期：2009-07-01 00:00:00

abstract：:Aggregates of Cu/Zn superoxide dismutase (SOD) have been demonstrated in familial amyotrophic lateral sclerosis (FALS) and other neurodegenerative diseases; however, their role in disease pathogenesis is unclear. In this study, we investigated the presence of SOD aggregates in nerve growth factor (NGF)-differentiated ...

journal_title：Journal of neurochemistry

authors： Lee JP,Gerin C,Bindokas VP,Miller R,Ghadge G,Roos RP

更新日期：2002-09-01 00:00:00

abstract：:Peptidyl-glycine alpha-amidation enzyme activity has been measured in 36 nuclei or areas in the rat CNS and pituitary using D-Tyr-Phe-Gly as the substrate. The distribution of this enzyme is highly uneven, with highest activity levels (greater than 30 pmol/mg of protein/h) in hypothalamic nuclei, substantia grisea cen...

journal_title：Journal of neurochemistry

authors： Meng F,Tsou K

更新日期：1988-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized pathologically by motor neuron degeneration and associated with aggregation of RNA-binding proteins. TATA-binding protein-associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, and clearance of these...

journal_title：Journal of neurochemistry

authors： Choi HJ,Joo Cha S,Do HA,Kim HJ,Lee JW,Kim K

更新日期：2020-09-11 00:00:00

abstract：:Excitotoxicity, caused by exaggerated neuronal stimulation by Glutamate (Glu), is a major cause of neurodegeneration in brain ischemia. While we know that neurodegeneration is triggered by overstimulation of Glu-receptors (GluRs), the subsequent mechanisms that lead to cellular demise remain controversial. Surprisingl...

journal_title：Journal of neurochemistry

authors： Feldmann KG,Chowdhury A,Becker JL,McAlpin N,Ahmed T,Haider S,Richard Xia JX,Diaz K,Mehta MG,Mano I

更新日期：2019-02-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) in the brain striatum has recently been shown to bind at a putatively vesicular site labeled by [3H]tyramine ([3H]TY). Whereas in the rat and mouse striatum MPP+ antagonized TY binding competitively, in the cerebellum there was a mixed-type antagonism, which sugges...

journal_title：Journal of neurochemistry

authors： Vaccari A,Saba PL,Gessa GL,Del Zompo M

更新日期：1993-02-01 00:00:00

abstract：:We have synthesized and characterized a series of novel fluorescently labeled ligands with high affinity and specificity for D1 and D2 dopamine receptors. D1-selective probes were synthesized using (R,S)-5-(4'-aminophenyl)-8-chloro-2,3,4,5-tetrahydro-3-methyl- [1H]-3-benzazepin-7-ol, the 4'-amino derivative of the hig...

journal_title：Journal of neurochemistry

authors： Monsma FJ Jr,Barton AC,Kang HC,Brassard DL,Haugland RP,Sibley DR

更新日期：1989-05-01 00:00:00

abstract：:Gangliosides administered exogenously are well-known effectors of differentiation in many neuroblastoma lines and primary neuronal cultures. Previous studies suggested the phosphoinositide signaling mechanism could be a contributing factor. We have found that treatment of Neuro-2A cells with bovine brain ganglioside m...

journal_title：Journal of neurochemistry

authors： Vaswani KK,Wu GS,Ledeen RW

更新日期：1990-08-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) receptor (PAC1R) is a class B Gprotein-coupled receptor (GPCR) that is widely expressed in the human body and is involved in neuronal differentiation. As class B GPCRs are known to form heterocomplexes with family members, we hypothesized that PAC1R mediates neuro...

journal_title：Journal of neurochemistry

authors： Ke R,Lok SIS,Singh K,Chow BKC,Lee LTO

更新日期：2020-10-20 00:00:00

abstract：:Oxidative stress may play a crucial role in age-related neurodegenerative disorders. Here, we examined the ability of two antioxidants, alpha-lipoic acid (LA) and N-acetylcysteine (NAC), to reverse the cognitive deficits found in the SAMP8 mouse. By 12 months of age, this strain develops elevated levels of Abeta and s...

journal_title：Journal of neurochemistry

authors： Farr SA,Poon HF,Dogrukol-Ak D,Drake J,Banks WA,Eyerman E,Butterfield DA,Morley JE

更新日期：2003-03-01 00:00:00

abstract：:Protein aggregation is a common feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. How protein aggregates are formed and contribute to neurodegeneration, however, is not clear. Mutation of Ubiquilin 2 (UBQLN2) has recently been linked to ...

journal_title：Journal of neurochemistry

authors： Xia Y,Yan LH,Huang B,Liu M,Liu X,Huang C

更新日期：2014-04-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the extracellular levels of taurine and on excitability in the dentate gyrus were studied in anesthetized rats by the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode with Krebs-Ringer-bicarbonate or GABA solutions. Amino acid contents in pe...

journal_title：Journal of neurochemistry

authors： Lerma J,Herranz AS,Herreras O,Muñoz D,Solís JM,del Río RM,Delgado JM

更新日期：1985-03-01 00:00:00

abstract：:To examine the effects of glutamatergic neurotransmission on amyloid processing, we stably expressed the metabotropic glutamate receptor subtype 1alpha (mGlu-R1alpha) in HEK 293 cells. Both glutamate and the selective metabotropic agonist 1-amino-1,3-cyclopentanedicarboxylic acid (ACPD) rapidly increased phosphatidyli...

journal_title：Journal of neurochemistry

authors： Nitsch RM,Deng A,Wurtman RJ,Growdon JH

更新日期：1997-08-01 00:00:00

abstract：:Since emotional stress elicits brain activation, mitochondria should be a key component of stressed brain response. However, few studies have focused on mitochondria functioning in these conditions. In this work, we aimed to determine the effects of an acute restraint stress on rat brain mitochondrial functions, with ...

journal_title：Journal of neurochemistry

authors： Batandier C,Poulet L,Hininger I,Couturier K,Fontaine E,Roussel AM,Canini F

更新日期：2014-11-01 00:00:00