Neuropeptide Y in frontal cortex is not altered in major depression.


:Previously, we reported a modest but significant reduction in the concentration of neuropeptide Y in frontal cortices from victims of suicide relative to age-matched natural or accidental death control subjects. The reduction in neuropeptide Y appeared to be greatest in a subgroup of victims of suicide for which there was indirect evidence of histories of depression. We pursued these initial findings in the present study by measuring neuropeptide Y concentrations in frontal cortices from natural or accidental death control subjects and from suicide victims in whom a firm diagnosis of major depression was established by psychiatric autopsy. Because several subjects with major depression had a comorbid diagnosis of alcoholism, a group of victims of suicide that had an Axis I diagnosis of alcohol dependence was also studied. No significant differences in neuropeptide Y concentrations were observed between control subjects and victims of suicide with major depression or victims of suicide with alcohol dependence. These findings do not support a role for neuropeptide Y in major depression.


J Neurochem


Ordway GA,Stockmeier CA,Meltzer HY,Overholser JC,Jaconetta S,Widdowson PS




Has Abstract


1995-10-01 00:00:00












  • Tissue distribution, metabolism, anticonvulsant efficacy and effect on brain amino acid levels of the glia-selective gamma-aminobutyric acid transport inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol in mice and chicks.

    abstract::Using tritium-labelled 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO) its tissue distribution and metabolism were investigated in adult mice and 4-day-old chicks after systemic administration of the drug. It was found not to be significantly metabolized in the brain since metabolites of THPO corresponding to on...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Schousboe A,Hjeds H,Engler J,Krogsgaard-Larsen P,Wood JD

    更新日期:1986-09-01 00:00:00

  • Determination of the equilibrium dissociation constants and number of glycine binding sites in several areas of the rat central nervous system, using a sodium-independent system.

    abstract::Parameters affecting the binding of [3H]glycine to membrane fractions isolated from the cerebral cortex, midbrain, cerebellum, medulla oblongata, and spinal cord of the rat were investigated in a Na+-free medium. A [3H]glycine binding assay was established in which the binding was specific, saturable, pH-sensitive, an...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Kishimoto H,Simon JR,Aprison MH

    更新日期:1981-10-01 00:00:00

  • Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis.

    abstract::Multiple sclerosis (MS) pathology is marked by the massive infiltration of myelin-specific T cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro-inflammatory Th1/Th17 cells that predominate over immunoregulatory Th2/Treg cells. Neurodegeneration, a major factor in progressive MS, is ofte...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Trager N,Smith A,Wallace Iv G,Azuma M,Inoue J,Beeson C,Haque A,Banik NL

    更新日期:2014-07-01 00:00:00

  • D-Aspartate as a putative cell-cell signaling molecule in the Aplysia californica central nervous system.

    abstract::The content, synthesis and transport of D-aspartate (D-Asp) in the CNS of Aplysia californica is investigated using capillary electrophoresis (CE) with both laser-induced fluorescence and radionuclide detection. Millimolar concentrations of D-Asp are found in various regions of the CNS. In the cerebral ganglion, three...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Miao H,Rubakhin SS,Scanlan CR,Wang L,Sweedler JV

    更新日期:2006-04-01 00:00:00

  • Phosphorylation of neuronal kinesin heavy and light chains in vivo.

    abstract::The microtubule-based motor protein kinesin is thought to drive anterograde organelle transport in axons, but nothing is known about how its force-generating activity or organelle-binding properties are regulated. Studies in other motility systems suggest that protein phosphorylation is a reasonable candidate for this...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Hollenbeck PJ

    更新日期:1993-06-01 00:00:00

  • Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro.

    abstract::Fascin-1 is a putative bundling factor of actin filaments in the filopodia of neuronal growth cones. Here, we examined the structure of the actin bundle formed by human fascin-1 (actin/fascin bundle), and its mode of interaction with myosin in vitro. The distance between cross-linked filaments in the actin/bundle was ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Ishikawa R,Sakamoto T,Ando T,Higashi-Fujime S,Kohama K

    更新日期:2003-11-01 00:00:00

  • Effects of chronic nicotine infusion on kinetics of high-affinity nicotine binding.

    abstract::It is well established that chronic nicotine treatment produces a dose-dependent increase in high-affinity L-[3H]nicotine binding. This increase may be due to chronic desensitization of the receptor. Sophisticated kinetic analyses of high-affinity nicotine binding to rat brain have demonstrated that the association ra...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Bhat RV,Marks MJ,Collins AC

    更新日期:1994-02-01 00:00:00

  • Desensitization of muscarinic receptor-coupled phosphoinositide hydrolysis in rat hippocampus: comparisons with the alpha 1-adrenergic response.

    abstract::In the presence of lithium, carbamylcholine chloride (carbachol) and epinephrine increase the accumulation of inositol monophosphate severalfold in hippocampal slices from the rat. The stimulation by carbachol (EC50, 31 microM) is mediated by muscarinic receptors, whereas the effects of epinephrine (EC50, 2 microM) ar...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Lenox RH,Hendley D,Ellis J

    更新日期:1988-02-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP.

    abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) and tissue plasminogen activator (tPA) play important roles in neuronal migration and survival. However, a direct link between the neurotrophic effects of PACAP and tPA has never been investigated. In this study, we show that, in PC12 cells, PACAP induced a 9....

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Raoult E,Roussel BD,Bénard M,Lefebvre T,Ravni A,Ali C,Vivien D,Komuro H,Fournier A,Vaudry H,Vaudry D,Galas L

    更新日期:2011-12-01 00:00:00

  • Expression of multiple AQP4 pools in the plasma membrane and their association with the dystrophin complex.

    abstract::Altered aquaporin-4 (AQP4) expression has been reported in brain edema, tumors, muscular dystrophy, and neuromyelitis optica. However, the plasma membrane organization of AQP4 and its interaction with proteins such as the dystrophin-associated protein complex are not well understood. In this study, we used sucrose den...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Nicchia GP,Cogotzi L,Rossi A,Basco D,Brancaccio A,Svelto M,Frigeri A

    更新日期:2008-06-01 00:00:00

  • An in vivo kinetic model with L-[35S]methionine for the determination of local cerebral rates for methionine incorporation into protein in the rat.

    abstract::A method has been developed for the simultaneous in vivo measurement of local rates for methionine incorporation into cerebral protein in the rat. It is based on the use of L-[35S]methionine as a tracer for reflecting the bidirectional exchange of methionine between plasma and brain and its incorporation into cerebral...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Lestage P,Gonon M,Lepetit P,Vitte PA,Debilly G,Rossatto C,Lecestre D,Bobillier P

    更新日期:1987-02-01 00:00:00

  • Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells.

    abstract::Parkinson's disease is a debilitating neurodegenerative disease characterized by loss of midbrain dopaminergic neurons. These neurons are particularly sensitive to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which causes parkinsonian ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Chu CT,Zhu JH,Cao G,Signore A,Wang S,Chen J

    更新日期:2005-09-01 00:00:00

  • Rosiglitazone up-regulates glial fibrillary acidic protein via HB-EGF secreted from astrocytes and neurons through PPARγ pathway and reduces apoptosis in high-fat diet-fed mice.

    abstract::The anti-diabetic drug and peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, rosiglitazone, alters astrocyte activation; however, its mechanism remains less-known. We hypothesized participation of epidermal growth factor receptor (EGFR), known to control astrocyte reactivity. We first detected that ros...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Kushwaha R,Mishra J,Gupta AP,Gupta K,Vishwakarma J,Chattopadhyay N,Gayen JR,Kamthan M,Bandyopadhyay S

    更新日期:2019-06-01 00:00:00

  • Glycosylation of proteins in developing human brain.

    abstract::The carbohydrate content of human brain glycoproteins was studied during development from the age of 12 fetal weeks to 8 postnatal months. The concentration of all the glycoprotein monosaccharides increased with age. The total amount of glycoprotein monosaccharides per lipid-free dry tissue increased by about 150% fro...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Korpeinen T,Mononen I,Krusius T,Järnefelt J

    更新日期:1982-12-01 00:00:00

  • Niemann-Pick type C disease: cellular pathology and pharmacotherapy.

    abstract::Niemann-Pick type C disease (NPCD) was first described in 1914 and affects approximately 1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver, spleen, motor control, and brain; premature death invariably results. Its molecular origins were traced, as late as 1997, to a protein o...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Wheeler S,Sillence DJ

    更新日期:2020-06-01 00:00:00

  • Netrin-1-independent adenosine A2b receptor activation regulates the response of axons to netrin-1 by controlling cell surface levels of UNC5A receptors.

    abstract::Growth cone response to the bifunctional guidance cue netrin-1 is regulated by the activity of intracellular signaling intermediates such as protein kinase C-alpha (PKCalpha) and adenylyl cyclase. Among the diverse cellular events these enzymes regulate is receptor trafficking. Netrin-1, itself, may govern the activit...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: McKenna WL,Wong-Staal C,Kim GC,Macias H,Hinck L,Bartoe JL

    更新日期:2008-02-01 00:00:00

  • Analysis on the promoter region of exon IV brain-derived neurotrophic factor in NG108-15 cells.

    abstract::We have reported that the nuclear isoforms of Ca2+/calmodulin-dependent protein kinase II (CaM KII) are involved in the expression of the exon IV-containing brain-derived neurotrophic factor (BDNF) mRNA. We document here the cis-elements and transcription factors responsive to CaM KII in the activation of the promoter...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Takeuchi Y,Miyamoto E,Fukunaga K

    更新日期:2002-10-01 00:00:00

  • Nidogen is a prosurvival and promigratory factor for adult Schwann cells.

    abstract::Schwann cells provide a favorable microenvironment for successful regeneration of the injured peripheral nerve. Even though the roles of extracellular matrix proteins in the Schwann cell physiology have long been studied, the precise function of nidogen, a ubiquitous component of the basal lamina, in Schwann cells is ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Lee HK,Seo IA,Park HK,Park YM,Ahn KJ,Yoo YH,Park HT

    更新日期:2007-08-01 00:00:00

  • Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk.

    abstract::Excitotoxicity mediated via the (S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtype of receptor for l-glutamate contributes to various neuropathologies involving acute brain injury and chronic degenerative disorders. In this study, AMPA-induced neuronal injury and staurosporine (STS)-mediated apopt...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Beart PM,Lim ML,Chen B,Diwakarla S,Mercer LD,Cheung NS,Nagley P

    更新日期:2007-12-01 00:00:00

  • Opposing contributions of NR1 and NR2 to protein kinase C modulation of NMDA receptors.

    abstract::N-Methyl-D-aspartate (NMDA) receptors mediate increases in intracellular calcium that can be modulated by protein kinase C (PKC). As PKC modulation of NMDA receptors in neurons is complex, we studied the effects of PKC activation on recombinant NMDA receptor-mediated calcium rises in a nonneuronal mammalian cell line,...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Grant ER,Bacskai BJ,Anegawa NJ,Pleasure DE,Lynch DR

    更新日期:1998-10-01 00:00:00

  • Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism.

    abstract::The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine-synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Sacchetti P,Mitchell TR,Granneman JG,Bannon MJ

    更新日期:2001-03-01 00:00:00

  • Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase (ERK-2) and p70 S6 kinase signaling systems.

    abstract::Little is known about the coupling of serotonin 5-HT1B receptors to cellular signals other than cyclic AMP. In the present studies, the activation by 5-HT1B receptors of p70 S6 kinase and the mitogen-activated protein kinase (MAP kinase) ERK-2 was investigated. Studies were performed by using both nontransfected Chine...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Pullarkat SR,Mysels DJ,Tan M,Cowen DS

    更新日期:1998-09-01 00:00:00

  • Nuclear sialyl cholesterol causes changes in the structure of chromatin and its transcription level followed by the promotion of neuritogenesis.

    abstract::Exogenously added sialyl cholesterol (SC) induced neuritogenesis and accumulated in the nuclear fraction of a mouse neuroblastoma cell line, Neuro2a, as reported elsewhere. To clarify the significance of nuclear SC, we examined the structure of chromatin and its transcriptional level. The chromatin of SC-treated cells...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Yamashita T,Tsuji S

    更新日期:1992-04-01 00:00:00

  • Brain edema induced by in vitro ischemia: causal factors and neuroprotection.

    abstract::Decreased cerebral blood flow, hence decreased oxygen and glucose, leads to ischemic brain injury via complex pathophysiological events, including excitotoxicity, mitochondrial dysfunction, increased intracellular Ca2+, and reactive oxygen species (ROS) generation. Each of these could also contribute to cerebral edema...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: MacGregor DG,Avshalumov MV,Rice ME

    更新日期:2003-06-01 00:00:00

  • Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism.

    abstract::We designed as candidate metabolites and synthesized two 1-benzyl-1,2,3,4-tetrahydroisoquinoline derivatives containing a dopamine moiety: 1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline (3',4'DHBnTIQ) and 1-benzyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (6,7DHBnTIQ). Both were detected in mouse brain as...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Kawai H,Makino Y,Hirobe M,Ohta S

    更新日期:1998-02-01 00:00:00

  • Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation.

    abstract::We have characterised the induction of the mitogen-inducible form of cyclooxygenase, COX-2, in the rat cerebral cortex in response to excitotoxin injection into the nucleus basalis. This model is associated with intense stimulation of the ascending pathway to the cerebral cortex, seizure activity, and subsequent ipsil...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Adams J,Collaço-Moraes Y,de Belleroche J

    更新日期:1996-01-01 00:00:00

  • Cholesterol esterifying enzyme in normal and degenerating peripheral nerve.

    abstract::The cholesterol esterifying enzyme which incorporates exogenous free [1-14C]oleate into cholesteryl ester is present in rat sciatic endoneurium. Cholesterol esterification is optimal at pH 4.8. Exogenous ATP, CoA, and oleyl-CoA do not greatly affect its activity. Various detergents and bile salts are inhibitory. Enzym...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Yao JK,Dyck PJ

    更新日期:1981-07-01 00:00:00

  • Kainate-induced apoptosis in cultured murine cerebellar granule cells elevates expression of the cell cycle gene cyclin D1.

    abstract::Recent evidence suggests that neuronal apoptosis is the consequence of an inappropriate reentry into the cell cycle. Expression of the cell cycle gene cyclin D1, a G1-phase cell cycle regulator, was examined in primary cultures of murine cerebellar granule cells (CGCs) during kainate (KA)-mediated apoptosis. Using cul...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Giardina SF,Cheung NS,Reid MT,Beart PM

    更新日期:1998-09-01 00:00:00

  • Rapid internalization and intracellular metabolic processing of exogenous ganglioside by cerebellar granule cells differentiated in culture.

    abstract::Ganglioside GM1, tritiated at the level of the long chain base (sphingosine) [( Sph-3H]GM1), sialic acid (N-acetylneuraminic acid) [( NeuAc-3H]GM1), or terminal galactose [( Gal-3H]GM1) was supplied to cerebellar granule cells differentiated in vitro, and its metabolic processing was followed with pulse time. Using [S...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Riboni L,Tettamanti G

    更新日期:1991-12-01 00:00:00

  • TRPV1-tubulin complex: involvement of membrane tubulin in the regulation of chemotherapy-induced peripheral neuropathy.

    abstract::Existence of microtubule cytoskeleton at the membrane and submembranous regions, referred as 'membrane tubulin' has remained controversial for a long time. Since we reported physical and functional interaction of Transient Receptor Potential Vanilloid Sub Type 1 (TRPV1) with microtubules and linked the importance of T...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Goswami C

    更新日期:2012-10-01 00:00:00