Neuropeptide Y in frontal cortex is not altered in major depression.

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:The effect of N-methyl-D-aspartate (NMDA) receptor antagonists on cell viability was studied in rat primary cortical cells. NMDA antagonists [MK-801 and 2-amino-5-phosphonovalerate (APV)] induced cell shrinkage, nuclear condensation or fragmentation, and internucleosomal DNA fragmentation. Treatment of cells with MK-8...

journal_title：Journal of neurochemistry

authors： Takadera T,Matsuda I,Ohyashiki T

更新日期：1999-08-01 00:00:00

abstract：:ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of painful stimuli and are modulated by extracellular algogenic substances, via changes in the receptor phosphorylation state. The present study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in interacti...

journal_title：Journal of neurochemistry

authors： Gnanasekaran A,Sundukova M,Hullugundi S,Birsa N,Bianchini G,Hsueh YP,Nistri A,Fabbretti E

更新日期：2013-07-01 00:00:00

abstract：:We have identified a novel mouse gene named pancortin that is expressed dominantly in the mature cerebral cortex. This gene produces four different species of proteins, Pancortin-1-4, sharing a common region in the middle of their structure with two variations at the N-terminal (A1 or A2 part) and C-terminal (C1 or C2...

journal_title：Journal of neurochemistry

authors： Nagano T,Nakamura A,Konno D,Kurata M,Yagi H,Sato M

更新日期：2000-07-01 00:00:00

abstract：:The activities of choline acetyltransferase (CAT) and glutamic acid decarboxylase (GAD), markers of cholinergic and GABAergic terminals, were measured in growing and adult Gunn rats, which possess an autosomal recessive gene for jaundice or kernicterus. In the olfactory tubercle, hippocampus, neostriatum, thalamus, an...

journal_title：Journal of neurochemistry

authors： Ohno T

更新日期：1981-10-01 00:00:00

abstract：:Complementary DNAs that encode two forms of the chicken gamma-aminobutyric acid type A (GABAA) receptor beta 2 subunit have been isolated. These polypeptides differ by the presence of (beta 2L) or absence (beta 2S) of 17 amino acids, which contain a possible target for phosphorylation by protein kinase C, in the large...

journal_title：Journal of neurochemistry

authors： Harvey RJ,Chinchetru MA,Darlison MG

更新日期：1994-01-01 00:00:00

abstract：:GD3 synthase (Sial-T2) is a key enzyme of ganglioside synthesis that, in concert with GM2 synthase (GalNAc-T), regulates the ratio of a- and b-pathway gangliosides. In this work, we study the sub-Golgi location of an epitope-tagged version of chicken Sial-T2 transfected to CHO-K1 cells. The expressed protein was enzym...

journal_title：Journal of neurochemistry

authors： Daniotti JL,Martina JA,Giraudo CG,Zurita AR,Maccioni HJ

更新日期：2000-04-01 00:00:00

abstract：:The effect of a unilateral perinatal hypoxic-ischemic brain injury on dopamine D1 and D2 receptors and uptake sites was investigated in rats by using in vitro quantitative binding autoradiography, 2-3 weeks after the insult. We observed significant decreases in the Bmax and KD for [3H]SCH 23390-labeled D1 and in the B...

journal_title：Journal of neurochemistry

authors： Przedborski S,Kostic V,Jackson-Lewis V,Cadet JL,Burke RE

更新日期：1991-12-01 00:00:00

abstract：:Patients with cancer cachexia often suffer from psychiatric disorders. In the present study, we investigated the changes in monoaminergic activities in the brain in tumor-bearing mice with reference to the development of cachexia. Two clones, clone-5 (noncachectic clone) and clone-20 (cachectic clone), derived from th...

journal_title：Journal of neurochemistry

authors： Uomoto M,Nishibori M,Nakaya N,Takeuchi Y,Iwagaki H,Tanaka N,Saeki K

更新日期：1998-01-01 00:00:00

abstract：:Carbamylcholine stimulated phospholipase C activity in astrocytes in primary culture from the mesencephalon but not from the striatum or cerebral cortex of the mouse embryo. An alpha 1-adrenergic-mediated response was observed in all astrocyte populations. 2-Chloroadenosine potentiated the alpha 1-adrenergic response ...

journal_title：Journal of neurochemistry

authors： el-Etr M,Cordier J,Torrens Y,Glowinski J,Prémont J

更新日期：1989-03-01 00:00:00

abstract：:This study investigated the temporal expression and cell subtype distribution of activated caspase-3 following cortical impact-induced traumatic brain injury in rats. The animals were killed and examined for protein expression of the proteolytically active subunit of caspase-3, p18, at intervals from 6 h to 14 days af...

journal_title：Journal of neurochemistry

authors： Beer R,Franz G,Srinivasan A,Hayes RL,Pike BR,Newcomb JK,Zhao X,Schmutzhard E,Poewe W,Kampfl A

更新日期：2000-09-01 00:00:00

abstract：:The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y(12) by extracellular ATP. We recently showed that P2Y(12) stimulation by ATP induces microglial process extension in collagen gels. In the present study, we found that a P2Y(12) agonis...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Sanagi T,Nakamura Y,Suzuki E,Inoue K,Kohsaka S

更新日期：2012-04-01 00:00:00

abstract：:[3H]Ouabain binding was studied in sections of rabbit somatosensory cortex by quantitative autoradiography and in rabbit brain microsomal membranes using a conventional filtration assay. KD values of 8-12 nM for specific high-affinity binding of [3H]ouabain were found by both methods. High-affinity binding was not uni...

journal_title：Journal of neurochemistry

authors： Antonelli MC,Baskin DG,Garland M,Stahl WL

更新日期：1989-01-01 00:00:00

abstract：:The release of gamma-aminobutyric acid (GABA) was studied in slices of the head of the rabbit caudate nucleus. The slices were preincubated with [3H]GABA and then superfused. Aminooxyacetic acid was present throughout. Both the tritium in the slices and that in the superfusate consisted practically entirely of [3H]GAB...

journal_title：Journal of neurochemistry

authors： Limberger N,Späth L,Starke K

更新日期：1986-04-01 00:00:00

abstract：:Cystatin C, a well-established biomarker of renal function, has been associated with a protective effect against stroke. However, the potential neuroprotective mechanism of cystatin C in ischemic brain injury remains unclear. Our study hypothesized that cystatin C can ameliorate blood-brain barrier (BBB) disruption by...

journal_title：Journal of neurochemistry

authors： Yang B,Xu J,Chang L,Miao Z,Heang D,Pu Y,Zhou X,Zhang L,Xie H

更新日期：2020-05-01 00:00:00

abstract：:Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down-regulation by antidepressants of the noradrenergic cyclic AMP-generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade ...

journal_title：Journal of neurochemistry

authors： Janowsky A,Steranka LR,Gillespie DD,Sulser F

更新日期：1982-07-01 00:00:00

abstract：:Galanin is a recently isolated neuropeptide that is of particular interest in dementing disorders because of its known colocalization with choline acetyltransferase in magnocellular neurons of the basal nucleus of Meynert. These neurons degenerate in Alzheimer's disease, and there is a corresponding deficiency of cort...

journal_title：Journal of neurochemistry

authors： Beal MF,Clevens RA,Chattha GK,MacGarvey UM,Mazurek MF,Gabriel SM

更新日期：1988-12-01 00:00:00

abstract：:A neutral, mannose-rich, concanavalin A (Con A)-binding glycopeptide fraction was obtained by proteolytic digestion of defatted beef brain tissue. Hydrazinolysis followed by gel filtration of the reaction products provided three oligosaccharides. A portion of each oligosaccharide was treated by exhaustive digestion wi...

journal_title：Journal of neurochemistry

authors： Somawardhana CW,Brunngraber EG

更新日期：1983-08-01 00:00:00

abstract：:Thiamine (vitamin B1) deficiency (TD) causes mild and chronic impairment of oxidative metabolism and induces neuronal death in specific brain regions. The mechanisms underlying TD-induced cell death, however, remain unclear. The double-stranded RNA-activated protein kinase (PKR), has been well known for its anti-viral...

journal_title：Journal of neurochemistry

authors： Wang X,Fan Z,Wang B,Luo J,Ke ZJ

更新日期：2007-12-01 00:00:00

abstract：:We studied whether microtubule organization is important for actions of ethanol on GABAA ergic responses by testing the effects of microtubule depolymerization on ethanol enhancement of GABA action in mouse L(tk-) cells stably transfected with GABAA receptor alpha 1 beta 1 gamma 2L subunits. The microtubule-disrupting...

journal_title：Journal of neurochemistry

authors： Whatley VJ,Brozowski SJ,Hadingham KL,Whiting PJ,Harris RA

更新日期：1996-03-01 00:00:00

abstract：:The formation and refinement of synaptic connections are key steps of neural development to establish elaborate brain networks. To investigate the functional role of protein tyrosine phosphatase (PTP) σ, we employed an olfactory sensory neuron (OSN)-specific gene manipulation system in combination with in vivo imaging...

journal_title：Journal of neurochemistry

authors： Chen X,Yoshida T,Sagara H,Mikami Y,Mishina M

更新日期：2011-11-01 00:00:00

abstract：:Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures. The extracellular signal-regulated kinase (ERK) signaling cascade is activated by M(1) mAChR and is elevated during status epi...

journal_title：Journal of neurochemistry

authors： Berkeley JL,Decker MJ,Levey AI

更新日期：2002-07-01 00:00:00

abstract：:Limited information is available on the identity of antigens targeted by antibodies present in cerebrospinal fluid (CSF) of patients with clinically isolated syndrome (CIS). The aim of this study was to identify novel antigens for CIS and investigate their prognostic potential to predict conversion to multiple scleros...

journal_title：Journal of neurochemistry

authors： Rouwette M,Somers K,Govarts C,De Deyn PP,Hupperts R,Van Wijmeersch B,De Jong BA,Verbeek MM,Van Pesch V,Sindic C,Villar LM,Álvarez-Cermeño JC,Stinissen P,Somers V

更新日期：2012-11-01 00:00:00

abstract：:Electrical stimulation of an ascending path of the locus ceruleus-norepinephrine system was used to elicit release of norepinephrine at noradrenergic terminal fields of the rat thalamus. Overflow into the extracellular fluid space was measured by fast in vivo chronoamperometry. At pretreated carbon fibers, the electro...

journal_title：Journal of neurochemistry

authors： Ghasemzadeh MB,Capella P,Mitchell K,Adams RN

更新日期：1993-02-01 00:00:00

abstract：:The current study used an ethanol antagonist, increased atmospheric pressure, to test the hypothesis that ethanol acts on multiple sites in glycine receptors (GlyRs). The effects of 12 times normal atmospheric pressure of helium-oxygen gas (pressure) on ethanol-induced potentiation of GlyR function in Xenopus oocytes ...

journal_title：Journal of neurochemistry

authors： Davies DL,Crawford DK,Trudell JR,Mihic SJ,Alkana RL

更新日期：2004-06-01 00:00:00

abstract：:Caspase cleavage of amyloid precursor protein (APP) has been reported to be important in amyloid beta protein (Aβ)-mediated neurotoxicity. However, the underlying mechanisms are not clearly understood. In this study, we explored the effect of caspase cleavage of APP on tau phosphorylation in relation to Aβ. We found t...

journal_title：Journal of neurochemistry

authors： Park SS,Jung HJ,Kim YJ,Park TK,Kim C,Choi H,Mook-Jung IH,Koo EH,Park SA

更新日期：2012-12-01 00:00:00

abstract：:We sought to investigate whether dexamethasone produces a coordinated, time-dependent effect on all enzymes in the catecholamine biosynthetic pathway in PC12 cells. The levels of mRNAs of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and dopamine beta-hydroxylase (DBH) were examined at 0, 6, 1...

journal_title：Journal of neurochemistry

authors： Kim KT,Park DH,Joh TH

更新日期：1993-03-01 00:00:00

abstract：:Existence of microtubule cytoskeleton at the membrane and submembranous regions, referred as 'membrane tubulin' has remained controversial for a long time. Since we reported physical and functional interaction of Transient Receptor Potential Vanilloid Sub Type 1 (TRPV1) with microtubules and linked the importance of T...

journal_title：Journal of neurochemistry

authors： Goswami C

更新日期：2012-10-01 00:00:00

abstract：:Vinpocetine is a neuroprotective drug that exerts beneficial effects on neurological symptoms and cerebrovascular disease. 3-nitropropionic acid (3-NPA) is a toxin that irreversibly inhibits succinate dehydrogenase, the mitochondrial enzyme that acts in the electron transport chain at complex II. In previous studies i...

journal_title：Journal of neurochemistry

authors： Herrera-Mundo N,Sitges M

更新日期：2013-01-01 00:00:00

abstract：:Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral pain. In this study, chronic visceral pain animal model was...

journal_title：Journal of neurochemistry

authors： Liu SB,Wang XS,Yue J,Yang L,Li XH,Hu LN,Lu JS,Song Q,Zhang K,Yang Q,Zhang MM,Bernabucci M,Zhao MG,Zhuo M

更新日期：2020-04-01 00:00:00