Neuropeptide Y in frontal cortex is not altered in major depression.

Abstract:

:Previously, we reported a modest but significant reduction in the concentration of neuropeptide Y in frontal cortices from victims of suicide relative to age-matched natural or accidental death control subjects. The reduction in neuropeptide Y appeared to be greatest in a subgroup of victims of suicide for which there was indirect evidence of histories of depression. We pursued these initial findings in the present study by measuring neuropeptide Y concentrations in frontal cortices from natural or accidental death control subjects and from suicide victims in whom a firm diagnosis of major depression was established by psychiatric autopsy. Because several subjects with major depression had a comorbid diagnosis of alcoholism, a group of victims of suicide that had an Axis I diagnosis of alcohol dependence was also studied. No significant differences in neuropeptide Y concentrations were observed between control subjects and victims of suicide with major depression or victims of suicide with alcohol dependence. These findings do not support a role for neuropeptide Y in major depression.

journal_name

J Neurochem

authors

Ordway GA,Stockmeier CA,Meltzer HY,Overholser JC,Jaconetta S,Widdowson PS

doi

10.1046/j.1471-4159.1995.65041646.x

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

1646-50

issue

4

eissn

0022-3042

issn

1471-4159

journal_volume

65

pub_type

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