Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain.

abstract：:Preincubation of D384 cells, derived from the human astrocytoma cell line G-CCM, with dopamine resulted in a time-dependent attenuation of cyclic AMP responsiveness to subsequent dopamine stimulation. This effect was agonist specific because the prostaglandin E1 (PGE1) stimulation of cyclic AMP of similarly treated ce...

journal_title：Journal of neurochemistry

authors： Balmforth AJ,Warburton P,Ball SG

更新日期：1990-12-01 00:00:00

abstract：:The levels of mRNA encoding glutamic acid decarboxylase (GAD) and preproenkephalin (PPE) were measured by Northern blot analysis, in the dorsal and the ventral part of the striatum, following long-term treatments with drugs acting selectively on D1 or D2 dopaminergic receptors. Chronic injection of the selective D1 an...

journal_title：Journal of neurochemistry

authors： Caboche J,Vernier P,Julien JF,Rogard M,Mallet J,Besson MJ

更新日期：1991-02-01 00:00:00

abstract：:Rarefaction of the dendritic tree leading to neuronal dysfunction is a hallmark of many neurodegenerative diseases and we have shown previously that heat shock protein B5 (HspB5)/αB-crystallin is able to increase dendritic complexity in vitro. The aim of this study was to investigate if this effect is also present in ...

journal_title：Journal of neurochemistry

authors： Bartelt-Kirbach B,Wiegreffe C,Birk S,Baur T,Moron M,Britsch S,Golenhofen N

更新日期：2020-11-21 00:00:00

abstract：:The presence of 5-hydroxytryptamine was investigated in cultured and propagated cerebrovascular endothelium using immunohistochemistry and high pressure liquid chromatography. These studies demonstrate that the endothelium has the ability to take up and metabolize 5-hydroxytryptamine as well as to synthesize this amin...

journal_title：Journal of neurochemistry

authors： Maruki C,Spatz M,Ueki Y,Nagatsu I,Bembry J

更新日期：1984-08-01 00:00:00

abstract：:The mechanisms of injury-induced apoptosis of neurons within the spinal cord are poorly understood. In this study, we show that spinal cord injury (SCI) induces endoplasmic reticulum stress revealed by the activation of an unbalanced unfolded protein response (UPR). Using a weight-drop contusion model of SCI, the UPR ...

journal_title：Journal of neurochemistry

authors： Penas C,Guzmán MS,Verdú E,Forés J,Navarro X,Casas C

更新日期：2007-08-01 00:00:00

abstract：:We investigated the role of mitogen-activated protein kinase (MAPK) pathways in hypoxic neuronal injury using primary cultures from murine cerebral cortex. Hypoxia caused the death of approximately 50% of neurons at 16 h and approximately 65% of neurons at 24 h. This was associated with phospho-activation of the MAPK/...

journal_title：Journal of neurochemistry

authors： Jin K,Mao XO,Zhu Y,Greenberg DA

更新日期：2002-01-01 00:00:00

abstract：:Rabbit retinas were maintained in a physiological state in vitro and exposed to 0.5-h pulses of labeled leucine. Protein synthesis was determined from incorporation of the label, and degradation from its subsequent release. The retinas were treated as test-control pairs. The control retina remained in darkness while t...

journal_title：Journal of neurochemistry

authors： Ames A 3rd,Parks JM,Nesbett FB

更新日期：1980-07-01 00:00:00

abstract：:Noradrenaline (NA) release and its modulation via presynaptic opioid receptors were studied in rabbit hippocampal slices, which were preincubated with [3H]NA, continuously superfused in the presence of 30 microM cocaine and stimulated electrically. The evoked release of [3H]NA was strongly reduced by the preferential ...

journal_title：Journal of neurochemistry

authors： Jackisch R,Geppert M,Illes P

更新日期：1986-06-01 00:00:00

abstract：:delta 1-Pyrroline, 5-methyl-delta 1-pyrroline, and 5,5-dimethyl-delta 1-pyrroline have been identified as substances metabolized to gamma-aminobutyric acid (GABA), 4-aminopentanoic acid (methylGABA), and 4-amino-4-methylpentanoic acid (dimethylGABA), respectively. An enzyme system residing in the soluble fraction of r...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA,Nayar MS,Stogniew M,Rao KG

更新日期：1982-04-01 00:00:00

abstract：:Carnitine is known to accumulate in brain, therefore transport of carnitine through the blood-brain barrier was studied in an in vitro system using bovine brain capillary endothelial cells (BBCEC) grown on filter inserts in a co-culture system with glial cells. Long-term exposure of BBCEC to carnitine resulted in a hi...

journal_title：Journal of neurochemistry

authors： Berezowski V,Miecz D,Marszałek M,Bröer A,Bröer S,Cecchelli R,Nałecz KA

更新日期：2004-11-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is emerging as a neuronal protein kinase involved in multiple aspects of neurotransmission in both post- and presynaptic compartments. Within the reward/motor circuitry of the basal ganglia, Cdk5 regulates dopamine neurotransmission via phosphorylation of the postsynaptic signal transd...

journal_title：Journal of neurochemistry

authors： Kansy JW,Daubner SC,Nishi A,Sotogaku N,Lloyd MD,Nguyen C,Lu L,Haycock JW,Hope BT,Fitzpatrick PF,Bibb JA

更新日期：2004-10-01 00:00:00

abstract：:Although palmitoylation of the beta(2)-adrenergic receptor (beta(2)AR), as well as its phosphorylation by the cyclic AMP-dependant protein kinase (PKA) and the beta-adrenergic receptor kinase (beta ARK), are known to play important roles in agonist-promoted desensitization, their relative contribution and mutual regul...

journal_title：Journal of neurochemistry

authors： Moffett S,Rousseau G,Lagacé M,Bouvier M

更新日期：2001-01-01 00:00:00

abstract：:Based on our initial finding that the nitric oxide (NO) sensitive fluorochrome diaminofluorescein (DAF) was localized to mitochondria in cultured primary neurons, we investigated whether brain mitochondria produce NO through a mitochondrial NO synthase (mtNOS) enzyme. Isolated brain mitochondria were loaded with DAF a...

journal_title：Journal of neurochemistry

authors： Lacza Z,Horn TF,Snipes JA,Zhang J,Roychowdhury S,Horváth EM,Figueroa JP,Kollai M,Szabó C,Busija DW

更新日期：2004-08-01 00:00:00

abstract：:We measured putrescine levels in minute sites of single rat brains using a sensitive, specific assay involving gas chromatography-mass spectrometry. The putrescine level was measured in 20 sites of single rat brains: three sites in the cerebral cortex, six sites in the hypothalamus, three sites in the basal ganglia, t...

journal_title：Journal of neurochemistry

authors： Noto T,Hasegawa T,Hashimoto H,Nakajima T

更新日期：1987-03-01 00:00:00

abstract：:Phosphoinositide hydrolysis was studied in neurohybrid NCB-20 cells prelabeled with myo-[3H]inositol. Among nearly 20 neurotransmitters and neuromodulators examined, only bradykinin, carbachol, and histamine significantly increased the accumulation of [3H]inositol monophosphate (IP1) in the presence of lithium. The EC...

journal_title：Journal of neurochemistry

authors： Chuang DM,Dillon-Carter O

更新日期：1988-08-01 00:00:00

abstract：:Published evidence has linked glutamate with the pathogenesis of Alzheimer's disease (AD) and the up-regulation of a variety of chemokines, including monocyte chemotactic protein-1 (MCP-1)/chemokine ligand 2, with AD-associated pathological changes. In this study, we assessed the potential molecular basis for the role...

journal_title：Journal of neurochemistry

authors： Lee EO,Park HJ,Kang JL,Kim HS,Chong YH

更新日期：2010-03-01 00:00:00

abstract：:Cue-induced reinstatement of cocaine seeking after self-administration (SA) and extinction relies on glutamate release in the nucleus accumbens core (NAcore), which activates neuronal nitric oxide synthase interneurons. Nitric oxide (NO) is required for structural plasticity in NAcore medium spiny neurons, as well as ...

journal_title：Journal of neurochemistry

authors： Siemsen BM,McFaddin JA,Haigh K,Brock AG,Nan Leath M,Hooker KN,McGonegal LK,Scofield MD

更新日期：2020-06-01 00:00:00

abstract：:Fragile X syndrome (FXS) is caused by the loss of functional fragile X mental retardation protein (FMRP). Loss of FMRP results in an elevated basal protein expression profile of FMRP targeted mRNAs, a loss of local metabotropic glutamate receptor (mGluR)-regulated protein synthesis, exaggerated long-term depression an...

journal_title：Journal of neurochemistry

authors： Schmit TL,Dowell JA,Maes ME,Wilhelm M

更新日期：2013-12-01 00:00:00

abstract：:Mitochondria are important in the pathophysiology of several neurodegenerative diseases, and mitochondrial production of reactive oxygen species (ROS), membrane depolarization, permeability changes and release of apoptogenic proteins are involved in these processes. Following brain insults, cell death often occurs in ...

journal_title：Journal of neurochemistry

authors： Mattiasson G,Friberg H,Hansson M,Elmér E,Wieloch T

更新日期：2003-10-01 00:00:00

abstract：:We have assessed the expression, molecular identification and functional role of Na+ channels (Na(v)) in carotid bodies (CB) obtained from normoxic and chronically hypoxic adult rats. Veratridine evoked release of catecholamines (CA) from an in vitro preparation of intact CBs obtained from normoxic animals, the respon...

journal_title：Journal of neurochemistry

authors： Caceres AI,Obeso A,Gonzalez C,Rocher A

更新日期：2007-07-01 00:00:00

abstract：:Rat brain benzodiazepine receptors have been solubilized by means of the zwitterionic detergent CHAPS under conditions in which the GABA stimulation of [3H]flunitrazepam binding to the benzodiazepine receptors is maintained intact. This stimulation is partially or totally abolished when using other conventional deterg...

journal_title：Journal of neurochemistry

authors： Mernoff ST,Cherwinski HM,Becker JW,de Blas AL

更新日期：1983-09-01 00:00:00

abstract：:Dietary lipids modify brain fatty acid profile, but evidence of their direct effect on neuronal function is sparse. The enthorinal cortex (EC) neurons connecting to the hippocampus play a critical role in learning and memory. Here, we have exposed mice to diets based on canola:soybean oils (40 : 10, g/kg) or safflower...

journal_title：Journal of neurochemistry

authors： Arsenault D,Julien C,Chen CT,Bazinet RP,Calon F

更新日期：2012-07-01 00:00:00

abstract：:Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a s...

journal_title：Journal of neurochemistry

authors： Sztriha L,Joó F,Dux L,Böti Z

更新日期：1987-07-01 00:00:00

abstract：:Methods are described for the determination of sheep spinal cord tissue fluid content and norepinephrine, serotonin, and dopamine concentrations after experimental injury. The amount of tissue fluid varied in different regions of sheep spinal cord following injury. Norepinephrine and serotonin wet weight concentration...

journal_title：Journal of neurochemistry

authors： Hinwood BG,Yeo JD,Kidman AD

更新日期：1980-10-01 00:00:00

abstract：:This study focused on the molecular and pharmacological characterization of muscarinic acetylcholine receptors expressed by progenitors and differentiated oligodendrocytes. We also analyzed the role of muscarinic receptors in regulating downstream signal transduction pathways and the functional significance of recepto...

journal_title：Journal of neurochemistry

authors： Ragheb F,Molina-Holgado E,Cui QL,Khorchid A,Liu HN,Larocca JN,Almazan G

更新日期：2001-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) released from the activated microglia upon neurotropic virus infection may exacerbate the neuronal damage. Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs over-expressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JE...

journal_title：Journal of neurochemistry

authors： Mukherjee S,Akbar I,Kumari B,Vrati S,Basu A,Banerjee A

更新日期：2019-05-01 00:00:00

abstract：:Purkinje cell degeneration (pcd) was first identified in a spontaneous mouse mutant showing cerebellar ataxia. In addition to cerebellar Purkinje cells (PCs), retinal photoreceptors, mitral cells in the olfactory bulb, and a discrete subpopulation of thalamic neurons also degenerate in the mutant brains. The gene resp...

journal_title：Journal of neurochemistry

authors： Zhou L,Hossain MI,Yamazaki M,Abe M,Natsume R,Konno K,Kageyama S,Komatsu M,Watanabe M,Sakimura K,Takebayashi H

更新日期：2018-11-01 00:00:00

abstract：:Activation of the apoptogenic sphingomyelin-dependent signaling pathway in neuronally differentiated PC12 cells with cell-permeant C2-ceramide resulted in a transient and short-lived emission of reactive oxygen species that was maximal 6 h after the beginning of treatment, followed immediately by nuclear translocation...

journal_title：Journal of neurochemistry

authors： France-Lanord V,Brugg B,Michel PP,Agid Y,Ruberg M

更新日期：1997-10-01 00:00:00

abstract：:Using a sensitive perfusion system we have studied the nicotine-induced release of [3H]dopamine ([( 3H]DA) from striatal synaptosomes. Nicotine-evoked release was concentration dependent with an EC50 of 3.8 microM. The response to 1 microM nicotine was comparable to that to 16 mM K+; 10 microM veratridine evoked a lar...

journal_title：Journal of neurochemistry

authors： Rapier C,Lunt GG,Wonnacott S

更新日期：1988-04-01 00:00:00

abstract：:Brain gangliosides from four vertebrate classes (fish, amphibia, aves, and mammalia) were studied by patterns generated with the use of two-dimensional thin-layer chromatography. In an effort to retain possible alkalilabile gangliosides, samples were not base-hydrolyzed. Resultant chromatograms revealed complex patter...

journal_title：Journal of neurochemistry

authors： Hunter GD,Wiegant VM,Dunn AJ

更新日期：1981-10-01 00:00:00