Cerebrovascular endothelial cell culture: metabolism and synthesis of 5-hydroxytryptamine.

abstract：:A central role of iron in the pathogenesis of Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. Recent transcranial ultrasound findings ...

journal_title：Journal of neurochemistry

authors： Berg D,Gerlach M,Youdim MB,Double KL,Zecca L,Riederer P,Becker G

更新日期：2001-10-01 00:00:00

abstract：:rho(1) GABA(C) receptor antagonists inhibit myopia in chick but the site of this effect is not known. The sclera ultimately determines the shape and size of the globe and thus an untested possibility is that GABA agents have a scleral mechanism. Whether rho(1) GABA(C) receptors are expressed and located in chick scler...

journal_title：Journal of neurochemistry

authors： Cheng ZY,Chebib M,Schmid KL

更新日期：2011-07-01 00:00:00

abstract：:Male copulatory behavior in the snail Lymnaea stagnalis is controlled by several types of peptidergic neurons, including a cluster of neurons in the ventral lobe of the right cerebral ganglion that show immunoreactivity to myomodulin-A of Aplysia and innervate the penis complex. We identified structurally myomodulin-A...

journal_title：Journal of neurochemistry

authors： van Golen FA,Li KW,Chen S,Jiménez CR,Geraerts WP

更新日期：1996-01-01 00:00:00

abstract：:The release of endogenous dopamine from the axon terminal field in the nucleus accumbens and from the A10 dopamine cell bodies of conscious rats was measured using intracranial dialysis. Release of dopamine from both areas was calcium-dependent and markedly inhibited by the presence of the D2 agonist, quinpirole, in t...

journal_title：Journal of neurochemistry

authors： Kalivas PW,Duffy P

更新日期：1991-03-01 00:00:00

abstract：:Multiple lines of evidence implicate lysosomes in a variety of pathogenic events that produce neurodegeneration. Genetic mutations that cause specific enzyme deficiencies account for more than 40 lysosomal storage disorders. These mostly pre-adult diseases are associated with abnormal brain development and mental reta...

journal_title：Journal of neurochemistry

authors： Bahr BA,Bendiske J

更新日期：2002-11-01 00:00:00

abstract：:We demonstrate that 1-methyl-4-phenylpyridinium (MPP+) is toxic to chick peripheral sympathetic neurons maintained in culture in the presence of nerve growth factor (NGF). When MPP+ was added to the culture medium at the time the neurons were plated, cell loss after 3 days in culture was evident at concentrations as l...

journal_title：Journal of neurochemistry

authors： Bhave SV,Johannessen JN,Lash LH,Wakade TD,Wakade AR

更新日期：1996-08-01 00:00:00

abstract：:We are very sad that the ISN lost its President Kazuhiro Ikenaka, Professor and Chairman at National Institute for Physiological Sciences (NIPS), Director of Okazaki Institute of Integrative Biology. JNeurochem published an Obituary to value his outstanding achievements: Akio Wanaka et al. (2019) OBITUARY Kazuhiro Ike...

journal_title：Journal of neurochemistry

authors：

更新日期：2019-06-01 00:00:00

abstract：:Specific binding of [3H]granisetron was examined to serotonin 5-HT3 receptors in synaptosomal membranes of rat cerebral cortex between 1 and 37 degrees C. Displacing potencies were determined for 5-HT3 antagonists (granisetron, ondansetron, tropisetron, and d-tubocurarine) and agonists (5-hydroxytryptamine, 2-methyl-5...

journal_title：Journal of neurochemistry

authors： Maksay G

更新日期：1996-07-01 00:00:00

abstract：:The neurochemical profile of a new compound, Lu 19-005 [(+/-)trans-3-(3,4-dichlorophenyl)-N-methyl-1-indanamine hydrochloride], has been investigated. Lu 19-005 is a potent inhibitor of the synaptosomal uptake of 3,4-dihydroxyphenylethylamine (dopamine, DA), noradrenaline (NA), and 5-hydroxytryptamine (5-HT, serotonin...

journal_title：Journal of neurochemistry

authors： Hyttel J,Larsen JJ

更新日期：1985-05-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins that modulate neurotransmitter and G protein signaling. RGS7 and its binding partners Galpha and Gbeta5 are enriched in brain, but biochemical mechanisms governing RGS7/Galpha/Gbeta5 interactions and membrane association are poorly defined....

journal_title：Journal of neurochemistry

authors： Rose JJ,Taylor JB,Shi J,Cockett MI,Jones PG,Hepler JR

更新日期：2000-11-01 00:00:00

abstract：:Recently, a tyrosine hydroxylase (TH)-expressing CNS-derived cell line, CAD, was obtained that is capable of undergoing reversible morphological differentiation. The isolation of the CAD line allowed us to ask whether different DNA regulatory elements direct TH transcription when cells are growing and undifferentiated...

journal_title：Journal of neurochemistry

authors： Lazaroff M,Qi Y,Chikaraishi DM

更新日期：1998-07-01 00:00:00

abstract：:The behavioral and functional significance of the extrasynaptic inhibitory GABA(A) receptors in the brain is still poorly known. We used a transgenic mouse line expressing the GABA(A) receptor alpha6 subunit gene in the forebrain under the Thy-1.2 promoter (Thy1alpha6) mice ectopically expressing alpha6 subunits espec...

journal_title：Journal of neurochemistry

authors： Saarelainen KS,Ranna M,Rabe H,Sinkkonen ST,Möykkynen T,Uusi-Oukari M,Linden AM,Lüddens H,Korpi ER

更新日期：2008-04-01 00:00:00

abstract：:The in vitro and ex vivo effects of lithium on muscarinic cholinergic inositol phospholipid hydrolysis and muscarinic cholinergic inhibition of dopamine D1-receptor-stimulated cyclic AMP formation were examined in rat brain slices. Following chronic lithium feeding, carbachol-stimulated inositol phosphate accumulation...

journal_title：Journal of neurochemistry

authors： Whitworth P,Kendall DA

更新日期：1989-08-01 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is expressed in myelin oligodendrocytes and co-localizes with myelin basic protein (MBP). Alternative splicing of DDR1 generates five isoforms designated DDR1a-e. The MBP mRNA contains an hnRNP A2 response element (A2RE) sequence that is recognized by heterogeneous nuclear ribonucleo...

journal_title：Journal of neurochemistry

authors： Roig B,Moyano S,Martorell L,Costas J,Vilella E

更新日期：2012-02-01 00:00:00

abstract：:High-affinity binding sites (apparent KD = 1.5 nM) for [3H]desipramine have been demonstrated and characterized in membranes prepared from rat brain. The binding of [3H]desipramine was found to be saturable, reversible, heat-sensitive, sodium-dependent, and regionally distributed among various regions of the brain. Hi...

journal_title：Journal of neurochemistry

authors： Rehavi M,Skolnick P,Brownstein MJ,Paul SM

更新日期：1982-04-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:The phosphorylation of microtubule-associated protein 2 (MAP2) by four different kinases was studied in vitro to determine whether MAP2 is phosphorylated in its tubulin binding region or in the microtubule projection portion. Fragments corresponding to both regions of MAP2 were produced not only by chymotrypsin or try...

journal_title：Journal of neurochemistry

authors： Hernández MA,Wandosell F,Avila J

更新日期：1987-01-01 00:00:00

abstract：:Nociception evoked prostaglandin (PG) release in the spinal cord considerably contributes to the induction of hyperalgesia and allodynia. To evaluate the relative contribution of cyclooxygenase-1 (COX-1) and COX-2 in this process we assessed the effects of the selective COX-1 inhibitor SC560 and the selective COX-2 in...

journal_title：Journal of neurochemistry

authors： Tegeder I,Niederberger E,Vetter G,Bräutigam L,Geisslinger G

更新日期：2001-11-01 00:00:00

abstract：:The ability of cholinergic vesicles to incorporate acetylcholine (ACh) was studied using highly purified synaptic vesicles from Torpedo electric organ. Depleted vesicles were capable of rapidly taking up exogenous ACh. Evidence that this represented true incorporation was that labelled ACh comigrated with vesicular AT...

journal_title：Journal of neurochemistry

authors： Diebler MF,Morot-Gaudry Y

更新日期：1981-08-01 00:00:00

abstract：:Drebrin is a well-known side-binding protein of F-actin in the brain. Immunohistochemical data suggest that the peripheral parts of growing axons are enriched in the drebrin E isoform and mature axons are not. It has also been observed that drebrin E is concentrated in the growth cones of PC12 cells. These data strong...

journal_title：Journal of neurochemistry

authors： Mizui T,Kojima N,Yamazaki H,Katayama M,Hanamura K,Shirao T

更新日期：2009-04-01 00:00:00

abstract：:A cDNA clone, pCP9, has been isolated from a common carp liver cDNA library by immunoscreening with polyclonal antiserum raised against purified bighead carp alpha 1-antitrypsin. This clone is 1,396 bp in length and has an open reading frame encoding a protein of 410 amino acid residues. The deduced amino acid sequenc...

journal_title：Journal of neurochemistry

authors： Huang CJ,Lee MS,Huang FL,Chang GD

更新日期：1995-04-01 00:00:00

abstract：:The genetic defect in Friedreich's ataxia (FRDA) is the expansion of a GAA·TCC triplet in the first intron of the FXN gene, which encodes the mitochondrial protein frataxin. Previous studies have established that the repeats reduce transcription of this essential gene, with a concomitant decrease in frataxin protein i...

journal_title：Journal of neurochemistry

authors： Gottesfeld JM,Rusche JR,Pandolfo M

更新日期：2013-08-01 00:00:00

abstract：:It is well known that caspases are produced as proforms, which are proteolytically cleaved and activated during apoptosis or programmed cell death. We report here that caspases are activated during apoptosis by treatment with NOC18, a nitric oxide (NO) donor. Our present experiments have examined the way in which NO i...

journal_title：Journal of neurochemistry

authors： Uehara T,Kikuchi Y,Nomura Y

更新日期：1999-01-01 00:00:00

abstract：:Vinpocetine is a neuroprotective drug that exerts beneficial effects on neurological symptoms and cerebrovascular disease. 3-nitropropionic acid (3-NPA) is a toxin that irreversibly inhibits succinate dehydrogenase, the mitochondrial enzyme that acts in the electron transport chain at complex II. In previous studies i...

journal_title：Journal of neurochemistry

authors： Herrera-Mundo N,Sitges M

更新日期：2013-01-01 00:00:00

abstract：:The effects of phenytoin, a potent antiepileptic drug, on the active transport of cations within membranes remain controversial. To assess the direct effects of phenytoin on the Na+,K+ pump, we studied the drug's influence on the phosphorylation of partially purified (Na+,K+)-ATPase from mouse brain. (Na+,K+)-ATPase s...

journal_title：Journal of neurochemistry

authors： Guillaume D,Grisar T,Delgado-Escueta AV

更新日期：1986-09-01 00:00:00

abstract：:Adrenomedullary chromaffin cells represent an excellent model to study the molecular events linked to exocytosis, because they use the same type of SNAREs for vesicle docking and fusion as neurons. In these cells, both in the intact tissue and in isolated cells in culture, syntaxin-1 and SNAP-25 are present in the pla...

journal_title：Journal of neurochemistry

authors： López-Font I,Torregrosa-Hetland CJ,Villanueva J,Gutiérrez LM

更新日期：2010-09-01 00:00:00

abstract：:The rat substance P (SP) receptor (SPR) was expressed in insect Sf9 cells by infection with recombinant baculovirus. The receptor bound SP with high affinity (KD = 360 pM) and had a rank order of affinity of SP > neurokinin A > neurokinin B. Ligand activation of the receptor resulted in an increase in both inositol li...

journal_title：Journal of neurochemistry

authors： Schreurs J,Yamamoto R,Lyons J,Munemitsu S,Conroy L,Clark R,Takeda Y,Krause JE,Innis M

更新日期：1995-04-01 00:00:00

abstract：:The effect of L-glutamate on the adrenergic-stimulated release of melatonin in the rat pineal gland was examined using an in vitro perfusion system. L-Glutamate by itself had no effect on melatonin secretion whereas L-glutamate administered prior to (-)-isoproterenol (beta-adrenergic agonist) and L-phenylephrine (alph...

journal_title：Journal of neurochemistry

authors： Kus L,Handa RJ,McNulty JA

更新日期：1994-06-01 00:00:00

abstract：:Protein synthesis in the brain is known to be affected by a wide range of treatments. The detailed analysis of the mechanisms that are involved would be facilitated by the development of cell-free translation systems derived from brain tissue. To date, brain cell-free systems have not been fully characterized to demon...

journal_title：Journal of neurochemistry

authors： Cosgrove JW,Brown IR

更新日期：1981-03-01 00:00:00

abstract：:The RNA integrity number (RIN) is often considered to be a critical measure of the quality of postmortem human brains. However, it has been suggested that RINs do not necessarily reflect the availability of intact mRNA. Using the Agilent bioanalyzer and qRT-PCR, we explored whether RINs provide a meaningful way of ass...

journal_title：Journal of neurochemistry

authors： Sonntag KC,Tejada G,Subburaju S,Berretta S,Benes FM,Woo TU

更新日期：2016-07-01 00:00:00