Distribution of putrescine in rat brain measured by gas chromatography-mass spectrometry.

abstract：:The (R) and (S) forms of 5-amino-2-hydroxyvaleric acid (2-OH-DAVA) and 5-amino-4-hydroxyvaleric acid (4-OH-DAVA) were designed as structural hybrids of the 4-aminobutyric acidB (GABAB) agonist (R)-(-)-4-amino-3-hydroxybutyric acid [(R)-(-)-3-OH-GABA] and the GABAB antagonist 5-aminovaleric acid (DAVA). (S)-(-)-2-OH-DA...

journal_title：Journal of neurochemistry

authors： Kristiansen U,Hedegaard A,Herdeis C,Lund TM,Nielsen B,Hansen JJ,Falch E,Hjeds H,Krogsgaard-Larsen P

更新日期：1992-03-01 00:00:00

abstract：:Action mechanism of lipopolysaccharide (LPS), interleukin-1β (IL-1β), and lysophosphatidic acid (LPA) to regulate motility, an important process of astrogliosis, was investigated in rat astrocytes. While LPA exerted no significant effect on the cell migration, the prior treatment of the cells with LPS or IL-1β resulte...

journal_title：Journal of neurochemistry

authors： Sato K,Horiuchi Y,Jin Y,Malchinkhuu E,Komachi M,Kondo T,Okajima F

更新日期：2011-04-01 00:00:00

abstract：:Previously, we identified protein kinase FA/glycogen synthase kinase-3 (GSK-3) as a microtubule-associated protein tau kinase that can incorporate 4 mol of phosphates into 1 mol of tau protein and cause its electrophoretic mobility shift in sodium dodecyl sulfate gels, a unique property characteristic of paired helica...

journal_title：Journal of neurochemistry

authors： Yang SD,Song JS,Yu JS,Shiah SG

更新日期：1993-11-01 00:00:00

abstract：:GM1 ganglioside binding to the crude mitochondrial fraction of rat brain and its effect on (Na+, K+)-ATPase were studied, the following results being obtained: (a) the binding process followed a biphasic kinetics with a break at 50 nM-GM1; GM1 at concentrations below the break was stably associated, while over the bre...

journal_title：Journal of neurochemistry

authors： Leon A,Facci L,Toffano G,Sonnino S,Tettamanti G

更新日期：1981-08-01 00:00:00

abstract：:Although accumulating evidence demonstrates that white matter degeneration contributes to pathology in Alzheimer's disease (AD), the underlying mechanisms are unknown. In order to study the roles of the amyloid-beta peptide in inducing oxidative stress damage in white matter of AD, we investigated the effects of amylo...

journal_title：Journal of neurochemistry

authors： Zeng C,Lee JT,Chen H,Chen S,Hsu CY,Xu J

更新日期：2005-08-01 00:00:00

abstract：:A cDNA clone encoding a novel G protein-linked receptor was isolated from a rat cerebral cortex cDNA library using a polymerase chain reaction-amplified cDNA fragment as a probe. This 2.4-kb clone encodes a 367 amino acid protein with seven putative transmembrane spanning domains. The protein is highly homologous to t...

journal_title：Journal of neurochemistry

authors： Lachowicz JE,Shen Y,Monsma FJ Jr,Sibley DR

更新日期：1995-01-01 00:00:00

abstract：:Neuropeptide S (NPS) is known to produce anxiolytic-like effects and facilitate extinction of conditioned fear. Catecholaminergic neurotransmission in the medial prefrontal cortex (mPFC) has been suggested to be crucially involved in these brain functions. In the current study, we investigated the effect of NPS on the...

journal_title：Journal of neurochemistry

authors： Si W,Aluisio L,Okamura N,Clark SD,Fraser I,Sutton SW,Bonaventure P,Reinscheid RK

更新日期：2010-10-01 00:00:00

abstract：:Microglia, the resident macrophage of the brain, can release substances that aid neuronal development, differentiation and survival. We have investigated the effects of non-activated microglia on the survival of cultured rat cerebellar granule neurones. Microglial-conditioned medium, collected from primary rat microgl...

journal_title：Journal of neurochemistry

authors： Morgan SC,Taylor DL,Pocock JM

更新日期：2004-07-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor complex as defined by the binding of [3H]MK-801 has been solubilized from membranes prepared from both rat and porcine brain using the anionic detergent deoxycholate (DOC). Of the detergents tested DOC extracted the most receptors (21% for rat, 34% for pig), and the soluble com...

journal_title：Journal of neurochemistry

authors： McKernan RM,Castro S,Poat JA,Wong EH

更新日期：1989-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a complex injury involving several physiological alterations, potentially leading to neurological impairment. Previous mouse studies using high-density oligonucleotide array analysis have confirmed the upregulation of transforming growth-interacting factor (TGIF) mRNA in TBI. TGIF is a ...

journal_title：Journal of neurochemistry

authors： Chio CC,Chang CP,Lin MT,Su FC,Yang CZ,Tseng HY,Liu ZM,Huang HS

更新日期：2014-12-01 00:00:00

abstract：:Nitric oxide (NO) has a number of physiological and pathophysiological effects in the nervous system. One target of NO is the mitochondrion, where it inhibits respiration and ATP synthesis, which may contribute to NO-mediated neuronal injury. Our recent studies suggested that impaired mitochondrial function impairs mi...

journal_title：Journal of neurochemistry

authors： Rintoul GL,Bennett VJ,Papaconstandinou NA,Reynolds IJ

更新日期：2006-05-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:We describe here two types of apoptotic cell death observed in the rat CNS-derived neuroblastoma B50 and B104 cells. One type was induced by dibutyryl cyclic AMP (DBcAMP) after differentiation, and the other was induced by treatment of proliferating cells with cycloheximide. When B50 and B104 cells were treated with 1...

journal_title：Journal of neurochemistry

authors： Honma N,Uchida A,Hirose H,Srsen V,Kishimoto T,Hisanaga S

更新日期：1996-11-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) provides neuroprotection, but its neuroprotective mechanism has not been resolved. We investigated the neuroprotective mechanism of GDNF using primary culture of the rat mesencephalon. Bleomycin sulfate (BLM) and L-buthionine-[S,R]-sulfoximine (BSO) caused apoptosis i...

journal_title：Journal of neurochemistry

authors： Sawada H,Ibi M,Kihara T,Urushitani M,Nakanishi M,Akaike A,Shimohama S

更新日期：2000-03-01 00:00:00

abstract：:Extracellular adenosine in the brain, which modulates various physiological and pathological processes, fluctuates in a complicated manner that reflects the circadian cycle, neuronal activity, metabolism, and disease states. The dynamics of extracellular adenosine in the brain are not fully understood, largely because...

journal_title：Journal of neurochemistry

authors： Yamashiro K,Fujii Y,Maekawa S,Morita M

更新日期：2017-01-01 00:00:00

abstract：:Schwannoma-derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF recepto...

journal_title：Journal of neurochemistry

authors： Maher PA,Schubert D

更新日期：1995-10-01 00:00:00

abstract：:Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

journal_title：Journal of neurochemistry

authors： Wade JV,Samson FE,Nelson SR,Pazdernik TL

更新日期：1987-08-01 00:00:00

abstract：:The effect of ethanol on insulin-like growth factor-1 (IGF-I)-mediated signal transduction and functional activation in neuronal cells was examined. In human SH-SY5Y neuroblastoma cells, ethanol inhibited tyrosine autophosphorylation of the IGF-I receptor. This corresponded to the inhibition of IGF-I-induced phosphory...

journal_title：Journal of neurochemistry

authors： Seiler AE,Ross BN,Rubin R

更新日期：2001-01-01 00:00:00

abstract：:In contrast to typical neuroleptic drugs, which have high affinities for dopamine D2 receptors, clozapine binds to multiple neurotransmitter receptors. The mechanisms responsible for its superior clinical efficacy over typical neuroleptics remain unknown. Using an automated genomics approach, total gene expression ana...

journal_title：Journal of neurochemistry

authors： Thomas EA,Danielson PE,Nelson PA,Pribyl TM,Hilbush BS,Hasel KW,Sutcliffe JG

更新日期：2001-02-01 00:00:00

abstract：:Parameters affecting the binding of [3H]glycine to membrane fractions isolated from the cerebral cortex, midbrain, cerebellum, medulla oblongata, and spinal cord of the rat were investigated in a Na+-free medium. A [3H]glycine binding assay was established in which the binding was specific, saturable, pH-sensitive, an...

journal_title：Journal of neurochemistry

authors： Kishimoto H,Simon JR,Aprison MH

更新日期：1981-10-01 00:00:00

abstract：:Neurotensin modulates dopaminergic transmission in the nigrostriatal system. DARPP-32, a dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa, is phosphorylated on Thr34 by cAMP-dependent protein kinase, resulting in its conversion into a potent inhibitor of protein phosphatase-1 (PP 1). Here, we examined the effe...

journal_title：Journal of neurochemistry

authors： Matsuyama S,Higashi H,Maeda H,Greengard P,Nishi A

更新日期：2002-04-01 00:00:00

abstract：:The effects of glutamatergic excitotoxins on intracellular Cl- were investigated in the CA1 pyramidal cell layer of the hippocampal slice. Hippocampal slices from rats (14-19 days old) were loaded with 6-methoxy-N-ethylquinolinium chloride (MEQ), a Cl(-)-sensitive fluorescent probe with a fluorescence intensity that c...

journal_title：Journal of neurochemistry

authors： Inglefield JR,Schwartz-Bloom RD

更新日期：1998-10-01 00:00:00

abstract：:alpha-Synuclein has been identified as a component of Lewy bodies in Parkinson's disease and diffuse Lewy body disease, and glial cytoplasmic inclusions (GCIs) in multiple system atrophy (MSA). To explore the role of alpha-synuclein in the pathogenesis, we searched for molecules interacting with alpha-synuclein and di...

journal_title：Journal of neurochemistry

authors： Iwata A,Miura S,Kanazawa I,Sawada M,Nukina N

更新日期：2001-04-01 00:00:00

abstract：:Overactivation of glutamate receptors mediates neuronal death in several acute and chronic neurodegenerative diseases. The intracellular processes underlying this form of death, however, remain poorly understood. Depending on the severity of insult, N-methyl-D-aspartate (NMDA) receptor activation induces either apopto...

journal_title：Journal of neurochemistry

authors： Tenneti L,D'Emilia DM,Troy CM,Lipton SA

更新日期：1998-09-01 00:00:00

abstract：:The contents of cystathionine and taurine, as well as cystathionine beta-synthase activity in various regions of the brains of normal and DL-propargylglycine-treated rats, were measured. The content of cystathionine in each region of brain increased gradually from 0.5 mg to 20 mg/200 g body weight in relation to the d...

journal_title：Journal of neurochemistry

authors： Kodama H,Ikeda H,Awata S,Nakayama K

更新日期：1985-04-01 00:00:00

abstract：:The binding of L-2-[3H]amino-4-phosphonobutyrate ([3H]L-AP4) was examined in brain sections of wild-type mice and mice lacking the mGluR4 subtype of metabotropic glutamate receptors (mGluRs). Very high relative densities of [3H]L-AP4 binding were observed in the molecular layer of the cerebellar cortex, the nucleus ba...

journal_title：Journal of neurochemistry

authors： Thomsen C,Hampson DR

更新日期：1999-02-01 00:00:00

abstract：:The P2Y11 nucleotide receptor detects high extracellular ATP concentrations. Mutations of the human P2RY11 gene can play a role in brain autoimmune responses, and the P2Y11 receptor alanine-87-threonine (A87T) polymorphism has been suggested to affect immune-system functions. We investigated receptor functionality of ...

journal_title：Journal of neurochemistry

authors： Haas M,Shaaban A,Reiser G

更新日期：2014-05-01 00:00:00

abstract：:Ethanol provides neuroprotection following ischemia/reperfusion. This study assessed ethanol's effect on hyperglycolysis and NADPH oxidase (NOX) activation. Adult, male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h. Three sets of experiments were conducted to determine ethanol's...

journal_title：Journal of neurochemistry

authors： Kochanski R,Peng C,Higashida T,Geng X,Hüttemann M,Guthikonda M,Ding Y

更新日期：2013-07-01 00:00:00

abstract：:The adaptor protein Disabled1 (Dab1) interacts with amyloid precursor protein (APP) and decreases its pathological processing, an effect mediated by Fyn tyrosine kinase. Fyn is highly enriched in lipid rafts, a major site of pathological APP processing. To investigate the role of Fyn in the localization and phosphoryl...

journal_title：Journal of neurochemistry

authors： Minami SS,Hoe HS,Rebeck GW

更新日期：2011-09-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are known to occur following acute seizure activity but their contribution during epileptogenesis is largely unknown. The goal of this study was to determine the extent of mitochondrial oxidative stress, changes to redox status, and mitochondrial DNA (mtDNA) damage during...

journal_title：Journal of neurochemistry

authors： Waldbaum S,Liang LP,Patel M

更新日期：2010-12-01 00:00:00