Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons.

abstract：:Prothymosin alpha (ProTα), a nuclear protein devoid of signal sequence, has been shown to possess a number of cellular functions including cell survival. Most recently, we demonstrated that ProTα is localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of ad...

journal_title：Journal of neurochemistry

authors： Halder SK,Matsunaga H,Ueda H

更新日期：2012-10-01 00:00:00

abstract：:C-type natriuretic peptide and sodium nitroprusside, a nitric oxide donor molecule, induced large increases in cyclic GMP formation in cultured rat brain capillary endothelial cells. Isoproterenol, a potent agonist of adenylate cyclase, potentiated the actions of C-type natriuretic peptide and of sodium nitroprusside....

journal_title：Journal of neurochemistry

authors： Vigne P,Lund L,Frelin C

更新日期：1994-06-01 00:00:00

abstract：:Purified rat brain Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) is stimulated by brain gangliosides to a level of about 30% the activity obtained in the presence of Ca2+/calmodulin (CaM). Of the various gangliosides tested, GT1b was the most potent, giving half-maximal activation at 25 microM. Gangliosi...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Miyamoto E,Soderling TR

更新日期：1990-01-01 00:00:00

abstract：:Recombinant baculoviral vectors efficiently transduce several types of cells in the brain. To characterize host responses to virus challenge, thus verifying the suitability of using baculovirus for the development of gene therapy strategies in the central nervous system, we used cDNA microarray technology to examine i...

journal_title：Journal of neurochemistry

authors： Boulaire J,Zhao Y,Wang S

更新日期：2009-06-01 00:00:00

abstract：:We have shown previously that N-(4-hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid derivative, induces neuronal differentiation in cultured human retinal pigment epithelial (RPE) cells [Chen et al., J. Neurochem., 84 (2003), 972]. We asked the question whether the mitogen-activated protein kinase (MAPK) ...

journal_title：Journal of neurochemistry

authors： Samuel W,Kutty RK,Sekhar S,Vijayasarathy C,Wiggert B,Redmond TM

更新日期：2008-07-01 00:00:00

abstract：:Interleukin-1β (IL-1β) is released from activated microglia and involved in the neurodegeneration of acute and chronic brain disorders, such as stroke and Alzheimer's disease, in which extracellular acidification has been shown to occur. Here, we examined the extracellular acidic pH regulation of IL-1β production, esp...

journal_title：Journal of neurochemistry

authors： Jin Y,Sato K,Tobo A,Mogi C,Tobo M,Murata N,Ishii S,Im DS,Okajima F

更新日期：2014-05-01 00:00:00

abstract：:A sensitive enzyme-linked immunosorbent assay (ELISA) for nerve growth factor (NGF) has been developed. The sensitivity of this assay (0.1 pg/well) permits the quantification of endogenous immunoreactive NGF in the peripheral nervous system and the CNS. Studies on the regulatory mechanisms involved in NGF production i...

journal_title：Journal of neurochemistry

authors： Weskamp G,Otten U

更新日期：1987-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with worldwide prevalence. Its clinical manifestation involves the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs). NFTs occur in brain tissues as a result of both Aβ agglomeration and Tau phosphory...

journal_title：Journal of neurochemistry

authors： Jha NK,Jha SK,Kar R,Nand P,Swati K,Goswami VK

更新日期：2019-07-01 00:00:00

abstract：:We have screened a human cDNA library using an expressed sequence tag related to the BM-40/secreted protein, acidic and rich in cysteine (SPARC)/osteonectin family of proteins and isolated a novel cDNA. It encodes a protein precursor of 424 amino acids that consists of a signal peptide, a follistatin-like domain, a Ca...

journal_title：Journal of neurochemistry

authors： Vannahme C,Schübel S,Herud M,Gösling S,Hülsmann H,Paulsson M,Hartmann U,Maurer P

更新日期：1999-07-01 00:00:00

abstract：:Our previous work demonstrated that immunoproteasome is up-regulated in the retina and brain in response to injury that does not involve an inflammatory response (J. Neurochem. 2008; 106:158). These results suggest additional non-immune functions for the immunoproteasome in the cellular stress response pathway. The pr...

journal_title：Journal of neurochemistry

authors： Hussong SA,Kapphahn RJ,Phillips SL,Maldonado M,Ferrington DA

更新日期：2010-06-01 00:00:00

abstract：:The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We sought to dissec...

journal_title：Journal of neurochemistry

authors： Khanna S,Roy S,Parinandi NL,Maurer M,Sen CK

更新日期：2006-09-01 00:00:00

abstract：:The normal cellular form of prion protein (PrP(C)) has been shown to exhibit a diverse range of biological activities. Several recent studies highlighted potential involvement of PrP(C) in embryogenesis or in regulating stem cell self-renewal and proliferation. In the current study, we employed human embryonic stem ce...

journal_title：Journal of neurochemistry

authors： Lee YJ,Baskakov IV

更新日期：2010-07-01 00:00:00

abstract：:The ability of activated glia to affect cerebral vascular tone has been evaluated using an in vitro experimental system in which basilar arteries were incubated with glial cultures activated by treatment with lipopolysaccharide (LPS). Vascular tone was measured with an isometric myograph. Contraction in response to hi...

journal_title：Journal of neurochemistry

authors： Chisari M,Salomone S,Laureanti F,Copani A,Sortino MA

更新日期：2004-12-01 00:00:00

abstract：:Our results provide evidence that 6-hydroxydopamine induced, after auto-oxidation, toxic levels of hydrogen peroxide (H2O2) that caused bovine chromaffin cell toxicity and death. 6-Hydroxydopamine (6-OHDA) treatment markedly reduced, in a dose-response fashion, chromaffin cell viability. Cell death was accompanied by ...

journal_title：Journal of neurochemistry

authors： Galindo MF,Jordán J,González-García C,Ceña V

更新日期：2003-03-01 00:00:00

abstract：:The mu-opioid receptor agonists have a preferential effect on nociception in adults but their analgesic effect is less selective in neonates. Here we presented our finding that the mu-opioid receptor agonists had no effect on high voltage-activated Ca(2+) channels (HVACCs) in adult dorsal root ganglion (DRG) neurons t...

journal_title：Journal of neurochemistry

authors： Wu ZZ,Cai YQ,Pan HL

更新日期：2009-05-01 00:00:00

abstract：:The monoamines dopamine, norepinephrine, epinephrine, and serotonin and their major metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxy-4-hydroxyphenylethylene glycol, and 5-hydroxyindoleacetic acid were measured in the CNS of the rat during development from fetal day 18 to young adult. The catech...

journal_title：Journal of neurochemistry

authors： Herregodts P,Velkeniers B,Ebinger G,Michotte Y,Vanhaelst L,Hooghe-Peters E

更新日期：1990-09-01 00:00:00

abstract：:Astrogliosis occurs after brain ischemia, and excessive astrogliosis can devastate the neuronal recovery. Previous reports show that galectin-1 (Gal-1) regulates proliferation of several cell types and plays an important role after nervous system injuries. Here, we found that expression of Gal-1 was remarkably up-regu...

journal_title：Journal of neurochemistry

authors： Qu WS,Wang YH,Ma JF,Tian DS,Zhang Q,Pan DJ,Yu ZY,Xie MJ,Wang JP,Wang W

更新日期：2011-01-01 00:00:00

abstract：:The nuclear mitochondrial and synaptosomal fractions of rat brain were each found to contain some 25-30% of the total aldehyde dehydrogenase activity. The cytoplasmic fraction had a very low total aldehyde dehydrogenase activity. There were differences in the distribution of the activity when different aldehydes were ...

journal_title：Journal of neurochemistry

authors： Koivula T,Turner AJ,Huttunen M,Koivusalo M

更新日期：1981-06-01 00:00:00

abstract：:Obesity is a worldwide health problem that urgently needs to be solved. Leptin is an anti-obesity hormone that activates satiety signals to the brain. Evidence to suggest that leptin resistance is involved in the development of obesity is increasing; however, the molecular mechanisms involved remain unclear. We herein...

journal_title：Journal of neurochemistry

authors： Hosoi T,Matsuzaki S,Miyahara T,Shimizu K,Hasegawa Y,Ozawa K

更新日期：2015-05-01 00:00:00

abstract：:The question of developmental relationships amongst myelin-related membranes in subfractions of myelinating mouse brain (15 days) was investigated by a time-staggered double isotope protocol using [3H]leucine and [14C]leucine. Preliminary results are interpreted and discussed in the context of a mathematical conceptua...

journal_title：Journal of neurochemistry

authors： Pereyra PM,Braun PE,Greenfield S,Hogan EL

更新日期：1983-10-01 00:00:00

abstract：:Aggregate-prone mutant proteins, such as α-synuclein and huntingtin, play a prominent role in the pathogenesis of various neurodegenerative disorders; thus, it has been hypothesized that reducing the aggregate-prone proteins may be a beneficial therapeutic strategy for these neurodegenerative disorders. Here, we ident...

journal_title：Journal of neurochemistry

authors： Shen W,Henry AG,Paumier KL,Li L,Mou K,Dunlop J,Berger Z,Hirst WD

更新日期：2014-06-01 00:00:00

abstract：:The novel N-methyl-D-aspartate receptor channel ligand (+)-[3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5, 10-imine maleate ([3H]MK-801) has been utilized to label this receptor in human brain tissue. Characteristics of [3H]MK-801 binding to well-washed membranes from 17 control subjects and 16 patients with...

journal_title：Journal of neurochemistry

authors： Procter AW,Wong EH,Stratmann GC,Lowe SL,Bowen DM

更新日期：1989-09-01 00:00:00

abstract：:Signaling by muscarinic agonists is thought to result from the activation of cell surface acetylcholine receptors (mAChRs) that transmit extracellular signals to intracellular systems. In N1E-115 neuroblastoma cells, we detected both plasma membrane and intracellular M(1) -mAChRs using both biochemical and pharmacolog...

journal_title：Journal of neurochemistry

authors： Uwada J,Anisuzzaman AS,Nishimune A,Yoshiki H,Muramatsu I

更新日期：2011-09-01 00:00:00

abstract：:Both increased gamma-aminobutyric acid (GABA)-ergic and decreased glutamatergic neurotransmission have been suggested relative to the pathophysiology of hepatic encephalopathy. This proposed disturbance in neurotransmitter balance, however, is based mainly on brain tissue analysis. Because the approach of whole tissue...

journal_title：Journal of neurochemistry

authors： Bosman DK,Deutz NE,Maas MA,van Eijk HM,Smit JJ,de Haan JG,Chamuleau RA

更新日期：1992-08-01 00:00:00

abstract：:The expression of inducible nitric oxide synthase (NOS2) in glial cells is inhibited by neurotransmitters such as norepinephrine (NE) which elevate cAMP levels. We examined the molecular basis for this effect using a 2.2-kb fragment of the rat NOS2 promoter transfected into rat C6 glioma cells. Promoter activation (up...

journal_title：Journal of neurochemistry

authors： Gavrilyuk V,Horvath P,Weinberg G,Feinstein DL

更新日期：2001-07-01 00:00:00

abstract：:Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD(2), the main PG in the CNS. PGD(2) is an endogenous sleep inducer, and it is involved in the control of odor and pain responses and body temperature. In addition, PGD synthase transports lipophilic molecules in the subarachn...

journal_title：Journal of neurochemistry

authors： García-Fernández LF,Iñiguez MA,Eguchi N,Fresno M,Urade Y,Muñoz A

更新日期：2000-08-01 00:00:00

abstract：:Transient exposure to ethanol (EtOH) results in a massive neurodegeneration in the developing brain leading to behavioral and cognitive deficits observed in fetal alcohol syndrome. There is now compelling evidence that K+ channels play an important role in the control of programmed cell death. The aim of the present w...

journal_title：Journal of neurochemistry

authors： Lefebvre T,Gonzalez BJ,Vaudry D,Desrues L,Falluel-Morel A,Aubert N,Fournier A,Tonon MC,Vaudry H,Castel H

更新日期：2009-08-01 00:00:00

abstract：:Multiple molecular defects trigger cell death in amyotrophic lateral sclerosis (ALS). Among these, altered transcriptional activity may perturb many cellular functions, leading to a cascade of secondary pathological effects. We showed that pharmacological treatment, using the histone deacetylase inhibitor sodium pheny...

journal_title：Journal of neurochemistry

authors： Ryu H,Smith K,Camelo SI,Carreras I,Lee J,Iglesias AH,Dangond F,Cormier KA,Cudkowicz ME,Brown RH Jr,Ferrante RJ

更新日期：2005-06-01 00:00:00

abstract：:Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited neurodegenerative disorder for which no curative therapy is available. The cause of this disease is the expansion of a CAG repeat in the so-called ATXN3 gene leading to an expanded polyglutamine stretch in the ataxin-3 protein. Although the func...

journal_title：Journal of neurochemistry

authors： Schmidt J,Schmidt T,Golla M,Lehmann L,Weber JJ,Hübener-Schmid J,Riess O

更新日期：2016-07-01 00:00:00

abstract：:The RNA integrity number (RIN) is often considered to be a critical measure of the quality of postmortem human brains. However, it has been suggested that RINs do not necessarily reflect the availability of intact mRNA. Using the Agilent bioanalyzer and qRT-PCR, we explored whether RINs provide a meaningful way of ass...

journal_title：Journal of neurochemistry

authors： Sonntag KC,Tejada G,Subburaju S,Berretta S,Benes FM,Woo TU

更新日期：2016-07-01 00:00:00