Endogenous peptides that inhibit brain cyclic AMP phosphodiesterase.

abstract：:After a brief period of global ischemia, the hippocampal CA1 region is more susceptible to irreversible damage than the paramedian neocortex. To test whether primary differences in bioenergetic parameters may be present between these regions, respiration rates and respiratory control activities were measured. In synap...

journal_title：Journal of neurochemistry

authors： Davey GP,Canevari L,Clark JB

更新日期：1997-12-01 00:00:00

abstract：:Microinfarcts are small, but strikingly common, ischemic brain lesions in the aging human brain. There is mounting evidence that microinfarcts contribute to vascular cognitive impairment and dementia, but the origins of microinfarcts are unclear. Understanding the vascular pathologies that cause microinfarcts may yiel...

journal_title：Journal of neurochemistry

authors： Hartmann DA,Hyacinth HI,Liao FF,Shih AY

更新日期：2018-03-01 00:00:00

abstract：:Unilateral frontal cortex ablations were performed in rats so that the glutamate terminals in the ipsilateral rostral neostriatum were removed. At 1 or 7 days later, intraperitoneal injections of ammonium acetate induced different changes in amino acid concentrations in the intact and deafferentated neostriatum. After...

journal_title：Journal of neurochemistry

authors： Engelsen BA,Fosse VM,Fonnum F

更新日期：1987-03-01 00:00:00

abstract：:Extracellular dopamine (DA) concentrations estimated by transcerebral dialysis and D1-dependent c-fos expression, as demonstrated by Fos immunohistochemistry, were studied after blockade of DA reuptake by GBR-12909. Rats implanted with dialysis probes in the dorsal caudate-putamen did not show any Fos-positive neurona...

journal_title：Journal of neurochemistry

authors： Morelli M,Carboni E,Cozzolino A,Tanda GL,Pinna A,Di Chiara G

更新日期：1992-09-01 00:00:00

abstract：:The alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) is a peptide-coupling agent that is being used to inactivate irreversibly alpha 2-adrenoceptors and other receptors. The aim of the present study was to assess the in vitro and in vivo effects of EEDQ on the newly discovered brain I2-imidazolin...

journal_title：Journal of neurochemistry

authors： Miralles A,Ribas C,Olmos G,García-Sevilla JA

更新日期：1993-11-01 00:00:00

abstract：:We previously reported that annexin V promoted the survival of cultured rat neocortical neurons. In an effort to elucidate the mechanism underlying this neurotrophic activity of annexin V, we have attempted to identify the target or binding proteins of annexin V in neuronal cells. Herein, we screened an embryonic day ...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Imai Y,Ito D,Kohsaka S

更新日期：1996-07-01 00:00:00

abstract：:Several lines of evidence indicate that a rapid loss of neuronal protein kinase C (PKC) activity is a characteristic feature of cerebral ischemia and is a necessary step in the NMDA-induced death of cultured neurons. Exposing embryonic day 18 primary rat cortical neurons to 50 microM NMDA or 50 microM glutamate for 10...

journal_title：Journal of neurochemistry

authors： Tremblay R,Hewitt K,Lesiuk H,Mealing G,Morley P,Durkin JP

更新日期：1999-01-01 00:00:00

abstract：:Nerve growth factor (NGF) plays a key role in the differentiation of neurons. In this study, we established three NGF-induced neurite-positive (NIN+) subclones that showed high responsiveness to NGF-induced neurite outgrowth and three NGF-induced neurite-negative (NIN-) subclones that abolished NGF-induced neurite out...

journal_title：Journal of neurochemistry

authors： Oe T,Sasayama T,Nagashima T,Muramoto M,Yamazaki T,Morikawa N,Okitsu O,Nishimura S,Aoki T,Katayama Y,Kita Y

更新日期：2005-09-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00

abstract：:We have examined the ability of KW-6002, an adenosine A2a antagonist, to modulate the dyskinetic effects of L-DOPA in 6-hydroxydopamine-lesioned rats. In animals rendered dyskinetic by a previous course of L-DOPA treatment, KW-6002 did not elicit any abnormal involuntary movements on its own, but failed to reduce the ...

journal_title：Journal of neurochemistry

authors： Lundblad M,Vaudano E,Cenci MA

更新日期：2003-03-01 00:00:00

abstract：:Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) have an extraordinary capacity to withstand prolonged and profound reductions in blood flow and oxygen delivery to the brain without incurring any cellular damage. As such, the hibernation torpor of I. tridecemlineatus provides a valuable model of tolerance ...

journal_title：Journal of neurochemistry

authors： Miyake S,Wakita H,Bernstock JD,Castri P,Ruetzler C,Miyake J,Lee YJ,Hallenbeck JM

更新日期：2015-12-01 00:00:00

abstract：:The purpose of this study was to assess and compare the toxicity of beta-amyloid (Abeta) on primary cortical and mesencephalic neurons cultured with and without microglia in order to determine the mechanism underlying microglia-mediated Abeta-induced neurotoxicity. Incubation of cortical or mesencephalic neuron-enrich...

journal_title：Journal of neurochemistry

authors： Qin L,Liu Y,Cooper C,Liu B,Wilson B,Hong JS

更新日期：2002-11-01 00:00:00

abstract：:Amylin forms large beta-pleated neurotoxic oligomers but shows only 38% sequence similarity to A beta. As patterns of gene expression during neuronal apoptosis appear stimulus and cell type specific, we compared the pattern of amylin-induced gene expression in rat cortical neurons with that shown previously to be indu...

journal_title：Journal of neurochemistry

authors： Tucker HM,Rydel RE,Wright S,Estus S

更新日期：1998-08-01 00:00:00

abstract：:Quinolinic acid (QUIN), an excitotoxic compound present in the mammalian CNS and periphery, has been hypothetically linked to human neurodegenerative disorders such as Huntington's disease and epilepsy. Quinolinic acid phosphoribosyltransferase (QPRT), the catabolic enzyme of QUIN, is found in the CNS and peripheral o...

journal_title：Journal of neurochemistry

authors： Foster AC,Schwarcz R

更新日期：1985-07-01 00:00:00

abstract：:Peripherin is a type III intermediate filament (IF) abundantly expressed in developing neurons, but in the adult, it is primarily found in neurons extending to the peripheral nervous system. It has been suggested that peripherin may play a role in axonal elongation and/or cytoskeletal stabilization during development ...

journal_title：Journal of neurochemistry

authors： Larivière RC,Nguyen MD,Ribeiro-da-Silva A,Julien JP

更新日期：2002-05-01 00:00:00

abstract：:Glycine receptor (GlyR) truncations in the intracellular TM3-4 loop, documented in patients suffering from hyperekplexia and in the mouse mutant oscillator, lead to non-functionality of GlyRs. The missing part that contains the TM3-4 loop, TM4 and C-terminal sequences is essential for pentameric receptor arrangements....

journal_title：Journal of neurochemistry

authors： Langlhofer G,Villmann C

更新日期：2017-07-01 00:00:00

abstract：:Gliomas are the most common primary malignant brain tumor in adults, but current treatment for glioblastoma multiforme (GBM) is insufficient. Even though glucose is the primary energetic substrate of glioma cells, they are capable of using fatty acids to generate energy. Fatty acid oxidation (FAO) in mitochondria requ...

journal_title：Journal of neurochemistry

authors： Juraszek B,Czarnecka-Herok J,Nałęcz KA

更新日期：2020-07-12 00:00:00

abstract：:Integrin-mediated interactions of cells with components of the extracellular matrix (ECM) regulate cell survival, cell proliferation, cell differentiation and cell migration through activation of multiple intracellular signal transduction pathways. In this study, we have demonstrated that integrin-matrix interactions ...

journal_title：Journal of neurochemistry

authors： Li BS,Daniels MP,Pant HC

更新日期：2001-02-01 00:00:00

abstract：:In spite of biochemical and autoradiographic evidence for glucocorticoid binding sites in the spinal cord (SC), events occurring after the preliminary step of hormone binding were not studied. In this investigation, we have examined the transformation (activation) of the cytosolic receptor coupled to [3H]dexamethasone...

journal_title：Journal of neurochemistry

authors： Ortí E,Tornello S,De Nicola AF

更新日期：1985-12-01 00:00:00

abstract：:The membrane-bound or solubilized melatonin receptors were treated with protein-modifying agents under specific conditions and then assayed for 125I-melatonin binding in order to obtain information on amino acids present in the ligand binding domain. The reagents specific for sulfhydryl (N-ethylmaleimide and p-chlorom...

journal_title：Journal of neurochemistry

authors： Kosar E,Teisinger J,Vyskocil F,Vanĕcek J

更新日期：1994-08-01 00:00:00

abstract：:N-Acetyl-L-aspartic acid was identified and determined in human cerebrospinal fluid. The concentration in lumbar fluid was about 2 nmol/ml and about 20 nmol/ml in ventricular fluid. There was no difference between healthy subjects and schizophrenic patients. ...

journal_title：Journal of neurochemistry

authors： Swahn CG

更新日期：1990-05-01 00:00:00

abstract：:Microglia, macrophage-like cells in the CNS, are multifunctional cells; they play an important role in removal of dead cells or their remnants by phagocytosis in the CNS degeneration and are one of important cells in the CNS cytokine network to produce and respond to a variety of cytokines. The functions of microglia ...

journal_title：Journal of neurochemistry

authors： Sawada M,Suzumura A,Hosoya H,Marunouchi T,Nagatsu T

更新日期：1999-04-01 00:00:00

abstract：:Both acidosis and oxidative stress contribute to ischemic brain injury. The present study examines interactions between acidosis and oxidative stress in murine cortical cultures. Acidosis (pH 6.2) was found to potentiate markedly neuronal death induced by H2O2 exposure. To determine if this effect was mediated by decr...

journal_title：Journal of neurochemistry

authors： Ying W,Han SK,Miller JW,Swanson RA

更新日期：1999-10-01 00:00:00

abstract：:Synaptosomal-associated protein of 25 kDa (SNAP-25) is thought to play a key role in vesicle exocytosis and in the control of transmitter release. However, the precise mechanisms of action as well as the regulation of SNAP-25 remain unclear. Here we show by immunoprecipitation that activation of protein kinase C (PKC)...

journal_title：Journal of neurochemistry

authors： Genoud S,Pralong W,Riederer BM,Eder L,Catsicas S,Muller D

更新日期：1999-04-01 00:00:00

abstract：:The role of protein kinase C (PKC) in modulating the release of the octapeptide cholecystokinin (CCK-8) was investigated in rat hippocampal nerve terminals (synaptosomes). The PKC-activating phorbol ester 4beta-phorbol 12,13-dibutyrate (beta-PDBu) dose dependently (5-5,000 nM) increased CCK-8 release in a strictly Ca2...

journal_title：Journal of neurochemistry

authors： Breukel AI,Wiegant VM,Lopes da Silva FH,Ghijsen WE

更新日期：1998-01-01 00:00:00

abstract：:Exogenously added sialyl cholesterol (SC) induced neuritogenesis and accumulated in the nuclear fraction of a mouse neuroblastoma cell line, Neuro2a, as reported elsewhere. To clarify the significance of nuclear SC, we examined the structure of chromatin and its transcriptional level. The chromatin of SC-treated cells...

journal_title：Journal of neurochemistry

authors： Yamashita T,Tsuji S

更新日期：1992-04-01 00:00:00

abstract：:β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the transmembrane aspartyl protease that catalyzes the first cleavage step in the proteolysis of the APP to the amyloid β-protein (Aβ), a process involved in the pathogenesis of Alzheimer disease. BACE1 pre-mRNA undergoes complex alternative splicing,...

journal_title：Journal of neurochemistry

authors： Fisette JF,Montagna DR,Mihailescu MR,Wolfe MS

更新日期：2012-06-01 00:00:00

abstract：:Although considerable evidence supports a role for excitatory amino acids in the pathogenesis of ischemic neuronal injury, few in vivo studies have examined the effect of increasing durations of ischemia on the extracellular concentrations of these agents. Recently, other neurotransmitters (e.g., glycine and dopamine)...

journal_title：Journal of neurochemistry

authors： Baker AJ,Zornow MH,Scheller MS,Yaksh TL,Skilling SR,Smullin DH,Larson AA,Kuczenski R

更新日期：1991-10-01 00:00:00

abstract：:The double C2 (Doc2) family is characterized by an N-terminal Munc13-1-interacting domain and C-terminal tandem C2 domains, and it comprises three isoforms, Doc2alpha, Doc2beta, and Doc2gamma, in humans and mice. Doc2alpha, the best-characterized, brain-specific isoform, exhibits Ca(2+)-dependent phospholipid-binding ...

journal_title：Journal of neurochemistry

authors： Sato M,Mori Y,Matsui T,Aoki R,Oya M,Yanagihara Y,Fukuda M,Tsuboi T

更新日期：2010-07-01 00:00:00

abstract：:We have previously reported that the intrinsic ability of motor axons to sprout can vary considerably from nerve to nerve with an inverse correlation to axonal length. In this study we asked whether this variation might be associated with differences in one axonal component, neurofilaments, near the site of outgrowth....

journal_title：Journal of neurochemistry

authors： Pestronk A,Watson DF,Yuan CM

更新日期：1990-03-01 00:00:00