Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.

abstract：:Molecular mechanisms underlying tauopathy remain undetermined. In the current study, single cell gene expression profiling was coupled with custom-designed cDNA array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (NCI...

journal_title：Journal of neurochemistry

authors： Ginsberg SD,Che S,Counts SE,Mufson EJ

更新日期：2006-03-01 00:00:00

abstract：:Abstract The dualistic activities of the amyloid beta (Abeta) peptide as a pro-oxidant and ubiquitous constituent of amyloid deposits in Alzheimer's disease plaques and as an antioxidant of purported physiological function has been suggested but the mechanisms are far from being understood. In this report we measure s...

journal_title：Journal of neurochemistry

authors： Kuperstein F,Brand A,Yavin E

更新日期：2004-11-01 00:00:00

abstract：:The unique modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) is tightly associated with nervous system development and plasticity. The prevailing view that this large carbohydrate polymer acts as an anti-adhesive factor seems straightforward at first sight. However, during almost 25...

journal_title：Journal of neurochemistry

authors： Hildebrandt H,Mühlenhoff M,Weinhold B,Gerardy-Schahn R

更新日期：2007-11-01 00:00:00

abstract：:Potassium-induced depolarization of synaptoneurosomes prepared from rat telencephalon was found to increase [3H]amino-3-hydroxy-5-methylisoxazole-4-propionate ([3H]AMPA) binding to the AMPA receptor. The effect required the presence of calcium because it was blocked by the calcium chelator EGTA but was not blocked by ...

journal_title：Journal of neurochemistry

authors： Bernard J,Massicotte G,Baudry M

更新日期：1992-01-01 00:00:00

abstract：:The metabolic pathway of inositol phospholipids represents a series of synthetic and hydrolytic reactions with inositol as a by-product. Hence, the rate of [3H]inositol release from prelabeled phospholipids can be used as a reflection of activity of this pathway. In the frog sympathetic ganglion prelabeled with [3H]in...

journal_title：Journal of neurochemistry

authors： Rubio R,Bencherif M,Berne RM

更新日期：1989-03-01 00:00:00

abstract：:P-glycoprotein (P-gp), an adenosine triphosphate (ATP)-binding cassette transporter which acts as a drug efflux pump, is highly expressed at the blood-brain barrier (BBB) where it plays an important role in brain protection. Recently, P-gp has been reported to be located in the caveolae of multidrug-resistant cells. I...

journal_title：Journal of neurochemistry

authors： Jodoin J,Demeule M,Fenart L,Cecchelli R,Farmer S,Linton KJ,Higgins CF,Béliveau R

更新日期：2003-11-01 00:00:00

abstract：:Nuclear factor (NF)-κB-mediated neuroinflammation is an important mechanism of intracerebral hemorrhage (ICH)-induced neurotoxicity. Silent information regulator 1 (SIRT1) plays a multi-protective effect in a variety of diseases by deacetylating and inhibiting NF-κB/p65. However, the role of SIRT1 in brain damage foll...

journal_title：Journal of neurochemistry

authors： Deng HJ,Zhou CH,Huang LT,Wen LB,Zhou ML,Wang CX

更新日期：2020-12-02 00:00:00

abstract：:The ability of cells to control the balance between the generation and quenching of reactive oxygen species is important in combating potentially damaging effects of oxidative stress. One mechanism that cells use to maintain redox homeostasis is the antioxidant response pathway. Antioxidant response elements (AREs) ar...

journal_title：Journal of neurochemistry

authors： Cao TT,Ma L,Kandpal G,Warren L,Hess JF,Seabrook GR

更新日期：2005-10-01 00:00:00

abstract：:The effects of long-term treatment with imipramine or mirtazapine, two antidepressant drugs with different mechanisms of action, on the response of cortical dopaminergic neurons to foot-shock stress or to the anxiogenic drug FG7142 were evaluated in freely moving rats. As expected, foot shock induced a marked increase...

journal_title：Journal of neurochemistry

authors： Dazzi L,Spiga F,Pira L,Ladu S,Vacca G,Rivano A,Jentsch JD,Biggio G

更新日期：2001-02-01 00:00:00

abstract：:The effects of phorbol esters were investigated on the survival of chick sympathetic neurons in a serum-free culture medium. The protein kinase C activator phorbol 12,13-dibutyrate (PDB) supported about 40% of the plated sympathetic neurons. This number was comparable to that supported by nerve growth factor (NGF). A ...

journal_title：Journal of neurochemistry

authors： Wakade AR,Wakade TD,Malhotra RK,Bhave SV

更新日期：1988-09-01 00:00:00

abstract：:PEA-15 has recently been identified as a major phosphoprotein in astrocytes and an endogenous substrate for protein kinase C. This 15-kDa protein exists under three molecular forms, an unphosphorylated form, N, and two phosphorylated forms, Pa and Pb. Antisera were raised against synthetic peptides corresponding to th...

journal_title：Journal of neurochemistry

authors： Danziger N,Yokoyama M,Jay T,Cordier J,Glowinski J,Chneiweiss H

更新日期：1995-03-01 00:00:00

abstract：:The proportion of major depressive disorder (MDD) patients around the world has increased remarkably. Although many studies of MDD have been conducted based on classic hypotheses, like alteration of the hypothalamic-pituitary-adrenal axis or monoamine neurotransmitters, the mechanisms underlying MDD remain unclear. Ai...

journal_title：Journal of neurochemistry

authors： Xu K,He Y,Chen X,Tian Y,Cheng K,Zhang L,Wang Y,Yang D,Wang H,Wu Z,Li Y,Lan T,Dong Z,Xie P

更新日期：2019-06-01 00:00:00

abstract：:Increased cerebrovascular permeability is an important factor for the development of cerebral edema. To investigate the effect of hypoxia on the transport of blood-borne proteins to the brain, we used a cell culture model of the blood-brain barrier (BBB) consisting of a coculture of brain capillary endothelial cells a...

journal_title：Journal of neurochemistry

authors： Plateel M,Teissier E,Cecchelli R

更新日期：1997-02-01 00:00:00

abstract：:A cDNA clone encoding a novel G protein-linked receptor was isolated from a rat cerebral cortex cDNA library using a polymerase chain reaction-amplified cDNA fragment as a probe. This 2.4-kb clone encodes a 367 amino acid protein with seven putative transmembrane spanning domains. The protein is highly homologous to t...

journal_title：Journal of neurochemistry

authors： Lachowicz JE,Shen Y,Monsma FJ Jr,Sibley DR

更新日期：1995-01-01 00:00:00

abstract：:The I1-imidazoline receptor (I1R) is a proposed target for drug action relevant to blood pressure and glucose control. The imidazoline receptor antisera-selected (IRAS) gene, also known as Nischarin, has several characteristics of an I1R. To test the contribution of IRAS to I1R binding capacity and cell-signaling func...

journal_title：Journal of neurochemistry

authors： Sun Z,Chang CH,Ernsberger P

更新日期：2007-04-01 00:00:00

abstract：:Damage or stress in many organelles may trigger apoptosis by several not yet fully elucidated mechanisms. A cell death pathway is induced by endoplasmic reticulum (ER) stress elicited by the unfolded protein response and/or by aberrant Ca(2+) signalling. Reticulon-1C (RTN-1C) belongs to the reticulon family, neuroendo...

journal_title：Journal of neurochemistry

authors： Di Sano F,Fazi B,Tufi R,Nardacci R,Piacentini M

更新日期：2007-07-01 00:00:00

abstract：:After intraperitoneal injection of rats with 6-fluorotryptophan (6-FT), brain 5-hydroxytryptamine (5-HT) levels decreased exponentially over 1 h. Depletion was dose-dependent and maximum depletion was observed at 200 mg/kg. 6-FT (200 mg/kg) did not significantly alter the content of 5-hydroxyindoleacetic acid. Turnove...

journal_title：Journal of neurochemistry

authors： Miwa S,Fujiwara M,Lee K,Fujiwara M

更新日期：1987-05-01 00:00:00

abstract：:Fused in sarcoma (FUS) is a ubiquitously expressed RNA/DNA-binding protein that plays different roles in the cell. FUS pathology has been reported in neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in FUS have also been linked to a subset of familial ALS. FUS...

journal_title：Journal of neurochemistry

authors： Arenas A,Kuang L,Zhang J,Kingren MS,Zhu H

更新日期：2020-12-22 00:00:00

abstract：:In cerebellum, 13 different GABA(A) receptor subunits are expressed. The number of different receptor subtypes formed in this tissue, their subunit composition and their quantitative importance so far has not been determined. In the present study, immunodepletion by immunoaffinity chromatography, as well as immunoprec...

journal_title：Journal of neurochemistry

authors： Pöltl A,Hauer B,Fuchs K,Tretter V,Sieghart W

更新日期：2003-12-01 00:00:00

abstract：:The cause of neuronal degeneration in Alzheimer's disease (AD) has not been completely clarified, but has been variously attributed to increases in cytosolic calcium and increased generation of reactive oxygen species (ROS). The beta-amyloid fragment (Abeta) of the amyloid precursor protein induces calcium influx, ROS...

journal_title：Journal of neurochemistry

authors： Ho PI,Collins SC,Dhitavat S,Ortiz D,Ashline D,Rogers E,Shea TB

更新日期：2001-07-01 00:00:00

abstract：:Choline acetyltransferase (ChAT) is specifically expressed in cholinergic neurons. To identify control mechanisms regulating the cell-specific expression of the gene encoding ChAT, transient expression of the luciferase gene driven by human ChAT gene 5'flanking sequences was compared in cholinergic and noncholinergic ...

journal_title：Journal of neurochemistry

authors： Li YP,Baskin F,Davis R,Hersh LB

更新日期：1993-08-01 00:00:00

abstract：:Gs alpha, the GTP-binding protein that mediates receptor stimulation of adenylyl cyclase, exists in small (Gs alpha-S) and large (Gs alpha-L) molecular forms. Previous work has established that these Gs alpha isoforms are products of alternatively spliced Gs alpha pre-mRNA. The present work examined the splicing patte...

journal_title：Journal of neurochemistry

authors： Granneman JG,Bannon MJ

更新日期：1991-09-01 00:00:00

abstract：:Agonist-induced down-regulation of opioid receptors appears to require the phosphorylation of the receptor protein. However, the identities of the specific protein kinases that perform this task remain uncertain. Protein kinase C (PKC) has been shown to catalyze the phosphorylation of several G protein-coupled recepto...

journal_title：Journal of neurochemistry

authors： Kramer HK,Simon EJ

更新日期：1999-02-01 00:00:00

abstract：:Fresh myelin, isolated from brainstems of adult rats, was incubated in the presence of Cu2+ and H2O2. Electrophoretic analysis of the reisolated myelin membrane revealed a gradual loss of the protein moiety from the characteristic pattern and an increase in aggregated material appearing at the origin of the gel. The a...

journal_title：Journal of neurochemistry

authors： Konat GW,Wiggins RC

更新日期：1985-10-01 00:00:00

abstract：:Expression of the carboxyl-terminal fragment (CT) of the beta-amyloid precursor protein (APP) in transgenic animals has been linked with neurotoxicity. However, it remains to be clarified whether the neurotoxicity is caused by beta-amyloid proteins (A betas) derived from CT or by CT itself. To study the in vivo neurot...

journal_title：Journal of neurochemistry

authors： Song DK,Won MH,Jung JS,Lee JC,Kang TC,Suh HW,Huh SO,Paek SH,Kim YH,Kim SH,Suh YH

更新日期：1998-08-01 00:00:00

abstract：:The incorporation of radioactive phosphate into proteins of both normal and regenerating ganglia of the sympathetic nervous system of the rat is reported. The incorporation reactions were carried out in vitro by incubating homogenates of excised ganglia with [gamma-32P]ATP under various conditions. It was found that i...

journal_title：Journal of neurochemistry

authors： Watterson JG,Good R,Moses E,Hearn MT,Austin L

更新日期：1989-06-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has central functions in development, tissue maintenance, and repair and has been implicated in major diseases. We discovered that TGF-beta1 contains several amphipathic helices and hydrophobic domains similar to apolipoprotein E (apoE), a protein involved in lipoprotein me...

journal_title：Journal of neurochemistry

authors： Tesseur I,Zhang H,Brecht W,Corn J,Gong JS,Yanagisawa K,Michikawa M,Weisgraber K,Huang Y,Wyss-Coray T

更新日期：2009-08-01 00:00:00

abstract：:The effect of glucose concentration on the in vitro release of histamine (HA) was examined, using two different preparations of the mouse hypothalamus. The HA and tele-methylhistamine released from whole blocks of the hypothalamus into the medium linearly increased during 2-h incubation in normal Krebs-Ringer bicarbon...

journal_title：Journal of neurochemistry

authors： Nishibori M,Oishi R,Itoh Y,Saeki K

更新日期：1986-12-01 00:00:00

abstract：:Rat retina tissue contains relatively high amounts of GD3 in relation to ganglio-series gangliosides even in the adult stages. This was attributed in part to an activity ratio between the enzyme that converts GM3 to GD3 [sialytransferase II (ST-II)] and the enzyme that converts GM3 to GM2 [N-acetylgalactosaminyltransf...

journal_title：Journal of neurochemistry

authors： Martina JA,Daniotti JL,Maccioni HJ

更新日期：1995-03-01 00:00:00

abstract：:The inhibition of [3H]5-hydroxytryptamine [( 3H]5-HT) binding in rat brain by 1-[2-(3-bromoacetamidophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (BrAcTFMPP) and that by spiperone were compared. Spiperone inhibition of [3H]5-HT binding in cortex was consistent with displacement from two sites with dissociation ...

journal_title：Journal of neurochemistry

authors： Ransom RW,Asarch KB,Shih JC

更新日期：1985-03-01 00:00:00