Cholinergic neuron-specific expression of the human choline acetyltransferase gene is controlled by silencer elements.

abstract：:Carboxymethylation and phosphorylation of protein phosphatase 2A (PP2A) catalytic C subunit are evolutionary conserved mechanisms that critically control PP2A holoenzyme assembly and substrate specificity. Down-regulation of PP2A methylation and PP2A enzymes containing the B alpha regulatory subunit occur in Alzheimer...

journal_title：Journal of neurochemistry

authors： Nunbhakdi-Craig V,Schuechner S,Sontag JM,Montgomery L,Pallas DC,Juno C,Mudrak I,Ogris E,Sontag E

更新日期：2007-05-01 00:00:00

abstract：:The circadian rhythm of methionine S-adenosyltransferase, which catalyzes the formation of S-adenosylmethionine, a cosubstrate for melatonin in the pineal gland, follows the pattern of hydroxyindole-O-methyltransferase. Around the middle of the dark period, methionine S-adenosyltransferase and hydroxyindole-O-methyltr...

journal_title：Journal of neurochemistry

authors： Guchhait RB,Monjan AA

更新日期：1981-06-01 00:00:00

abstract：:The effect of ascorbic acid on Ca2+ uptake in cultured rat astrocytes was examined in the presence of ouabain and monensin, which are considered to drive the Na(+)-Ca2+ exchanger in the reverse mode. Ascorbic acid at 0.1-1 mM inhibited Na(+)-dependent Ca2+ uptake significantly but not Na(+)-dependent glutamate uptake ...

journal_title：Journal of neurochemistry

authors： Takuma K,Matsuda T,Asano S,Baba A

更新日期：1995-04-01 00:00:00

abstract：:delta 1-Pyrroline, 5-methyl-delta 1-pyrroline, and 5,5-dimethyl-delta 1-pyrroline have been identified as substances metabolized to gamma-aminobutyric acid (GABA), 4-aminopentanoic acid (methylGABA), and 4-amino-4-methylpentanoic acid (dimethylGABA), respectively. An enzyme system residing in the soluble fraction of r...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA,Nayar MS,Stogniew M,Rao KG

更新日期：1982-04-01 00:00:00

abstract：:We have shown previously that N-(4-hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid derivative, induces neuronal differentiation in cultured human retinal pigment epithelial (RPE) cells [Chen et al., J. Neurochem., 84 (2003), 972]. We asked the question whether the mitogen-activated protein kinase (MAPK) ...

journal_title：Journal of neurochemistry

authors： Samuel W,Kutty RK,Sekhar S,Vijayasarathy C,Wiggert B,Redmond TM

更新日期：2008-07-01 00:00:00

abstract：:Regulated intramembrane proteolysis (RIP) controls the communication between cells and the extracellular environment. RIP is essential in the nervous system, but also in other tissues. In the RIP process, a membrane protein typically undergoes two consecutive cleavages. The first one results in the shedding of its ect...

journal_title：Journal of neurochemistry

authors： Lichtenthaler SF,Haass C,Steiner H

更新日期：2011-06-01 00:00:00

abstract：:Primary cortical neurones exposed to an oxidative insult in the form of hydrogen peroxide (H(2)O(2)) for 30 min showed a concentration-dependent increase in oxidative stress followed by a delayed NMDA receptor-dependent cell death measured 24 h later. Extracellular signal-regulated protein kinase (ERK1/2), c-jun N-ter...

journal_title：Journal of neurochemistry

authors： Crossthwaite AJ,Hasan S,Williams RJ

更新日期：2002-01-01 00:00:00

abstract：:The rat pheochromocytoma PC12 cell line has been an invaluable model system for studying neuritogenesis. Nerve growth factor (NGF) elicits multiple aspects of neurite outgrowth in PC12 cells. It is therefore difficult to dissect and assign an individual signaling pathway to each stage of neuritogenesis. We have recent...

journal_title：Journal of neurochemistry

authors： Xiao J,Liu Y

更新日期：2003-09-01 00:00:00

abstract：:Modulation of [3H]muscimol binding by picrotoxin, pentobarbitone, and etomidate was investigated in rat cerebellar and cerebral cortical membranes. In cerebellum, at 37 degrees C in the presence of chloride ions (150 mM), picrotoxin and picrotoxinin decreased specific [3H]muscimol binding to 43 +/- 3% of control, with...

journal_title：Journal of neurochemistry

authors： Quast U,Brenner O

更新日期：1983-08-01 00:00:00

abstract：:Monoamine oxidases (MAOs) are mitochondrial enzymes which control the levels of neurotransmitters in the brain and dietary amines in peripheral tissues via oxidative deamination. MAO has also been implicated in cell signalling. In this study, we describe the MAO-A isoform as functional in apoptosis induced by staurosp...

journal_title：Journal of neurochemistry

authors： Fitzgerald JC,Ufer C,De Girolamo LA,Kuhn H,Billett EE

更新日期：2007-12-01 00:00:00

abstract：:Microscopic fluorescence analysis of fura-2-loaded bovine adrenal chromaffin cells demonstrates that approximately 70% of the cells responded to arachidonic acid in increasing the intracellular Ca2+ concentration. Because this increase was markedly less in the absence of external Ca2+, we examined the effect of arachi...

journal_title：Journal of neurochemistry

authors： Mochizuki-Oda N,Negishi M,Mori K,Ito S

更新日期：1993-11-01 00:00:00

abstract：:The mu-opioid receptor agonists have a preferential effect on nociception in adults but their analgesic effect is less selective in neonates. Here we presented our finding that the mu-opioid receptor agonists had no effect on high voltage-activated Ca(2+) channels (HVACCs) in adult dorsal root ganglion (DRG) neurons t...

journal_title：Journal of neurochemistry

authors： Wu ZZ,Cai YQ,Pan HL

更新日期：2009-05-01 00:00:00

abstract：:The metabolism and blood-brain transport of choline (Ch) were investigated in perfused canine brain under control conditions and for 60 min after inhibition of brain cholinesterases by the organophosphorus (OP) compounds soman (pinacolylmethylphosphonofluoridate). Ch and acetylcholine (ACh) in blood and brain samples ...

journal_title：Journal of neurochemistry

authors： Drewes LR,Singh AK

更新日期：1988-03-01 00:00:00

abstract：:Fast-performance liquid chromatography was used to purify assembly-competent tubulin from porcine brain microtubule protein prepared by two cycles of assembly-disassembly. Microtubule protein (1-100 mg at 1.5-2.5 mg/ml) in buffer consisting of 0.1 M 2-(N-morpholino)ethanesulfonic acid, 0.5 mM MgCl2, 1 mM EGTA, 0.3 M K...

journal_title：Journal of neurochemistry

authors： Roychowdhury S,Gaskin F

更新日期：1986-05-01 00:00:00

abstract：:A major hallmark of mutant superoxide dismutase (SOD1)-linked familial amyotrophic lateral sclerosis is SOD1-immunopositive inclusions found within motor neurons. The mechanism by which SOD1 becomes aggregated, however, remains unclear. In this study, we aimed to investigate the role of nitrosative stress and S-nitros...

journal_title：Journal of neurochemistry

authors： Chen X,Zhang X,Li C,Guan T,Shang H,Cui L,Li XM,Kong J

更新日期：2013-01-01 00:00:00

abstract：:We have screened a human cDNA library using an expressed sequence tag related to the BM-40/secreted protein, acidic and rich in cysteine (SPARC)/osteonectin family of proteins and isolated a novel cDNA. It encodes a protein precursor of 424 amino acids that consists of a signal peptide, a follistatin-like domain, a Ca...

journal_title：Journal of neurochemistry

authors： Vannahme C,Schübel S,Herud M,Gösling S,Hülsmann H,Paulsson M,Hartmann U,Maurer P

更新日期：1999-07-01 00:00:00

abstract：:We looked at the possible interactions between astrocytes and neurones during reperfusion using an in vitro model of ischaemia-reperfusion injury, as a controlled environment that lends itself easily to manipulation of the numerous variables involved in such an insult. We constructed a chamber in which O2 can be lower...

journal_title：Journal of neurochemistry

authors： Griffin S,Clark JB,Canevari L

更新日期：2005-11-01 00:00:00

abstract：:In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. These adult NSCs retain their self-renewal ability and capacity t...

journal_title：Journal of neurochemistry

authors： Hayashi Y,Jinnou H,Sawamoto K,Hitoshi S

更新日期：2018-12-01 00:00:00

abstract：:The ontogeny of muscarinic receptors was studied in human fetal striatum, brainstem, and cerebellum to investigate general principles of synaptogenesis as well as the physiological balance between various chemical synapses during development in a given region of the brain. [3H]Quinuclidinyl benzilate ([3H]QNB) binding...

journal_title：Journal of neurochemistry

authors： Ravikumar BV,Sastry PS

更新日期：1985-12-01 00:00:00

abstract：:We have identified a novel mouse gene named pancortin that is expressed dominantly in the mature cerebral cortex. This gene produces four different species of proteins, Pancortin-1-4, sharing a common region in the middle of their structure with two variations at the N-terminal (A1 or A2 part) and C-terminal (C1 or C2...

journal_title：Journal of neurochemistry

authors： Nagano T,Nakamura A,Konno D,Kurata M,Yagi H,Sato M

更新日期：2000-07-01 00:00:00

abstract：:Uptake and release of alanine were measured in lumbar sympathetic chains excised from embryos of white leghorn chickens, 14-15 days old, and incubated in a modified Eagle's minimum essential medium. In the presence of [U-14C]glucose, glucose carbon accumulated in alanine in the medium at a rate that increased when unl...

journal_title：Journal of neurochemistry

authors： Larrabee MG

更新日期：1984-09-01 00:00:00

abstract：:The P2X7 receptor/channel responds to extracellular ATP and is associated with neuronal death and neuroinflammation in spinal cord injury and amyotrophic lateral sclerosis. Whether activation of P2X7 directly causes motor neuron death is unknown. We found that cultured motor neurons isolated from embryonic rat spinal ...

journal_title：Journal of neurochemistry

authors： Gandelman M,Levy M,Cassina P,Barbeito L,Beckman JS

更新日期：2013-08-01 00:00:00

abstract：:In an established rat model of penetrating ballistic-like brain injury (PBBI), arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase) activity was significantly reduced at the ipsilateral site of injury, but unaffected at the contralateral site or in sham controls. In addition, the ARSB substrate chondroitin 4-sulf...

journal_title：Journal of neurochemistry

authors： Bhattacharyya S,Zhang X,Feferman L,Johnson D,Tortella FC,Guizzetti M,Tobacman JK

更新日期：2015-08-01 00:00:00

abstract：:Neural transplantation is an experimental treatment for Parkinson's disease. Widespread clinical application of the grafting technique is hampered by a relatively poor survival (around 10%) of implanted embryonic dopamine neurones. Earlier animal studies have indicated that a large proportion of the grafted cells die ...

journal_title：Journal of neurochemistry

authors： Emgård M,Hallin U,Karlsson J,Bahr BA,Brundin P,Blomgren K

更新日期：2003-09-01 00:00:00

abstract：:Immunoaffinity chromatography with a monoclonal antibody produced against bovine tau protein was used to purify tau proteins from human brain. Fifty grams of brain tissue yielded approximately 2 mg of pure tau proteins. The affinity-purified human tau was used to produce a high-titered rabbit anti-human tau serum. The...

journal_title：Journal of neurochemistry

authors： Mercken M,Vandermeeren M,Lübke U,Six J,Boons J,Vanmechelen E,Van de Voorde A,Gheuens J

更新日期：1992-02-01 00:00:00

abstract：:The activities of monoamine oxidase A (MAO A) and monoamine oxidase B (MAO B) represent two independent types of substrate binding site, as indicated by experiments with selective inhibitors and also by substrate competition. We have tried to determine whether A and B active sites of human brain and liver MAO are loca...

journal_title：Journal of neurochemistry

authors： White HL,Stine DK

更新日期：1982-05-01 00:00:00

abstract：:IMP-GMP 5'-nucleotidase has been purified to homogeneity from total rat brain extracts. This preparation showed a unique band (Mr 54,000 +/- 1,509) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme presented the following properties: optimal pH value, 6.5-6.8; relative velocity measured in the p...

journal_title：Journal of neurochemistry

authors： Marques AF,Teixeira NA,Gambaretto C,Sillero A,Sillero MA

更新日期：1998-09-01 00:00:00

abstract：:Intracellular protein inclusions in Alzheimer's disease and progressive supranuclear palsy contain UBB+1, a variant ubiquitin. UBB+1 is able block the 26S proteasome in cell lines. Proteasome inhibition by drug action has previously been shown to induce a heat-shock response and render protection against stress. We in...

journal_title：Journal of neurochemistry

authors： Hope AD,de Silva R,Fischer DF,Hol EM,van Leeuwen FW,Lees AJ

更新日期：2003-07-01 00:00:00

abstract：:Astrogliosis occurs after brain ischemia, and excessive astrogliosis can devastate the neuronal recovery. Previous reports show that galectin-1 (Gal-1) regulates proliferation of several cell types and plays an important role after nervous system injuries. Here, we found that expression of Gal-1 was remarkably up-regu...

journal_title：Journal of neurochemistry

authors： Qu WS,Wang YH,Ma JF,Tian DS,Zhang Q,Pan DJ,Yu ZY,Xie MJ,Wang JP,Wang W

更新日期：2011-01-01 00:00:00

abstract：:Cell culture studies have shown that the Alzheimer amyloid precursor protein (APP) is secreted after full-length APP is cleaved by a putative secretase at the Lys16-Leu17 bond (secretase cleavage I) of the amyloid peptide sequence. Because this cleavage event is incompatible with amyloid production, it has been assume...

journal_title：Journal of neurochemistry

authors： Anderson JP,Chen Y,Kim KS,Robakis NK

更新日期：1992-12-01 00:00:00