Localisation of microtubule-associated protein 1B phosphorylation sites recognised by monoclonal antibody SMI-31.

abstract：:Neuropathic pain is a debilitating chronic pain condition occurring after damage in the nervous system and is refractory to the currently available treatments. Major challenges include elucidating its mechanisms and developing new medications to treat it. Nerve injury-induced pain hypersensitivity involves aberrant ex...

journal_title：Journal of neurochemistry

authors： Tsuda M,Koga K,Chen T,Zhuo M

更新日期：2017-05-01 00:00:00

abstract：:Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited neurodegenerative disorder for which no curative therapy is available. The cause of this disease is the expansion of a CAG repeat in the so-called ATXN3 gene leading to an expanded polyglutamine stretch in the ataxin-3 protein. Although the func...

journal_title：Journal of neurochemistry

authors： Schmidt J,Schmidt T,Golla M,Lehmann L,Weber JJ,Hübener-Schmid J,Riess O

更新日期：2016-07-01 00:00:00

abstract：:Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease, is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated disease genes. Polyglutamine disorders are characterized by disease protein misfolding and aggregation; often within th...

journal_title：Journal of neurochemistry

authors： Berke SJ,Schmied FA,Brunt ER,Ellerby LM,Paulson HL

更新日期：2004-05-01 00:00:00

abstract：:Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

journal_title：Journal of neurochemistry

authors： Wade JV,Samson FE,Nelson SR,Pazdernik TL

更新日期：1987-08-01 00:00:00

abstract：:Signaling by muscarinic agonists is thought to result from the activation of cell surface acetylcholine receptors (mAChRs) that transmit extracellular signals to intracellular systems. In N1E-115 neuroblastoma cells, we detected both plasma membrane and intracellular M(1) -mAChRs using both biochemical and pharmacolog...

journal_title：Journal of neurochemistry

authors： Uwada J,Anisuzzaman AS,Nishimune A,Yoshiki H,Muramatsu I

更新日期：2011-09-01 00:00:00

abstract：:Caspase cleavage of amyloid precursor protein (APP) has been reported to be important in amyloid beta protein (Aβ)-mediated neurotoxicity. However, the underlying mechanisms are not clearly understood. In this study, we explored the effect of caspase cleavage of APP on tau phosphorylation in relation to Aβ. We found t...

journal_title：Journal of neurochemistry

authors： Park SS,Jung HJ,Kim YJ,Park TK,Kim C,Choi H,Mook-Jung IH,Koo EH,Park SA

更新日期：2012-12-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the spontaneous release of endogenous glutamic acid (Glu) or aspartic acid (Asp) and the effects of Glu on the release of endogenous GABA or [3H]GABA were studied in superfused rat cerebral cortex synaptosomes. GABA increased the outflow of Glu (EC50 17.2 microM) and As...

journal_title：Journal of neurochemistry

authors： Bonanno G,Pittaluga A,Fedele E,Fontana G,Raiteri M

更新日期：1993-07-01 00:00:00

abstract：:Oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. Here, we investigated the effect of peroxide exposure on the expression of genes coding for cytoplasmic and endoplasmic reticulum (ER) stress proteins. Primary neuronal cell cultures were exp...

journal_title：Journal of neurochemistry

authors： Paschen W,Mengesdorf T,Althausen S,Hotop S

更新日期：2001-03-01 00:00:00

abstract：:Three major subtypes of glutamate receptors that are coupled to cation channels--N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors--are known as ionotropic receptors in the mammalian CNS. Recently, an additional subtype that is coupled to GTP binding protei...

journal_title：Journal of neurochemistry

authors： Itano Y,Murayama T,Kitamura Y,Nomura Y

更新日期：1992-09-01 00:00:00

abstract：:Changes in the free fatty acid pool size and fatty acyl chain composition of mitochondrial membrane phospholipids and their relation to disruption of mitochondrial function were examined in rat brains after 30 min of cerebral ischemia (Pulsinelli-Brierley model) and 60 min of normoxic reoxygenation. During ischemia, s...

journal_title：Journal of neurochemistry

authors： Sun D,Gilboe DD

更新日期：1994-05-01 00:00:00

abstract：:Several Good buffers (MOPS, ACES, BES, HEPES, ADA, and PIPES) competitively inhibited both high-affinity and low-affinity [3H]gamma-aminobutyric acid receptor binding to rat brain synaptic membranes. The most potent inhibitor was MOPS, which had Ki values of 180 nM and 79 nM for the high- and low-affinity binding site...

journal_title：Journal of neurochemistry

authors： Tunnicliff G,Smith JA

更新日期：1981-03-01 00:00:00

abstract：:Histamine stimulates cyclic AMP accumulation in astrocyte-enriched and neuronal primary cultures from rat brain in the presence of the phosphodiesterase inhibitor isobutylmethylxanthine. The response in the astrocyte cultures (Emax = 304 +/- 44% over basal, EC50 = 43 +/- 5 microM) was much higher than in neuronal cult...

journal_title：Journal of neurochemistry

authors： Agulló L,Picatoste F,García A

更新日期：1990-11-01 00:00:00

abstract：:The antisense strategy was used to unravel the functional contribution of the mRNAs encoding dopamine (DA) receptors to the multiple transduction mechanisms operated by DA in rat pituitary cells. An antisense oligonucleotide was designed to recognize seven nucleotides upstream and 11 nucleotides downstream from the in...

journal_title：Journal of neurochemistry

authors： Valerio A,Alberici A,Tinti C,Spano P,Memo M

更新日期：1994-04-01 00:00:00

abstract：:Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several-fold increases in soluble QC (sQC) expression in the brain and peripheral circulation of AD individuals has prompted the development of QC inhib...

journal_title：Journal of neurochemistry

authors： Gunn AP,Wong BX,McLean C,Fowler C,Barnard PJ,Duce JA,Roberts BR,AIBL Research Group.

更新日期：2020-07-02 00:00:00

abstract：:We have analyzed brain coated vesicles and synaptic plasma membrane for the presence of the plasma membrane proteolipid protein. Coated vesicles were isolated from calf brain gray matter with a final purification on Sephacryl S-1000 and reisolated twice by chromatography to ensure homogeneity. Fractions were analyzed ...

journal_title：Journal of neurochemistry

authors： Sapirstein VS,Nolan C,Stern R,Ciocci M,Masur SK

更新日期：1988-09-01 00:00:00

abstract：:Glutamate is the major excitatory transmitter in the vertebrate brain and its extracellular levels are tightly regulated to prevent excitotoxic effects. The Na(+)-dependent glutamate/aspartate transporter GLAST/EAAT1 is regulated in the short and in the long term by glutamate. A receptors-independent change in its mem...

journal_title：Journal of neurochemistry

authors： Rosas S,Vargas MA,López-Bayghen E,Ortega A

更新日期：2007-05-01 00:00:00

abstract：:Myelination of peripheral nerves by Schwann cells depends upon a gene regulatory network controlled by early growth response Egr2/Krox20, which is specifically required for Schwann cells to initiate and maintain myelination. To elucidate the mechanism by which Egr2 regulates gene expression during myelination, we have...

journal_title：Journal of neurochemistry

authors： Jang SW,Srinivasan R,Jones EA,Sun G,Keles S,Krueger C,Chang LW,Nagarajan R,Svaren J

更新日期：2010-12-01 00:00:00

abstract：:A reporter epitope was inserted at 11 positions in a region encompassing proposed transmembrane segments S1 and S2 in the second repeat domain (D2) of the rat skeletal muscle type 1 sodium channel. All mutations produced full-length membrane-associated protein following transfection into cultured cells, although the l...

journal_title：Journal of neurochemistry

authors： Kraner SD,Filatov GN,Sun W,Bannerman P,Lindstrom J,Barchi RL

更新日期：1998-04-01 00:00:00

abstract：:Myelin P2 protein is a small (14,800 Da) protein found in peripheral and central nervous system myelin. To investigate the regulation of expression of this myelin protein, a mouse genomic library was screened with a rabbit P2 cDNA (pSN2.2-2), and a single positive phage clone containing a 20-kb insert was obtained. Th...

journal_title：Journal of neurochemistry

authors： Narayanan V,Kaestner KH,Tennekoon GI

更新日期：1991-07-01 00:00:00

abstract：:Rats fasted overnight were allowed to consume single meals containing 0, 18, or 40% protein or continued to fast; after 2 h, brains and sera were taken and assayed for various amino acids. In general, serum levels of most amino acids were reduced by the 0% protein meal and elevated by the high-protein meal when compar...

journal_title：Journal of neurochemistry

authors： Glaeser BS,Maher TJ,Wurtman RJ

更新日期：1983-10-01 00:00:00

abstract：:The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain. Rats were treated intraperitoneally, with gabapentin (30, 100 and 300 mg/kg), lamotrigine (2, 10 and 50 mg/kg) or riluzole (6 and 12 mg/kg) prior to, and eve...

journal_title：Journal of neurochemistry

authors： Coderre TJ,Kumar N,Lefebvre CD,Yu JS

更新日期：2007-03-01 00:00:00

abstract：:At present, treatment for Parkinson's disease (PD) is only symptomatic; therefore, it is important to identify new targets tackling the molecular causes of the disease. We previously found that lymphoblasts from sporadic PD patients display increased activity of the cyclin D3/CDK6/pRb pathway and higher proliferation ...

journal_title：Journal of neurochemistry

authors： Alquézar C,Barrio E,Esteras N,de la Encarnación A,Bartolomé F,Molina JA,Martín-Requero Á

更新日期：2015-06-01 00:00:00

abstract：:Silent information regulator 2, a member of NAD+-dependent histone deacetylase in yeast, and its homologs in mice and humans, participate in numerous important cell functions, including cell protection and cell cycle regulation. The sirtuin family members are highly conserved evolutionarily, and are predicted to have ...

journal_title：Journal of neurochemistry

authors： Anekonda TS,Reddy PH

更新日期：2006-01-01 00:00:00

abstract：:The effect of manipulating the activity of central 5-hydroxytryptamine (5-HT) neurones on extracellular 5-HT in ventral hippocampus of the chloral hydrate-anaesthetized rat was studied using the brain perfusion method, microdialysis. Basal levels of 5-HT in the dialysates were close to the detection limits of our assa...

journal_title：Journal of neurochemistry

authors： Sharp T,Bramwell SR,Clark D,Grahame-Smith DG

更新日期：1989-07-01 00:00:00

abstract：:We investigated the mechanism of increases in cyclic GMP levels in bovine superior cervical ganglion (SCG) in response to muscarinic receptor stimulation. Acetylcholine increased cyclic GMP levels in SCG. This increase was inhibited by NG-methyl-L-arginine (NMA), and the inhibition was reversed by L-arginine. Soluble ...

journal_title：Journal of neurochemistry

authors： Sheng H,Gagne GD,Matsumoto T,Miller MF,Förstermann U,Murad F

更新日期：1993-09-01 00:00:00

abstract：:The effect of a unilateral perinatal hypoxic-ischemic brain injury on dopamine D1 and D2 receptors and uptake sites was investigated in rats by using in vitro quantitative binding autoradiography, 2-3 weeks after the insult. We observed significant decreases in the Bmax and KD for [3H]SCH 23390-labeled D1 and in the B...

journal_title：Journal of neurochemistry

authors： Przedborski S,Kostic V,Jackson-Lewis V,Cadet JL,Burke RE

更新日期：1991-12-01 00:00:00

abstract：:Interleukin-1β (IL-1β) is released from activated microglia and involved in the neurodegeneration of acute and chronic brain disorders, such as stroke and Alzheimer's disease, in which extracellular acidification has been shown to occur. Here, we examined the extracellular acidic pH regulation of IL-1β production, esp...

journal_title：Journal of neurochemistry

authors： Jin Y,Sato K,Tobo A,Mogi C,Tobo M,Murata N,Ishii S,Im DS,Okajima F

更新日期：2014-05-01 00:00:00

abstract：:The blood-brain barrier (BBB) formed by brain microvascular endothelial cells (BMVEC) regulates the passage of molecules and leukocytes in and out of the brain. Oxidative stress is a major underlying cause of neurodegenerative and neuroinflammatory disorders and BBB injury associated with them. Using human BMVEC grown...

journal_title：Journal of neurochemistry

authors： Haorah J,Ramirez SH,Schall K,Smith D,Pandya R,Persidsky Y

更新日期：2007-04-01 00:00:00

abstract：:Phosphodiesterase (PDE) 7B, a cAMP-specific PDE which is dominantly expressed in striatum, is expected to be involved in dopaminergic signaling in striatal neurons. Here we show, for the first time, the involvement of the dopaminergic signaling pathway in transcriptional activation of rat PDE7B in primary striatal cul...

journal_title：Journal of neurochemistry

authors： Sasaki T,Kotera J,Omori K

更新日期：2004-04-01 00:00:00

abstract：:Malonaldehyde formation by cortical brain slices from rat brain was determined as a function of incubation time and of oxygen pressure. This substance, a byproduce of lipid peroxidation, was detected by the thiobarbituric acid test. Significant amounts of malonaldehyde were formed by brain slices during incubation in ...

journal_title：Journal of neurochemistry

authors： Kovachich GB,Mishra OP

更新日期：1980-12-01 00:00:00