Abstract:
:For many years, zebrafish have been the prototypical model for studies in developmental biology. In recent years, zebrafish has emerged as a powerful model system to study infectious diseases, including viral infections. Experiments conducted with herpes simplex virus type-1 in adult zebrafish or in embryo models are encouraging as they establish proof of concept with viral-host tropism and possible screening of antiviral compounds. In addition, the presence of human homologs of viral entry receptors in zebrafish such as 3-O sulfated heparan sulfate, nectins, and tumor necrosis factor receptor superfamily member 14-like receptor bring strong rationale for virologists to test their in vivo significance in viral entry in a zebrafish model and compare the structure-function basis of virus zebrafish receptor interaction for viral entry. On the other end, a zebrafish model is already being used for studying inflammation and angiogenesis, with or without genetic manipulations, and therefore can be exploited to study viral infection-associated pathologies. The major advantage with zebrafish is low cost, easy breeding and maintenance, rapid lifecycle, and a transparent nature, which allows visualizing dissemination of fluorescently labeled virus infection in real time either at a localized region or the whole body. Further, the availability of multiple transgenic lines that express fluorescently tagged immune cells for in vivo imaging of virus infected animals is extremely attractive. In addition, a fully developed immune system and potential for receptor-specific knockouts further advocate the use of zebrafish as a new tool to study viral infections. In this review, we focus on expanding the potential of zebrafish model system in understanding human infectious diseases and future benefits.
journal_name
Zebrafishjournal_title
Zebrafishauthors
Antoine TE,Jones KS,Dale RM,Shukla D,Tiwari Vdoi
10.1089/zeb.2013.0920subject
Has Abstractpub_date
2014-02-01 00:00:00pages
17-25issue
1eissn
1545-8547issn
1557-8542journal_volume
11pub_type
杂志文章相关文献
Zebrafish文献大全abstract::Analysis of genes compromising the glomerular filtration barrier in rodent models using transgenic or knockdown approaches is time- and resource-consuming and often leads to unsatisfactory results. Therefore, it would be beneficial to have a selection tool indicating that your gene of interest is in fact associated wi...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1093
更新日期:2015-10-01 00:00:00
abstract::A husbandry workshop on July 3, 2017, at the 10th European Zebrafish Meeting in Budapest, Hungary (July 3-July 7, 2017), focused on the standardization, optimization, and streamlining of fish facility procedures. Standardization can be achieved for example by developing novel software and hardware tools, such as a fis...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1548
更新日期:2018-04-01 00:00:00
abstract::The zebrafish system has been established as a useful model for the study of carcinogenesis. The cytogenetic characterization of the genome is vital for furthering our understanding of the progression of the disease. Establishing a basic description of the zebrafish chromosomal karyotype and markers for each specific ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2009.0600
更新日期:2009-12-01 00:00:00
abstract::Traditional working heart preparations, based on the original Langendorff setup, are widely used experimental models that have tremendously advanced the cardiovascular field. However, these systems can be deceivingly complex, requiring the maintenance of pH with CO(2), the delivery of oxygenated perfusate, and the nee...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2008.0550
更新日期:2008-12-01 00:00:00
abstract::Morpholino oligonucleotides are the most common anti-sense "knockdown" technique used in zebrafish (Danio rerio). This review discusses common practices for the design, preparation, and deployment of morpholinos in this vertebrate model system. Off-targeting effects of morpholinos are discussed as well as method to mi...
journal_title:Zebrafish
pub_type: 杂志文章,评审
doi:10.1089/zeb.2008.0555
更新日期:2009-03-01 00:00:00
abstract::Astyanax is a genus with a wide distribution ranging from the south United States to north of Patagonia (Argentina). The available cytogenetic data on Astyanax indicate a high karyotypic diversity, with diploid number of 36-52 chromosomes, presence of B chromosomes, heterochromatin polymorphism, and variations with re...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2018.1647
更新日期:2019-02-01 00:00:00
abstract::After its introduction for scientific investigation in the 1950s, the cypriniform zebrafish, Danio rerio, has become a valuable model for the study of regenerative processes and mechanisms. Zebrafish exhibit epimorphic regeneration, in which a nondifferentiated cell mass formed after amputation is able to fully regene...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2020.1926
更新日期:2020-12-01 00:00:00
abstract::The Cannabis sativa plant contains numerous phytocannabinoids and terpenes with known or potential biological activity. For decades, plant breeders have been breeding the Cannabis plant to control for a desired ratio of the major cannabinoids. A high-throughput in vivo model to understand the relationship between the ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1541
更新日期:2018-08-01 00:00:00
abstract::The second European Zebrafish Principal Investigator (PI) Meeting was held in March, 2012, in Karlsruhe, Germany. It brought together PIs from all over Europe who work with fish models such as zebrafish and medaka to discuss their latest results, as well as to resolve strategic issues faced by this research community....
journal_title:Zebrafish
pub_type:
doi:10.1089/zeb.2012.0829
更新日期:2013-03-01 00:00:00
abstract::Our first Zebrafish Enhancer TRAP lines database (ZETRAP) generated a few years ago was a web-based system informing the scientific community about the developmental, genetic, and genomic aspects of transgenic zebrafish lines expressing the cytosolic version of EGFP. These transgenic lines were obtained in a primary s...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0718
更新日期:2011-12-01 00:00:00
abstract::The use of antibiotics for anti-infection and growth promotion has caused the overuse of antibiotics in aquaculture. However, the benefit or risk of the long-term use of antibiotics on fish growth or health has not been fully addressed. In the present study, zebrafish were fed with sulfamethoxazole (SMX) or oxytetracy...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1526
更新日期:2018-08-01 00:00:00
abstract::The study of myocardial transmembrane ion currents is fundamental to understand frequent pathologies such as arrhythmias and ischemia. Conventional electrocardiography (ECG) is not able to record ion currents, while the use of intracellular microelectrodes in a beating heart has technical limitations. Myocardial monop...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1753
更新日期:2019-10-01 00:00:00
abstract::β-Cells of the islet of Langerhans produce insulin to maintain glucose homeostasis. Self-replication of β-cells is the predominant mode of postnatal β-cell production in mammals, with about 20% of rodent β cells dividing in a 24-hour period. However, replicating β-cells are rare in adults. Induction of self-replicatio...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2012.0816
更新日期:2013-06-01 00:00:00
abstract::Spring viremia of carp virus (SVCV) causes the skin hemorrhagic disease in cyprinid species, but its molecular mechanism of skin immune response remains unclear at the protein level. In the present study, the differential proteomics of the zebrafish (Danio rerio) skin in response to SVCV infection were examined by iso...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1843
更新日期:2020-04-01 00:00:00
abstract::The completion of the zebrafish genome sequence and advances in miniaturization and multiplexing were essential to the creation of techniques such as RNA-seq, ChIP-seq, and high-throughput behavioral and chemical screens. Multiplexing was also instrumental in the recent enhancement of the classic yeast one-hybrid inte...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1486
更新日期:2018-04-01 00:00:00
abstract::Understanding living systems requires an in-depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication, and contribute to cell fates during development. Several resources exist to provide high-throughput data sets or manually curated interaction information from hum...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1277
更新日期:2016-12-01 00:00:00
abstract::The zebrafish had landed in Singapore as an ornamental fish long before it became a fashionable model of scientific research. By the early 1990s, however, it became a part of the local scientific landscape. During the past decade the number of groups using zebrafish as a research model increased dramatically. In June ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2005.1.327
更新日期:2005-01-01 00:00:00
abstract::We have shown that zebrafish (Danio rerio) are an excellent model for evaluating the link between early life stage exposure to environmental chemicals and disease in adulthood and subsequent unexposed generations. Previously, we used this model to identify transgenerational effects of dioxin (2,3,7,8-tetrachlorodibenz...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1275
更新日期:2016-10-01 00:00:00
abstract::The family Cichlidae is one of the most species-rich taxa in the Neotropics. However, the factors that determine these high levels of biodiversity remain unexplored. We have analyzed the morphological, cytogenetic, and molecular data from 62 specimens of a widespread cichlid, Geophagus brasiliensis, from three adjacen...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2014.0999
更新日期:2015-02-01 00:00:00
abstract::Wild zebrafish exhibit a wide range of behavior. We found abundant wild zebrafish in flowing rivers and still water, in large, tightly-knit groups of hundreds of individuals, as well as in small, loose shoals. In two still-water populations, zebrafish were quite small in body size, common, and in tight groups of up to...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1159
更新日期:2016-02-01 00:00:00
abstract::Although zebrafish is used as a major model species for understanding a number of biological functions and mechanisms involved, there is practically no information on the nutritional requirements of this cyprinid. The rearing practices, especially with regard to feeds and feeding, also vary considerably. To obtain bas...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0696
更新日期:2011-06-01 00:00:00
abstract::Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1321
更新日期:2017-02-01 00:00:00
abstract::Extracellular matrix (ECM) remodeling is a process that is crucial to the development of embryos, the growth and metastasis of tumors, and wound healing and homeostasis of tissues in adults. As such, it involves dozens of gene products that are regulated by mechanisms operating at transcriptional and multiple posttran...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2009.0609
更新日期:2009-12-01 00:00:00
abstract::Considering the numbers of zebrafish held in the laboratories, it is relevant to develop some tools to monitor the health of the animals, as well as their biotope. Environmental samples can be used to detect aquatic pathogens. Comprehensive health monitoring would thus seek pathogens in three dimensions of the animals...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1200
更新日期:2016-07-01 00:00:00
abstract::Spatiotemporal regulation of DNA replication in the S-phase nucleus has been extensively studied in mammalian cells because it is tightly coupled with the regulation of other nuclear processes such as transcription. However, little is known about the replication dynamics in nonmammalian cells. Here, we analyzed the DN...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1151
更新日期:2015-12-01 00:00:00
abstract::To promote application of the fruits of zebrafish research, we need to cultivate understanding of the use of zebrafish not only in the research community but also among the general public. On Open Days at our institute, the National Institute for Environmental Studies (NIES), our zebrafish group exhibits our research ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2008.0565
更新日期:2009-06-01 00:00:00
abstract::Comprising a large number of species, the genus Astyanax has been intensively studied by several approaches to elucidate its evolutionary relationships. Such studies have demonstrated that many nominal species are artificial clusters where distinct taxa are grouped under the same denomination. Astyanax aff. fasciatus ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1272
更新日期:2016-08-01 00:00:00
abstract::Dr. Zhiyuan Gong is Associate Professor in the Department of Biological Sciences, National University of Singapore. He graduated with a B.Sc. degree in marine biology from Ocean University of China and received his Ph.D. degree in developmental biology from McGill University in Canada. He spent many years at the Unive...
journal_title:Zebrafish
pub_type: 面试
doi:10.1089/zeb.2004.1.185
更新日期:2004-01-01 00:00:00
abstract::A study was conducted to preliminarily assess the contribution of the intestinal microflora to biotin supply in zebrafish. Biotin and avidin were added to three isonitrogenous and isocaloric purified diets to provide molar avidin: biotin ratios of 0:0 (basal diet), 0:1 (biotin-supplemented diet), and 120:0. Another di...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0706
更新日期:2011-12-01 00:00:00
abstract::By means of scientometric indicators, this study investigated the characteristics of scientific production and research collaboration involving zebrafish (Danio rerio) in Brazilian Science indexed by the Web of Science (WoS). Citation data were collected from the WoS and data regarding Impact Factor (IF) were gathered...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1183
更新日期:2016-06-01 00:00:00