解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::After its introduction for scientific investigation in the 1950s, the cypriniform zebrafish, Danio rerio, has become a valuable model for the study of regenerative processes and mechanisms. Zebrafish exhibit epimorphic regeneration, in which a nondifferentiated cell mass formed after amputation is able to fully regene...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2020.1926
更新日期:2020-12-01 00:00:00
abstract::Embryo surface disinfection is utilized in aquaculture to decrease the risk of pathogen introduction into established colonies. Zebrafish embryos are commonly disinfected with unbuffered sodium hypochlorite at 25-50 ppm for 10 min with or without concurrent treatment with chemicals, including pronase (Pron), sodium th...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2020.1917
更新日期:2020-10-01 00:00:00
abstract::The genetic compensation response (GCR), triggered by deleterious mutations but not by gene knockdown, has been proposed to explain many phenotypic discrepancies between gene-knockout and gene-knockdown models. GCRs have been observed in many model organisms from mice to Arabidopsis. Although the GCR is beneficial for...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1824
更新日期:2020-05-20 00:00:00
abstract::Spring viremia of carp virus (SVCV) causes the skin hemorrhagic disease in cyprinid species, but its molecular mechanism of skin immune response remains unclear at the protein level. In the present study, the differential proteomics of the zebrafish (Danio rerio) skin in response to SVCV infection were examined by iso...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1843
更新日期:2020-04-01 00:00:00
abstract::Since the use of the zebrafish Danio rerio genetic model organism within the scientific research community continues to grow rapidly, continued procedural refinement to support high-quality, reproducible research and improve animal welfare remains an important focus. As such, anesthesia remains one of the most frequen...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1737
更新日期:2019-10-01 00:00:00
abstract::The study of myocardial transmembrane ion currents is fundamental to understand frequent pathologies such as arrhythmias and ischemia. Conventional electrocardiography (ECG) is not able to record ion currents, while the use of intracellular microelectrodes in a beating heart has technical limitations. Myocardial monop...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1753
更新日期:2019-10-01 00:00:00
abstract::The monotypic Astroblepidae fish family includes 81 species distributed along Central and Northern Andes in South America and Panamá in Central America; most aspects regarding its biology, taxonomy, and chromosomal features remain largely unknown. This study reports the karyotype of two sympatric Astroblepus species f...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2018.1659
更新日期:2019-02-01 00:00:00
abstract::Astyanax is a genus with a wide distribution ranging from the south United States to north of Patagonia (Argentina). The available cytogenetic data on Astyanax indicate a high karyotypic diversity, with diploid number of 36-52 chromosomes, presence of B chromosomes, heterochromatin polymorphism, and variations with re...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2018.1647
更新日期:2019-02-01 00:00:00
abstract::Electronic databases provide effective and efficient management of zebrafish colony operations, but commercially available options are expensive. In this study we have developed a free zebrafish management repository alternative using free Google applications. Husbandry information is logged into a Google Sheets-based...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2018.1583
更新日期:2018-12-01 00:00:00
abstract::Microcystin-leucine arginine (MC-LR) is a natural toxin produced by cyanobacterial blooms that causes severe liver damage in fish. It is crucial to investigate if housekeeping genes are affected by MC-LR in zebrafish, to permit the adequate evaluation of gene expression by RT-qPCR. We evaluated the gene expression sta...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2018.1598
更新日期:2018-10-01 00:00:00
abstract::The use of antibiotics for anti-infection and growth promotion has caused the overuse of antibiotics in aquaculture. However, the benefit or risk of the long-term use of antibiotics on fish growth or health has not been fully addressed. In the present study, zebrafish were fed with sulfamethoxazole (SMX) or oxytetracy...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1526
更新日期:2018-08-01 00:00:00
abstract::The Cannabis sativa plant contains numerous phytocannabinoids and terpenes with known or potential biological activity. For decades, plant breeders have been breeding the Cannabis plant to control for a desired ratio of the major cannabinoids. A high-throughput in vivo model to understand the relationship between the ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1541
更新日期:2018-08-01 00:00:00
abstract::Doradidae has been a target of phylogenetic studies over the last few years, but chromosomal information about the family is still scarce. Therefore, new cytogenetic data are provided herein and they are correlated with phylogenetic proposals to contribute to the knowledge of chromosomal evolution within doradids. Cyt...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1554
更新日期:2018-06-01 00:00:00
abstract::A husbandry workshop on July 3, 2017, at the 10th European Zebrafish Meeting in Budapest, Hungary (July 3-July 7, 2017), focused on the standardization, optimization, and streamlining of fish facility procedures. Standardization can be achieved for example by developing novel software and hardware tools, such as a fis...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1548
更新日期:2018-04-01 00:00:00
abstract::We have developed a simple method for the induction of cataracts in adult zebrafish using hydrogen peroxide. Our method uses a corneal puncture followed by intraocular injection of hydrogen peroxide into the anterior chamber. The procedure can be done rapidly, forming a highly opaque cataract almost immediately, and f...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1533
更新日期:2018-04-01 00:00:00
abstract::Studies on parental aging are a very attractive field, although it is poorly understood how parental age affects embryonic development and adult traits of the offspring. In this study, we used the turquoise killifish Nothobranchius furzeri, as is the vertebrate with shortest captive lifespan and an interesting model. ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1494
更新日期:2018-04-01 00:00:00
abstract::An emergent field of animal personality necessitates a method for repeated high-throughput quantification of behavioral traits across contexts. In this study, we have developed an automated video stimulus approach to sequentially present different contexts relevant to five "personality" traits (exploration, boldness, ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1532
更新日期:2018-04-01 00:00:00
abstract::The completion of the zebrafish genome sequence and advances in miniaturization and multiplexing were essential to the creation of techniques such as RNA-seq, ChIP-seq, and high-throughput behavioral and chemical screens. Multiplexing was also instrumental in the recent enhancement of the classic yeast one-hybrid inte...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1486
更新日期:2018-04-01 00:00:00
abstract::Intestinal motility, the spontaneous and rhythmic smooth muscle contraction, is a complex process that is regulated by overlapping and redundant regulatory mechanisms. Primary regulators intrinsic to the gastrointestinal tract include interstitial cells of Cajal, enteric neurons, and smooth muscle cells. Extrinsic pri...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1440
更新日期:2017-10-01 00:00:00
abstract::Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has been applied to edit genomes in a wide variety of model systems. Although this process can be quite efficient, editing at precise locations in the genome remains difficult without a suitable single guide RNA (sgRNA). We have developed a method...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1358
更新日期:2017-08-01 00:00:00
abstract::Dimethyl sulfoxide (DMSO), a widely used carrier solvent, can be toxic to test organisms and has species-specific sensitivity. In this study, the developmental toxicity and stress protein responses of DMSO to rare minnow (Gobiocypris rarus) and zebrafish (Danio rerio) with two tests were compared in the early life sta...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1287
更新日期:2017-02-01 00:00:00
abstract::Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1321
更新日期:2017-02-01 00:00:00
abstract::Understanding living systems requires an in-depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication, and contribute to cell fates during development. Several resources exist to provide high-throughput data sets or manually curated interaction information from hum...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1277
更新日期:2016-12-01 00:00:00
abstract::The European Zebrafish Principal Investigator Meeting (EZPM) is an ideal forum for group leaders using this fantastic animal model not only to discuss science but also to strengthen their interactions, to push forward technological advances, and to define guidelines for the use of this fish in research. The city of Li...
journal_title:Zebrafish
pub_type:
doi:10.1089/zeb.2016.1364
更新日期:2016-12-01 00:00:00
abstract::We have shown that zebrafish (Danio rerio) are an excellent model for evaluating the link between early life stage exposure to environmental chemicals and disease in adulthood and subsequent unexposed generations. Previously, we used this model to identify transgenerational effects of dioxin (2,3,7,8-tetrachlorodibenz...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1275
更新日期:2016-10-01 00:00:00
abstract::Comprising a large number of species, the genus Astyanax has been intensively studied by several approaches to elucidate its evolutionary relationships. Such studies have demonstrated that many nominal species are artificial clusters where distinct taxa are grouped under the same denomination. Astyanax aff. fasciatus ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1272
更新日期:2016-08-01 00:00:00
abstract::Zebrafish are increasingly used in neurobiological and behavioral studies. Possible stimuli to manipulate zebrafish behavior are being investigated. The presentation of colors appears to be one of the most used approaches, but there is much debate about the exact color preference. Here we have investigated the color p...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1150
更新日期:2016-08-01 00:00:00
abstract::Managing the welfare of laboratory animals is critical to animal health, vital in the understanding of phenotypes created by treatment or genetic alteration and ensures compliance of regulations. Part of an animal welfare assessment is the requirement to record observations, ensuring all those responsible for the anim...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1248
更新日期:2016-07-01 00:00:00
abstract::Considering the numbers of zebrafish held in the laboratories, it is relevant to develop some tools to monitor the health of the animals, as well as their biotope. Environmental samples can be used to detect aquatic pathogens. Comprehensive health monitoring would thus seek pathogens in three dimensions of the animals...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1200
更新日期:2016-07-01 00:00:00
abstract::Many facilities house fish in separate static containers post-procedure, for example, while awaiting genotyping results. This ensures fish can be easily identified, but it does not allow for provision of continuous filtered water or diet. At the Wellcome Trust Sanger Institute, concern over the housing conditions led ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1165
更新日期:2016-07-01 00:00:00
abstract::Mycobacteriosis is a common bacterial infection in laboratory zebrafish caused by several different species and strains of Mycobacterium, including both rapid and slow growers. One control measure used to prevent mycobacterial spread within and between facilities is surface disinfection of eggs. Recent studies have hi...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1229
更新日期:2016-07-01 00:00:00
abstract::The diversity of Hypancistrus species in the Xingu River is remarkable and the variation in color morphs represents a real challenge to taxonomists to delimit species boundaries. One of the most recognizable Hypancistrus complexes is the worm-lined species, known in the aquarium trade as King Tiger Plec in English, Hy...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1213
更新日期:2016-06-01 00:00:00
abstract::Zebrafish (Danio rerio) as a model research organism continues to expand its relevance and role in multiple research disciplines, with recent work directed toward models of metabolism, nutrition, and energetics. Multiple technologies exist to assess body composition in animal research models at various levels of detai...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1157
更新日期:2016-06-01 00:00:00
abstract::By means of scientometric indicators, this study investigated the characteristics of scientific production and research collaboration involving zebrafish (Danio rerio) in Brazilian Science indexed by the Web of Science (WoS). Citation data were collected from the WoS and data regarding Impact Factor (IF) were gathered...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1183
更新日期:2016-06-01 00:00:00
abstract::Wild zebrafish exhibit a wide range of behavior. We found abundant wild zebrafish in flowing rivers and still water, in large, tightly-knit groups of hundreds of individuals, as well as in small, loose shoals. In two still-water populations, zebrafish were quite small in body size, common, and in tight groups of up to...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1159
更新日期:2016-02-01 00:00:00
abstract::There is now strong evidence that early nutrition plays an important role in shaping later physiology. We assessed here whether soy protein concentrate (SPC) or soybean meal (SBM) in early diet would modify zebrafish responses to these products in later life. We fed zebrafish larvae with SPC-, SBM-, or a control-diet ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1131
更新日期:2016-02-01 00:00:00
abstract::Spatiotemporal regulation of DNA replication in the S-phase nucleus has been extensively studied in mammalian cells because it is tightly coupled with the regulation of other nuclear processes such as transcription. However, little is known about the replication dynamics in nonmammalian cells. Here, we analyzed the DN...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1151
更新日期:2015-12-01 00:00:00
abstract::Immediate early genes (IEGs) are transcription factors whose own transcription is initiated rapidly, for example, in the brain in response to environmental stimuli. c-fos is an IEG often used as a marker of neuronal activation. c-fos mRNA expression has started to be quantified and localized in the zebrafish brain fol...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1147
更新日期:2015-12-01 00:00:00
abstract::Analysis of genes compromising the glomerular filtration barrier in rodent models using transgenic or knockdown approaches is time- and resource-consuming and often leads to unsatisfactory results. Therefore, it would be beneficial to have a selection tool indicating that your gene of interest is in fact associated wi...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1093
更新日期:2015-10-01 00:00:00
abstract::Imbalances in glutamatergic signaling have been proposed as the cause of several neurological disturbances. The use of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, to mimic features of these neurological disorders is effective both in mammals and in fish. However, the variability of the subunits compris...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2014.1018
更新日期:2015-04-01 00:00:00