Use of tissue expansion to facilitate liver and small bowel transplant in young children with contracted abdominal cavities.

Abstract:

:Liver and small bowel transplant is an established treatment for infants with IFALD. Despite organ reduction techniques, mortality on the waiting list remains high due to shortage of size-matched pediatric donors. Small abdominal cavity volume due to previous intestinal resection poses a significant challenge to achieve abdominal closure post-transplant. Seven children underwent tissue expansion of abdominal skin prior to multiorgan transplant. In total, 17 tissue expanders were placed subcutaneously in seven children. All seven subjects underwent re-exploration to deal with complications: hematoma, extrusion, infection, or port related. Three expanders had to be removed. Four children went on to have successful combined liver and small bowel transplant. Two children died on the waiting list of causes not related to the expander and one child died from sepsis attributed to an infected expander. Tissue expansion can generate skin to facilitate closure of abdomen post-transplant, thus allowing infants with small abdominal volumes to be considered for transplant surgery. Tissue expansion in children with end-stage liver disease and portal hypertension is associated with a very high complication rate and needs to be closely monitored during the expansion process.

journal_name

Pediatr Transplant

authors

Vidyadharan R,van Bommel AC,Kuti K,Gupte GL,Sharif K,Richard BM

doi

10.1111/petr.12138

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

646-52

issue

7

eissn

1397-3142

issn

1399-3046

journal_volume

17

pub_type

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