Immune-mediated hemolytic anemia in pediatric renal transplantation.

Abstract:

:The aim of the study was to demonstrate clinical course of the first reported cases of PLS in pediatric kidney transplantation and therapeutic outcome for such condition using a combination of high-dose corticosteroid and tacrolimus. We report a single case (a nine-year-old Thai boy) with end-stage kidney disease secondary to obstructive uropathy developed immune-mediated hemolytic anemia from the PLS at second week after a pre-emptive living-related kidney transplantation. The alloimmune hemolysis was a result of anti-B antibodies, derived from blood group O-donor lymphocytes. Using a combination of high-dose corticosteroid and a substitution of cyclosporin with tacrolimus, there was no further hemolysis although the anti-B antibodies remained detectable until the eighth week post-transplantation. An impairment of the graft function because of hemoglobinuria was resolved after the hemolysis was stopped. The alloimmune hemolysis caused by PLS in pediatric kidney transplantation could be controlled with a combination of high-dose corticosteroid and tacrolimus.

journal_name

Pediatr Transplant

authors

Pattaragarn A,Viprakasit V,Supavekin S,Sumboonnanonda A

doi

10.1111/j.1399-3046.2006.00560.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

740-3

issue

6

eissn

1397-3142

issn

1399-3046

pii

PTR560

journal_volume

10

pub_type

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