Abstract:
:To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration since the number of hybridisation sites of the RAPD probes was significantly modified after CdSNPs exposure. In addition, selected stress response genes were either repressed or upregulated in tissues of CdSNPs-exposed fish. Mitochondrial dysfunction was also caused by the presence of CdSNPs in food. Cadmium accumulation in fish tissues (brain and muscles) could only be observed after 60 days of exposure. CdSNPs toxicity was dependent on their size and concentration.
journal_name
Nanotoxicologyjournal_title
Nanotoxicologyauthors
Ladhar C,Geffroy B,Cambier S,Treguer-Delapierre M,Durand E,Brèthes D,Bourdineaud JPdoi
10.3109/17435390.2013.822116subject
Has Abstractpub_date
2014-09-01 00:00:00pages
676-85issue
6eissn
1743-5390issn
1743-5404journal_volume
8pub_type
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