Abstract:
:Administration of poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs, 10 µg intravenously on alternate days) induced a sustained anemia in mice. Using a modified double in vivo biotinylation (DIB) technique, blood counts of reticulocytes and erythrocytes of different age groups were simultaneously enumerated in control and AF-SWCNT treated mice. A sustained reticulocytosis was observed in AF-SWCNT treated mice. Young erythrocytes (up to 7 days old) that are normally resistant to elimination in control mice were eliminated at a significant rate in AF-SWCNT treated mice. Old erythrocytes, however, accumulated in circulation indicating that younger erythrocytes were selectively eliminated from the blood circulation of AF-SWCNT treated mice. Cells representing various stages of erythroid differentiation in bone marrow and spleen were enumerated flow cytometrically by double staining with anti-Ter119 and anti-transferrin receptor (CD71) monoclonal antibodies. Proportion of erythroid cells was significantly reduced (up to 27%) in bone marrow (BM) indicating a fall in erythropoietic activity. A concomitant increase in the spleen erythroid population was however observed that could be a compensatory response. Changes in erythroid populations in bone marrow and spleen correlated with changes in erythroblast-A population in these organs that represent an early stage of erythroid differentiation. Uptake of intravenously administered fluorescence tagged AF-SWCNTs (FAF-SWCNTs) was relatively low (3-4%) in erythroid cells in bone marrow and spleen. A significantly higher proportion of pro-erythroblasts and erythroblast-A (early stages of erythroid differentiation) took-up FAF-SWCNTs. Uptake of AF-SWCNTs by early precursors of erythroid differentiation with toxic consequences may be a contributing factor in AF-SWCNT induced anemia.
journal_name
Nanotoxicologyjournal_title
Nanotoxicologyauthors
Bhardwaj N,Saxena RKdoi
10.3109/17435390.2014.998307subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1032-40issue
8eissn
1743-5390issn
1743-5404journal_volume
9pub_type
杂志文章相关文献
Nanotoxicology文献大全abstract::Since nanomaterials are a heterogeneous group of substances used in various applications, risk assessment needs to be done on a case-by-case basis. Here the authors assess the risk (hazard and exposure) of a glass cleaner with synthetic amorphous silicon dioxide (SAS) nanoparticles during production and consumer use (...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.689881
更新日期:2013-08-01 00:00:00
abstract::Dose-response by in vitro testing is only valid if the fraction of the particle dose that deposits onto adherent cells is known. Modeling tools such as the 'distorted grid' (DG) code are common practices to predict that fraction. As another challenge, workflow efficiency depends on parallelized sample preparation, for...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1836281
更新日期:2020-10-26 00:00:00
abstract::The levels of exposure and internal doses of nanomaterials are becoming more and more important for estimating the health effects resulting from exposure to nanomaterials. Health surveillance can be used as an indicator of whether exposure is occurring, rather than in determining if levels of exposure are safe. We hav...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.600840
更新日期:2012-09-01 00:00:00
abstract::We aimed to create transgenic (Tg) mice engineered for magnetic resonance imaging (MRI). To ascertain if MagA expression contributes to oxidative stress and iron metabolism, we report the generation of Tg mice in which ubiquitous expression of MagA can be detected by MRI in vivo. Expression of MagA in diverse tissues ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1090029
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The enormous physicochemical and structural diversity of metal oxide nanoparticles (MeONPs) poses significant challenges to the testing of their biological uptake, biodistribution, and effects that can be used to develop understanding of key nano-bio modes of action. This has generated considerable uncertain...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2016.1202352
更新日期:2016-11-01 00:00:00
abstract::Silver nanoparticles (Ag-NPs) are used in a wide variety of products, prompting concerns regarding their potential environmental impacts. To accurately determine the toxicity of Ag-NPs it is necessary to differentiate between the toxicity of the nanoparticles themselves and the toxicity of ionic silver (Ag) released f...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.994570
更新日期:2015-01-01 00:00:00
abstract::ZnO nanoparticles (NPs) elicit significant adverse effects in various cell types, organisms and in the environment. The toxicity of nanoscale ZnO has often been ascribed to the release of zinc ions from the NPs but it is not yet understood to which extent these ions contribute to ZnO NP toxicity and what are the under...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.666575
更新日期:2013-06-01 00:00:00
abstract::Metal oxide nanoparticles are highly reactive from the biological point of view and, for this reason, it exists important reservations in regard human health impact. We used Drosophila as a promising in vivo model to diagnose the biological effects of copper oxide nanoparticles (CuO-NPs). Due to the potential role of ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1121413
更新日期:2016-08-01 00:00:00
abstract::Despite the rapid ongoing expansion in the use of nanomaterials, we still know little about their biological interaction and biodistribution within the human body. If medically relevant nanoparticles can cross specific cell barriers they may disseminate through the body beyond the original target and may reach particu...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.833317
更新日期:2015-05-01 00:00:00
abstract::Little information exists on the toxicological hazards associated to organo-modified clays. We evaluated the cytotoxicity of a series of pristine and organo-modified nanoclays in different cell lines. The calculated IC50 values for cell viability ranged from 1.4 to 47 µg/mL for the six organoclays used and were above ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.776123
更新日期:2014-05-01 00:00:00
abstract::The lung provides the main route for nanomaterial exposure. Surfactant protein A (SP-A) is an important respiratory innate immune molecule with the ability to bind or opsonise pathogens to enhance phagocytic removal from the airways. We hypothesised that SP-A, like surfactant protein D, may interact with inhaled nanop...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.992487
更新日期:2015-01-01 00:00:00
abstract::The widespread increase in the production and use of nanomaterials has increased the potential for nanoparticle exposure; however, the biological effects of nanoparticle inhalation are poorly understood. Rats were exposed to nanosized titanium dioxide aerosols (10 μg lung burden); at 24 h post-exposure, the spinotrape...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.606926
更新日期:2012-11-01 00:00:00
abstract::The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.976603
更新日期:2015-01-01 00:00:00
abstract::Upon inhalation, multi-walled carbon nanotubes (MWCNTs) may reach the subpleura and pleural spaces, and induce pleural inflammation and/or mesothelioma in humans. However, the mechanisms of MWCNT-induced pathology after direct intrapleural injections are still only partly elucidated. In particular, a role of the proin...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1465139
更新日期:2018-08-01 00:00:00
abstract::Enhanced in vitro human and ex vivo rat platelet aggregation from direct exposure to silver nanoparticles is previously reported. Given the increasing human use of engineered silver nanoscale products, platelet aggregation prompted by silver nanoparticles may contribute to human cardiovascular events. To understand ho...
journal_title:Nanotoxicology
pub_type: 临床试验,杂志文章
doi:10.3109/17435390.2013.788749
更新日期:2014-05-01 00:00:00
abstract::This study aims to assess the effects of Ag particles synthesised by a chemical (Ag 20, 200 nm) and biological method (Ag 23, 27 nm) in aquatic organisms: the bacterium Vibrio fischeri, the alga Desmodesmus subspicatus and the crustacean Daphnia magna. Ag particles exerted toxic effects in all organisms studied with A...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.715312
更新日期:2013-11-01 00:00:00
abstract::Titanium-dioxide nanoparticles (TiO2-NPs) are increasingly released in agricultural soils through, e.g. biosolids, irrigation or nanoagrochemicals. Soils are submitted to a wide range of concentrations of TiO2-NPs depending on the type of exposure. However, most studies have assessed the effects of unrealistically hig...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1290845
更新日期:2017-03-01 00:00:00
abstract::With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human and environmental exposures to silver nanoparticles are inevitably increasing. In particular, persons manufacturing and handling silver nanoparticles and silver nanoparticle containing products are at risk of exposure, p...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2016.1148793
更新日期:2016-09-01 00:00:00
abstract::The objective of this study was to evaluate the distribution of silver nanoparticles (NPs) in pregnant mice and their developing embryos. Silver NPs (average diameter 50 nm) were intravenously injected into pregnant CD-1 mice on gestation days (GDs) 7, 8, and 9 at dose levels of 0, 35, or 66 μg Ag/mouse. Mice were eut...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.626539
更新日期:2012-12-01 00:00:00
abstract::Nanodiamonds have been suggested as biocompatible materials and are suitable for various biomedical applications, but little is known about how to synthesize safer nanodiamonds. Herein, seven different detonation-synthesized nanodiamonds (DNDs) with sequential sp3/sp2 carbon ratios were assembled by controlling the ch...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1813825
更新日期:2020-11-01 00:00:00
abstract::Six TiO₂ and two CeO₂ nanomaterials with dry sizes ranging from 6-410 nm were tested for their ability to cause DNA centered free radicals in vitro in the concentration range of 10-3,000 ug/ml. All eight of the nanomaterials significantly increased the adduction of the spin trap agent 5,5-dimethyl-1-pyroline N-oxide (...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2010.539711
更新日期:2011-12-01 00:00:00
abstract::To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration sin...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.822116
更新日期:2014-09-01 00:00:00
abstract::We systematically investigated how the combinations of size, shape and the natural organic matter (NOM)-ecocorona of gold (Au) engineered nanoparticles (ENPs) influence the attachment of the particles to algae and physical toxicity to the cells. Spherical (10, 60 and 100 nm), urchin-shaped (60 nm), rod-shaped (10 × 45...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1692381
更新日期:2020-04-01 00:00:00
abstract::Abstract To examine gold nanoparticle reprotoxicity, bovine spermatozoa were challenged with ligand-free or oligonucleotide-conjugated gold nanoparticles synthesized purely without any surfactants by laser ablation. Sperm motility declined at nanoparticle mass dose of 10 µg/ml (corresponding to ∼14 000 nanoparticles p...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.859321
更新日期:2014-08-01 00:00:00
abstract::The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that w...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.779757
更新日期:2014-05-01 00:00:00
abstract::Surface coatings of nanoparticles (NPs) are known to influence advantageous features of NPs as well as potential toxicity. Iron oxide (Fe3O4) NPs are applied for both medical diagnostics and targeted drug delivery. We investigated the potential cytotoxicity and genotoxicity of uncoated iron oxide (U-Fe3O4) NPs in comp...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.847505
更新日期:2015-05-01 00:00:00
abstract::Nanosized zeolite particles are important materials for many applications in the field of nanotechnology. The possible adverse effects of these nanomaterials on human health have been scarcely investigated and remain largely unknown. This study reports the synthesis of nanozeolites Y and A with particle sizes of 25-10...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.587901
更新日期:2012-08-01 00:00:00
abstract::A thorough understanding of nanoparticle bio-distribution at the feto-maternal interface will be a prerequisite for their diagnostic or therapeutic application in women of childbearing age and for teratologic risk assessment. Therefore, the tissue interaction of biocompatible dendritic polyglycerol nanoparticles (dPG-...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1425496
更新日期:2018-03-01 00:00:00
abstract::Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential orga...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1498551
更新日期:2018-10-01 00:00:00
abstract::Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Following oral exposure, AgNPs can accumulate in various organs including kidneys where they show gender specific accumulation. There is limited information on their effect on renal system following long-term animal exposure especially at the ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1343874
更新日期:2017-06-01 00:00:00