The toxicity, transport and uptake of nanoparticles in the in vitro BeWo b30 placental cell barrier model used within NanoTEST.

Abstract:

:Despite the rapid ongoing expansion in the use of nanomaterials, we still know little about their biological interaction and biodistribution within the human body. If medically relevant nanoparticles can cross specific cell barriers they may disseminate through the body beyond the original target and may reach particularly sensitive areas such as the foetus. This study utilised an in vitro barrier model of the placenta to explore toxicity, uptake and transport of iron oxide and silica nanoparticles. The findings indicate that these nanoparticles can transfer extensively across the placental barrier model but physico-chemical characteristics such as surface chemistry impact upon both uptake and transport. Iron oxide cytotoxicity was evident at lower doses and shorter exposure compared with silica and may be of clinical relevance. In vivo correlation of in vitro findings is essential but in vitro models may provide worst case-exposure estimates to help reduce the amount of testing required.

journal_name

Nanotoxicology

journal_title

Nanotoxicology

authors

Correia Carreira S,Walker L,Paul K,Saunders M

doi

10.3109/17435390.2013.833317

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

66-78

eissn

1743-5390

issn

1743-5404

journal_volume

9 Suppl 1

pub_type

杂志文章
  • Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.

    abstract::Despite the increasing commercial use of nanoparticles, little is known about their effects on placental inflammation and pregnancy complications. In this study, nanosilica (NS) particles upregulated the inflammasome component nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2014.956156

    authors: Shirasuna K,Usui F,Karasawa T,Kimura H,Kawashima A,Mizukami H,Ohkuchi A,Nishimura S,Sagara J,Noda T,Ozawa K,Taniguchi S,Takahashi M

    更新日期:2015-01-01 00:00:00

  • Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model.

    abstract::The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2014.976603

    authors: Sisler JD,Pirela SV,Friend S,Farcas M,Schwegler-Berry D,Shvedova A,Castranova V,Demokritou P,Qian Y

    更新日期:2015-01-01 00:00:00

  • Zinc oxide nanoparticles in modern sunscreens: an analysis of potential exposure and hazard.

    abstract::Sunscreens containing metal oxide nanoparticles appear transparent on the skin and provide excellent protection against sunburn caused by UV radiation. While it is likely that nanoparticles remain on the surface of the skin of healthy adult humans, and thus are considered safe for use in sunscreens, there has been no ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/17435390903502028

    authors: Osmond MJ,McCall MJ

    更新日期:2010-03-01 00:00:00

  • Complete transformation of ZnO and CuO nanoparticles in culture medium and lymphocyte cells during toxicity testing.

    abstract::Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24 h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2017.1282049

    authors: Ivask A,Scheckel KG,Kapruwan P,Stone V,Yin H,Voelcker NH,Lombi E

    更新日期:2017-03-01 00:00:00

  • Nano-silver - feasibility and challenges for human health risk assessment based on open literature.

    abstract::This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435391003690549

    authors: Christensen FM,Johnston HJ,Stone V,Aitken RJ,Hankin S,Peters S,Aschberger K

    更新日期:2010-09-01 00:00:00

  • Elevated internalization and cytotoxicity of polydispersed single-walled carbon nanotubes in activated B cells can be basis for preferential depletion of activated B cells in vivo.

    abstract::Uptake of polydispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) in resting and LPS-activated B cells was studied using fluorescence-tagged AF-SWCNTs (FAF-SWCNTs). Activated B cells internalized substantially higher amounts of FAF-SWCNTs [76.5% AF-SWCNT+ B cells, mean fluorescence intensity (MFI)...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2019.1593541

    authors: Dutt TS,Mia MB,Saxena RK

    更新日期:2019-08-01 00:00:00

  • Fluorescent nanoparticles present in Coca-Cola and Pepsi-Cola: physiochemical properties, cytotoxicity, biodistribution and digestion studies.

    abstract::Foodborne nanoparticles (NPs) have drawn great attention due to human health concerns. This study reports the detection of the presence of fluorescent NPs, about 5 nm, in two of the most popular beverages, Coca-Cola (Coke) and Pepsi-Cola (Pepsi). The NPs contain H, C and O, three elements with a tunable emission and w...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2017.1418443

    authors: Li S,Jiang C,Wang H,Cong S,Tan M

    更新日期:2018-02-01 00:00:00

  • Uptake and elimination kinetics of silver nanoparticles and silver nitrate by Raphidocelis subcapitata: The influence of silver behaviour in solution.

    abstract::Raphidocelis subcapitata is a freshwater algae species that constitutes the basis of many aquatic trophic chains. In this study, R. subcapitata was used as a model species to investigate the kinetics of uptake and elimination of silver nanoparticles (AgNP) in comparison to silver nitrate (AgNO3) with particular focus ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2014.963724

    authors: Ribeiro F,Gallego-Urrea JA,Goodhead RM,Van Gestel CA,Moger J,Soares AM,Loureiro S

    更新日期:2015-01-01 00:00:00

  • Effects of nano-TiO2 on perfluorooctanesulfonate bioaccumulation in fishes living in different water layers: Implications for enhanced risk of perfluorooctanesulfonate.

    abstract::Nano-titanium dioxide (nano-TiO2) is one of the most universal engineered nano-materials while perfluorooctanesulfonate (PFOS) is a typical new persistent organic pollutant. They are widely used and present in aquatic environment. In this study, a novel semi-static multilayer microcosm was setup to investigate the imp...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2015.1084058

    authors: Qiang L,Pan X,Zhu L,Fang S,Tian S

    更新日期:2016-01-01 00:00:00

  • Titanium dioxide nanoparticles induced intracellular calcium homeostasis modification in primary human keratinocytes. Towards an in vitro explanation of titanium dioxide nanoparticles toxicity.

    abstract::Deciphering the molecular basis of toxicology mechanism induced by nanoparticles (NPs) remains an essential challenge. Ion Beam Analysis (IBA) was applied in combination with Transmission Electron Microscopy and Confocal Microscopy to analyze human keratinocytes exposed to TiO(2)-NPs. Investigating chemical elemental ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2010.502979

    authors: Simon M,Barberet P,Delville MH,Moretto P,Seznec H

    更新日期:2011-06-01 00:00:00

  • Copper oxide nanoparticles alter cellular morphology via disturbing the actin cytoskeleton dynamics in Arabidopsis roots.

    abstract::Copper oxide nanoparticles (CuO NPs) have severe nano-toxic effects on organisms. Limited data is available on influence of CuO NPs on plant cells. Here, the molecular mechanisms involved in the toxicity of CuO NPs are studied. Exposure to CuO NPs significantly increased copper content in roots (0.062-0.325 mg/g FW), ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2019.1678693

    authors: Jia H,Chen S,Wang X,Shi C,Liu K,Zhang S,Li J

    更新日期:2020-02-01 00:00:00

  • Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model.

    abstract::The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that w...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2013.779757

    authors: Sager TM,Wolfarth MW,Andrew M,Hubbs A,Friend S,Chen TH,Porter DW,Wu N,Yang F,Hamilton RF,Holian A

    更新日期:2014-05-01 00:00:00

  • Toxicity of TiO2 nanoparticles on soil nitrification at environmentally relevant concentrations: Lack of classical dose-response relationships.

    abstract::Titanium-dioxide nanoparticles (TiO2-NPs) are increasingly released in agricultural soils through, e.g. biosolids, irrigation or nanoagrochemicals. Soils are submitted to a wide range of concentrations of TiO2-NPs depending on the type of exposure. However, most studies have assessed the effects of unrealistically hig...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2017.1290845

    authors: Simonin M,Martins JM,Le Roux X,Uzu G,Calas A,Richaume A

    更新日期:2017-03-01 00:00:00

  • Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity.

    abstract::Despite the wide use of silver nanoparticles (nano Ag), its toxicity still remains poorly understood. In this report, nano Ag induced an increase in platelet aggregation and procoagulant activation which are the key contributors to thrombotic diseases. In freshly isolated human platelets, nano Ag induced platelet aggr...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2010.506250

    authors: Jun EA,Lim KM,Kim K,Bae ON,Noh JY,Chung KH,Chung JH

    更新日期:2011-06-01 00:00:00

  • Uptake of titanium from TiO₂ nanoparticle exposure in the isolated perfused intestine of rainbow trout: nystatin, vanadate and novel CO₂-sensitive components.

    abstract::Nanoparticle (NP) uptake across the gut is poorly understood. In vitro gut sac preparations and isolated perfused intestines were used to investigate the absorption mechanism(s). Exposure of whole gut sacs to 1 mg/l TiO₂ NPs for 4 h caused total Ti metal concentrations to increase in the intestine, with 80% or more of...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2012.735268

    authors: Al-Jubory AR,Handy RD

    更新日期:2013-12-01 00:00:00

  • Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes.

    abstract::Upon inhalation, multi-walled carbon nanotubes (MWCNTs) may reach the subpleura and pleural spaces, and induce pleural inflammation and/or mesothelioma in humans. However, the mechanisms of MWCNT-induced pathology after direct intrapleural injections are still only partly elucidated. In particular, a role of the proin...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2018.1465139

    authors: Arnoldussen YJ,Skaug V,Aleksandersen M,Ropstad E,Anmarkrud KH,Einarsdottir E,Chin-Lin F,Granum Bjørklund C,Kasem M,Eilertsen E,Apte RN,Zienolddiny S

    更新日期:2018-08-01 00:00:00

  • Physicochemical analysis and repeated-dose 90-days oral toxicity study of nanocalcium carbonate in Sprague-Dawley rats.

    abstract::In our previous studies of nanocalcium carbonate, in which we performed physicochemical analysis, genotoxicity, acute single-dose and repeated-dose 14-day oral toxicity testings in Sprague-Dawley (SD) rats, nanocalcium carbonate did not show a difference in toxicity compared to vehicle control. Here, we provide the fi...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2014.958587

    authors: Sung JH,Park SJ,Jeong MS,Song KS,Ahn KS,Ryu HR,Lee H,Song MR,Cho MH,Kim JS

    更新日期:2015-01-01 00:00:00

  • Elucidating differential nano-bio interactions of multi-walled andsingle-walled carbon nanotubes using subcellular proteomics.

    abstract::Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable t...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2018.1465141

    authors: Ndika JDT,Sund J,Alenius H,Puustinen A

    更新日期:2018-08-01 00:00:00

  • Effect of titanium dioxide nanoparticles on DNA methylation in multiple human cell lines.

    abstract::Nanoscale titanium dioxide (TiO2) is manufactured in wide scale, with a range of applications in consumer products. Significant toxicity of TiO2 nanoparticles has, however, been recognized, suggesting considerable risk to human health. To evaluate fully their toxicity, assessment of the epigenetic action of these nano...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2020.1723730

    authors: Pogribna M,Koonce NA,Mathew A,Word B,Patri AK,Lyn-Cook B,Hammons G

    更新日期:2020-05-01 00:00:00

  • Computer-aided design of carbon nanotubes with the desired bioactivity and safety profiles.

    abstract::Growing experimental evidences suggest the existence of direct relationships between the surface chemistry of nanomaterials and their biological effects. Herein, we have employed computational approaches to design a set of biologically active carbon nanotubes (CNTs) with controlled protein binding and cytotoxicity. Qu...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2015.1073397

    authors: Fourches D,Pu D,Li L,Zhou H,Mu Q,Su G,Yan B,Tropsha A

    更新日期:2016-01-01 00:00:00

  • Occupational exposure limit for silver nanoparticles: considerations on the derivation of a general health-based value.

    abstract::With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human and environmental exposures to silver nanoparticles are inevitably increasing. In particular, persons manufacturing and handling silver nanoparticles and silver nanoparticle containing products are at risk of exposure, p...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2016.1148793

    authors: Weldon BA,M Faustman E,Oberdörster G,Workman T,Griffith WC,Kneuer C,Yu IJ

    更新日期:2016-09-01 00:00:00

  • Assessment of orally dosed commercial silver nanoparticles on human ex vivo platelet aggregation.

    abstract::Enhanced in vitro human and ex vivo rat platelet aggregation from direct exposure to silver nanoparticles is previously reported. Given the increasing human use of engineered silver nanoscale products, platelet aggregation prompted by silver nanoparticles may contribute to human cardiovascular events. To understand ho...

    journal_title:Nanotoxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/17435390.2013.788749

    authors: Smock KJ,Schmidt RL,Hadlock G,Stoddard G,Grainger DW,Munger MA

    更新日期:2014-05-01 00:00:00

  • 28-Day inhalation toxicity study with evaluation of lung deposition and retention of tangled multi-walled carbon nanotubes.

    abstract::Lung deposition and retention measurements are now required by the newly revised OECD inhalation toxicity testing guidelines 412 and 413 when evaluating the clearance and biopersistence of poorly soluble nanomaterials, such as multi-walled carbon nanotubes (MWCNTs). However, evaluating the lung deposition concentratio...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2019.1700568

    authors: Kim JK,Jo MS,Kim Y,Kim TG,Shin JH,Kim BW,Kim HP,Lee HK,Kim HS,Ahn K,Oh SM,Cho WS,Yu IJ

    更新日期:2020-03-01 00:00:00

  • Evaluation of in vivo cytogenetic toxicity of europium hydroxide nanorods (EHNs) in male and female Swiss albino mice.

    abstract::Our group already demonstrated that europium hydroxide nanorods (EHNs) show none or mild toxicity in C57BL/6 mice even at high dose and exhibited excellent pro-angiogenic activity towards in vitro and in vivo models. In the present study, we evaluated the in vivo cytogenetic toxicity of intraperitoneally administered ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2015.1073398

    authors: Bollu VS,Nethi SK,Dasari RK,Rao SS,Misra S,Patra CR

    更新日期:2016-01-01 00:00:00

  • Harmful effects of silver nanoparticles on a complex detrital model system.

    abstract::The rapid proliferation of silver nanoparticles (AgNP) in industry and the environment requires realistic toxicity assessments based on approaches that consider the biological complexity of ecosystems. Here we assessed the acute toxicity of carbonate-coated AgNP and, for comparison, AgNO3 (Ag(+)) by using a model syst...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2015.1117673

    authors: Tlili A,Cornut J,Behra R,Gil-Allué C,Gessner MO

    更新日期:2016-08-01 00:00:00

  • Dendritic polyglycerol nanoparticles show charge dependent bio-distribution in early human placental explants and reduce hCG secretion.

    abstract::A thorough understanding of nanoparticle bio-distribution at the feto-maternal interface will be a prerequisite for their diagnostic or therapeutic application in women of childbearing age and for teratologic risk assessment. Therefore, the tissue interaction of biocompatible dendritic polyglycerol nanoparticles (dPG-...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2018.1425496

    authors: Juch H,Nikitina L,Reimann S,Gauster M,Dohr G,Obermayer-Pietsch B,Hoch D,Kornmueller K,Haag R

    更新日期:2018-03-01 00:00:00

  • Mechanisms of cellular adaptation to quantum dots--the role of glutathione and transcription factor EB.

    abstract::Cellular adaptation is the dynamic response of a cell to adverse changes in its intra/extra cellular environment. The aims of this study were to investigate the role of: (i) the glutathione antioxidant system, and (ii) the transcription factor EB (TFEB), a newly revealed master regulator of lysosome biogenesis, in cel...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2011.572195

    authors: Neibert KD,Maysinger D

    更新日期:2012-05-01 00:00:00

  • STEM mode in the SEM: a practical tool for nanotoxicology.

    abstract::The addition of a transmitted electron detector to a scanning electron microscope (SEM) allows the recording of bright and dark field scanning transmission electron microscope (STEM) images and the corresponding in-lens secondary electron images from the same region of a thin sample. These combined imaging techniques ...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2010.535622

    authors: Hondow N,Harrington J,Brydson R,Doak SH,Singh N,Manshian B,Brown A

    更新日期:2011-06-01 00:00:00

  • Organ burden of inhaled nanoceria in a 2-year low-dose exposure study: dump or depot?

    abstract::No detailed information on in vivo biokinetics of CeO2 nanoparticles (NPs) following chronic low-dose inhalation is available. The CeO2 burden for lung, lung-associated lymph nodes, and major non-pulmonary organs, blood, and feces, was determined in a chronic whole-body inhalation study in female Wistar rats undertake...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.1080/17435390.2020.1736355

    authors: Tentschert J,Laux P,Jungnickel H,Brunner J,Estrela-Lopis I,Merker C,Meijer J,Ernst H,Ma-Hock L,Keller J,Landsiedel R,Luch A

    更新日期:2020-05-01 00:00:00

  • Impact of non-functionalized and amino-functionalized multiwall carbon nanotubes on pesticide uptake by lettuce (Lactuca sativa L.).

    abstract::The effect of non-functionalized and amino-functionalized multiwall carbon nanotube (CNT) exposure, as well as the impact of CNT presence on coexistent pesticide accumulation, was investigated in lettuce (Lactuca sativa L.). Lettuce seeds were sown directly into CNT-amended vermiculite (1000 mg L(-1)) to monitor phyto...

    journal_title:Nanotoxicology

    pub_type: 杂志文章

    doi:10.3109/17435390.2014.907456

    authors: Hamdi H,De La Torre-Roche R,Hawthorne J,White JC

    更新日期:2015-03-01 00:00:00