Abstract:
:In the present study, ZnS and ZnO quantum dots (QDs) were synthesized via an all-aqueous process with polyethylene glycol (PEG) chains on their surface, and their toxicity as well as biodistribution were evaluated. No haemolysis occurred at a high concentration of 1600 µg/mL in vitro haemolytic assay, which demonstrated that the QDs-PEG displayed good blood compatibility. Following intravenous administration at 2, 6, and 20 mg/kg of the QDs-PEG in mice, the biodistribution, excretion and biocompatibility were characterized at 1 h, 24 h and 7 days, respectively. Quantitative analysis results indicated that the biodistribution trend of ZnS QDs-PEG was similar to that of ZnO QDs-PEG. The QDs-PEG were mainly trapped in the lung and liver, and almost removed from blood within 1 h. QDs-PEG were primarily excreted in faeces at the 2 and 6 mg/kg doses. Coefficients, haematology, blood biochemistry and histopathology results indicated that the QDs-PEG were safe and biocompatible.
journal_name
Nanotoxicologyjournal_title
Nanotoxicologyauthors
Yang Y,Lan J,Xu Z,Chen T,Zhao T,Cheng T,Shen J,Lv S,Zhang Hdoi
10.3109/17435390.2012.760014subject
Has Abstractpub_date
2014-02-01 00:00:00pages
107-16issue
1eissn
1743-5390issn
1743-5404journal_volume
8pub_type
杂志文章相关文献
Nanotoxicology文献大全abstract::Cadmium (Cd) is a component in quantum dot 705 (QD705). Whether QD705 behaves similar to Cd in vivo is of great concern. We compared the distributional kinetics of cadmium chloride (CdCl(2)) and QD705 in mice after intravenous injection. QD705 showed a longer plasma and body retention than CdCl(2) and could be detecte...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2010.502260
更新日期:2011-03-01 00:00:00
abstract::This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435391003690549
更新日期:2010-09-01 00:00:00
abstract::The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, due to the novel properties they exhibit. Clearly, it is important to understand and minimize any risks to health or the environment posed by the presence of ENMs. Data-driven models that decode the relationships between the...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2016.1161857
更新日期:2016-09-01 00:00:00
abstract::Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable t...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1465141
更新日期:2018-08-01 00:00:00
abstract::Deciphering the molecular basis of toxicology mechanism induced by nanoparticles (NPs) remains an essential challenge. Ion Beam Analysis (IBA) was applied in combination with Transmission Electron Microscopy and Confocal Microscopy to analyze human keratinocytes exposed to TiO(2)-NPs. Investigating chemical elemental ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2010.502979
更新日期:2011-06-01 00:00:00
abstract::Multi-walled carbon nanotubes (MWCNTs) are one of the most widely used types of novel nano-fiber materials. The aim of this study was to establish an experimental system based on actual exposure dosage and environments and explore the roles and mechanisms of inflammation in the malignant transformation of pleural meso...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1777477
更新日期:2020-09-01 00:00:00
abstract::We evaluated and compared the pulmonary clearance kinetics and extrapulmonary translocations of seven titanium dioxide (TiO2) nano- and submicron particles with different characteristics, including size, shape and surface coating. Varying doses of TiO2 nano- and submicron particles dispersed in 0.2% disodium phosphate...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1015644
更新日期:2015-01-01 00:00:00
abstract::Surface coatings of nanoparticles (NPs) are known to influence advantageous features of NPs as well as potential toxicity. Iron oxide (Fe3O4) NPs are applied for both medical diagnostics and targeted drug delivery. We investigated the potential cytotoxicity and genotoxicity of uncoated iron oxide (U-Fe3O4) NPs in comp...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.847505
更新日期:2015-05-01 00:00:00
abstract::Here, we evaluate the extent of sorption of silver nanoparticles (AgNPs) with different primary sizes (30 and 70 nm) and surface properties (branched polyethylene imine, "bPEI" and citrate coating) to laboratory plastic during (eco)toxicological testing. Under conditions of algal growth inhibition assay, up to 97% of ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1084059
更新日期:2016-01-01 00:00:00
abstract::We aimed to create transgenic (Tg) mice engineered for magnetic resonance imaging (MRI). To ascertain if MagA expression contributes to oxidative stress and iron metabolism, we report the generation of Tg mice in which ubiquitous expression of MagA can be detected by MRI in vivo. Expression of MagA in diverse tissues ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1090029
更新日期:2016-01-01 00:00:00
abstract::The levels of exposure and internal doses of nanomaterials are becoming more and more important for estimating the health effects resulting from exposure to nanomaterials. Health surveillance can be used as an indicator of whether exposure is occurring, rather than in determining if levels of exposure are safe. We hav...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.600840
更新日期:2012-09-01 00:00:00
abstract::Suspensions of the UV filter, zinc oxide nanoparticles (ZnO NP), are widely used in sunscreen products. This paper compared the relative disposition and local cytotoxicity of ZnO NP, and zinc ions formed on its dissolution, against keratinocyte cultures and in the human epidermis (ex vivo) after application of suspens...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1692382
更新日期:2020-03-01 00:00:00
abstract::Raphidocelis subcapitata is a freshwater algae species that constitutes the basis of many aquatic trophic chains. In this study, R. subcapitata was used as a model species to investigate the kinetics of uptake and elimination of silver nanoparticles (AgNP) in comparison to silver nitrate (AgNO3) with particular focus ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.963724
更新日期:2015-01-01 00:00:00
abstract::The use of imaging tools to probe nanoparticle-cell interactions will be crucial to elucidating the mechanisms of nanoparticle-induced toxicity. Of particular interest are mechanisms associated with cell penetration, translocation and subsequent accumulation inside the cell, or in cellular compartments. The objective ...
journal_title:Nanotoxicology
pub_type: 杂志文章,评审
doi:10.3109/17435390.2010.512987
更新日期:2011-09-01 00:00:00
abstract::Single-walled carbon nanotubes (SWCNTs) are widely used in industrial and medical sectors, and the increasing exposure of SWCNTs necessitates the studies of their potential environmental and health effects. Considerable efforts have been made to improve the dispersion of SWCNTs by chemical modifications. However, the ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.573101
更新日期:2012-05-01 00:00:00
abstract::Graphene, a two-dimensional engineered nanomaterial, is now being used in many applications, such as electronics, biological engineering, filtration, lightweight and strong nanocomposite materials, and energy storage. However, there is a lack of information on the potential health effects of graphene in humans based o...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1133865
更新日期:2016-09-01 00:00:00
abstract::Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24 h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1282049
更新日期:2017-03-01 00:00:00
abstract::There is a paucity of data regarding the safety of administering solid gold nanoparticles (AuNPs) in large animal tumor models. We assessed the acute toxicity and biodistribution of 5 nm and 25 nm solid AuNPs in New Zealand White rabbits (n = 6 in each) with implanted liver Vx2 tumors 24 h after intravenous injection....
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2010.516026
更新日期:2011-12-01 00:00:00
abstract::Growing experimental evidences suggest the existence of direct relationships between the surface chemistry of nanomaterials and their biological effects. Herein, we have employed computational approaches to design a set of biologically active carbon nanotubes (CNTs) with controlled protein binding and cytotoxicity. Qu...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1073397
更新日期:2016-01-01 00:00:00
abstract::Nanoparticle (NP) uptake across the gut is poorly understood. In vitro gut sac preparations and isolated perfused intestines were used to investigate the absorption mechanism(s). Exposure of whole gut sacs to 1 mg/l TiO₂ NPs for 4 h caused total Ti metal concentrations to increase in the intestine, with 80% or more of...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.735268
更新日期:2013-12-01 00:00:00
abstract::Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known abou...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.801089
更新日期:2014-08-01 00:00:00
abstract::Abstract Nickel, zinc, and copper oxide nanoparticles (NiONP, ZnONP, and CuONP) and their aqueous extracts (AEs) were applied to A549 lung epithelial cells to determine the cytotoxicity, IL-8 production, and activation of transcription factors. Nanoparticles (NPs) and their AEs were also instilled into rat lungs to ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.552810
更新日期:2012-02-01 00:00:00
abstract::Since nanomaterials are a heterogeneous group of substances used in various applications, risk assessment needs to be done on a case-by-case basis. Here the authors assess the risk (hazard and exposure) of a glass cleaner with synthetic amorphous silicon dioxide (SAS) nanoparticles during production and consumer use (...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.689881
更新日期:2013-08-01 00:00:00
abstract::To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration sin...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.822116
更新日期:2014-09-01 00:00:00
abstract::Despite the increasing commercial use of nanoparticles, little is known about their effects on placental inflammation and pregnancy complications. In this study, nanosilica (NS) particles upregulated the inflammasome component nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.956156
更新日期:2015-01-01 00:00:00
abstract::Engineered nanoparticles are increasingly discharged into the environment. After discharge, these nanoparticles can interact with co-existing organic contaminants, resulting in a phenomena referred to as 'joint toxicity'. This study evaluated joint toxicities of TiO2 nanoparticles (TiO2NPs) with four different (atrazi...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1398358
更新日期:2017-01-01 00:00:00
abstract::If engineered nanomaterials are released into the environment, some are likely to end up associated with the food of animals due to aggregation and sorption processes. However, few studies have considered dietary exposure of nanomaterials. Here we show that zinc (Zn) from isotopically modified (67)ZnO particles is eff...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2010.501914
更新日期:2011-03-01 00:00:00
abstract::Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Following oral exposure, AgNPs can accumulate in various organs including kidneys where they show gender specific accumulation. There is limited information on their effect on renal system following long-term animal exposure especially at the ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1343874
更新日期:2017-06-01 00:00:00
abstract::The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that w...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.779757
更新日期:2014-05-01 00:00:00
abstract::Sunscreens containing metal oxide nanoparticles appear transparent on the skin and provide excellent protection against sunburn caused by UV radiation. While it is likely that nanoparticles remain on the surface of the skin of healthy adult humans, and thus are considered safe for use in sunscreens, there has been no ...
journal_title:Nanotoxicology
pub_type: 杂志文章,评审
doi:10.3109/17435390903502028
更新日期:2010-03-01 00:00:00