Nano-silver - feasibility and challenges for human health risk assessment based on open literature.

abstract：:The use of imaging tools to probe nanoparticle-cell interactions will be crucial to elucidating the mechanisms of nanoparticle-induced toxicity. Of particular interest are mechanisms associated with cell penetration, translocation and subsequent accumulation inside the cell, or in cellular compartments. The objective ...

journal_title：Nanotoxicology

authors： Tantra R,Knight A

更新日期：2011-09-01 00:00:00

abstract：:The spread of antibiotic resistance genes (ARGs) has become a global environmental issue; it has been found that nanoparticles (NPs) can promote the transfer of ARGs between bacteria. However, it remains unclear whether NPs can affect this kind of conjugation in Streptomyces, which mainly conjugate with other bacteria...

journal_title：Nanotoxicology

authors： Liu X,Tang J,Song B,Zhen M,Wang L,Giesy JP

更新日期：2019-12-01 00:00:00

abstract：:Suspensions of the UV filter, zinc oxide nanoparticles (ZnO NP), are widely used in sunscreen products. This paper compared the relative disposition and local cytotoxicity of ZnO NP, and zinc ions formed on its dissolution, against keratinocyte cultures and in the human epidermis (ex vivo) after application of suspens...

journal_title：Nanotoxicology

authors： Holmes AM,Mackenzie L,Roberts MS

更新日期：2020-03-01 00:00:00

abstract：:Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by Cu NPs and explored the effects of a 28-day repeated oral adm...

journal_title：Nanotoxicology

authors： Lee IC,Ko JW,Park SH,Shin NR,Shin IS,Moon C,Kim SH,Yun WK,Kim HC,Kim JC

更新日期：2018-08-01 00:00:00

abstract：:Deciphering the molecular basis of toxicology mechanism induced by nanoparticles (NPs) remains an essential challenge. Ion Beam Analysis (IBA) was applied in combination with Transmission Electron Microscopy and Confocal Microscopy to analyze human keratinocytes exposed to TiO(2)-NPs. Investigating chemical elemental ...

journal_title：Nanotoxicology

authors： Simon M,Barberet P,Delville MH,Moretto P,Seznec H

更新日期：2011-06-01 00:00:00

abstract：:The addition of a transmitted electron detector to a scanning electron microscope (SEM) allows the recording of bright and dark field scanning transmission electron microscope (STEM) images and the corresponding in-lens secondary electron images from the same region of a thin sample. These combined imaging techniques ...

journal_title：Nanotoxicology

authors： Hondow N,Harrington J,Brydson R,Doak SH,Singh N,Manshian B,Brown A

更新日期：2011-06-01 00:00:00

abstract：:Silver nanoparticles (Ag-NPs) are used in a wide variety of products, prompting concerns regarding their potential environmental impacts. To accurately determine the toxicity of Ag-NPs it is necessary to differentiate between the toxicity of the nanoparticles themselves and the toxicity of ionic silver (Ag) released f...

journal_title：Nanotoxicology

authors： Sekine R,Khurana K,Vasilev K,Lombi E,Donner E

更新日期：2015-01-01 00:00:00

abstract：:The objective of this study was to evaluate the distribution of silver nanoparticles (NPs) in pregnant mice and their developing embryos. Silver NPs (average diameter 50 nm) were intravenously injected into pregnant CD-1 mice on gestation days (GDs) 7, 8, and 9 at dose levels of 0, 35, or 66 μg Ag/mouse. Mice were eut...

journal_title：Nanotoxicology

authors： Austin CA,Umbreit TH,Brown KM,Barber DS,Dair BJ,Francke-Carroll S,Feswick A,Saint-Louis MA,Hikawa H,Siebein KN,Goering PL

更新日期：2012-12-01 00:00:00

abstract：:Cadmium (Cd) is a component in quantum dot 705 (QD705). Whether QD705 behaves similar to Cd in vivo is of great concern. We compared the distributional kinetics of cadmium chloride (CdCl(2)) and QD705 in mice after intravenous injection. QD705 showed a longer plasma and body retention than CdCl(2) and could be detecte...

journal_title：Nanotoxicology

authors： Yeh TK,Wu JP,Chang LW,Tsai MH,Chang WH,Tsai HT,Yang CS,Lin P

更新日期：2011-03-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Following oral exposure, AgNPs can accumulate in various organs including kidneys where they show gender specific accumulation. There is limited information on their effect on renal system following long-term animal exposure especially at the ...

journal_title：Nanotoxicology

authors： Tiwari R,Singh RD,Khan H,Gangopadhyay S,Mittal S,Singh V,Arjaria N,Shankar J,Roy SK,Singh D,Srivastava V

更新日期：2017-06-01 00:00:00

abstract：:Lung deposition and retention measurements are now required by the newly revised OECD inhalation toxicity testing guidelines 412 and 413 when evaluating the clearance and biopersistence of poorly soluble nanomaterials, such as multi-walled carbon nanotubes (MWCNTs). However, evaluating the lung deposition concentratio...

journal_title：Nanotoxicology

authors： Kim JK,Jo MS,Kim Y,Kim TG,Shin JH,Kim BW,Kim HP,Lee HK,Kim HS,Ahn K,Oh SM,Cho WS,Yu IJ

更新日期：2020-03-01 00:00:00

abstract：:To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration sin...

journal_title：Nanotoxicology

authors： Ladhar C,Geffroy B,Cambier S,Treguer-Delapierre M,Durand E,Brèthes D,Bourdineaud JP

更新日期：2014-09-01 00:00:00

abstract：:The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, due to the novel properties they exhibit. Clearly, it is important to understand and minimize any risks to health or the environment posed by the presence of ENMs. Data-driven models that decode the relationships between the...

journal_title：Nanotoxicology

authors： Oksel C,Winkler DA,Ma CY,Wilkins T,Wang XZ

更新日期：2016-09-01 00:00:00

abstract：:Although the production of engineered nanoparticles increases our knowledge of toxicity and mechanisms of bioactivity during relevant exposures is lacking. In the present study mice were exposed to PbO nanoparticles (PbONP; 192.5 µg/m3; 1.93 × 106 particles/cm3) for 2, 5 and 13 weeks through continuous inhalation. The...

journal_title：Nanotoxicology

authors： Bláhová L,Nováková Z,Večeřa Z,Vrlíková L,Dočekal B,Dumková J,Křůmal K,Mikuška P,Buchtová M,Hampl A,Hilscherová K,Bláha L

更新日期：2020-03-01 00:00:00

abstract：:There is a paucity of data regarding the safety of administering solid gold nanoparticles (AuNPs) in large animal tumor models. We assessed the acute toxicity and biodistribution of 5 nm and 25 nm solid AuNPs in New Zealand White rabbits (n = 6 in each) with implanted liver Vx2 tumors 24 h after intravenous injection....

journal_title：Nanotoxicology

authors： Glazer ES,Zhu C,Hamir AN,Borne A,Thompson CS,Curley SA

更新日期：2011-12-01 00:00:00

abstract：:Nano-titanium dioxide (nano-TiO2) is one of the most universal engineered nano-materials while perfluorooctanesulfonate (PFOS) is a typical new persistent organic pollutant. They are widely used and present in aquatic environment. In this study, a novel semi-static multilayer microcosm was setup to investigate the imp...

journal_title：Nanotoxicology

authors： Qiang L,Pan X,Zhu L,Fang S,Tian S

更新日期：2016-01-01 00:00:00

abstract：:ZnO nanoparticles (NPs) elicit significant adverse effects in various cell types, organisms and in the environment. The toxicity of nanoscale ZnO has often been ascribed to the release of zinc ions from the NPs but it is not yet understood to which extent these ions contribute to ZnO NP toxicity and what are the under...

journal_title：Nanotoxicology

authors： Buerki-Thurnherr T,Xiao L,Diener L,Arslan O,Hirsch C,Maeder-Althaus X,Grieder K,Wampfler B,Mathur S,Wick P,Krug HF

更新日期：2013-06-01 00:00:00

abstract：:Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable t...

journal_title：Nanotoxicology

authors： Ndika JDT,Sund J,Alenius H,Puustinen A

更新日期：2018-08-01 00:00:00

abstract：:The effect of non-functionalized and amino-functionalized multiwall carbon nanotube (CNT) exposure, as well as the impact of CNT presence on coexistent pesticide accumulation, was investigated in lettuce (Lactuca sativa L.). Lettuce seeds were sown directly into CNT-amended vermiculite (1000 mg L(-1)) to monitor phyto...

journal_title：Nanotoxicology

authors： Hamdi H,De La Torre-Roche R,Hawthorne J,White JC

更新日期：2015-03-01 00:00:00

abstract：:Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m(3) Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 10, 15 and 18, wit...

journal_title：Nanotoxicology

authors： Jackson P,Hougaard KS,Boisen AM,Jacobsen NR,Jensen KA,Møller P,Brunborg G,Gutzkow KB,Andersen O,Loft S,Vogel U,Wallin H

更新日期：2012-08-01 00:00:00

abstract：:Despite the wide use of silver nanoparticles (nano Ag), its toxicity still remains poorly understood. In this report, nano Ag induced an increase in platelet aggregation and procoagulant activation which are the key contributors to thrombotic diseases. In freshly isolated human platelets, nano Ag induced platelet aggr...

journal_title：Nanotoxicology

authors： Jun EA,Lim KM,Kim K,Bae ON,Noh JY,Chung KH,Chung JH

更新日期：2011-06-01 00:00:00

abstract：:Boron and boron nitride nanotubes (BNNTs) are increasingly used in different industrial fields and, potentially, in some biomedical areas. As occurs with other nanomaterials (NMs), to increase our knowledge on their potential health hazards is a priority. Although in vitro approaches are a routine in getting biologica...

journal_title：Nanotoxicology

authors： Demir E,Marcos R

更新日期：2018-10-01 00:00:00

abstract：:Little information exists on the toxicological hazards associated to organo-modified clays. We evaluated the cytotoxicity of a series of pristine and organo-modified nanoclays in different cell lines. The calculated IC50 values for cell viability ranged from 1.4 to 47 µg/mL for the six organoclays used and were above ...

journal_title：Nanotoxicology

authors： Janer G,Fernández-Rosas E,Mas del Molino E,González-Gálvez D,Vilar G,López-Iglesias C,Ermini V,Vázquez-Campos S

更新日期：2014-05-01 00:00:00

abstract：:With the advent of nanoparticles produced in high quantities and employed in products or processes, the need to evaluate their potential toxicological effects is necessary. For this purpose, biopersistence studies are needed to assess the possible effects of nanoparticles in parallel with a proper characterization. Th...

journal_title：Nanotoxicology

authors： Lozano O,Mejia J,Masereel B,Toussaint O,Lison D,Lucas S

更新日期：2012-05-01 00:00:00

abstract：:In the present study, ZnS and ZnO quantum dots (QDs) were synthesized via an all-aqueous process with polyethylene glycol (PEG) chains on their surface, and their toxicity as well as biodistribution were evaluated. No haemolysis occurred at a high concentration of 1600 µg/mL in vitro haemolytic assay, which demonstrat...

journal_title：Nanotoxicology

authors： Yang Y,Lan J,Xu Z,Chen T,Zhao T,Cheng T,Shen J,Lv S,Zhang H

更新日期：2014-02-01 00:00:00

abstract：:The lung provides the main route for nanomaterial exposure. Surfactant protein A (SP-A) is an important respiratory innate immune molecule with the ability to bind or opsonise pathogens to enhance phagocytic removal from the airways. We hypothesised that SP-A, like surfactant protein D, may interact with inhaled nanop...

journal_title：Nanotoxicology

authors： McKenzie Z,Kendall M,Mackay RM,Whitwell H,Elgy C,Ding P,Mahajan S,Morgan C,Griffiths M,Clark H,Madsen J

更新日期：2015-01-01 00:00:00

abstract：:The biological fate of nanoparticles (NPs) taken up by organisms from their environment is a crucial issue for assessing ecological hazard. Despite its importance, it has scarcely been addressed due to the technical difficulties of doing so in whole organism in vivo studies. Here, by using transmission electron micros...

journal_title：Nanotoxicology

authors： Noventa S,Hacker C,Correia A,Drago C,Galloway T

更新日期：2018-10-01 00:00:00

abstract：:The influence of size, surface charge and surface functionality of poly(amido amine) dendrimers and silica nanoparticles (SNPs) on their toxicity was studied in immunocompetent mice. After systematic characterization of nanoparticles, they were administered to CD-1 (caesarean derived-1) mice to evaluate acute toxicity...

journal_title：Nanotoxicology

authors： Greish K,Thiagarajan G,Herd H,Price R,Bauer H,Hubbard D,Burckle A,Sadekar S,Yu T,Anwar A,Ray A,Ghandehari H

更新日期：2012-11-01 00:00:00

abstract：:Multifunctional nanomaterials are rapidly emerging for ophthalmic delivery of therapeutics to facilitate safe and effective targeting with improved patient compliance. Because of their extremely high area to volume ratio, nanomaterials often have physicochemical properties that are different from those of their larger...

journal_title：Nanotoxicology

authors： Mehra NK,Cai D,Kuo L,Hein T,Palakurthi S

更新日期：2016-09-01 00:00:00

abstract：:With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human and environmental exposures to silver nanoparticles are inevitably increasing. In particular, persons manufacturing and handling silver nanoparticles and silver nanoparticle containing products are at risk of exposure, p...

journal_title：Nanotoxicology

authors： Weldon BA,M Faustman E,Oberdörster G,Workman T,Griffith WC,Kneuer C,Yu IJ

更新日期：2016-09-01 00:00:00