Abstract:
:There is a paucity of data regarding the safety of administering solid gold nanoparticles (AuNPs) in large animal tumor models. We assessed the acute toxicity and biodistribution of 5 nm and 25 nm solid AuNPs in New Zealand White rabbits (n = 6 in each) with implanted liver Vx2 tumors 24 h after intravenous injection. Gold concentration was determined by inductively coupled plasma atomic emission spectrometry (ICP) and imaged with transmission electron microscopy (TEM). There was no clinico-pathologic evidence of renal, hepatic, pulmonary, or other organ dysfunction. After 25 nm AuNP administration, the concentration of white blood cells increased after treatment (p = 0.001). Most other blood studies were unchanged. AuNPs were distributed to the spleen, liver, and Vx2 tumors, but not to other tissues. The urinary excretion of AuNPs was bimodal as measured by ICP. 25 nm AuNPs were more evenly distributed throughout tissues and may be better tools for medical therapy.
journal_name
Nanotoxicologyjournal_title
Nanotoxicologyauthors
Glazer ES,Zhu C,Hamir AN,Borne A,Thompson CS,Curley SAdoi
10.3109/17435390.2010.516026subject
Has Abstractpub_date
2011-12-01 00:00:00pages
459-68issue
4eissn
1743-5390issn
1743-5404journal_volume
5pub_type
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