Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.

abstract：:Surface coatings of nanoparticles (NPs) are known to influence advantageous features of NPs as well as potential toxicity. Iron oxide (Fe3O4) NPs are applied for both medical diagnostics and targeted drug delivery. We investigated the potential cytotoxicity and genotoxicity of uncoated iron oxide (U-Fe3O4) NPs in comp...

journal_title：Nanotoxicology

authors： Magdolenova Z,Drlickova M,Henjum K,Rundén-Pran E,Tulinska J,Bilanicova D,Pojana G,Kazimirova A,Barancokova M,Kuricova M,Liskova A,Staruchova M,Ciampor F,Vavra I,Lorenzo Y,Collins A,Rinna A,Fjellsbø L,Volkovova K,Mar

更新日期：2015-05-01 00:00:00

abstract：:Single-walled carbon nanotubes (SWCNTs) are widely used in industrial and medical sectors, and the increasing exposure of SWCNTs necessitates the studies of their potential environmental and health effects. Considerable efforts have been made to improve the dispersion of SWCNTs by chemical modifications. However, the ...

journal_title：Nanotoxicology

authors： Dong PX,Wan B,Guo LH

更新日期：2012-05-01 00:00:00

abstract：:Lung deposition and retention measurements are now required by the newly revised OECD inhalation toxicity testing guidelines 412 and 413 when evaluating the clearance and biopersistence of poorly soluble nanomaterials, such as multi-walled carbon nanotubes (MWCNTs). However, evaluating the lung deposition concentratio...

journal_title：Nanotoxicology

authors： Kim JK,Jo MS,Kim Y,Kim TG,Shin JH,Kim BW,Kim HP,Lee HK,Kim HS,Ahn K,Oh SM,Cho WS,Yu IJ

更新日期：2020-03-01 00:00:00

abstract：:Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately, health impacts of ENM are not fully realized. Titanium dioxide (TiO2) is among the most widely produced ENM due to its use in numerous applications. Extrapulmonary e...

journal_title：Nanotoxicology

authors： Nichols CE,Shepherd DL,Hathaway QA,Durr AJ,Thapa D,Abukabda A,Yi J,Nurkiewicz TR,Hollander JM

更新日期：2018-02-01 00:00:00

abstract：:Due to the increasing use of nanometric cerium oxide in applications, concerns about the toxicity of these particles have been raised and have resulted in a large number of studies. We report here on the interactions between 7 nm anionically charged cerium oxide particles and living mammalian cells. By a modification ...

journal_title：Nanotoxicology

authors： Ould-Moussa N,Safi M,Guedeau-Boudeville MA,Montero D,Conjeaud H,Berret JF

更新日期：2014-11-01 00:00:00

abstract：:Metal oxide nanoparticles are highly reactive from the biological point of view and, for this reason, it exists important reservations in regard human health impact. We used Drosophila as a promising in vivo model to diagnose the biological effects of copper oxide nanoparticles (CuO-NPs). Due to the potential role of ...

journal_title：Nanotoxicology

authors： Alaraby M,Hernández A,Marcos R

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The enormous physicochemical and structural diversity of metal oxide nanoparticles (MeONPs) poses significant challenges to the testing of their biological uptake, biodistribution, and effects that can be used to develop understanding of key nano-bio modes of action. This has generated considerable uncertain...

journal_title：Nanotoxicology

authors： Mu Y,Wu F,Zhao Q,Ji R,Qie Y,Zhou Y,Hu Y,Pang C,Hristozov D,Giesy JP,Xing B

更新日期：2016-11-01 00:00:00

abstract：:Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by Cu NPs and explored the effects of a 28-day repeated oral adm...

journal_title：Nanotoxicology

authors： Lee IC,Ko JW,Park SH,Shin NR,Shin IS,Moon C,Kim SH,Yun WK,Kim HC,Kim JC

更新日期：2018-08-01 00:00:00

abstract：:Inhalation of zinc oxide nanoparticles (ZnONP) has potential health impact. Because zinc ion may involve in the toxicity of ZnONP, we compared adverse effects of inhaled aerosolized ZnONP and zinc nitrate in mice. Aerosolized ZnONP and zinc nitrate were well-dispersed in the inhalation chamber. Inhalation of 0.86 mg/m...

journal_title：Nanotoxicology

authors： Chen JK,Ho CC,Chang H,Lin JF,Yang CS,Tsai MH,Tsai HT,Lin P

更新日期：2015-02-01 00:00:00

abstract：:The use of imaging tools to probe nanoparticle-cell interactions will be crucial to elucidating the mechanisms of nanoparticle-induced toxicity. Of particular interest are mechanisms associated with cell penetration, translocation and subsequent accumulation inside the cell, or in cellular compartments. The objective ...

journal_title：Nanotoxicology

authors： Tantra R,Knight A

更新日期：2011-09-01 00:00:00

abstract：:Nanoparticle (NP) uptake across the gut is poorly understood. In vitro gut sac preparations and isolated perfused intestines were used to investigate the absorption mechanism(s). Exposure of whole gut sacs to 1 mg/l TiO₂ NPs for 4 h caused total Ti metal concentrations to increase in the intestine, with 80% or more of...

journal_title：Nanotoxicology

authors： Al-Jubory AR,Handy RD

更新日期：2013-12-01 00:00:00

abstract：:Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable t...

journal_title：Nanotoxicology

authors： Ndika JDT,Sund J,Alenius H,Puustinen A

更新日期：2018-08-01 00:00:00

abstract：:This study aims to assess the effects of Ag particles synthesised by a chemical (Ag 20, 200 nm) and biological method (Ag 23, 27 nm) in aquatic organisms: the bacterium Vibrio fischeri, the alga Desmodesmus subspicatus and the crustacean Daphnia magna. Ag particles exerted toxic effects in all organisms studied with A...

journal_title：Nanotoxicology

authors： Georgantzopoulou A,Balachandran YL,Rosenkranz P,Dusinska M,Lankoff A,Wojewodzka M,Kruszewski M,Guignard C,Audinot JN,Girija S,Hoffmann L,Gutleb AC

更新日期：2013-11-01 00:00:00

abstract：:Suspensions of the UV filter, zinc oxide nanoparticles (ZnO NP), are widely used in sunscreen products. This paper compared the relative disposition and local cytotoxicity of ZnO NP, and zinc ions formed on its dissolution, against keratinocyte cultures and in the human epidermis (ex vivo) after application of suspens...

journal_title：Nanotoxicology

authors： Holmes AM,Mackenzie L,Roberts MS

更新日期：2020-03-01 00:00:00

abstract：:Engineered nanoparticles are increasingly discharged into the environment. After discharge, these nanoparticles can interact with co-existing organic contaminants, resulting in a phenomena referred to as 'joint toxicity'. This study evaluated joint toxicities of TiO2 nanoparticles (TiO2NPs) with four different (atrazi...

journal_title：Nanotoxicology

authors： Zhang S,Deng R,Lin D,Wu F

更新日期：2017-01-01 00:00:00

abstract：:Nanowires (NWs) have unique electrical and optical properties of value for many applications including lighting, sensing, and energy harnessing. Consumer products containing NWs increase the risk of NWs being released in the environment, especially into aquatic ecosystems through sewage systems. Daphnia magna is a com...

journal_title：Nanotoxicology

authors： Mattsson K,Adolfsson K,Ekvall MT,Borgström MT,Linse S,Hansson LA,Cedervall T,Prinz CN

更新日期：2016-10-01 00:00:00

abstract：:If engineered nanomaterials are released into the environment, some are likely to end up associated with the food of animals due to aggregation and sorption processes. However, few studies have considered dietary exposure of nanomaterials. Here we show that zinc (Zn) from isotopically modified (67)ZnO particles is eff...

journal_title：Nanotoxicology

authors： Croteau MN,Dybowska AD,Luoma SN,Valsami-Jones E

更新日期：2011-03-01 00:00:00

abstract：:Sunscreens containing metal oxide nanoparticles appear transparent on the skin and provide excellent protection against sunburn caused by UV radiation. While it is likely that nanoparticles remain on the surface of the skin of healthy adult humans, and thus are considered safe for use in sunscreens, there has been no ...

journal_title：Nanotoxicology

authors： Osmond MJ,McCall MJ

更新日期：2010-03-01 00:00:00

abstract：:Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential orga...

journal_title：Nanotoxicology

authors： d'Amora M,Cassano D,Pocoví-Martínez S,Giordani S,Voliani V

更新日期：2018-10-01 00:00:00

abstract：:Glycodendrimers (Glyco-DDMs) represent a rapidly growing class of nanoparticles with promising properties for biomedical applications but concerns regarding the impact on human health and environment are still justified. Here we report, for the first time, the comparative study of in vivo developmental toxicity of car...

journal_title：Nanotoxicology

authors： Liegertová M,Wrobel D,Herma R,Müllerová M,Šťastná LČ,Cuřínová P,Strašák T,Malý M,Čermák J,Smejkal J,Štofik M,Maly J

更新日期：2018-10-01 00:00:00

abstract：:Raphidocelis subcapitata is a freshwater algae species that constitutes the basis of many aquatic trophic chains. In this study, R. subcapitata was used as a model species to investigate the kinetics of uptake and elimination of silver nanoparticles (AgNP) in comparison to silver nitrate (AgNO3) with particular focus ...

journal_title：Nanotoxicology

authors： Ribeiro F,Gallego-Urrea JA,Goodhead RM,Van Gestel CA,Moger J,Soares AM,Loureiro S

更新日期：2015-01-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) are one of the most widely used types of novel nano-fiber materials. The aim of this study was to establish an experimental system based on actual exposure dosage and environments and explore the roles and mechanisms of inflammation in the malignant transformation of pleural meso...

journal_title：Nanotoxicology

authors： Huang X,Tian Y,Shi W,Chen J,Yan L,Ren L,Zhang X,Zhu J

更新日期：2020-09-01 00:00:00

abstract：:Silver nanoparticles (Ag-NPs) are used in a wide variety of products, prompting concerns regarding their potential environmental impacts. To accurately determine the toxicity of Ag-NPs it is necessary to differentiate between the toxicity of the nanoparticles themselves and the toxicity of ionic silver (Ag) released f...

journal_title：Nanotoxicology

authors： Sekine R,Khurana K,Vasilev K,Lombi E,Donner E

更新日期：2015-01-01 00:00:00

abstract：:The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, due to the novel properties they exhibit. Clearly, it is important to understand and minimize any risks to health or the environment posed by the presence of ENMs. Data-driven models that decode the relationships between the...

journal_title：Nanotoxicology

authors： Oksel C,Winkler DA,Ma CY,Wilkins T,Wang XZ

更新日期：2016-09-01 00:00:00

abstract：:In the present study, ZnS and ZnO quantum dots (QDs) were synthesized via an all-aqueous process with polyethylene glycol (PEG) chains on their surface, and their toxicity as well as biodistribution were evaluated. No haemolysis occurred at a high concentration of 1600 µg/mL in vitro haemolytic assay, which demonstrat...

journal_title：Nanotoxicology

authors： Yang Y,Lan J,Xu Z,Chen T,Zhao T,Cheng T,Shen J,Lv S,Zhang H

更新日期：2014-02-01 00:00:00

abstract：:With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human and environmental exposures to silver nanoparticles are inevitably increasing. In particular, persons manufacturing and handling silver nanoparticles and silver nanoparticle containing products are at risk of exposure, p...

journal_title：Nanotoxicology

authors： Weldon BA,M Faustman E,Oberdörster G,Workman T,Griffith WC,Kneuer C,Yu IJ

更新日期：2016-09-01 00:00:00

abstract：:Nanodiamonds have been suggested as biocompatible materials and are suitable for various biomedical applications, but little is known about how to synthesize safer nanodiamonds. Herein, seven different detonation-synthesized nanodiamonds (DNDs) with sequential sp3/sp2 carbon ratios were assembled by controlling the ch...

journal_title：Nanotoxicology

authors： Lee DK,Ha S,Jeon S,Jeong J,Kim DJ,Lee SW,Cho WS

更新日期：2020-11-01 00:00:00

abstract：:The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that w...

journal_title：Nanotoxicology

authors： Sager TM,Wolfarth MW,Andrew M,Hubbs A,Friend S,Chen TH,Porter DW,Wu N,Yang F,Hamilton RF,Holian A

更新日期：2014-05-01 00:00:00

abstract：:The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the ...

journal_title：Nanotoxicology

authors： Sisler JD,Pirela SV,Friend S,Farcas M,Schwegler-Berry D,Shvedova A,Castranova V,Demokritou P,Qian Y

更新日期：2015-01-01 00:00:00

abstract：:Dendrimers are nanosized hyperbranched polymers synthesized through an iterative step-by-step process; their size and structure are perfectly controlled, and they are widely used for biomedical purposes. Previously, we showed that a phosphorous-based dendrimer capped with anionic AzaBisPhosphonate groups (so-called AB...

journal_title：Nanotoxicology

authors： Fruchon S,Mouriot S,Thiollier T,Grandin C,Caminade AM,Turrin CO,Contamin H,Poupot R

更新日期：2015-05-01 00:00:00