Abstract:
:If engineered nanomaterials are released into the environment, some are likely to end up associated with the food of animals due to aggregation and sorption processes. However, few studies have considered dietary exposure of nanomaterials. Here we show that zinc (Zn) from isotopically modified (67)ZnO particles is efficiently assimilated by freshwater snails when ingested with food. The (67)Zn from nano-sized (67)ZnO appears as bioavailable as (67)Zn internalized by diatoms. Apparent agglomeration of the zinc oxide (ZnO) particles did not reduce bioavailability, nor preclude toxicity. In the diet, ZnO nanoparticles damage digestion: snails ate less, defecated less and inefficiently processed the ingested food when exposed to high concentrations of ZnO. It was not clear whether the toxicity was due to the high Zn dose achieved with nanoparticles or to the ZnO nanoparticles themselves. Further study of exposure from nanoparticles in food would greatly benefit assessment of ecological and human health risks.
journal_name
Nanotoxicologyjournal_title
Nanotoxicologyauthors
Croteau MN,Dybowska AD,Luoma SN,Valsami-Jones Edoi
10.3109/17435390.2010.501914subject
Has Abstractpub_date
2011-03-01 00:00:00pages
79-90issue
1eissn
1743-5390issn
1743-5404journal_volume
5pub_type
杂志文章相关文献
Nanotoxicology文献大全abstract::Here, we evaluate the extent of sorption of silver nanoparticles (AgNPs) with different primary sizes (30 and 70 nm) and surface properties (branched polyethylene imine, "bPEI" and citrate coating) to laboratory plastic during (eco)toxicological testing. Under conditions of algal growth inhibition assay, up to 97% of ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1084059
更新日期:2016-01-01 00:00:00
abstract::Little information exists on the toxicological hazards associated to organo-modified clays. We evaluated the cytotoxicity of a series of pristine and organo-modified nanoclays in different cell lines. The calculated IC50 values for cell viability ranged from 1.4 to 47 µg/mL for the six organoclays used and were above ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.776123
更新日期:2014-05-01 00:00:00
abstract::Dose-response by in vitro testing is only valid if the fraction of the particle dose that deposits onto adherent cells is known. Modeling tools such as the 'distorted grid' (DG) code are common practices to predict that fraction. As another challenge, workflow efficiency depends on parallelized sample preparation, for...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1836281
更新日期:2020-10-26 00:00:00
abstract::The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, due to the novel properties they exhibit. Clearly, it is important to understand and minimize any risks to health or the environment posed by the presence of ENMs. Data-driven models that decode the relationships between the...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2016.1161857
更新日期:2016-09-01 00:00:00
abstract::With the advent of nanoparticles produced in high quantities and employed in products or processes, the need to evaluate their potential toxicological effects is necessary. For this purpose, biopersistence studies are needed to assess the possible effects of nanoparticles in parallel with a proper characterization. Th...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.572301
更新日期:2012-05-01 00:00:00
abstract::Multifunctional nanomaterials are rapidly emerging for ophthalmic delivery of therapeutics to facilitate safe and effective targeting with improved patient compliance. Because of their extremely high area to volume ratio, nanomaterials often have physicochemical properties that are different from those of their larger...
journal_title:Nanotoxicology
pub_type: 杂志文章,评审
doi:10.3109/17435390.2016.1153165
更新日期:2016-09-01 00:00:00
abstract::Dendrimers are nanosized hyperbranched polymers synthesized through an iterative step-by-step process; their size and structure are perfectly controlled, and they are widely used for biomedical purposes. Previously, we showed that a phosphorous-based dendrimer capped with anionic AzaBisPhosphonate groups (so-called AB...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.940406
更新日期:2015-05-01 00:00:00
abstract::Uptake of polydispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) in resting and LPS-activated B cells was studied using fluorescence-tagged AF-SWCNTs (FAF-SWCNTs). Activated B cells internalized substantially higher amounts of FAF-SWCNTs [76.5% AF-SWCNT+ B cells, mean fluorescence intensity (MFI)...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1593541
更新日期:2019-08-01 00:00:00
abstract::Abstract Nickel, zinc, and copper oxide nanoparticles (NiONP, ZnONP, and CuONP) and their aqueous extracts (AEs) were applied to A549 lung epithelial cells to determine the cytotoxicity, IL-8 production, and activation of transcription factors. Nanoparticles (NPs) and their AEs were also instilled into rat lungs to ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.552810
更新日期:2012-02-01 00:00:00
abstract::Enhanced in vitro human and ex vivo rat platelet aggregation from direct exposure to silver nanoparticles is previously reported. Given the increasing human use of engineered silver nanoscale products, platelet aggregation prompted by silver nanoparticles may contribute to human cardiovascular events. To understand ho...
journal_title:Nanotoxicology
pub_type: 临床试验,杂志文章
doi:10.3109/17435390.2013.788749
更新日期:2014-05-01 00:00:00
abstract::Foodborne nanoparticles (NPs) refer to the nanostructures generated during food processing, rather than the man-made nano-structural additives that are added to improve the property of food. In this research, discovery of fluorescent NPs in roasted pork was reported at different temperature of 180, 230, and 280 °C. Th...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1652943
更新日期:2019-12-01 00:00:00
abstract::Deciphering the molecular basis of toxicology mechanism induced by nanoparticles (NPs) remains an essential challenge. Ion Beam Analysis (IBA) was applied in combination with Transmission Electron Microscopy and Confocal Microscopy to analyze human keratinocytes exposed to TiO(2)-NPs. Investigating chemical elemental ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2010.502979
更新日期:2011-06-01 00:00:00
abstract::This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435391003690549
更新日期:2010-09-01 00:00:00
abstract::Boron and boron nitride nanotubes (BNNTs) are increasingly used in different industrial fields and, potentially, in some biomedical areas. As occurs with other nanomaterials (NMs), to increase our knowledge on their potential health hazards is a priority. Although in vitro approaches are a routine in getting biologica...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1482379
更新日期:2018-10-01 00:00:00
abstract::No detailed information on in vivo biokinetics of CeO2 nanoparticles (NPs) following chronic low-dose inhalation is available. The CeO2 burden for lung, lung-associated lymph nodes, and major non-pulmonary organs, blood, and feces, was determined in a chronic whole-body inhalation study in female Wistar rats undertake...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1736355
更新日期:2020-05-01 00:00:00
abstract::The levels of exposure and internal doses of nanomaterials are becoming more and more important for estimating the health effects resulting from exposure to nanomaterials. Health surveillance can be used as an indicator of whether exposure is occurring, rather than in determining if levels of exposure are safe. We hav...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.600840
更新日期:2012-09-01 00:00:00
abstract::We aimed to create transgenic (Tg) mice engineered for magnetic resonance imaging (MRI). To ascertain if MagA expression contributes to oxidative stress and iron metabolism, we report the generation of Tg mice in which ubiquitous expression of MagA can be detected by MRI in vivo. Expression of MagA in diverse tissues ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1090029
更新日期:2016-01-01 00:00:00
abstract::The influence of size, surface charge and surface functionality of poly(amido amine) dendrimers and silica nanoparticles (SNPs) on their toxicity was studied in immunocompetent mice. After systematic characterization of nanoparticles, they were administered to CD-1 (caesarean derived-1) mice to evaluate acute toxicity...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.604442
更新日期:2012-11-01 00:00:00
abstract::Cellular adaptation is the dynamic response of a cell to adverse changes in its intra/extra cellular environment. The aims of this study were to investigate the role of: (i) the glutathione antioxidant system, and (ii) the transcription factor EB (TFEB), a newly revealed master regulator of lysosome biogenesis, in cel...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.572195
更新日期:2012-05-01 00:00:00
abstract::To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration sin...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.822116
更新日期:2014-09-01 00:00:00
abstract::Multi-walled carbon nanotubes (MWCNTs) are one of the most widely used types of novel nano-fiber materials. The aim of this study was to establish an experimental system based on actual exposure dosage and environments and explore the roles and mechanisms of inflammation in the malignant transformation of pleural meso...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1777477
更新日期:2020-09-01 00:00:00
abstract::With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human and environmental exposures to silver nanoparticles are inevitably increasing. In particular, persons manufacturing and handling silver nanoparticles and silver nanoparticle containing products are at risk of exposure, p...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2016.1148793
更新日期:2016-09-01 00:00:00
abstract::The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that w...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.779757
更新日期:2014-05-01 00:00:00
abstract::Iron nanoparticles (NPs) have been proposed as a tool in very different fields such as environmental remediation and biomedical applications, including food fortification against iron deficiency, even if there is still concern about their safety. Here, we propose Xenopus laevis embryos as a suitable model to investiga...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1685695
更新日期:2020-03-01 00:00:00
abstract::Copper oxide nanoparticles (CuO NPs) have severe nano-toxic effects on organisms. Limited data is available on influence of CuO NPs on plant cells. Here, the molecular mechanisms involved in the toxicity of CuO NPs are studied. Exposure to CuO NPs significantly increased copper content in roots (0.062-0.325 mg/g FW), ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1678693
更新日期:2020-02-01 00:00:00
abstract::The effect of non-functionalized and amino-functionalized multiwall carbon nanotube (CNT) exposure, as well as the impact of CNT presence on coexistent pesticide accumulation, was investigated in lettuce (Lactuca sativa L.). Lettuce seeds were sown directly into CNT-amended vermiculite (1000 mg L(-1)) to monitor phyto...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.907456
更新日期:2015-03-01 00:00:00
abstract::Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential orga...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1498551
更新日期:2018-10-01 00:00:00
abstract::Titanium-dioxide nanoparticles (TiO2-NPs) are increasingly released in agricultural soils through, e.g. biosolids, irrigation or nanoagrochemicals. Soils are submitted to a wide range of concentrations of TiO2-NPs depending on the type of exposure. However, most studies have assessed the effects of unrealistically hig...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1290845
更新日期:2017-03-01 00:00:00
abstract::In the present study, ZnS and ZnO quantum dots (QDs) were synthesized via an all-aqueous process with polyethylene glycol (PEG) chains on their surface, and their toxicity as well as biodistribution were evaluated. No haemolysis occurred at a high concentration of 1600 µg/mL in vitro haemolytic assay, which demonstrat...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.760014
更新日期:2014-02-01 00:00:00
abstract::Graphene, a two-dimensional engineered nanomaterial, is now being used in many applications, such as electronics, biological engineering, filtration, lightweight and strong nanocomposite materials, and energy storage. However, there is a lack of information on the potential health effects of graphene in humans based o...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1133865
更新日期:2016-09-01 00:00:00